{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:28:25Z","timestamp":1784921305847,"version":"3.55.0"},"reference-count":62,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:p>In gut endocrine L cells, the Wnt signaling pathway effector \u03b2-catenin (\u03b2-cat)\/transcription factor 7-like 2 mediates the stimulatory effect of insulin on proglucagon (gcg) expression and glucagon-like peptide-1 (GLP-1) production. In several other cell lineages, insulin is able to stimulate p21-activated protein kinase 1 (Pak1). Here we determined the role of Pak1 in gcg expression and the effect of Pak1 deletion on glucose homeostasis. Insulin stimulated Pak1 activation through increasing its Thr423 phosphorylation in gut gcg-expressing cell lines, associated with increased gcg mRNA levels. This stimulation was attenuated by the Pak inhibitor 2,2\u2032-dihydroxy-1,1\u2032-dinaphthyldisulfide (IPA3) or dominant-negative Pak1. Both insulin and cAMP-promoting agents activated \u03b2-cat Ser675 phosphorylation, which was attenuated by IPA3 or protein kinase A inhibition, respectively. Gut gcg levels were reduced in male Pak1\u2212\/\u2212 mice, associated with impaired glucose tolerance after an ip or oral glucose challenge. These mice had lower circulating active GLP-1 levels after a glucose challenge as well as reduced distal ileum GLP-1 content after insulin treatment. Finally, the Pak1\u2212\/\u2212 mice exhibited reduced brainstem gcg level and abolished \u03b2-cat Ser675 phosphorylation in brain neurons after insulin treatment. We suggest that Pak1 mediates the cross talk between insulin and Wnt signaling pathways on gut and brain gcg expression, and its ablation impairs glucose homeostasis.<\/jats:p>","DOI":"10.1210\/en.2012-1781","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T05:29:21Z","timestamp":1353994161000},"page":"77-88","source":"Crossref","is-referenced-by-count":42,"title":["P21-Activated Protein Kinase 1 (Pak1) Mediates the Cross Talk between Insulin and \u03b2-Catenin on Proglucagon Gene Expression and Its Ablation Affects Glucose Homeostasis in Male C57BL\/6 Mice"],"prefix":"10.1210","volume":"154","author":[{"given":"Yuting Alex","family":"Chiang","sequence":"first","affiliation":[{"name":"Departments of Physiology (Y.A.C., T.J)., University of Toronto, Ontario, Canada M5S 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Shao","sequence":"first","affiliation":[{"name":"Division of Cellular and Molecular Biology (W.S., X.X.X., T.J.), University Health Network, Toronto, Ontario, Canada M5G 1L7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Xue","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Cellular and Molecular Biology (W.S., X.X.X., T.J.), University Health Network, Toronto, Ontario, Canada M5G 1L7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chernoff","sequence":"first","affiliation":[{"name":"Fox Chase Cancer Center (J.C.), Philadelphia, Pennsylvania 19111"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianru","family":"Jin","sequence":"first","affiliation":[{"name":"Departments of Physiology (Y.A.C., T.J)., University of Toronto, Ontario, Canada M5S 1A8"},{"name":"Laboratory Medicine and Pathobiology (T.J.), University of Toronto, Ontario, Canada M5S 1A8"},{"name":"Division of Cellular and Molecular Biology (W.S., X.X.X., T.J.), University Health Network, Toronto, Ontario, Canada M5G 1L7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612110746200_B1","first-page":"357","article-title":"Proglucagon-derived peptides: mechanisms of action and therapeutic potential.","volume":"20","author":"Sinclair","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"2020071612110746200_B2","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1073\/pnas.93.15.7911","article-title":"Induction of intestinal epithelial proliferation by glucagon-like peptide 2.","volume":"93","author":"Drucker","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612110746200_B3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0003-4266(04)95625-9","article-title":"Gastro-intestinal hormones GIP and GLP-1.","volume":"65","author":"Kieffer","year":"2004","journal-title":"Ann Endocrinol (Paris)"},{"key":"2020071612110746200_B4","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of incretins: GLP-1 and GIP.","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology"},{"key":"2020071612110746200_B5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1677\/JOE-08-0085","article-title":"Mechanisms underlying proglucagon gene expression.","volume":"198","author":"Jin","year":"2008","journal-title":"J Endocrinol"},{"key":"2020071612110746200_B6","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/MCB.7.1.560","article-title":"Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line.","volume":"7","author":"Philippe","year":"1987","journal-title":"Mol Cell Biol"},{"key":"2020071612110746200_B7","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1128\/MCB.01543-08","article-title":"Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.","volume":"29","author":"Katz","year":"2009","journal-title":"Mol Cell Biol"},{"key":"2020071612110746200_B8","doi-asserted-by":"crossref","first-page":"28984","DOI":"10.1074\/jbc.271.46.28984","article-title":"The caudal-related homeodomain protein Cdx-2\/3 regulates glucagon gene expression in islet