{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:03:27Z","timestamp":1791270207119,"version":"4.1.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The physiological and beneficial actions of vitamin D in bone health have been experimentally and clinically proven in mammals. The active form of vitamin D [1\u03b1,25(OH)2D3] binds and activates its specific nuclear receptor, the vitamin D receptor (VDR). Activated VDR prevents the release of calcium from its storage in bone to serum by stimulating intestinal calcium absorption and renal reabsorption. However, the direct action of VDR in bone tissue is poorly understood because serum Ca2+ homeostasis is maintained through tightly regulated ion transport by the kidney, intestine, and bone. In addition, conventional genetic approaches using VDR knockout (VDR-KO, VDR\u2212\/\u2212) mice could not identify VDR action in bone because of the animals' systemic defects in calcium metabolism. In this study, we report that systemic VDR heterozygous KO (VDR+\/L\u2212) mice generated with the Cre\/loxP system as well as conventional VDR heterozygotes (VDR+\/\u2212) showed increased bone mass in radiological assessments. Because mineral metabolism parameters were unaltered in both types of mice, these bone phenotypes imply that skeletal VDR plays a role in bone mass regulation. To confirm this assumption, osteoblast-specific VDR-KO (VDR\u0394Ob\/\u0394Ob) mice were generated with 2.3 kb \u03b11(I)-collagen promoter-Cre transgenic mice. They showed a bone mass increase without any dysregulation of mineral metabolism. Although bone formation parameters were not affected in bone histomorphometry, bone resorption was obviously reduced in VDR\u0394Ob\/\u0394Ob mice because of decreased expression of receptor activator of nuclear factor kappa-B ligand (an essential molecule in osteoclastogenesis) in VDR\u0394Ob\/\u0394Ob osteoblasts. These findings establish that VDR in osteoblasts is a negative regulator of bone mass control.<\/jats:p>","DOI":"10.1210\/en.2012-1542","type":"journal-article","created":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T07:19:34Z","timestamp":1360221574000},"page":"1008-1020","source":"Crossref","is-referenced-by-count":159,"title":["Vitamin D Receptor in Osteoblasts Is a Negative Regulator of Bone Mass Control"],"prefix":"10.1210","volume":"154","author":[{"given":"Yoko","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Yoshizawa","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Fukuda","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Shirode-Fukuda","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiyong","family":"Yu","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Sekine","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sato","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Kawano","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Aihara","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nakamichi","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayo","family":"Shindo","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Inoue","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erina","family":"Inoue","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Tsuji","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Hoshino","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Karsenty","sequence":"first","affiliation":[{"name":"Department of Genetics and Development (G.K.), Columbia University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Metzger","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (D.M., P.C.), Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, 67404 Illkirch, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (D.M., P.C.), Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, 67404 Illkirch, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeaki","family":"Kato","sequence":"first","affiliation":[{"name":"Soma Central Hospital (S.K.), Fukushima, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Imai","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Biosciences (Y.Y., T.Yo., T.F., Y.S-F., T.Yu, K.S., T.S., H.K., K.A., Y.N., T.W., M.S., K.I., E.I., N.T., M.H., Y.I.), The University of Tokyo, Bunkyo-ku, 113-0032, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612235959800_B1","first-page":"719","article-title":"Newly identified actions of the vitamin D endocrine system","volume":"13","author":"Walters","year":"1992","journal-title":"Endocr Rev"},{"key":"2020071612235959800_B2","first-page":"200","article-title":"Structure-function relationships in the vitamin D endocrine system","volume":"16","author":"Bouillon","year":"1995","journal-title":"Endocr Rev"},{"key":"2020071612235959800_B3","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1753-4887.2008.00105.x","article-title":"Evolution of our understanding of vitamin D","volume":"66","author":"DeLuca","year":"2008","journal-title":"Nutr Rev"},{"key":"2020071612235959800_B4","doi-asserted-by":"crossref","first-page":"1159S","DOI":"10.1093\/jn\/126.suppl_4.1159S","article-title":"Vitamin D and bone health","volume":"126","author":"Holick","year":"1996","journal-title":"J Nutr"},{"key":"2020071612235959800_B5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bone.2011.07.011","article-title":"A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures\u2014a randomized, active comparator, double-blind study","volume":"49","author":"Matsumoto","year":"2011","journal-title":"Bone"},{"key":"2020071612235959800_B6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00223-004-0005-4","article-title":"Vitamin D analogs versus native vitamin D in preventing bone loss and osteoporosis-related fractures: a comparative meta-analysis","volume":"76","author":"Richy","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"2020071612235959800_B7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJM199202063260601","article-title":"Treatment of postmenopausal osteoporosis with calcitriol or calcium","volume":"326","author":"Tilyard","year":"1992","journal-title":"N Engl J Med"},{"key":"2020071612235959800_B8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nri2378","article-title":"Vitamin effects on the immune system: vitamins A and D take centre stage","volume":"8","author":"Mora","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2020071612235959800_B9","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1111\/j.1753-4887.2008.00094.x","article-title":"Vitamin D's role in cell proliferation and differentiation","volume":"66","author":"Samuel","year":"2008","journal-title":"Nutr Rev"},{"key":"2020071612235959800_B10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1359\/jbmr.1998.13.3.325","article-title":"The nuclear vitamin D receptor: biological and molecular regulatory properties revealed","volume":"13","author":"Haussler","year":"1998","journal-title":"J Bone Miner Res"},{"key":"2020071612235959800_B11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/oxfordjournals.jbchem.a022662","article-title":"The function of vitamin D receptor in vitamin D action","volume":"127","author":"Kato","year":"2000","journal-title":"J Biochem"},{"key":"2020071612235959800_B12","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/jcb.10423","article-title":"New insights into the mechanisms of vitamin D action","volume":"88","author":"Christakos","year":"2003","journal-title":"J Cell Biochem"},{"key":"2020071612235959800_B13","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612235959800_B14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat Genet"},{"key":"2020071612235959800_B15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr