{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:22:19Z","timestamp":1760984539208},"reference-count":32,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p>H\u00fcrthle cells have long been described in Hashimoto thyroiditis but remain of undetermined significance. We have previously shown that H\u00fcrthle cells and hypothyroidism develop in C57BL\/6J mice expressing interferon-\u03b3 (IFN\u03b3) in the thyroid. To assess the influence of genetic backgrounds on H\u00fcrthle cell development, we crossed C57BL\/6J IFN\u03b3 transgenic mice to 14 strains and analyzed thyroid histopathology and function in a cohort of 389 mice (225 transgenic and 164 wild type) using a multiple linear regression model that also included strain, sex, genotype, and major histocompatibility complex haplotype. We then queried the Johns Hopkins surgical pathology electronic archive for \u201cHashimoto\u201d and\/or \u201cthyroiditis\u201d keywords, reviewed the reports, and reexamined the Hashimoto slides. H\u00fcrthle cells were markedly affected by the genetic background: they were prominent and associated with hypothyroidism in the C57BL\/6J, C57BL\/6ByJ, C57BL\/10J, C57BLKS\/J, C57L\/J, C58\/J, and BPN\/3J IFN\u03b3 transgenic strains, whereas they are mild or absent in the BPH\/2J, BPL\/1J, LP\/J, CBA\/J, Balb\/cJ, DBA\/1J, and NOD\/ShiLtJ strains. H\u00fcrthle cells were the strongest predictor of hypothyroidism after adjusting for all the other covariates in the regression model. Interestingly, transgenic mice of the BPL\/1J, DBA\/1J, and NOD\/ShiLtJ strains developed a marked accumulation of intrathyroidal brown adipocytes that was significantly associated with improved thyroid function. H\u00fcrthle cells were mentioned in 23% of the Hashimoto reports but increased to 79% upon our slide review. This study reports a novel association of H\u00fcrhtle cells and brown adipocytes on thyroid function that should prompt a reconsideration of their significance and role in pathogenesis of autoimmune thyroiditis.<\/jats:p>","DOI":"10.1210\/en.2012-1236","type":"journal-article","created":{"date-parts":[[2012,6,20]],"date-time":"2012-06-20T02:20:51Z","timestamp":1340158851000},"page":"4059-4066","source":"Crossref","is-referenced-by-count":8,"title":["H\u00fcrthle Cells Predict Hypothyroidism in Interferon-\u03b3 Transgenic Mice of Different Genetic Backgrounds"],"prefix":"10.1210","volume":"153","author":[{"given":"Shintaro","family":"Iwama","sequence":"first","affiliation":[{"name":"Department of Pathology (S.I., A.D., J.A.B., P.C.), Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"De Remigis","sequence":"first","affiliation":[{"name":"Department of Pathology (S.I., A.D., J.A.B., P.C.), Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin A.","family":"Bishop","sequence":"first","affiliation":[{"name":"Department of Pathology (S.I., A.D., J.A.B., P.C.), Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki J.","family":"Kimura","sequence":"first","affiliation":[{"name":"Division of Bioimaging Sciences (H.J.K.), Center for Molecular Medicine, Jichi Medical University, Shimotsuke 329-0498, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Caturegli","sequence":"first","affiliation":[{"name":"Department of Pathology (S.I., A.D., J.A.B., P.C.), Baltimore, Maryland 21205"},{"name":"Johns Hopkins University School of Medicine, and Feinstone Department of Molecular Microbiology and Immunology (P.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"2020071612130597900_B1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1089\/thy.1994.4.333","article-title":"The pathology of autoimmune thyroid disease: a review.","volume":"4","author":"LiVolsi","year":"1994","journal-title":"Thyroid"},{"key":"2020071612130597900_B2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/jcem-58-5-942","article-title":"Intrathyroidal and circulating lymphocyte subsets in different stages of autoimmune postpartum thyroiditis.","volume":"58","author":"Jansson","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612130597900_B3","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1507\/endocrj.EJ11-0309","article-title":"IgG4-related disease of the thyroid gland.","volume":"59","author":"Kakudo","year":"2012","journal-title":"Endocr J"},{"key":"2020071612130597900_B4","first-page":"219","article-title":"Zur Kenntniss der lymphomat\u00f6sen Ver\u00e4nderung der Shilddr\u00fcse (Struma lymphomatosa).","volume":"97","author":"Hashimoto","year":"1912","journal-title":"Archiv f\u00fcr Klinische Chirurgie"},{"key":"2020071612130597900_B5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","article-title":"The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey.","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071612130597900_B6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/thy.2005.15.121","article-title":"Karl Hurthle! 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