{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:43:55Z","timestamp":1788835435375,"version":"build-2803163510"},"reference-count":58,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,1,1]]},"DOI":"10.1210\/en.2011-1572","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T03:05:57Z","timestamp":1319598357000},"page":"522-534","source":"Crossref","is-referenced-by-count":38,"title":["CDH16\/Ksp-Cadherin Is Expressed in the Developing Thyroid Gland and Is Strongly Down-Regulated in Thyroid Carcinomas"],"prefix":"10.1210","volume":"153","author":[{"given":"Gaetano","family":"Cal\u00ec","sequence":"first","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (G.Ca., F.G., P.P., A.Fu.), 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaviana","family":"Gentile","sequence":"additional","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (G.Ca., F.G., P.P., A.Fu.), 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mogavero","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Patologia Cellulare e Molecolare (S.M., R.N., L.N.), 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierlorenzo","family":"Pallante","sequence":"additional","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (G.Ca., F.G., P.P., A.Fu.), 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Nitsch","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Patologia Cellulare e Molecolare (S.M., R.N., L.N.), 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ciancia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomorfologiche e Funzionali (G.Ci.), University Federico II, 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Centro Ingegneria Genetica (A.Fe.), Biotecnologie Avanzate, 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Fusco","sequence":"additional","affiliation":[{"name":"Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (G.Ca., F.G., P.P., A.Fu.), 80131 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Nitsch","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia e Patologia Cellulare e Molecolare (S.M., R.N., L.N.), 80145 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041118223697600_B1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0092-8674(00)81279-9","article-title":"Cell adhesion: the molecular basis of tissue architecture and morphogenesis.","volume":"84","author":"Gumbiner","year":"1996","journal-title":"Cell"},{"key":"2019041118223697600_B2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/(SICI)1521-1878(199903)21:3<211::AID-BIES5>3.0.CO;2-P","article-title":"Cadherins and tissue formation: integrating adhesion and signaling.","volume":"21","author":"Vleminckx","year":"1999","journal-title":"Bioessays"},{"key":"2019041118223697600_B3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.biocel.2008.09.027","article-title":"Molecular evolution of the cadherin superfamily.","volume":"41","author":"Hulpiau","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"2019041118223697600_B4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1242\/jcs.114.4.629","article-title":"The cadherin superfamily: diversity in form and function.","volume":"114","author":"Angst","year":"2001","journal-title":"J Cell Sci"},{"key":"2019041118223697600_B5","first-page":"4987","article-title":"E-cadherin: a differentiation marker in thyroid malignancies.","volume":"53","author":"Brabant","year":"1993","journal-title":"Cancer Res"},{"key":"2019041118223697600_B6","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1210\/en.2003-0393","article-title":"Expression of classical cadherins in thyroid development: maintenance of an epithelial phenotype throughout organogenesis.","volume":"144","author":"Fagman","year":"2003","journal-title":"Endocrinology"},{"key":"2019041118223697600_B7","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1210\/en.2006-1344","article-title":"Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation.","volume":"148","author":"Cal\u00ec","year":"2007","journal-title":"Endocrinology"},{"key":"2019041118223697600_B8","doi-asserted-by":"crossref","first-page":"17594","DOI":"10.1074\/jbc.270.29.17594","article-title":"Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family.","volume":"270","author":"Thomson","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041118223697600_B9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1749-6632.2000.tb05236.x","article-title":"Intestinal cell adhesion molecules. Liver-intestine cadherin.","volume":"915","author":"Gessner","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"2019041118223697600_B10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jmb.2008.02.008","article-title":"\u03b1 B-crystallin is a cytoplasmic interaction partner of the kidney-specific cadherin-16.","volume":"378","author":"Thedieck","year":"2008","journal-title":"J Mol Biol"},{"key":"2019041118223697600_B11","first-page":"F146","article-title":"Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney.","volume":"277","author":"Thomson","year":"1999","journal-title":"Am J Physiol"},{"key":"2019041118223697600_B12","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1038\/sj.bjc.6602597","article-title":"Expression of Ksp-cadherin during kidney development and in renal cell carcinoma.","volume":"92","author":"Thedieck","year":"2005","journal-title":"Br J Cancer"},{"key":"2019041118223697600_B13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/geno.1998.5402","article-title":"cDNA cloning and chromosomal localization of the human and mouse isoforms of Ksp-cadherin.","volume":"51","author":"Thomson","year":"1998","journal-title":"Genomics"},{"key":"2019041118223697600_B14","first-page":"F599","article-title":"Ksp-cadherin gene promoter. II. Kidney-specific activity in transgenic mice.","volume":"277","author":"Igarashi","year":"1999","journal-title":"Am J Physiol"},{"key":"2019041118223697600_B15","first-page":"F587","article-title":"Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity.","volume":"277","author":"Whyte","year":"1999","journal-title":"Am J Physiol"},{"key":"2019041118223697600_B16","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1097\/01.ASN.0000016443.50138.CD","article-title":"A