{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:36:43Z","timestamp":1773419803627,"version":"3.50.1"},"reference-count":45,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"abstract":"<jats:p>Vitamin D exerts important regulatory effects on the endocrine and immune systems. Autoimmune type 1 diabetes (T1D) development in the inbred NOD mouse strain can be accelerated by vitamin D insufficiency or suppressed by chronic treatment with high levels of 1\u03b1,25-dihydroxyvitamin D3. Consequently, a report that T1D development was unaffected in NOD mice genetically lacking the vitamin D receptor (VDR) was unexpected. To further assess this result, the mutant stock was imported to The Jackson Laboratory, backcrossed once to NOD\/ShiLtJ, and progeny rederived through embryo transfer. VDR-deficient NOD mice of both sexes showed significant acceleration of T1D. This acceleration was not associated with alterations in immune cells targeting pancreatic \u03b2-cells. Rather, the capacity of \u03b2-cells to produce and\/or secrete insulin was severely impaired by the hypocalcaemia developing in VDR-deficient NOD mice fed a standard rodent chow diet. Feeding a high-lactose calcium rescue diet that circumvents a VDR requirement for calcium absorption from the intestine normalized serum calcium levels, restored \u03b2-cell insulin secretion, corrected glucose intolerance, and eliminated accelerated T1D in VDR-deficient NOD mice. These findings suggest that calcium and\/or vitamin D supplementation may improve disease outcomes in some T1D-prone individuals that are calcium deficient.<\/jats:p>","DOI":"10.1210\/en.2011-1074","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T05:20:05Z","timestamp":1317187205000},"page":"4620-4629","source":"Crossref","is-referenced-by-count":13,"title":["Calcium Insufficiency Accelerates Type 1 Diabetes in Vitamin D Receptor-Deficient Nonobese Diabetic (NOD) Mice"],"prefix":"10.1210","volume":"152","author":[{"given":"John P.","family":"Driver","sequence":"first","affiliation":[{"name":"The Jackson Laboratory (J.P.D., D.J.L., D.V.S.), Bar Harbor, Maine 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna J.","family":"Lamont","sequence":"first","affiliation":[{"name":"The Jackson Laboratory (J.P.D., D.J.L., D.V.S.), Bar Harbor, Maine 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