{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:01:43Z","timestamp":1790845303243,"version":"4.1.0"},"reference-count":61,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"DOI":"10.1210\/en.2011-2117","type":"journal-article","created":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T05:35:04Z","timestamp":1330493704000},"page":"2062-2069","source":"Crossref","is-referenced-by-count":88,"title":["Multiligand Specificity and Wide Tissue Expression of GPRC6A Reveals New Endocrine Networks"],"prefix":"10.1210","volume":"153","author":[{"given":"Min","family":"Pi","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Darryl","family":"Quarles","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2012,2,28]]},"reference":[{"key":"2019041119371511600_B1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1748-1716.2010.02235.x","article-title":"Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides.","volume":"201","author":"Rehfeld","year":"2011","journal-title":"Acta Physiol (Oxf)"},{"key":"2019041119371511600_B2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.pharmthera.2007.08.002","article-title":"G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.","volume":"116","author":"Winzell","year":"2007","journal-title":"Pharmacol Ther"},{"key":"2019041119371511600_B3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2010.06.003","article-title":"Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.","volume":"142","author":"Ferron","year":"2010","journal-title":"Cell"},{"key":"2019041119371511600_B4","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jbmr.321","article-title":"The osteoblast: an insulin target cell controlling glucose homeostasis.","volume":"26","author":"Clemens","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2019041119371511600_B5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2010.06.002","article-title":"Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.","volume":"142","author":"Fulzele","year":"2010","journal-title":"Cell"},{"key":"2019041119371511600_B6","doi-asserted-by":"crossref","DOI":"10.1101\/sqb.2011.76.010934","article-title":"Regulation of male fertility by bone","author":"Karsenty","year":"2011","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2019041119371511600_B7","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton.","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"2019041119371511600_B8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2009.04.004","article-title":"A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms.","volume":"310","author":"Confavreux","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"2019041119371511600_B9","doi-asserted-by":"crossref","first-page":"40201","DOI":"10.1074\/jbc.M505186200","article-title":"Identification of a novel extracellular cation-sensing G-protein-coupled receptor.","volume":"280","author":"Pi","year":"2005","journal-title":"J Biol Chem"},{"key":"2019041119371511600_B10","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jbmr.390","article-title":"GPRC6A mediates responses to osteocalcin in \u03b2-cells in vitro and pancreas in vivo.","volume":"26","author":"Pi","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2019041119371511600_B11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S8756-3282(99)00213-6","article-title":"Evidence that conditionally immortalized human osteoblasts express an osteocalcin receptor.","volume":"25","author":"Bodine","year":"1999","journal-title":"Bone"},{"key":"2019041119371511600_B12","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.cell.2011.02.004","article-title":"Endocrine regulation of male fertility by the skeleton.","volume":"144","author":"Oury","year":"2011","journal-title":"Cell"},{"key":"2019041119371511600_B13","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.bone.2011.04.017","article-title":"Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice.","volume":"50","author":"Ferron","year":"2012","journal-title":"Bone"},{"key":"2019041119371511600_B14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/138945007779315614","article-title":"Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.","volume":"8","author":"Br\u00e4uner-Osborne","year":"2007","journal-title":"Curr Drug Targets"},{"key":"2019041119371511600_B15","doi-asserted-by":"crossref","first-page":"e3858","DOI":"10.1371\/journal.pone.0003858","article-title":"GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome.","volume":"3","author":"Pi","year":"2008","journal-title":"PLoS ONE"},{"key":"2019041119371511600_B16","doi-asserted-by":"crossref","first-page":"39953","DOI":"10.1074\/jbc.M110.158063","article-title":"GPRC6A mediates the non-genomic effects of steroids.","volume":"285","author":"Pi","year":"2010","journal-title":"J Biol Chem"},{"key":"2019041119371511600_B17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1471-4159.2005.03025.x","article-title":"Cloning and characterization of a family C orphan G-protein coupled receptor.","volume":"93","author":"Kuang","year":"2005","journal-title":"J Neurochem"},{"key":"2019041119371511600_B18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.gene.2004.03.003","article-title":"Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.","volume":"335","author":"Wellendorph","year":"2004","journal-title":"Gene"},{"key":"2019041119371511600_B19","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/sj.bjp.0707121","article-title":"Pharmacological characterization of mouse GPRC6A, an l-\u03b1-amino-acid receptor modulated by divalent cations.","volume":"150","author":"Christiansen","year":"2007","journal-title":"Br J Pharmacol"},{"key":"2019041119371511600_B20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ceca.2009.09.004","article-title":"Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor.","volume":"46","author":"Faure","year":"2009","journal-title":"Cell