{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:35:32Z","timestamp":1790523332187,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":1788,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/us\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"abstract":"<jats:p>Glucocorticoids profoundly influence immune responses, and synthetic glucocorticoids are widely used clinically for their potent antiinflammatory effects. Endogenous glucocorticoid action is modulated by the two isozymes of 11\u03b2-hydroxysteroid dehydrogenase (11\u03b2-HSD). In vivo, 11\u03b2-HSD1 catalyzes the reduction of inactive cortisone or 11-dehydrocorticosterone into active cortisol or corticosterone, respectively, thereby increasing intracellular glucocorticoid levels. 11\u03b2-HSD2 catalyzes the reverse reaction, inactivating intracellular glucocorticoids. Both enzymes have been postulated to modulate inflammatory responses. In the K\/BxN serum transfer model of arthritis, 11\u03b2-HSD1-deficient mice showed earlier onset and slower resolution of inflammation than wild-type controls, with greater exostoses in periarticular bone and, uniquely, ganglion cysts, consistent with greater inflammation. In contrast, K\/BxN serum arthritis was unaffected by 11\u03b2-HSD2 deficiency. In a distinct model of inflammation, thioglycollate-induced sterile peritonitis, 11\u03b2-HSD1-deficient mice had more inflammatory cells in the peritoneum, but again 11\u03b2-HSD2-deficient mice did not differ from controls. Additionally, compared with control mice, 11\u03b2-HSD1-deficient mice showed greater numbers of inflammatory cells in pleural lavages in carrageenan-induced pleurisy with lung pathology consistent with slower resolution. These data suggest that 11\u03b2-HSD1 limits acute inflammation. In contrast, 11\u03b2-HSD2 plays no role in acute inflammatory responses in mice. Regulation of local 11\u03b2-HSD1 expression and\/or delivery of substrate may afford a novel approach for antiinflammatory therapy.<\/jats:p>","DOI":"10.1210\/en.2011-1398","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T07:45:20Z","timestamp":1320824720000},"page":"234-240","source":"Crossref","is-referenced-by-count":83,"title":["11\u03b2-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice"],"prefix":"10.1210","volume":"153","author":[{"given":"Agnes E.","family":"Coutinho","sequence":"first","affiliation":[{"name":"Centre for Cardiovascular Sciences (A.E.C., J.S.G., J.R.S., K.E.C.), dinburgh EH16 4TJ, United Kingdom"},{"name":"Centre for Inflammation Research (A.E.C., M.G., D.M.S., D.A.S., S.C., J.S.G., J.S.S.), dinburgh EH16 4TJ, United 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