{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:48:15Z","timestamp":1791038895601,"version":"4.1.0"},"reference-count":68,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:p>Thyroid hormone (T3) plays an important role in regulating multiple cellular and metabolic processes, including cell proliferation, cell death, and energy metabolism, in vertebrates. Dysregulation of T3 signaling results in developmental abnormalities, metabolic defects, and even cancer. We used T3-dependent Xenopus metamorphosis as a model to study how T3 regulates transcription during vertebrate development. T3 exerts its metamorphic effects through T3 receptors (TR). TR recruits, in a T3-dependent manner, cofactor complexes that can carry out chromatin remodeling\/histone modifications. Whether and how histone modifications change upon gene regulation by TR during vertebrate development is largely unknown. Here we analyzed histone modifications at T3 target genes during intestinal metamorphosis, a process that involves essentially total apoptotic degeneration of the simple larval epithelium and de novo development of the adult epithelial stem cells, followed by their proliferation and differentiation into the complex adult epithelium. We demonstrated for the first time in vivo during vertebrate development that TR induces the removal of core histones at the promoter region and the recruitment of RNA polymerase. Furthermore, a number of histone activation and repression marks have been defined based on correlations with mRNA levels in cell cultures. Most but not all correlate with gene expression induced by liganded TR during development, suggesting that tissue and developmental context influences the roles of histone modifications in gene regulation. Our findings provide important mechanistic insights on how chromatin remodeling affects developmental gene regulation in vivo.<\/jats:p>","DOI":"10.1210\/en.2011-1736","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T04:40:22Z","timestamp":1323232822000},"page":"961-972","source":"Crossref","is-referenced-by-count":44,"title":["Liganded Thyroid Hormone Receptor Induces Nucleosome Removal and Histone Modifications to Activate Transcription during Larval Intestinal Cell Death and Adult Stem Cell Development"],"prefix":"10.1210","volume":"153","author":[{"given":"Kazuo","family":"Matsuura","sequence":"first","affiliation":[{"name":"Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liezhen","family":"Fu","sequence":"first","affiliation":[{"name":"Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Bo","family":"Shi","sequence":"first","affiliation":[{"name":"Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612325380900_B1","first-page":"184","article-title":"Thyroid hormone receptors: multiple forms, multiple possibilities.","volume":"14","author":"Lazar","year":"1993","journal-title":"Endocr Rev"},{"key":"2020071612325380900_B2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","article-title":"Physiological and molecular basis of thyroid hormone action.","volume":"81","author":"Yen","year":"2001","journal-title":"Physiol Rev"},{"key":"2020071612325380900_B3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/bies.950150404","article-title":"Gene expression during metamorphosis: an ideal model for post-embryonic development.","volume":"15","author":"Tata","year":"1993","journal-title":"Bioessays"},{"key":"2020071612325380900_B4","article-title":"Amphibian metamorphosis: from morphology to molecular biology","author":"Shi","year":"1999"},{"key":"2020071612325380900_B5","article-title":"The story of iodine deficiency: an international challenge in nutrition","author":"Hetzel","year":"1989"},{"key":"2020071612325380900_B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ygcen.2005.07.009","article-title":"Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog.","volume":"145","author":"Buchholz","year":"2006","journal-title":"Gen Comp Endocrinol"},{"key":"2020071612325380900_B7","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1210\/en.2008-0751","article-title":"Developmental regulation and function of thyroid hormone receptors and 9-cis retinoic acid receptors during Xenopus tropicalis metamorphosis.","volume":"149","author":"Wang","year":"2008","journal-title":"Endocrinology"},{"key":"2020071612325380900_B8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1089\/thy.2009.0041","article-title":"Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes.","volume":"19","author":"Shi","year":"2009","journal-title":"Thyroid"},{"key":"2020071612325380900_B9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/dvdy.10300","article-title":"Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis.","volume":"227","author":"Nakajima","year":"2003","journal-title":"Dev Dyn"},{"key":"2020071612325380900_B10","doi-asserted-by":"crossref","first-page":"10739","DOI":"10.1073\/pnas.191361698","article-title":"Diverse developmental programs of Xenopus laevis metamorphosis are inhibited by a dominant negative thyroid hormone receptor.","volume":"98","author":"Schreiber","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612325380900_B11","doi-asserted-by":"crossref","first-page":"9026","DOI":"10.1128\/MCB.24.20.9026-9037.2004","article-title":"Transgenic analysis reveals that thyroid hormone receptor is sufficient to mediate the thyroid hormone signal in frog metamorphosis.","volume":"24","author":"Buchholz","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2020071612325380900_B12","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1128\/MCB.23.19.6750-6758.2003","article-title":"A