{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:48:55Z","timestamp":1791434935018,"version":"4.3.3"},"reference-count":129,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,9,1]]},"abstract":"<jats:p>Thyroid hormone (TH) signaling plays an important role in development and adult life. Many organisms may have evolved under selective pressure of exogenous TH, suggesting that thyroid hormone signaling is phylogenetically older than the systems that regulate their synthesis. Therefore, the negative feedback system by TH itself was probably the first mechanism of regulation of circulating TH levels. In humans and other vertebrates, it is well known that TH negatively regulates its own production through central actions that modulate the hypothalamic-pituitary-thyroid (HPT) axis. Indeed, primary hypothyroidism leads to the up-regulation of the genes encoding many key players in the HPT axis, such as TRH, type 2 deiodinase (dio2), pyroglutamyl peptidase II (PPII), TRH receptor 1 (TRHR1), and the TSH \u03b1- and \u03b2-subunits. However, in many physiological circumstances, the activity of the HPT axis is not always a function of circulating TH concentrations. Indeed, circadian changes in the HPT axis activity are not a consequence of oscillation in circulating TH levels. Similarly, during reduced food availability, several components of the HPT axis are down-regulated even in the presence of lower circulating TH levels, suggesting the presence of a regulatory pathway hierarchically higher than the feedback system. This minireview discusses the neural regulation of the HPT axis, focusing on both TH-dependent and -independent pathways and their potential integration.<\/jats:p>","DOI":"10.1210\/en.2012-1467","type":"journal-article","created":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T21:57:08Z","timestamp":1341439028000},"page":"4128-4135","source":"Crossref","is-referenced-by-count":113,"title":["Minireview: The Neural Regulation of the Hypothalamic-Pituitary-Thyroid Axis"],"prefix":"10.1210","volume":"153","author":[{"given":"Ricardo H.","family":"Costa-e-Sousa","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism (R.H.C.e.S., A.N.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"},{"name":"CAPES (Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior) Foundation (R.H.C.e.S.), Ministry of Education of Brazil, Bras\u00edlia, DF, 70040-020 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N.","family":"Hollenberg","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism (R.H.C.e.S., A.N.H.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612042791900_B1","doi-asserted-by":"crossref","first-page":"R726","DOI":"10.1016\/j.cub.2011.07.030","article-title":"The origins and evolution of vertebrate metamorphosis.","volume":"21","author":"Laudet","year":"2011","journal-title":"Curr Biol"},{"key":"2020071612042791900_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-10-0444","article-title":"Thyroid hormones and fetal neurological development.","volume":"209","author":"Patel","year":"2011","journal-title":"J Endocrinol"},{"key":"2020071612042791900_B3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1210\/endo-60-4-470","article-title":"The effect of dehydration, starvation, and pitressin injections on thyroid activity in the rat.","volume":"60","author":"Reichlin","year":"1957","journal-title":"Endocrinology"},{"key":"2020071612042791900_B4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0026-0495(76)90162-1","article-title":"Starvation-induced alterations of circulating thyroid hormone concentration in man.","volume":"25","author":"Merimee","year":"1976","journal-title":"Metabolism"},{"key":"2020071612042791900_B5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1089\/thy.2007.0253","article-title":"Fasting-induced changes in the hypothalamus-pituitary-thyroid axis.","volume":"18","author":"Boelen","year":"2008","journal-title":"Thyroid"},{"key":"2020071612042791900_B6","first-page":"347","article-title":"The histological changes in the thyroid gland of the white rat exposed to cold.","volume":"9","author":"Kenyon","year":"1933","journal-title":"Am J Pathol"},{"key":"2020071612042791900_B7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1210\/endo-56-2-143","article-title":"The response of the pituitary-thyroid system of the guinea pig to low environmental temperature.","volume":"56","author":"Stevens","year":"1955","journal-title":"Endocrinology"},{"key":"2020071612042791900_B8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1152\/physrev.00009.2005","article-title":"Thermogenic mechanisms and their hormonal regulation.","volume":"86","author":"Silva","year":"2006","journal-title":"Physiol