{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:38:48Z","timestamp":1791427128290,"version":"4.3.3"},"reference-count":72,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:p>The present study examined the effects in mice of exposure to di(2-ethyl-hexyl) phthalate (DEHP) throughout pregnancy and lactation on the development and function of the pituitary-gonadal axis in male and female offspring once they have attained adulthood. Groups of two to three dams were exposed with the diet from gestational d 0.5 until the end of lactation, at 0, 0.05, 5, and 500 mg DEHP\/kg \u00b7 d. The experiment was repeated three times (total: seven to 10 dams per treatment). The 500-mg dose caused complete pregnancy failure, whereas exposure to doses of 0.05 and 5 mg did not affect pregnancy and litter size. In total, about 30 male and 30 female offspring per group were analyzed. Offspring of the DEHP-treated groups, compared with controls, at sexual maturity showed: 1) lower body weight (decrease 20\u201325%, P &amp;lt; 0.001); 2) altered gonad weight (testes were \u223c13% lighter and ovaries \u223c40% heavier; P &amp;lt; 0.001); 3) poor germ cell quality (semen was \u223c50% less concentrated and 20% less viable, and \u223c10% fewer oocytes reached MII stage, P &amp;lt; 0.001); 4) significant lower expression of steroidogenesis and gonadotropin-receptor genes in the gonads; and 5) up-regulated gonadotropin subunit gene expression in the pituitary. In conclusion, our findings suggest that, in maternally exposed male and female mice, DEHP acts on multiple pathways involved in maintaining steroid homeostasis. Specifically, in utero and lactational DEHP exposure may alter estrogen synthesis in both sexes. This, in turn, induces dysregulation of pituitary-gonadal feedback and alters the reproductive performance of exposed animals.<\/jats:p>","DOI":"10.1210\/en.2011-1450","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T04:40:22Z","timestamp":1323232822000},"page":"937-948","source":"Crossref","is-referenced-by-count":122,"title":["Exposure to Di(2-ethyl-hexyl) phthalate (DEHP) in Utero and during Lactation Causes Long-Term Pituitary-Gonadal Axis Disruption in Male and Female Mouse Offspring"],"prefix":"10.1210","volume":"153","author":[{"given":"Paola","family":"Pocar","sequence":"first","affiliation":[{"name":"Dipartimento di Patologia Animale, Igiene e Sanit\u00e0 Pubblica Veterinaria (P.P., N.F., C.S., A.B., V.B.), Facolt\u00e0 di Medicina Veterinaria, Universit\u00e0 degli Studi di Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Fiandanese","sequence":"first","affiliation":[{"name":"Dipartimento di 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Final Report NTP-84\u2013079","author":"National Toxicology Program","year":"1984"},{"key":"2020071612295546400_B40","first-page":"1","article-title":"NTP technical report on the toxicity studies of dibutyl phthalate (CAS No. 84\u201374-2) administered in feed to F344\/N rats and B6C3F1 mice.","volume":"30","author":"Marsman","year":"1995","journal-title":"Toxic Rep Ser"},{"key":"2020071612295546400_B41","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jpeds.2009.04.007","article-title":"Phthalate levels and low birth weight: a nested case-control study of Chinese newborns.","volume":"155","author":"Zhang","year":"2009","journal-title":"J Pediatr"},{"key":"2020071612295546400_B42","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1203\/00006450-199712000-00029","article-title":"Low birth weight and subsequent male subfertility.","volume":"42","author":"Francois","year":"1997","journal-title":"Pediatr Res"},{"key":"2020071612295546400_B43","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1210\/jcem.83.10.5205","article-title":"Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth.","volume":"83","author":"Ib\u00e1\u00f1ez","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612295546400_B44","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1742-7843.2007.00180.x","article-title":"Endocrine disruptors and abnormalities of pubertal development.","volume":"102","author":"Schoeters","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2020071612295546400_B45","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2004.11.013","article-title":"Evaluation of anti-androgenic activity of 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suckling in the Long-Evans rat.","volume":"36","author":"Arcadi","year":"1998","journal-title":"Food Chem Toxicol"},{"key":"2020071612295546400_B49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.toxlet.2003.09.012","article-title":"Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis.","volume":"146","author":"Wilson","year":"2004","journal-title":"Toxicol Lett"},{"key":"2020071612295546400_B50","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.tiv.2008.12.017","article-title":"Effects of selected endocrine disruptors on meiotic maturation, cumulus expansion, synthesis of hyaluronan and progesterone by porcine oocyte-cumulus complexes.","volume":"23","author":"Mlynarcikov\u00e1","year":"2009","journal-title":"Toxicol In Vitro"},{"key":"2020071612295546400_B51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/biof.5520330207","article-title":"Effect of mono-(2-ethylhexyl) 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of DEHP (di-2-ethyl hexyl-phthalate) on resumption of meiosis and in-vitro maturation of mouse oocytes and development of resulting embryos.","volume":"7","author":"Eimani","year":"2005","journal-title":"Yakhteh Med J"},{"key":"2020071612295546400_B55","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.taap.2009.05.022","article-title":"Effect of mono-(2-ethylhexyl) phthalate on steroid production of human granulosa cells.","volume":"239","author":"Reinsberg","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"2020071612295546400_B56","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.taap.2009.10.011","article-title":"Di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate inhibit growth and reduce estradiol levels of antral follicles in vitro.","volume":"242","author":"Gupta","year":"2010","journal-title":"Toxicol Appl 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