dominant negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.","volume":"23","author":"Buchholz","year":"2003","journal-title":"Mol Cell Biol"},{"key":"2020071612325380900_B13","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: the second decade.","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"2020071612325380900_B14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.bi.63.070194.002315","article-title":"Molecular mechanisms of action of steroid\/thyroid receptor superfamily members.","volume":"63","author":"Tsai","year":"1994","journal-title":"Ann Rev Biochem"},{"key":"2020071612325380900_B15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1043-2760(00)00355-6","article-title":"The TRAP\/SMCC\/Mediator complex and thyroid hormone receptor function.","volume":"12","author":"Ito","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"2020071612325380900_B16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0378-1119(00)00052-4","article-title":"Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions.","volume":"246","author":"Rachez","year":"2000","journal-title":"Gene"},{"key":"2020071612325380900_B17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.physiol.62.1.439","article-title":"The mechanism of action of thyroid hormones.","volume":"62","author":"Zhang","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"2020071612325380900_B18","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1096\/fj.99-0943rev","article-title":"Co-repressors 2000.","volume":"14","author":"Burke","year":"2000","journal-title":"FASEB J"},{"key":"2020071612325380900_B19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1242\/jcs.115.4.689","article-title":"Biological roles and mechanistic actions of co-repressor complexes.","volume":"115","author":"Jepsen","year":"2002","journal-title":"J Cell Sci"},{"key":"2020071612325380900_B20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-3-642-55747-7_9","article-title":"N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors","volume-title":"Current topics in microbiology and immunology: protein complexes that modify chromatin","author":"Jones","year":"2003"},{"key":"2020071612325380900_B21","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0955-0674(00)00209-X","article-title":"Mediator complexes and transcription.","volume":"13","author":"Rachez","year":"2001","journal-title":"Curr Opin Cell Biol"},{"key":"2020071612325380900_B22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S1043-2760(99)00215-5","article-title":"Transcriptional repression by nuclear hormone receptors.","volume":"11","author":"Hu","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"2020071612325380900_B23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg2736","article-title":"Deconstructing repression: evolving models of co-repressor action.","volume":"11","author":"Perissi","year":"2010","journal-title":"Nat Rev Genet"},{"key":"2020071612325380900_B24","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/stem.529","article-title":"An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development.","volume":"28","author":"Matsuda","year":"2010","journal-title":"Stem Cells"},{"key":"2020071612325380900_B25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/MCB.00827-08","article-title":"Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis.","volume":"29","author":"Matsuda","year":"2009","journal-title":"Mol Cell Biol"},{"key":"2020071612325380900_B26","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.mod.2007.03.006","article-title":"A role of unliganded thyroid hormone receptor in postembryonic development in Xenopus laevis.","volume":"124","author":"Sato","year":"2007","journal-title":"Mech Dev"},{"key":"2020071612325380900_B27","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/sj.cr.7290188","article-title":"Distinct expression profiles of transcriptional coactivators for thyroid hormone receptors during Xenopus laevis metamorphosis.","volume":"13","author":"Paul","year":"2003","journal-title":"Cell Res"},{"key":"2020071612325380900_B28","doi-asserted-by":"crossref","first-page":"27165","DOI":"10.1074\/jbc.M503999200","article-title":"Tissue- and gene-specific recruitment of steroid receptor coactivator-3 by thyroid hormone receptor during development.","volume":"280","author":"Paul","year":"2005","journal-title":"J Biol Chem"},{"key":"2020071612325380900_B29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.embor.embor908","article-title":"Metamorphic T3-response genes have specific co-regulator requirements.","volume":"4","author":"Havis","year":"2003","journal-title":"EMBO Rep"},{"key":"2020071612325380900_B30","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1128\/MCB.25.13.5712-5724.2005","article-title":"Coactivator recruitment is essential for liganded thyroid hormone receptor to initiate amphibian metamorphosis.","volume":"25","author":"Paul","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2020071612325380900_B31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function.","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"2020071612325380900_B32","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.febslet.2004.12.007","article-title":"Transcriptional regulation and the role of diverse coactivators in animal cells.","volume":"579","author":"Roeder","year":"2005","journal-title":"FEBS