{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:15:46Z","timestamp":1783480546110,"version":"3.55.0"},"reference-count":29,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>Dysfunctional islet amyloid polypeptide (IAPP) biosynthesis and\/or processing are thought contribute to formation of islet amyloid in type 2 diabetes. However, it is unclear how normal pro-IAPP biosynthesis and processing are regulated to be able to define such dysfunction. Here, it was found that acute exposure to high glucose concentrations coordinately regulated the biosynthesis of pro-IAPP, proinsulin, and its proprotein convertase PC1\/3 in normal isolated rat islets, without affecting their respective mRNA levels. Pro-7B2 biosynthesis, like that of pro-PC2, did not appreciably change, but this was likely due to a much higher expression in pancreatic \u03b1-cells masking glucose regulation of their biosynthesis in \u03b2-cells. Biosynthesis of pro-SAAS, the putative PC1\/3 chaperone, was unaffected by glucose, consistent with its scarce expression in \u03b2-cells. We conclude that translational control of pro-IAPP biosynthesis, in parallel to the pro-PC1\/3, pro-PC2, and pro-7B2 proprotein-processing endopeptidases\/chaperones, is the predominate mechanism to produce IAPP in islet \u03b2-cells.<\/jats:p>","DOI":"10.1210\/en.2011-2019","type":"journal-article","created":{"date-parts":[[2012,3,10]],"date-time":"2012-03-10T04:02:58Z","timestamp":1331352178000},"page":"2082-2087","source":"Crossref","is-referenced-by-count":25,"title":["Translational Control of Glucose-Induced Islet Amyloid Polypeptide Production in Pancreatic Islets"],"prefix":"10.1210","volume":"153","author":[{"given":"Cristina","family":"Alarcon","sequence":"first","affiliation":[{"name":"The Kovler Diabetes Center (C.A., C.J.R.), Department of Medicine, Section Endocrinology, Diabetes, and Metabolism, University of Chicago, Illinois 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Bruce","family":"Verchere","sequence":"first","affiliation":[{"name":"Child and Family Research Institute and Department of Pathology and Laboratory Medicine (C.B.V.), University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Rhodes","sequence":"first","affiliation":[{"name":"The Kovler Diabetes Center (C.A., C.J.R.), Department of Medicine, Section Endocrinology, Diabetes, and Metabolism, University of Chicago, Illinois 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2012,3,9]]},"reference":[{"key":"2020071612105217400_B1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1210\/er.2007-0037","article-title":"Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.","volume":"29","author":"Haataja","year":"2008","journal-title":"Endocr Rev"},{"key":"2020071612105217400_B2","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1016\/S0021-9258(19)39539-0","article-title":"Islet amyloid polypeptide. 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