cells.","volume":"271","author":"Laser","year":"1996","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/MCB.16.1.19","article-title":"Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2\/3.","volume":"16","author":"Jin","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2020071612110746200_B10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","article-title":"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.","volume":"38","author":"Grant","year":"2006","journal-title":"Nat Genet"},{"key":"2020071612110746200_B11","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1074\/jbc.M206006200","article-title":"Transcriptional activation of the proglucagon gene by lithium and \u03b2-catenin in intestinal endocrine L cells.","volume":"278","author":"Ni","year":"2003","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1074\/jbc.M411487200","article-title":"TCF-4 mediates cell type-specific regulation of proglucagon gene expression by \u03b2-catenin and glycogen synthase kinase-3beta.","volume":"280","author":"Yi","year":"2005","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B13","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.cellsig.2008.04.014","article-title":"Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of \u03b2-catenin.","volume":"20","author":"Jin","year":"2008","journal-title":"Cell Signal"},{"key":"2020071612110746200_B14","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.1073\/pnas.88.16.7224","article-title":"Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element.","volume":"88","author":"Philippe","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612110746200_B15","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1172\/JCI114214","article-title":"Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.","volume":"84","author":"Philippe","year":"1989","journal-title":"J Clin Invest"},{"key":"2020071612110746200_B16","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1074\/jbc.M408560200","article-title":"Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription.","volume":"280","author":"Schinner","year":"2005","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B17","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1210\/en.2007-1142","article-title":"Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells.","volume":"149","author":"Yi","year":"2008","journal-title":"Endocrinology"},{"key":"2020071612110746200_B18","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1210\/en.2008-0726","article-title":"Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.","volume":"150","author":"Lim","year":"2009","journal-title":"Endocrinology"},{"key":"2020071612110746200_B19","doi-asserted-by":"crossref","first-page":"E298","DOI":"10.1152\/ajpendo.00319.2005","article-title":"MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness.","volume":"291","author":"Kim","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071612110746200_B20","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1242\/jcs.01392","article-title":"The genetics of Pak.","volume":"117","author":"Hofmann","year":"2004","journal-title":"J Cell Sci"},{"key":"2020071612110746200_B21","doi-asserted-by":"crossref","first-page":"25070","DOI":"10.1074\/jbc.270.42.25070","article-title":"Molecular cloning of a new member of the p21-Cdc42\/Rac-activated kinase (PAK) family.","volume":"270","author":"Manser","year":"1995","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1517\/14728222.2010.492779","article-title":"PAK1 as a therapeutic target.","volume":"14","author":"Kichina","year":"2010","journal-title":"Expert Opin Ther Targets"},{"key":"2020071612110746200_B23","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1038\/onc.2009.167","article-title":"P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.","volume":"28","author":"Sun","year":"2009","journal-title":"Oncogene"},{"key":"2020071612110746200_B24","doi-asserted-by":"crossref","first-page":"19664","DOI":"10.1074\/jbc.271.33.19664","article-title":"Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase.","volume":"271","author":"Tsakiridis","year":"1996","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B25","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1210\/en.2009-0508","article-title":"The rho guanosine 5\u2032-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell.","volume":"150","author":"Lim","year":"2009","journal-title":"Endocrinology"},{"key":"2020071612110746200_B26","doi-asserted-by":"crossref","first-page":"41359","DOI":"10.1074\/jbc.M111.291500","article-title":"Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.","volume":"286","author":"Wang","year":"2011","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B27","first-page":"1646","article-title":"Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.","volume":"8","author":"Drucker","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2020071612110746200_B28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1210\/en.2003-0946","article-title":"Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders.","volume":"145","author":"Belsham","year":"2004","journal-title":"Endocrinology"},{"key":"2020071612110746200_B29","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1182\/blood-2008-06-160861","article-title":"p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.","volume":"113","author":"Allen","year":"2009","journal-title":"Blood"},{"key":"2020071612110746200_B30","article-title":"Isolation