{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:47:05Z","timestamp":1791460025124,"version":"4.3.4"},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"DOI":"10.1210\/en.2012-1452","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T06:32:48Z","timestamp":1351146768000},"page":"4580-4587","source":"Crossref","is-referenced-by-count":45,"title":["Anatabine Ameliorates Experimental Autoimmune Thyroiditis"],"prefix":"10.1210","volume":"153","author":[{"given":"Patrizio","family":"Caturegli","sequence":"first","affiliation":[{"name":"Department of Pathology (P.C., A.D.R., M.A.L.-S., S.I., S.-C.T.), Baltimore, Maryland 21205"},{"name":"Divisions of Endocrinology and Metabolism (P.C., P.W.L.) and Cardiology (M.F.), Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"},{"name":"Feinstone Department of Molecular Microbiology and Immunology (P.C.), Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"De Remigis","sequence":"additional","affiliation":[{"name":"Department of Pathology (P.C., A.D.R., M.A.L.-S., S.I., S.-C.T.), Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Ferlito","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism (P.C., P.W.L.) and Cardiology (M.F.), Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Landek-Salgado","sequence":"additional","affiliation":[{"name":"Department of Pathology (P.C., A.D.R., M.A.L.-S., S.I., S.-C.T.), Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Iwama","sequence":"additional","affiliation":[{"name":"Department of Pathology (P.C., A.D.R., M.A.L.-S., S.I., S.-C.T.), Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shey-Cherng","family":"Tzou","sequence":"additional","affiliation":[{"name":"Department of Pathology (P.C., A.D.R., M.A.L.-S., S.I., S.-C.T.), Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Ladenson","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Metabolism (P.C., P.W.L.) and Cardiology (M.F.), Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122170219400_B1","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1210\/jc.2004-0431","article-title":"Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination Survey (NHANES III).","volume":"89","author":"Belin","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122170219400_B2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1365-2265.2003.01862.x","article-title":"Risk factors for and prevalence of thyroid disorders in a cross-sectional study among healthy female relatives of patients with autoimmune thyroid disease.","volume":"59","author":"Strieder","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041122170219400_B3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/EJE-07-0595","article-title":"Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study.","volume":"158","author":"Pedersen","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"2019041122170219400_B4","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1210\/jc.2008-1548","article-title":"Discontinuation of smoking increases the risk for developing thyroid peroxidase antibodies and\/or thyroglobulin antibodies: a prospective study.","volume":"94","author":"Effraimidis","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122170219400_B5","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3109\/00365528809090183","article-title":"Effects of cigarette smoking on the clinical course of ulcerative colitis.","volume":"23","author":"Boyko","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"2019041122170219400_B6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00042737-199707000-00007","article-title":"Effects of smoking on the presentation and clinical course of inflammatory bowel disease.","volume":"9","author":"Fraga","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2019041122170219400_B7","first-page":"858","article-title":"[Effect of smoking on the long-term course of ulcerative colitis].","volume":"22","author":"Mokbel","year":"1998","journal-title":"Gastroenterol Clin Biol"},{"key":"2019041122170219400_B8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.crohns.2011.12.010","article-title":"Low-dose smoking resumption in ex-smokers with refractory ulcerative colitis.","volume":"6","author":"Calabrese","year":"2012","journal-title":"J Crohns Colitis"},{"key":"2019041122170219400_B9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","article-title":"Effects of cigarette smoke on the immune system.","volume":"2","author":"Sopori","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"2019041122170219400_B10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway.","volume":"117","author":"Tracey","year":"2007","journal-title":"J Clin Invest"},{"key":"2019041122170219400_B11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuron.2011.03.014","article-title":"Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses.","volume":"70","author":"Miwa","year":"2011","journal-title":"Neuron"},{"key":"2019041122170219400_B12","doi-asserted-by":"crossref","first-page":"E885","DOI":"10.1208\/aapsj070486","article-title":"Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells.","volume":"7","author":"Gahring","year":"2005","journal-title":"AAPS