minimal Ksp-cadherin promoter linked to a green fluorescent protein reporter gene exhibits tissue-specific expression in the developing kidney and genitourinary tract.","volume":"13","author":"Shao","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"2019041118223697600_B17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.yexcr.2003.11.022","article-title":"Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin.","volume":"294","author":"Wendeler","year":"2004","journal-title":"Exp Cell Res"},{"key":"2019041118223697600_B18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0925-4773(99)00074-X","article-title":"Kidney-specific cadherin (cdh16) is expressed in embryonic kidney, lung, and sex ducts.","volume":"84","author":"Wertz","year":"1999","journal-title":"Mech Dev"},{"key":"2019041118223697600_B19","first-page":"11","article-title":"Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness.","volume":"1198","author":"Birchmeier","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"2019041118223697600_B20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0968-0004(98)01343-7","article-title":"The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene.","volume":"24","author":"Christofori","year":"1999","journal-title":"Trends Biochem Sci"},{"key":"2019041118223697600_B21","doi-asserted-by":"crossref","first-page":"a003129","DOI":"10.1101\/cshperspect.a003129","article-title":"Involvement of members of the cadherin superfamily in cancer.","volume":"1","author":"Berx","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2019041118223697600_B22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-540-68170-0_4","article-title":"Cadherins in cancer.","volume":"165","author":"Strumane","year":"2004","journal-title":"Handb Exp Pharmacol"},{"key":"2019041118223697600_B23","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin.","volume":"65","author":"van Roy","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"2019041118223697600_B24","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/1097-0142(19890301)63:5<908::AID-CNCR2820630520>3.0.CO;2-I","article-title":"The WHO histological classification of thyroid tumors: a commentary on the second edition.","volume":"63","author":"Hedinger","year":"1989","journal-title":"Cancer"},{"key":"2019041118223697600_B25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000185458","article-title":"Origin and progression of thyroid epithelial tumours: cellular and molecular mechanisms.","volume":"47","author":"Wynford-Thomas","year":"1997","journal-title":"Horm Res"},{"key":"2019041118223697600_B26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/jnci\/88.7.442","article-title":"Changes in integrin and E-cadherin expression in neoplastic versus normal thyroid tissue.","volume":"88","author":"Serini","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"2019041118223697600_B27","first-page":"54","article-title":"E-cadherin adhesion molecule and syndecan-1 expression in various thyroid pathologies.","volume":"29","author":"Mitselou","year":"2007","journal-title":"Exp Oncol"},{"key":"2019041118223697600_B28","first-page":"2168","article-title":"Clinical significance of E-cadherin as a prognostic marker in thyroid carcinomas.","volume":"80","author":"Scheumman","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041118223697600_B29","first-page":"2501","article-title":"Immunohistochemical detection of E-cadherin in differentiated thyroid carcinomas correlates with clinical outcome.","volume":"57","author":"von Wasielewski","year":"1997","journal-title":"Cancer Res"},{"key":"2019041118223697600_B30","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/modpathol.3800373","article-title":"Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms.","volume":"18","author":"Shen","year":"2005","journal-title":"Mod Pathol"},{"key":"2019041118223697600_B31","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/edrv.22.5.0444","article-title":"Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models.","volume":"22","author":"Kimura","year":"2001","journal-title":"Endocr Rev"},{"key":"2019041118223697600_B32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1677\/joe.0.1720163","article-title":"Hormonal control of the transcription factor Pax8 and its role in the regulation of thyroglobulin gene expression in thyroid cells.","volume":"172","author":"Mascia","year":"2002","journal-title":"J Endocrinol"},{"key":"2019041118223697600_B33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0167-4781(97)00127-9","article-title":"Transfection of TTF-1 gene induces thyroglobulin gene expression in undifferentiated FRT cells.","volume":"1354","author":"Mascia","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"2019041118223697600_B34","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1210\/endo-123-4-2067","article-title":"HLA-DR gene expression in a proliferating human thyroid cell clone (12S).","volume":"123","author":"Cone","year":"1988","journal-title":"Endocrinology"},{"key":"2019041118223697600_B35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.yexcr.2004.01.010","article-title":"The neuroendocrine protein VGF is sorted into dense-core granules and is secreted apically by polarized rat thyroid epithelial cells.","volume":"295","author":"Gentile","year":"2004","journal-title":"Exp Cell Res"},{"key":"2019041118223697600_B36","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.bjc.6602721","article-title":"UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas.","volume":"93","author":"Pallante","year":"2005","journal-title":"Br J Cancer"},{"key":"2019041118223697600_B37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0304-4157(93)90017-I","article-title":"Iodide transport in the thyroid gland.","volume":"1154","author":"Carrasco","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"2019041118223697600_B38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF00226141","article-title":"The epithelial tight junction: structure, function and preliminary biochemical characterization.","volume":"83","author":"Stevenson","year":"1988","journal-title":"Mol Cell