{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:38:19Z","timestamp":1792222699289,"version":"4.4.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"DOI":"10.1210\/en.2012-1135","type":"journal-article","created":{"date-parts":[[2012,6,14]],"date-time":"2012-06-14T23:24:10Z","timestamp":1339716250000},"page":"3668-3678","source":"Crossref","is-referenced-by-count":29,"title":["The Regulation of Rasd1 Expression by Glucocorticoids and Prolactin Controls Peripartum Maternal Insulin Secretion"],"prefix":"10.1210","volume":"153","author":[{"given":"Camilo","family":"Lellis-Santos","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano H.","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla R.","family":"Bromati","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane C.A.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana R.","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana S.","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrezza","family":"Kinote","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (A.K., G.F.A.), Faculty of Medical Sciences, State University of Campinas, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel F.","family":"Anh\u00ea","sequence":"additional","affiliation":[{"name":"Department of Pharmacology (A.K., G.F.A.), Faculty of Medical Sciences, State University of Campinas, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Bordin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics (C.L.-S., L.H.S., C.R.B., T.C.A.N., A.R.L., T.S.Y., S.B.), Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2012,6,14]]},"reference":[{"key":"2019041119485892500_B1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mce.2008.08.033","article-title":"Regulation of \u03b2 cell replication.","volume":"297","author":"Lee","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"2019041119485892500_B2","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1210\/endo.136.12.7588296","article-title":"Apoptosis contributes to the involution of \u03b2 cell mass in the post partum rat pancreas.","volume":"136","author":"Scaglia","year":"1995","journal-title":"Endocrinology"},{"key":"2019041119485892500_B3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-2007-979040","article-title":"Adaptation of islets of Langerhans to pregnancy: \u03b2-cell growth, enhanced insulin secretion and the role of lactogenic hormones.","volume":"29","author":"Sorenson","year":"1997","journal-title":"Horm Metab Res"},{"key":"2019041119485892500_B4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1677\/JOE-07-0010","article-title":"Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period.","volume":"195","author":"Anh\u00ea","year":"2007","journal-title":"J Endocrinol"},{"key":"2019041119485892500_B5","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1152\/ajpregu.00169.2010","article-title":"UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4\/CHOP stimulation of TRB3 expression.","volume":"300","author":"Bromati","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2019041119485892500_B6","doi-asserted-by":"crossref","first-page":"E1006","DOI":"10.1152\/ajpendo.00341.2010","article-title":"MKP-1 mediates glucocorticoid-induced ERK1\/2 dephosphorylation and reduction in pancreatic \u00df-cell proliferation in islets from early lactating mothers.","volume":"299","author":"Nicoletti-Carvalho","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2019041119485892500_B7","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1210\/endo.133.5.8404674","article-title":"Effects of steroid and lactogenic hormones on islets of Langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy.","volume":"133","author":"Sorenson","year":"1993","journal-title":"Endocrinology"},{"key":"2019041119485892500_B8","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.2337\/diabetes.50.2007.S25","article-title":"Regulation of \u03b2-cell mass by hormones and growth factors.","volume":"50","author":"Nielsen","year":"2001","journal-title":"Diabetes"},{"key":"2019041119485892500_B9","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1210\/endo.141.4.7409","article-title":"Dexamethasone counteracts the effect of prolactin on islet function: implications for islet regulation in late pregnancy.","volume":"141","author":"Weinhaus","year":"2000","journal-title":"Endocrinology"},{"key":"2019041119485892500_B10","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1210\/endo.138.4.5089","article-title":"Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation.","volume":"138","author":"Stout","year":"1997","journal-title":"Endocrinology"},{"key":"2019041119485892500_B11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/383726a0","article-title":"Functional interactions between Stat5 and the glucocorticoid receptor.","volume":"383","author":"St\u00f6cklin","year":"1996","journal-title":"Nature"},{"key":"2019041119485892500_B12","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1210\/me.2006-0160","article-title":"Integration of