J"},{"key":"2019041122170219400_B13","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s00018-010-0525-1","article-title":"\u03b17 Nicotinic receptors as novel therapeutic targets for inflammation-based diseases.","volume":"68","author":"Bencherif","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2019041122170219400_B14","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.4049\/jimmunol.0902212","article-title":"Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses.","volume":"183","author":"Nizri","year":"2009","journal-title":"J Immunol"},{"key":"2019041122170219400_B15","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ejphar.2011.09.019","article-title":"Anatabine lowers Alzheimer's A\u03b2 production in vitro and in vivo.","volume":"670","author":"Paris","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"2019041122170219400_B16","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1210\/en.2004-1165","article-title":"Expression of class II major histocompatibility complex molecules on thyrocytes does not cause spontaneous thyroiditis but mildly increases its severity after immunization.","volume":"146","author":"Kimura","year":"2005","journal-title":"Endocrinology"},{"key":"2019041122170219400_B17","doi-asserted-by":"crossref","DOI":"10.3791\/2182","article-title":"Induction of experimental autoimmune hypophysitis in SJL mice","author":"Landek-Salgado","year":"2010","journal-title":"J Vis Exp"},{"key":"2019041122170219400_B18","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited.","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J"},{"key":"2019041122170219400_B19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.0959-9673.2005.00418.x","article-title":"Increased thyroidal fat and goitrous hypothyroidism induced by interferon-\u03b3.","volume":"86","author":"Kimura","year":"2005","journal-title":"Int J Exp Pathol"},{"key":"2019041122170219400_B20","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1073\/pnas.0701319104","article-title":"Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness.","volume":"104","author":"Rocchi","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122170219400_B21","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1210\/jc.2002-020634","article-title":"A genome-wide scan for autoimmune thyroiditis in the Old Order Amish: replication of genetic linkage on chromosome 5q11.2-q14.3.","volume":"88","author":"Allen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122170219400_B22","doi-asserted-by":"crossref","first-page":"E1466","DOI":"10.1210\/jc.2011-0228","article-title":"Significance of prediagnostic thyroid antibodies in women with autoimmune thyroid disease.","volume":"96","author":"Hutfless","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122170219400_B23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*).","volume":"27","author":"Masters","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"2019041122170219400_B24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1365-2796.2009.02098.x","article-title":"Cholinergic control of inflammation.","volume":"265","author":"Rosas-Ballina","year":"2009","journal-title":"J Intern Med"},{"key":"2019041122170219400_B25","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis.","volume":"10","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"2019041122170219400_B26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1189\/jlb.0810470","article-title":"The biological paths of IL-1 family members IL-18 and IL-33.","volume":"89","author":"Smith","year":"2011","journal-title":"J Leukoc Biol"},{"key":"2019041122170219400_B27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1089\/105072502320908268","article-title":"Thyroid-stimulating hormone induces interleukin-18 gene expression in FRTL-5 cells: immunohistochemical detection of interleukin-18 in autoimmune thyroid disease.","volume":"12","author":"Takiyama","year":"2002","journal-title":"Thyroid"},{"key":"2019041122170219400_B28","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1365-2613.2010.00715.x","article-title":"Thyrocyte interleukin-18 expression is up-regulated by interferon-\u03b3 and may contribute to thyroid destruction in Hashimoto's thyroiditis.","volume":"91","author":"Liu","year":"2010","journal-title":"Int J Exp Pathol"},{"key":"2019041122170219400_B29","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrrheum.2010.4","article-title":"IL-1 pathways in inflammation and human diseases.","volume":"6","author":"Gabay","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"2019041122170219400_B30","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1210\/en.2012-1236","article-title":"H\u00fcrthle cells predict hypothyroidism in interferon-\u03b3 transgenic mice of different genetic backgrounds.","volume":"153","author":"Iwama","year":"2012","journal-title":"Endocrinology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/153\/9\/4580\/10390235\/endo4580.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T12:20:30Z","timestamp":1555071630000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/153\/9\/4580\/2424266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,1]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2012-1452","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,1]]}}}