Rev"},{"key":"2020071612042791900_B9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(74)92070-4","article-title":"Effect of severe chronic illness in thyroid function.","volume":"2","author":"Carter","year":"1974","journal-title":"Lancet"},{"key":"2020071612042791900_B10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-09-0412","article-title":"Mechanisms behind the non-thyroidal illness syndrome: an update.","volume":"205","author":"Warner","year":"2010","journal-title":"J Endocrinol"},{"key":"2020071612042791900_B11","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/er.2011-0007","article-title":"Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection.","volume":"32","author":"Boelen","year":"2011","journal-title":"Endocr Rev"},{"key":"2020071612042791900_B12","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3181\/00379727-214-44098","article-title":"Iodine metabolism and thyroid-related functions in organisms lacking thyroid follicles: are thyroid hormones also vitamins?","volume":"214","author":"Eales","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"key":"2020071612042791900_B13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ygcen.2009.09.016","article-title":"Endocrine interactions between plants and animals: Implication of exogenous hormone source for the evolution of hormone signaling.","volume":"166","author":"Miller","year":"2010","journal-title":"Gen Comp Endocrinol"},{"key":"2020071612042791900_B14","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1242\/jeb.01877","article-title":"Cross-kingdom hormonal signaling: an insight from thyroid hormone fnctions in marine larvae.","volume":"208","author":"Heyland","year":"2005","journal-title":"J Exp Biol"},{"key":"2020071612042791900_B15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0079-6123(06)53012-2","article-title":"The TRH neuron: a hypothalamic integrator of energy metabolism.","volume":"153","author":"Lechan","year":"2006","journal-title":"Prog Brain Res"},{"key":"2020071612042791900_B16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/thy.2007.0251","article-title":"The role of the thyrotropin-releasing hormone (TRH) neuron as a metabolic sensor.","volume":"18","author":"Hollenberg","year":"2008","journal-title":"Thyroid"},{"key":"2020071612042791900_B17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yfrne.2010.01.001","article-title":"Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neural and peripheral inputs.","volume":"31","author":"Nillni","year":"2010","journal-title":"Front Neuroendocrinol"},{"key":"2020071612042791900_B18","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1210\/endo-87-5-1032","article-title":"Feedback regulation of TSH secretion in rats with hypothalamic lesions.","volume":"87","author":"Martin","year":"1970","journal-title":"Endocrinology"},{"key":"2020071612042791900_B19","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1056\/NEJM198504253121703","article-title":"Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism.","volume":"312","author":"Beck-Peccoz","year":"1985","journal-title":"N Engl J Med"},{"key":"2020071612042791900_B20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0303-7207(86)90007-9","article-title":"Effects of in vivo bolus versus continuous TRH administration on TSH secretion, biosynthesis, and glycosylation in normal and hypothyroid rats.","volume":"46","author":"Taylor","year":"1986","journal-title":"Mol Cell Endocrinol"},{"key":"2020071612042791900_B21","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1074\/jbc.M511530200","article-title":"Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.","volume":"281","author":"Nikrodhanond","year":"2006","journal-title":"J Biol Chem"},{"key":"2020071612042791900_B22","doi-asserted-by":"crossref","first-page":"10862","DOI":"10.1073\/pnas.94.20.10862","article-title":"Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene.","volume":"94","author":"Yamada","year":"1997","journal-title":"Proc Nat Acad Sci USA"},{"key":"2020071612042791900_B23","doi-asserted-by":"crossref","first-page":"19958","DOI":"10.1074\/jbc.272.32.19958","article-title":"Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.","volume":"272","author":"Schaner","year":"1997","journal-title":"J Biol Chem"},{"key":"2020071612042791900_B24","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.2741\/2334","article-title":"The biosynthesis and processing of neuropeptides: lessons from prothyrotropin releasing hormone 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composition.","volume":"118","author":"Guillemin","year":"1965","journal-title":"Proc Soc Exp Biol Med"},{"key":"2020071612042791900_B28","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1016\/S0021-9258(17)36387-1","article-title":"Isolation