Calcium"},{"key":"2019041119371511600_B21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s10735-011-9339-1","article-title":"Nutrient sensing receptors in gastric endocrine cells.","volume":"42","author":"Haid","year":"2011","journal-title":"J Mol Histol"},{"key":"2019041119371511600_B22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/pros.21442","article-title":"GPRC6A regulates prostate cancer progression.","volume":"72","author":"Pi","year":"2012","journal-title":"Prostate"},{"key":"2019041119371511600_B23","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ceca.2007.11.011","article-title":"Evidence for the presence of GPRC6A receptors in rat mesenteric arteries.","volume":"44","author":"Harno","year":"2008","journal-title":"Cell Calcium"},{"key":"2019041119371511600_B24","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2007-8-2-r25","article-title":"DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies.","volume":"8","author":"Hovatta","year":"2007","journal-title":"Genome Biol"},{"key":"2019041119371511600_B25","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1073\/pnas.0711119105","article-title":"Osteocalcin differentially regulates \u03b2 cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice.","volume":"105","author":"Ferron","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041119371511600_B26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2741\/3690","article-title":"Amino acids and diabetes: implications for endocrine, metabolic and immune function.","volume":"16","author":"Newsholme","year":"2011","journal-title":"Front Biosci"},{"key":"2019041119371511600_B27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00125-009-1637-8","article-title":"Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men.","volume":"53","author":"Tai","year":"2010","journal-title":"Diabetologia"},{"key":"2019041119371511600_B28","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3945\/jn.108.102301","article-title":"Dietary supplementation of l-arginine and conjugated linoleic acid reduces retroperitoneal fat mass and increases lean body mass in rats.","volume":"139","author":"Nall","year":"2009","journal-title":"J Nutr"},{"key":"2019041119371511600_B29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00726-008-0192-9","article-title":"Metabolomic analysis of the response of growing pigs to dietary l-arginine supplementation.","volume":"37","author":"He","year":"2009","journal-title":"Amino Acids"},{"key":"2019041119371511600_B30","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.metabol.2011.01.002","article-title":"Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey.","volume":"60","author":"Tan","year":"2011","journal-title":"Metabolism"},{"key":"2019041119371511600_B31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.numecd.2009.02.011","article-title":"High protein diets and weight control.","volume":"19","author":"Clifton","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2019041119371511600_B32","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00726-010-0716-y","article-title":"Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models.","volume":"40","author":"de Oliveira","year":"2011","journal-title":"Amino Acids"},{"key":"2019041119371511600_B33","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1055\/s-2005-870575","article-title":"Testosterone rapidly stimulates insulin release from isolated pancreatic islets through a non-genomic dependent mechanism.","volume":"37","author":"Grillo","year":"2005","journal-title":"Horm Metab Res"},{"key":"2019041119371511600_B34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1006\/bbrc.1999.1577","article-title":"Expression of the calcium-sensing receptor in pancreatic islet B-cells.","volume":"264","author":"Rasschaert","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041119371511600_B35","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1055\/s-0029-1234087","article-title":"Evaluation of \u03b2 cell dysfunction by mixed meal tolerance test and oral l-arginine in patients with newly diagnosed type 2 diabetes mellitus.","volume":"117","author":"Ozbek","year":"2009","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"2019041119371511600_B36","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1210\/jc.2004-2190","article-title":"Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men.","volume":"90","author":"Pitteloud","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041119371511600_B37","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1002\/jbmr.421","article-title":"Relationship of testosterone and osteocalcin levels during growth.","volume":"26","author":"Kirmani","year":"2011","journal-title":"J Bone Miner Res"},{"key":"2019041119371511600_B38","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00198-011-1600-7","article-title":"Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study.","volume":"23","author":"Iki","year":"2012","journal-title":"Osteoporos Int"},{"key":"2019041119371511600_B39","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1210\/jc.2008-1422","article-title":"Association between serum osteocalcin and markers of metabolic phenotype.","volume":"94","author":"Pittas","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041119371511600_B40","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2265.2011.03997.x","article-title":"Androgens modulate osteocalcin release by human visceral adipose tissue","author":"Foresta","year":"2011","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041119371511600_B41","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCULATIONAHA.110.948570","article-title":"Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.","volume":"123","author":"Dehghan","year":"2011","journal-title":"Circulation"},{"key":"2019041119371511600_B42","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2337\/db06-0922","article-title":"Genetic variation, C-reactive protein levels, and incidence of