{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:52:53Z","timestamp":1780372373727,"version":"3.54.1"},"reference-count":29,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p>Primary ovarian insufficiency (POI) resulting from ovarian autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of the autoimmune response and induction of ovarian-specific tolerance would allow development of focused therapies to preserve fertility in an at-risk population. MATER (maternal antigen that embryos require) is a known ovarian autoantigen targeted in autoimmune syndromes of POI. We attempt to induce ovarian-specific tolerance via transgenic expression of the MATER antigen on potentially tolerogenic antigen-presenting cells (APC), which typically present antigen via the major histocompatibility complex (MHC) class II molecule. We hypothesize that expression of MATER in a MHC class II-dependent manner on APC can mediate induction of ovarian tolerance.<\/jats:p><jats:p>We utilized a well-characterized murine model of ovarian autoimmunity, whereby oophoritis develops after d 3 neonatal thymectomy (NTx). Wild-type and transgenic mice, carrying an MHC Class II-driven Mater gene (IE-Mater), were subjected to NTx and assessed for evidence of autoimmune oophoritis. After disease induction by NTx, female mice carrying the IE-Mater transgene had significant reductions in histological oophoritis (56%) and circulating ovarian autoantibodies (28%) compared with wild-type females (94% and 82%, respectively). Incidence of other autoimmunity was unaffected as assessed by antinuclear autoantibodies. Transgenic expression of MATER in APC can induce antigen-specific tolerance with a significant reduction in ovarian autoimmunity. Lack of complete disease protection suggests that other antigens may also play a role in autoimmune oophoritis. As a known autoantigen in the human APS1 (autoimmune polyglandular syndrome type 1), which is associated with POI, MATER may represent a relevant target for future diagnostic and therapeutic clinical interventions.<\/jats:p>","DOI":"10.1210\/en.2011-0022","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T02:10:23Z","timestamp":1301451023000},"page":"2465-2473","source":"Crossref","is-referenced-by-count":22,"title":["Autoimmune Oophoritis with Multiple Molecular Targets Mitigated by Transgenic Expression of Mater"],"prefix":"10.1210","volume":"152","author":[{"given":"Noriyuki","family":"Otsuka","sequence":"first","affiliation":[{"name":"Integrative Reproductive Medicine Group (N.O., Z.-B.T., K.V., W.T., L.M.N.), Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Bin","family":"Tong","sequence":"first","affiliation":[{"name":"Integrative Reproductive Medicine Group (N.O., Z.-B.T., K.V., W.T., L.M.N.), Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Vanevski","sequence":"first","affiliation":[{"name":"Integrative Reproductive Medicine Group (N.O., Z.-B.T., K.V., W.T., L.M.N.), Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tu","sequence":"first","affiliation":[{"name":"Integrative Reproductive Medicine Group (N.O., Z.-B.T., K.V., W.T., L.M.N.), Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mickie H.","family":"Cheng","sequence":"first","affiliation":[{"name":"University of California, San Francisco Diabetes Center (M.H.C.), San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence M.","family":"Nelson","sequence":"first","affiliation":[{"name":"Integrative Reproductive Medicine Group (N.O., Z.-B.T., K.V., W.T., L.M.N.), Intramural Research Program on Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"2020071612352708500_B1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2265.2007.03073.x","article-title":"Primary ovarian insufficiency: a more accurate term for premature ovarian failure.","volume":"68","author":"Welt","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071612352708500_B2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMcp0808697","article-title":"Clinical practice. 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