and properties of porcine thyrotropin-releasing hormone.","volume":"244","author":"Schally","year":"1969","journal-title":"J Biol Chem"},{"key":"2020071612042791900_B29","first-page":"E109","article-title":"Evidence that TRH stimulates secretion of TSH by two calcium-mediated mechanisms.","volume":"242","author":"Geras","year":"1982","journal-title":"Am J Physiol"},{"key":"2020071612042791900_B30","first-page":"90","article-title":"Thyrotropin (TSH)-releasing hormone stimulates TSH\u03b2 promoter activity by two distinct mechanisms involving calcium influx through L type Ca2+ channels and protein kinase C.","volume":"10","author":"Shupnik","year":"1996","journal-title":"Mol 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cerebellum.","volume":"110","author":"Crantz","year":"1982","journal-title":"Endocrinology"},{"key":"2020071612042791900_B37","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1210\/en.2008-1572","article-title":"Life without thyroxine to 3,5,3,-triiodothyronine conversion: Studies in mice devoid of the 5\u2032-deiodinases.","volume":"150","author":"Galton","year":"2009","journal-title":"Endocrinology"},{"key":"2020071612042791900_B38","first-page":"84","article-title":"Infundibular tanycytes as modulators of neuroendocrine function: hypothetical role in the regulation of the thyroid and gonadal axis.","volume":"78","author":"Lechan","year":"2007","journal-title":"Acta Biomed"},{"key":"2020071612042791900_B39","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/0006-8993(87)90260-5","article-title":"The regional hypothalamic distribution of type II 5\u2032-monodeiodinase in euthyroid and hypothyroid rats.","volume":"420","author":"Riskind","year":"1987","journal-title":"Brain Res"},{"key":"2020071612042791900_B40","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1210\/endo.138.8.5318","article-title":"Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone.","volume":"138","author":"Tu","year":"1997","journal-title":"Endocrinology"},{"key":"2020071612042791900_B41","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1210\/en.2010-0553","article-title":"Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment.","volume":"151","author":"Rosene","year":"2010","journal-title":"Endocrinology"},{"key":"2020071612042791900_B42","doi-asserted-by":"crossref","first-page":"40128","DOI":"10.1074\/jbc.M300909200","article-title":"Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter.","volume":"278","author":"Friesema","year":"2003","journal-title":"J Biol Chem"},{"key":"2020071612042791900_B43","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S0140-6736(04)17226-7","article-title":"Association between mutations in thyroid hormone transporter and severe X-linked psychomotor retardation.","volume":"364","author":"Friesema","year":"2004","journal-title":"Lancet"},{"key":"2020071612042791900_B44","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1086\/380999","article-title":"A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene.","volume":"74","author":"Dumitrescu","year":"2004","journal-title":"Am J Hum Genet"},{"key":"2020071612042791900_B45","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1210\/en.2004-1179","article-title":"The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in the thyroid hormone-sensitive neuron population.","volume":"146","author":"Heuer","year":"2005","journal-title":"Endocrinology"},{"key":"2020071612042791900_B46","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.1210\/en.2008-0378","article-title":"Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.","volume":"149","author":"Roberts","year":"2008","journal-title":"Endocrinology"},{"key":"2020071612042791900_B47","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1210\/en.2006-0390","article-title":"Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (Mct) 8-deficient mice.","volume":"147","author":"Dumitrescu","year":"2006","journal-title":"Endocrinology"},{"key":"2020071612042791900_B48","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1172\/JCI28253","article-title":"Abnormal thyroid hormone metabolism in mice lacking the 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thyrotropin.","volume":"58","author":"Burger","year":"1976","journal-title":"J Clin Invest"},{"key":"2020071612042791900_B52","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1089\/thy.2005.15.777","article-title":"Cellular and structural biology of the deiodinases.","volume":"15","author":"Bianco","year":"2005","journal-title":"Thyroid"},{"key":"2020071612042791900_B53","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1210\/endo.140.2.6486","article-title":"Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone.","volume":"140","author":"Tu","year":"1999","journal-title":"Endocrinology"},{"key":"2020071612042791900_B54","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1172\/JCI26240","article-title":"Type 