diabetes.","volume":"56","author":"Dehghan","year":"2007","journal-title":"Diabetes"},{"key":"2019041119371511600_B43","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease.","volume":"350","author":"Danesh","year":"2004","journal-title":"N Engl J Med"},{"key":"2019041119371511600_B44","article-title":"Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level","author":"Hwang","year":"2011","journal-title":"Osteoporos Int"},{"key":"2019041119371511600_B45","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0021-9258(17)42240-X","article-title":"The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.","volume":"269","author":"Desbois","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041119371511600_B46","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1210\/jc.2009-0402","article-title":"Acute effects of testosterone infusion on the serum luteinizing hormone profile in eumenorrheic and polycystic ovary syndrome adolescents.","volume":"94","author":"Ropelato","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041119371511600_B47","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.numecd.2005.10.017","article-title":"The pancreatic \u03b2-cell in human type 2 diabetes.","volume":"16","author":"Marchetti","year":"2006","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"2019041119371511600_B48","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/ng.635","article-title":"Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.","volume":"42","author":"Takata","year":"2010","journal-title":"Nat Genet"},{"key":"2019041119371511600_B49","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/carcin\/bgr279","article-title":"Replication and cumulative effects of GWAS-identified genetic variations for prostate cancer in Asians: a case-control study in the ChinaPCa consortium.","volume":"33","author":"Wang","year":"2012","journal-title":"Carcinogenesis"},{"key":"2019041119371511600_B50","doi-asserted-by":"crossref","first-page":"e17449","DOI":"10.1371\/journal.pone.0017449","article-title":"MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.","volume":"6","author":"Clegg","year":"2011","journal-title":"PLoS One"},{"key":"2019041119371511600_B51","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1158\/0008-5472.CAN-04-3448","article-title":"Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway.","volume":"65","author":"Huang","year":"2005","journal-title":"Cancer Res"},{"key":"2019041119371511600_B52","first-page":"903","article-title":"Differential expression of osteocalcin during the metastatic progression of prostate cancer.","volume":"21","author":"Gardner","year":"2009","journal-title":"Oncol Rep"},{"key":"2019041119371511600_B53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1158\/1055-9965.EPI-08-0554","article-title":"Serum undercarboxylated osteocalcin as biomarker of vitamin K intake and risk of prostate cancer: a nested case-control study in the Heidelberg cohort of the European prospective investigation into cancer and nutrition.","volume":"18","author":"Nimptsch","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2019041119371511600_B54","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/01635580802419756","article-title":"Intake of plant foods and associated nutrients in prostate cancer risk.","volume":"61","author":"Lewis","year":"2009","journal-title":"Nutr Cancer"},{"key":"2019041119371511600_B55","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/jnci\/dji402","article-title":"Prospective studies of dairy product and calcium intakes and prostate cancer risk: a meta-analysis.","volume":"97","author":"Gao","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"2019041119371511600_B56","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/aje\/kwq148","article-title":"Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial.","volume":"172","author":"Kristal","year":"2010","journal-title":"Am J Epidemiol"},{"key":"2019041119371511600_B57","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/ijc.25202","article-title":"Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.","volume":"126","author":"Delage","year":"2010","journal-title":"Int J Cancer"},{"key":"2019041119371511600_B58","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/sj.bjc.6604331","article-title":"Animal foods, protein, calcium and prostate cancer risk: the European Prospective Investigation into Cancer and Nutrition.","volume":"98","author":"Allen","year":"2008","journal-title":"Br J Cancer"},{"key":"2019041119371511600_B59","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1359\/jbmr.091037","article-title":"Impaired osteoblast function in GPRC6A null mice.","volume":"25","author":"Pi","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2019041119371511600_B60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1677\/JME-08-0149","article-title":"No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.","volume":"42","author":"Wellendorph","year":"2009","journal-title":"J Mol Endocrinol"},{"key":"2019041119371511600_B61","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.pharmthera.2010.04.007","article-title":"Broad-spectrum amino acid-sensing class C G-protein coupled receptors: molecular mechanisms, physiological significance and options for drug development.","volume":"127","author":"Conigrave","year":"2010","journal-title":"Pharmacol Ther"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/153\/5\/2062\/8977707\/endo2062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T21:39:40Z","timestamp":1713649180000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/153\/5\/2062\/2423696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,28]]},"references-count":61,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,2,28]]},"published-print":{"date-parts":[[2012,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2011-2117","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,28]]}}}