prolactin and glucocorticoid signaling at the \u03b2-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.","volume":"20","author":"Kabotyanski","year":"2006","journal-title":"Mol Endocrinol"},{"key":"2019041119485892500_B13","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1101\/gad.426007","article-title":"Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.","volume":"21","author":"Engblom","year":"2007","journal-title":"Genes Dev"},{"key":"2019041119485892500_B14","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1074\/jbc.273.6.3129","article-title":"Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT-20 cells.","volume":"273","author":"Kemppainen","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041119485892500_B15","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1210\/endo.142.6.8209","article-title":"Dexras1\/AGS-1, a steroid hormone-induced guanosine triphosphate-binding protein, inhibits 3\u2032,5\u2032-cyclic adenosine monophosphate-stimulated secretion in AtT-20 corticotroph cells.","volume":"142","author":"Graham","year":"2001","journal-title":"Endocrinology"},{"key":"2019041119485892500_B16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3109\/07420528.2011.592235","article-title":"Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice.","volume":"28","author":"Koletar","year":"2011","journal-title":"Chronobiol Int"},{"key":"2019041119485892500_B17","doi-asserted-by":"crossref","first-page":"12984","DOI":"10.1523\/JNEUROSCI.4253-06.2006","article-title":"The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.","volume":"26","author":"Cheng","year":"2006","journal-title":"J Neurosci"},{"key":"2019041119485892500_B18","doi-asserted-by":"crossref","first-page":"e24401","DOI":"10.1371\/journal.pone.0024401","article-title":"Rasd1 modulates the coactivator function of NonO in the cyclic AMP pathway.","volume":"6","author":"Ong","year":"2011","journal-title":"PLoS One"},{"key":"2019041119485892500_B19","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1038\/sj.onc.1207774","article-title":"The Ras-related protein AGS1\/RASD1 suppresses cell growth.","volume":"23","author":"Vaidyanathan","year":"2004","journal-title":"Oncogene"},{"key":"2019041119485892500_B20","first-page":"134","article-title":"Light-induced retinal ganglion cell damage in vivo involves Dexras1.","volume":"17","author":"Sang","year":"2011","journal-title":"Mol Vis"},{"key":"2019041119485892500_B21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.mce.2006.02.012","article-title":"ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion.","volume":"251","author":"Anh\u00ea","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"2019041119485892500_B22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mce.2004.04.001","article-title":"Prolactin-modulated gene expression profiles in pancreatic islets from adult female rats.","volume":"220","author":"Bordin","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"2019041119485892500_B23","doi-asserted-by":"crossref","first-page":"6326","DOI":"10.1210\/en.2008-0655","article-title":"Modulation of bone morphogenetic protein-9 expression and processing by insulin, glucose, and glucocorticoids: possible candidate for hepatic insulin-sensitizing substance.","volume":"149","author":"Caperuto","year":"2008","journal-title":"Endocrinology"},{"key":"2019041119485892500_B24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF00257788","article-title":"A method for the simultaneous measurement of insulin release and b-cell membrane potential in single mouse islets of Langerhans.","volume":"21","author":"Scott","year":"1981","journal-title":"Diabetologia"},{"key":"2019041119485892500_B25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0167-4781(99)00197-9","article-title":"Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone.","volume":"1489","author":"Tu","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"2019041119485892500_B26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1046\/j.1365-2265.1996.716535.x","article-title":"11\u03b2-Hydroxysteroid dehydrogenase: implications for clinical medicine.","volume":"44","author":"Stewart","year":"1996","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041119485892500_B27","first-page":"1853","article-title":"Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities.","volume":"83","author":"Rosmond","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041119485892500_B28","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1210\/endo.141.2.7297","article-title":"Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats.","volume":"141","author":"Livingstone","year":"2000","journal-title":"Endocrinology"},{"key":"2019041119485892500_B29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1124\/jpet.102.044842","article-title":"Is 11\u03b2-hydroxysteroid dehydrogenase type 1 a therapeutic target? Effects of carbenoxolone in lean and obese Zucker