Lett"},{"key":"2020071612325380900_B33","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35065132","article-title":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.","volume":"410","author":"Lachner","year":"2001","journal-title":"Nature"},{"key":"2020071612325380900_B34","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1126\/science.1076997","article-title":"Role of histone H3 lysine 27 methylation in Polycomb-group silencing.","volume":"298","author":"Cao","year":"2002","journal-title":"Science"},{"key":"2020071612325380900_B35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.gde.2004.02.001","article-title":"The functions of E(Z)\/EZH2-mediated methylation of lysine 27 in histone H3.","volume":"14","author":"Cao","year":"2004","journal-title":"Curr Opin Genet Dev"},{"key":"2020071612325380900_B36","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1038\/sj.emboj.7600402","article-title":"Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.","volume":"23","author":"Pasini","year":"2004","journal-title":"EMBO J"},{"key":"2020071612325380900_B37","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2007.01.015","article-title":"The role of chromatin during transcription.","volume":"128","author":"Li","year":"2007","journal-title":"Cell"},{"key":"2020071612325380900_B38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.gde.2009.02.001","article-title":"Characterization of human epigenomes.","volume":"19","author":"Wang","year":"2009","journal-title":"Curr Opin Genet Dev"},{"key":"2020071612325380900_B39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142422","article-title":"Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.","volume":"75","author":"Shilatifard","year":"2006","journal-title":"Annu Rev Biochem"},{"key":"2020071612325380900_B40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.physiol.010908.163145","article-title":"Stem cells, self-renewal, and differentiation in the intestinal epithelium.","volume":"71","author":"van der Flier","year":"2009","journal-title":"Annu Rev Physiol"},{"key":"2020071612325380900_B41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0070-2153(08)60429-9","article-title":"Biphasic intestinal development in amphibians: embryogensis and remodeling during metamorphosis.","volume":"32","author":"Shi","year":"1996","journal-title":"Curr Top Dev Biol"},{"key":"2020071612325380900_B42","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1096\/fj.08-128124","article-title":"Origin of the adult intestinal stem cells induced by thyroid hormone in Xenopus laevis.","volume":"23","author":"Ishizuya-Oka","year":"2009","journal-title":"FASEB J"},{"key":"2020071612325380900_B43","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1073\/pnas.0409868102","article-title":"Remodeling of the intestine during metamorphosis of Xenopus laevis.","volume":"102","author":"Schreiber","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612325380900_B44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/stem.560","article-title":"Epithelial-connective tissue interactions induced by thyroid hormone receptor are essential for adult stem cell development in the Xenopus laevis intestine.","volume":"29","author":"Hasebe","year":"2011","journal-title":"Stem Cells"},{"key":"2020071612325380900_B45","doi-asserted-by":"crossref","first-page":"e13605","DOI":"10.1371\/journal.pone.0013605","article-title":"Spatio-temporal expression profile of stem cell-associated gene LGR5 in the intestine during thyroid hormone-dependent metamorphosis in Xenopus laevis.","volume":"5","author":"Sun","year":"2010","journal-title":"PLoS One"},{"key":"2020071612325380900_B46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/2045-3701-1-30","article-title":"The development of the adult intestinal stem cells: insights from studies on thyroid hormone-dependent amphibian metamorphosis.","volume":"1","author":"Shi","year":"2011","journal-title":"Cell Biosci"},{"key":"2020071612325380900_B47","article-title":"Normal table of Xenopus laevis","author":"Nieuwkoop","year":"1965"},{"key":"2020071612325380900_B48","first-page":"2261","article-title":"La triiodothyronine: hormone de la m\u00e9tamorphose des amphibiens.","volume":"284","author":"Leloup","year":"1977","journal-title":"C R Acad Sci"},{"key":"2020071612325380900_B49","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1677\/joe.0.1810091","article-title":"Developmental expression and hormonal regulation of glucocorticoid and thyroid hormone receptors during metamorphosis in Xenopus laevis.","volume":"181","author":"Krain","year":"2004","journal-title":"J Endocrinol"},{"key":"2020071612325380900_B50","doi-asserted-by":"crossref","first-page":"34167","DOI":"10.1074\/jbc.M109.066084","article-title":"Identification of direct thyroid hormone response genes reveals the earliest gene regulation programs during frog metamorphosis.","volume":"284","author":"Das","year":"2009","journal-title":"J Biol Chem"},{"key":"2020071612325380900_B51","doi-asserted-by":"crossref","first-page":"41222","DOI":"10.1074\/jbc.M509593200","article-title":"Gene-specific changes in promoter occupancy by thyroid hormone receptor during frog metamorphosis. Implications for developmental gene regulation.","volume":"280","author":"Buchholz","year":"2005","journal-title":"J Biol Chem"},{"key":"2020071612325380900_B52","doi-asserted-by":"crossref","first-page":"18479","DOI":"10.1074\/jbc.270.31.18479","article-title":"Coordinated regulation of and transcriptional activation by Xenopus thyroid hormone and retinoid X receptors.","volume":"270","author":"Wong","year":"1995","journal-title":"J