Biochem"},{"key":"2019041118223697600_B39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1210\/er.2001-0029","article-title":"The sodium\/iodide symporter (NIS): characterization, regulation, and medical significance.","volume":"24","author":"Doh\u00e1n","year":"2003","journal-title":"Endocr Rev"},{"key":"2019041118223697600_B40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0167-4781(94)90176-7","article-title":"Thyroid-specific gene expression.","volume":"1218","author":"Damante","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"2019041118223697600_B41","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1210\/endo-122-1-127","article-title":"Adenosine 3\u2032,5\u2032-monophosphate mediates both the mitogenic effect of thyrotropin and its ability to amplify the response to insulin-like growth factor I in FRTL5 cells.","volume":"122","author":"Tramontano","year":"1988","journal-title":"Endocrinology"},{"key":"2019041118223697600_B42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0079-6603(00)66033-6","article-title":"A unique combination of transcription factors controls differentiation of thyroid cells.","volume":"66","author":"Damante","year":"2001","journal-title":"Prog Nucleic Acids Res Mol Biol"},{"key":"2019041118223697600_B43","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2121-10-94","article-title":"Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway.","volume":"10","author":"Das","year":"2009","journal-title":"BMC Cell Biol"},{"key":"2019041118223697600_B44","first-page":"281","article-title":"Transforming growth factor-\u03b2 induces cytoskeleton and extracellular matrix modifications in FRTL-5 thyroid epithelial cells.","volume":"53","author":"Garbi","year":"1990","journal-title":"Eur J Cell Biol"},{"key":"2019041118223697600_B45","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1128\/MCB.9.3.1083","article-title":"Expression of the murine \u03b1 B-crystallin gene is not restricted to the lens.","volume":"9","author":"Dubin","year":"1989","journal-title":"Mol Cell Biol"},{"key":"2019041118223697600_B46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/38.1.2294148","article-title":"Cellular distribution of \u03b1 B-crystallin in non-lenticular tissues.","volume":"38","author":"Iwaki","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"2019041118223697600_B47","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1083\/jcb.120.3.639","article-title":"Expression of the murine small heat shock proteins hsp 25 and \u03b1 B crystallin in the absence of stress.","volume":"120","author":"Klemenz","year":"1993","journal-title":"J Cell Biol"},{"key":"2019041118223697600_B48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1379\/CSC-107R.1","article-title":"Differential expression of \u03b1B-crystallin and Hsp27\u20131 in anaplastic thyroid carcinomas because of tumor-specific \u03b1B-crystallin gene (CRYAB) silencing.","volume":"10","author":"Mineva","year":"2005","journal-title":"Cell Stress Chaperones"},{"key":"2019041118223697600_B49","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/dvdy.1146","article-title":"LI-cadherin gene expression during mouse intestinal development.","volume":"221","author":"Angres","year":"2001","journal-title":"Dev Dyn"},{"key":"2019041118223697600_B50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jmb.2008.02.023","article-title":"Heterotypic trans-interaction of LI- and E-cadherin and their localization in plasmalemmal microdomains.","volume":"378","author":"Baumgartner","year":"2008","journal-title":"J Mol Biol"},{"key":"2019041118223697600_B51","doi-asserted-by":"crossref","first-page":"e1880","DOI":"10.1371\/journal.pone.0001880","article-title":"Physiology, pathology and relatedness of human tissues from gene expression meta-analysis.","volume":"3","author":"Greco","year":"2008","journal-title":"PLoS One"},{"key":"2019041118223697600_B52","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1210\/endo.136.7.7789339","article-title":"Regulation of the cell-cell adhesion protein, E-cadherin, in dog and human thyrocytes in vitro.","volume":"136","author":"Brabant","year":"1995","journal-title":"Endocrinology"},{"key":"2019041118223697600_B53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/bies.950170203","article-title":"E-cadherin as a tumor (invasion) suppressor gene.","volume":"17","author":"Birchmeier","year":"1995","journal-title":"Bioessays"},{"key":"2019041118223697600_B54","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/105072502760339343","article-title":"Follicular growth of a thyroid carcinoma cell line (KAT-4) with abnormal E-cadherin and impaired epithelial barrier.","volume":"12","author":"Husmark","year":"2002","journal-title":"Thyroid"},{"key":"2019041118223697600_B55","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.1038\/sj.onc.1210588","article-title":"Gene expression and the biological phenotype of papillary thyroid carcinomas.","volume":"26","author":"Delys","year":"2007","journal-title":"Oncogene"},{"key":"2019041118223697600_B56","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1073\/pnas.0610733104","article-title":"Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion.","volume":"104","author":"Vasko","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041118223697600_B57","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s10585-007-9104-8","article-title":"Soluble cadherins as cancer biomarkers.","volume":"24","author":"De Wever","year":"2007","journal-title":"Clin Exp Metastasis"},{"key":"2019041118223697600_B58","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/eje.0.1510367","article-title":"PAX8 and peroxisome proliferator-activated receptor \u03b3 1 gene expression status in benign and malignant thyroid tissues.","volume":"151","author":"Lacroix","year":"2004","journal-title":"Eur J Endocrinol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/153\/1\/522\/10389376\/endo0522.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T16:35:02Z","timestamp":1639326902000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/153\/1\/522\/2424516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2011-1572","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,1]]}}}