rats.","volume":"305","author":"Livingstone","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"2019041119485892500_B30","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1210\/endo.132.6.8504766","article-title":"Relation between glucose-stimulated insulin secretion and intracellular calcium accumulation studied with a superfusion system of a glucose-responsive pancreatic \u03b2-cell line MIN6.","volume":"132","author":"Sakurada","year":"1993","journal-title":"Endocrinology"},{"key":"2019041119485892500_B31","doi-asserted-by":"crossref","first-page":"H1826","DOI":"10.1152\/ajpheart.01085.2011","article-title":"Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.","volume":"302","author":"McGrath","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2019041119485892500_B32","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.bbrc.2004.02.049","article-title":"Dexras1 inhibits adenylyl cyclase.","volume":"316","author":"Graham","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041119485892500_B33","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1124\/mol.105.019133","article-title":"Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C \u03b4: implications for adenylyl cyclase 2 signaling.","volume":"69","author":"Nguyen","year":"2006","journal-title":"Mol Pharmacol"},{"key":"2019041119485892500_B34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10540-006-9001-4","article-title":"Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition.","volume":"26","author":"Liu","year":"2006","journal-title":"Biosci Rep"},{"key":"2019041119485892500_B35","doi-asserted-by":"crossref","first-page":"18686","DOI":"10.1074\/jbc.274.26.18686","article-title":"Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b.","volume":"274","author":"Galsgaard","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041119485892500_B36","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/379645a0","article-title":"Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.","volume":"379","author":"Meydan","year":"1996","journal-title":"Nature"},{"key":"2019041119485892500_B37","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1007\/s00125-008-1137-2","article-title":"11\u03b2-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets.","volume":"51","author":"Swali","year":"2008","journal-title":"Diabetologia"},{"key":"2019041119485892500_B38","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1210\/en.2004-0841","article-title":"Extracellularly regulated kinases 1\/2 (p44\/42 mitogen-activated protein kinases) phosphorylate synapsin I and regulate insulin secretion in the MIN6 \u03b2-cell line and islets of Langerhans.","volume":"146","author":"Longuet","year":"2005","journal-title":"Endocrinology"},{"key":"2019041119485892500_B39","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1172\/JCI119743","article-title":"Pancreatic \u03b2 cells are important targets for the diabetogenic effects of glucocorticoids.","volume":"100","author":"Delaunay","year":"1997","journal-title":"J Clin Invest"},{"key":"2019041119485892500_B40","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0167-4781(03)00079-4","article-title":"Identification of a glucocorticoid response element in the 3\u2032-flanking region of the human Dexras1 gene.","volume":"1627","author":"Kemppainen","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"2019041119485892500_B41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1210\/mend.13.2.0232","article-title":"Glucocorticoid receptor\/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation.","volume":"13","author":"Wyszomierski","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041119485892500_B42","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1210\/mend.15.7.0657","article-title":"Interleukin-2 inhibits glucocorticoid receptor transcriptional activity through a mechanism involving STAT5 (signal transducer and activator of transcription 5) but not AP-1.","volume":"15","author":"Biola","year":"2001","journal-title":"Mol Endocrinol"},{"key":"2019041119485892500_B43","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1128\/MCB.18.10.5852","article-title":"A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.","volume":"18","author":"Verdier","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041119485892500_B44","doi-asserted-by":"crossref","first-page":"6237","DOI":"10.2741\/3151","article-title":"The different functions of Stat5 and chromatin alteration through Stat5 proteins.","volume":"13","author":"Kornfeld","year":"2008","journal-title":"Front Biosci"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/153\/8\/3668\/8980344\/endo3668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T02:49:05Z","timestamp":1555037345000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/153\/8\/3668\/2423935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,14]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,6,14]]},"published-print":{"date-parts":[[2012,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2012-1135","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,14]]}}}