Biol Chem"},{"key":"2020071612325380900_B53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.modgep.2003.10.005","article-title":"Spatial and temporal expression pattern of a novel gene in the frog Xenopus laevis: correlations with adult intestinal epithelial differentiation during metamorphosis.","volume":"4","author":"Buchholz","year":"2004","journal-title":"Gene Expr Patterns"},{"key":"2020071612325380900_B54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02255588","article-title":"Autoactivation of Xenopus thyroid hormone receptor beta genes correlates with larval epithelial apoptosis and adult cell proliferation.","volume":"4","author":"Shi","year":"1997","journal-title":"J Biomed Sci"},{"key":"2020071612325380900_B55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/(SICI)1520-6408(1997)20:4<329::AID-DVG4>3.0.CO;2-9","article-title":"Temporal and spatial regulation of a putative transcriptional repressor implicates it as playing a role in thyroid hormone-dependent organ transformation.","volume":"20","author":"Ishizuya-Oka","year":"1997","journal-title":"Dev Genet"},{"key":"2020071612325380900_B56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1006\/dbio.1994.1006","article-title":"Thyroid hormone-dependent regulation of the intestinal fatty acid-binding protein gene during amphibian metamorphosis.","volume":"161","author":"Shi","year":"1994","journal-title":"Dev Biol"},{"key":"2020071612325380900_B57","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1093\/emboj\/16.11.3158","article-title":"Determinants of chromatin disruption and transcriptional regulation instigated by the thyroid hormone receptor: hormone-regulated chromatin disruption is not sufficient for transcriptinal activation.","volume":"16","author":"Wong","year":"1997","journal-title":"EMBO J"},{"key":"2020071612325380900_B58","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1101\/gad.9.21.2696","article-title":"A role for nucleosome assembly in both silencing and activation of the Xenopus TR \u03b2A gene by the thyroid hormone receptor.","volume":"9","author":"Wong","year":"1995","journal-title":"Genes Dev"},{"key":"2020071612325380900_B59","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ng.154","article-title":"Combinatorial patterns of histone acetylations and methylations in the human genome.","volume":"40","author":"Wang","year":"2008","journal-title":"Nat Genet"},{"key":"2020071612325380900_B60","doi-asserted-by":"crossref","first-page":"15782","DOI":"10.1073\/pnas.0607617103","article-title":"The genomic landscape of histone modifications in human T cells.","volume":"103","author":"Roh","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612325380900_B61","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome.","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"2020071612325380900_B62","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCRESAHA.110.222463","article-title":"Epigenome mapping in normal and disease states.","volume":"107","author":"Maunakea","year":"2010","journal-title":"Circ Res"},{"key":"2020071612325380900_B63","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.tibs.2010.05.006","article-title":"Fast signals and slow marks: the dynamics of histone modifications.","volume":"35","author":"Barth","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"2020071612325380900_B64","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1128\/MCB.22.12.4043-4052.2002","article-title":"Chromatin disruption and histone acetylation in regulation of the human immunodeficiency virus type 1 long terminal repeat by thyroid hormone receptor.","volume":"22","author":"Hsia","year":"2002","journal-title":"Mol Cell Biol"},{"key":"2020071612325380900_B65","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1093\/emboj\/cdg219","article-title":"A role for cofactor\u2014cofactor and cofactor\u2014histone interactions in targeting p300, SWI\/SNF and mediator for transcription.","volume":"22","author":"Huang","year":"2003","journal-title":"EMBO J"},{"key":"2020071612325380900_B66","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1210\/me.2007-0492","article-title":"Participation of BAF57 and BRG1-containing chromatin remodeling complexes in thyroid hormone-dependent gene activation during vertebrate development.","volume":"22","author":"Heimeier","year":"2008","journal-title":"Mol Endocrinol"},{"key":"2020071612325380900_B67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1210\/me.2010-0269","article-title":"Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses.","volume":"25","author":"Bilesimo","year":"2011","journal-title":"Mol Endocrinol"},{"key":"2020071612325380900_B68","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1210\/mend.13.12.0383","article-title":"In vitro and in vivo analysis of the regulation of a transcription factor gene by thyroid hormone during Xenopus laevis metamorphosis.","volume":"13","author":"Furlow","year":"1999","journal-title":"Mol Endocrinol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/153\/2\/961\/10389436\/endo0961.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/153\/2\/961\/10389436\/endo0961.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T03:04:51Z","timestamp":1639883091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/153\/2\/961\/2424559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,1]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2011-1736","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,1]]}}}