3 deiodinase is critical for the maturation and function of the thyroid axis.","volume":"116","author":"Hernandez","year":"2006","journal-title":"J Clin Invest"},{"key":"2020071612042791900_B55","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/endo.135.1.7516871","article-title":"Identification of thyroid hormone receptor isoforms in thyrotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus.","volume":"135","author":"Lechan","year":"1994","journal-title":"Endocrinology"},{"key":"2020071612042791900_B56","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.2539642","article-title":"Identification of a thyroid hormone receptor that is pituitary-specific.","volume":"244","author":"Hodin","year":"1989","journal-title":"Science"},{"key":"2020071612042791900_B57","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1210\/mend-5-8-1049","article-title":"Isolation and isolation and characterization of mouse complementary DNAs encoding \u03b1 and \u03b2 thyroid hormone receptors from thyrotrope cells: the mouse pituitary-specific \u03b22 isoform differs at the amino terminus from the corresponding species from rat pituitary tumor cells.","volume":"5","author":"Wood","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2020071612042791900_B58","first-page":"3099","article-title":"The thyroid hormone receptor-\u03b2 gene mutation R383H is associated with isolated central resistance to thyroid hormone.","volume":"84","author":"Safer","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612042791900_B59","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/emboj\/18.3.623","article-title":"Different functions for the thyroid hormone receptors TR\u03b1 and TR\u03b2 in the control of thyroid hormone production and post-natal development.","volume":"18","author":"Gauthier","year":"1999","journal-title":"EMBO J"},{"key":"2020071612042791900_B60","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1172\/JCI10858","article-title":"Critical role for thyroid hormone receptor \u03b22 in the regulation of paraventricular thyrotropin-releasing hormone neurons.","volume":"107","author":"Abel","year":"2001","journal-title":"J Clin Invest"},{"key":"2020071612042791900_B61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.yfrne.2007.09.003","article-title":"Mechanisms of nongenomic actions of thyroid hormone.","volume":"29","author":"Davis","year":"2008","journal-title":"Front Neuroendocrinol"},{"key":"2020071612042791900_B62","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1074\/jbc.M207264200","article-title":"Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.","volume":"278","author":"Shibusawa","year":"2003","journal-title":"J Biol Chem"},{"key":"2020071612042791900_B63","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/emboj\/18.7.1900","article-title":"Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone.","volume":"18","author":"Weiss","year":"1999","journal-title":"EMBO J"},{"key":"2020071612042791900_B64","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1210\/endo.143.4.8730","article-title":"Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T3-regulated transcription of gene in vivo.","volume":"143","author":"Takeuchi","year":"2002","journal-title":"Endocrinology"},{"key":"2020071612042791900_B65","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI24109","article-title":"Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface.","volume":"115","author":"Ortiga-Carvalho","year":"2005","journal-title":"J Clin Invest"},{"key":"2020071612042791900_B66","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1210\/me.2010-0462","article-title":"The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis.","volume":"25","author":"Astapova","year":"2011","journal-title":"Mol Endocrinol"},{"key":"2020071612042791900_B67","doi-asserted-by":"crossref","first-page":"17462","DOI":"10.1073\/pnas.1107474108","article-title":"Resistance to thyroid hormone is modulated in vivo by nuclear receptor corepressor (NCoR1).","volume":"108","author":"Fozzatti","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612042791900_B68","first-page":"45","article-title":"TRH inactivation in the extracellular compartment: role og pyroglutamyl peptidase II.","volume":"6","author":"Charli","year":"1998","journal-title":"Neurobiology"},{"key":"2020071612042791900_B69","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1210\/en.2008-1643","article-title":"Tanycyte pyroglutamil peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median 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