Rev"},{"key":"2020071612235959800_B16","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1210\/endo.139.10.6262","article-title":"Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice","volume":"139","author":"Li","year":"1998","journal-title":"Endocrinology"},{"key":"2020071612235959800_B17","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1359\/jbmr.2003.18.7.1217","article-title":"Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption","volume":"18","author":"Masuyama","year":"2003","journal-title":"J Bone Miner Res"},{"key":"2020071612235959800_B18","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/jcb.21929","article-title":"Modulation of mouse RANKL gene expression by Runx2 and vitamin D3","volume":"105","author":"Kitazawa","year":"2008","journal-title":"J Cell Biochem"},{"key":"2020071612235959800_B19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/edrv.20.3.0367","article-title":"Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families","volume":"20","author":"Suda","year":"1999","journal-title":"Endocr Rev"},{"key":"2020071612235959800_B20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2011.05.012","article-title":"Genome-wide principles of gene regulation by the vitamin D receptor and its activating ligand","volume":"347","author":"Pike","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"2020071612235959800_B21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/35036595","article-title":"Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis","volume":"407","author":"Li","year":"2000","journal-title":"Nature"},{"key":"2020071612235959800_B22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1993.1458","article-title":"A novel ES cell line, TT2, with high germline-differentiating potency","volume":"214","author":"Yagi","year":"1993","journal-title":"Anal Biochem"},{"key":"2020071612235959800_B23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2007.07.025","article-title":"Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts","volume":"130","author":"Nakamura","year":"2007","journal-title":"Cell"},{"key":"2020071612235959800_B24","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1242\/dev.124.2.399","article-title":"In vivo functional analysis of the = Hoxa-1 3\u2032 retinoic acid response element (3\u2032RARE)","volume":"124","author":"Dup\u00e9","year":"1997","journal-title":"Development"},{"key":"2020071612235959800_B25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/dvdy.10100","article-title":"Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast","volume":"224","author":"Dacquin","year":"2002","journal-title":"Dev Dyn"},{"key":"2020071612235959800_B26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee","volume":"2","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"2020071612235959800_B27","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2020071612235959800_B28","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1210\/endo-128-4-1792","article-title":"Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cells","volume":"128","author":"Takahashi","year":"1991","journal-title":"Endocrinology"},{"key":"2020071612235959800_B29","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.bone.2009.06.010","article-title":"Identification of differentially expressed genes between osteoblasts and osteocytes","volume":"45","author":"Paic","year":"2009","journal-title":"Bone"},{"key":"2020071612235959800_B30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00223-011-9505-1","article-title":"VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner","volume":"89","author":"de Paula","year":"2011","journal-title":"Calcif Tissue Int"},{"key":"2020071612235959800_B31","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1172\/JCI45890","article-title":"Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization","volume":"122","author":"Lieben","year":"2012","journal-title":"J Clin Invest"},{"key":"2020071612235959800_B32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"2020071612235959800_B33","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J Clin Invest"},{"key":"2020071612235959800_B34","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat Med"},{"key":"2020071612235959800_B35","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat Med"},{"key":"2020071612235959800_B36","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s001980070028","article-title":"Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption","volume":"11","author":"Aubin","year":"2000","journal-title":"Osteoporos Int"},{"key":"2020071612235959800_B37","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1210\/endo-122-4-1373","article-title":"Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures","volume":"122","author":"Takahashi","year":"1988","journal-title":"Endocrinology"},{"key":"2020071612235959800_B38","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat Rev Genet"},{"key":"2020071612235959800_B39","doi-asserted-by":"crossref","first-page":"12876","DOI":"10.1073\/pnas.0403606101","article-title":"Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling","volume":"101","author":"Mizwicki","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020071612235959800_B40","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1073\/pnas.0305802101","article-title":"Rapid modulation of osteoblast ion channel responses by 1alpha,25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptor","volume":"101","author":"Zanello","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020071612235959800_B41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00441-009-0832-8","article-title":"Regulation of bone development and extracellular matrix protein genes by RUNX2","volume":"339","author":"Komori","year":"2010","journal-title":"Cell Tissue Res"},{"key":"2020071612235959800_B42","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1172\/JCI24742","article-title":"c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs","volume":"116","author":"Takasu","year":"2006","journal-title":"J Clin Invest"},{"key":"2020071612235959800_B43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.abb.2008.03.027","article-title":"Osteoclast-osteoblast communication","volume":"473","author":"Matsuo","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"2020071612235959800_B44","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J Clin Invest"},{"key":"2020071612235959800_B45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cmet.2006.05.012","article-title":"Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis","volume":"4","author":"Zhao","year":"2006","journal-title":"Cell Metab"},{"key":"2020071612235959800_B46","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1359\/jbmr.060714","article-title":"Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast","volume":"21","author":"Baldock","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2020071612235959800_B47","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s00198-009-1136-2","article-title":"The efficacy of calcitriol therapy in the management of bone loss and fractures: a qualitative review","volume":"21","author":"Peppone","year":"2010","journal-title":"Osteoporos Int"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/3\/1008\/10385076\/endo1008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/3\/1008\/10385076\/endo1008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T23:41:31Z","timestamp":1644277291000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/154\/3\/1008\/2423339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,1]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2012-1542","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,1]]}}}