{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:18:15Z","timestamp":1778563095171,"version":"3.51.4"},"reference-count":41,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>Intrauterine growth restriction (IUGR) results in dysregulated glucose homeostasis and adiposity in the adult. We hypothesized that with aging, these perturbations will wane, and superimposition of postnatal growth restriction (PNGR) on IUGR [intrauterine and postnatal growth restriction (IPGR)] will reverse the residual IUGR phenotype. We therefore undertook hyperinsulinemic-euglycemic clamp, energy balance, and physical activity studies during fed, fasted, and refed states, in light and dark cycles, on postweaned chow diet-fed more than 17-month aging male IUGR, PNGR, and IPGR vs. control (CON) rat offspring. Hyperinsulinemic-euglycemic clamp revealed similar whole-body insulin sensitivity and physical activity in the nonobese IUGR vs. CON, despite reduced heat production and energy expenditure. Compared with CON and IUGR, IPGR mimicking PNGR was lean and growth restricted with increased physical activity, O2 consumption (VO2), energy intake, and expenditure. Although insulin sensitivity was no different in IPGR and PNGR, skeletal muscle insulin-induced glucose uptake was enhanced. This presentation proved protective against the chronologically earlier (5.5 months) development of obesity and dysregulated energy homeostasis after 19 wk on a postweaned high-fat diet. This protective role of PNGR on the metabolic IUGR phenotype needs future fine tuning aimed at minimizing unintended consequences.<\/jats:p>","DOI":"10.1210\/en.2012-1206","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T10:32:48Z","timestamp":1351161168000},"page":"4216-4226","source":"Crossref","is-referenced-by-count":23,"title":["Superimposition of Postnatal Calorie Restriction Protects the Aging Male Intrauterine Growth- Restricted Offspring from Metabolic Maladaptations"],"prefix":"10.1210","volume":"153","author":[{"given":"Yun","family":"Dai","sequence":"first","affiliation":[{"name":"Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine University of California, Los Angeles, California 90095-1752"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanthie","family":"Thamotharan","sequence":"first","affiliation":[{"name":"Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine University of California, Los Angeles, California 90095-1752"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Garg","sequence":"first","affiliation":[{"name":"Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine University of California, Los Angeles, California 90095-1752"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Chul","family":"Shin","sequence":"first","affiliation":[{"name":"Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine University of California, Los Angeles, California 90095-1752"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin U.","family":"Devaskar","sequence":"first","affiliation":[{"name":"Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine University of California, Los Angeles, California 90095-1752"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071612350437000_B1","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease.","volume":"23","author":"Barker","year":"2004","journal-title":"J Am Coll Nutr"},{"key":"2020071612350437000_B2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.clp.2006.10.001","article-title":"Glucose metabolism in the late preterm infant.","volume":"33","author":"Garg","year":"2006","journal-title":"Clin Perinatol"},{"key":"2020071612350437000_B3","doi-asserted-by":"crossref","first-page":"E489","DOI":"10.1152\/ajpendo.00361.2009","article-title":"Early exposure of the pregestational intrauterine and postnatal growth-restricted female offspring to a peroxisome proliferator-activated receptor-\u03b3 agonist.","volume":"298","author":"Garg","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071612350437000_B4","doi-asserted-by":"crossref","first-page":"477.e1","DOI":"10.1016\/j.ajog.2007.02.024","article-title":"Gender-specific programmed hepatic lipid dysregulation in intrauterine growth-restricted offspring.","volume":"196","author":"Choi","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"2020071612350437000_B5","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s001250051219","article-title":"Effect of ageing on \u03b2-cell mass and function in rats malnourished during the perinatal period.","volume":"42","author":"Garofano","year":"1999","journal-title":"Diabetologia"},{"key":"2020071612350437000_B6","doi-asserted-by":"crossref","first-page":"E83","DOI":"10.1152\/ajpendo.2000.279.1.E83","article-title":"Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition.","volume":"279","author":"Vickers","year":"2000","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071612350437000_B7","doi-asserted-by":"crossref","first-page":"R368","DOI":"10.1152\/ajpregu.00206.2004","article-title":"Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring.","volume":"288","author":"Fernandez-Twinn","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071612350437000_B8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1155\/EDR.2001.139","article-title":"Diabetes in old male offspring of rat dams fed a reduced protein diet.","volume":"2","author":"Petry","year":"2001","journal-title":"Int J Exp Diabetes Res"},{"key":"2020071612350437000_B9","first-page":"347","article-title":"Fetal growth retardation. 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