{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:08:40Z","timestamp":1791349720001,"version":"4.3.1"},"reference-count":48,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:p>Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)\u03b1 (RARA), RAR\u03b2, and RAR\u03b3 (RARG). Here, we show that 1) RARG is expressed by A aligned (Aal) spermatogonia, as well as during the transition from Aal to A1 spermatogonia, which is known to require RA; and 2) ablation of Rarg, either in the whole mouse or specifically in spermatogonia, does not affect meiosis and spermiogenesis but impairs the Aal to A1 transition in the course of some of the seminiferous epithelium cycles. Upon ageing, this phenomenon yields seminiferous tubules containing only spermatogonia and Sertoli cells. Altogether, our findings indicate that RARG cell-autonomously transduces, in undifferentiated spermatogonia of adult testes, a RA signal critical for spermatogenesis. During the prepubertal spermatogenic wave, the loss of RARG function can however be compensated by RARA, as indicated by the normal timing of appearance of meiotic cells in Rarg-null testes. Accordingly, RARG- and RARA-selective agonists are both able to stimulate Stra8 expression in wild-type prepubertal testes. Interestingly, inactivation of Rarg does not impair expression of the spermatogonia differentiation markers Kit and Stra8, contrary to vitamin A deficiency. This latter observation supports the notion that the RA-signaling pathway previously shown to operate in Sertoli cells also participates in spermatogonia differentiation.<\/jats:p>","DOI":"10.1210\/en.2011-1102","type":"journal-article","created":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T22:51:08Z","timestamp":1320187868000},"page":"438-449","source":"Crossref","is-referenced-by-count":134,"title":["Spermatogonia Differentiation Requires Retinoic Acid Receptor \u03b3"],"prefix":"10.1210","volume":"153","author":[{"given":"Aurore","family":"Gely-Pernot","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Raverdeau","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"C\u00e9l\u00e9bi","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"},{"name":"Facult\u00e9 de M\u00e9decine et Centre Hospitalier Universitaire (C.C., M.M.), 67091 Strasbourg, Cedex France; Division of Germ Cell Biology, National Institute of Basic Biology, and Department of Basic Biology, SOKENDAI 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dennefeld","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Feret","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Klopfenstein","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shosei","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert B.","family":"Ghyselinck","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mark","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (A.G-P., M.R., C.C., C.D., B.F., M.K., N.B.G., M.M.), Institut National de Sant\u00e9 et de Recherche M\u00e9dicale Unit\u00e9 964, Centre National de Recherche Scientifique Unit\u00e9 Mixte de Recherche 7104, Universit\u00e9 de Strasbourg, 67404 Illkirch, France"},{"name":"Facult\u00e9 de M\u00e9decine et Centre Hospitalier Universitaire (C.C., M.M.), 67091 Strasbourg, Cedex France; Division of Germ Cell Biology, National Institute of Basic Biology, and 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