and purification of primary rodent astrocytes","author":"Weinstein","year":"2001","journal-title":"Curr Protoc Neurosci"},{"key":"2020071612110746200_B31","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s00125-010-2001-8","article-title":"Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL\/6J mice.","volume":"54","author":"Yu","year":"2011","journal-title":"Diabetologia"},{"key":"2020071612110746200_B32","doi-asserted-by":"crossref","first-page":"9106","DOI":"10.1074\/jbc.275.13.9106","article-title":"The Akt proto-oncogene links Ras to Pak and cell survival signals.","volume":"275","author":"Tang","year":"2000","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B33","doi-asserted-by":"crossref","first-page":"e28784","DOI":"10.1371\/journal.pone.0028784","article-title":"Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes.","volume":"7","author":"Shao","year":"2012","journal-title":"PLoS One"},{"key":"2020071612110746200_B34","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chembiol.2008.03.005","article-title":"An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase.","volume":"15","author":"Deacon","year":"2008","journal-title":"Chem Biol"},{"key":"2020071612110746200_B35","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1074\/jbc.274.9.5851","article-title":"Characterization of a novel calcium response element in the glucagon gene.","volume":"274","author":"F\u00fcrstenau","year":"1999","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B36","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1210\/endo.137.9.8756537","article-title":"Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line.","volume":"137","author":"L\u00fc","year":"1996","journal-title":"Endocrinology"},{"key":"2020071612110746200_B37","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1074\/jbc.M508778200","article-title":"Phosphorylation of \u03b2-catenin by cyclic AMP-dependent protein kinase.","volume":"281","author":"Taurin","year":"2006","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B38","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1128\/MCB.25.20.9063-9072.2005","article-title":"Phosphorylation of \u03b2-catenin by cyclic AMP-dependent protein kinase stabilizes \u03b2-catenin through inhibition of its ubiquitination.","volume":"25","author":"Hino","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2020071612110746200_B39","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.1128\/MCB.10.12.6799","article-title":"Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.","volume":"10","author":"Knepel","year":"1990","journal-title":"Mol Cell Biol"},{"key":"2020071612110746200_B40","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00125-009-1429-1","article-title":"WNT\/\u03b2-catenin increases the production of incretins by entero-endocrine cells.","volume":"52","author":"Garc\u00eda-Mart\u00ednez","year":"2009","journal-title":"Diabetologia"},{"key":"2020071612110746200_B41","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/onc.2011.294","article-title":"A Rac1\/PAK1 cascade controls \u03b2-catenin activation in colon cancer cells.","volume":"31","author":"Zhu","year":"2012","journal-title":"Oncogene"},{"key":"2020071612110746200_B42","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1172\/JCI25764","article-title":"Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.","volume":"115","author":"Knauf","year":"2005","journal-title":"J Clin Invest"},{"key":"2020071612110746200_B43","doi-asserted-by":"crossref","first-page":"E334","DOI":"10.1152\/ajpendo.00409.2011","article-title":"Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice.","volume":"302","author":"Burmeister","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071612110746200_B44","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.2337\/diabetes.51.9.2719","article-title":"Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.","volume":"51","author":"Konrad","year":"2002","journal-title":"Diabetes"},{"key":"2020071612110746200_B45","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.cellsig.2011.05.022","article-title":"Rac1 signalling towards GLUT4\/glucose uptake in skeletal muscle.","volume":"23","author":"Chiu","year":"2011","journal-title":"Cell Signal"},{"key":"2020071612110746200_B46","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1210\/er.2009-0022","article-title":"Small G proteins in islet \u03b2-cell function.","volume":"31","author":"Kowluru","year":"2010","journal-title":"Endocr Rev"},{"key":"2020071612110746200_B47","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1074\/jbc.M610553200","article-title":"Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion.","volume":"282","author":"Wang","year":"2007","journal-title":"J Biol Chem"},{"key":"2020071612110746200_B48","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2337\/db09-1334","article-title":"Protein farnesylation-dependent Raf\/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic \u03b2-cells.","volume":"59","author":"Kowluru","year":"2010","journal-title":"Diabetes"},{"key":"2020071612110746200_B49","doi-asserted-by":"crossref","first-page":"15852","DOI":"10.1073\/pnas.1107394108","article-title":"PKA phosphorylation couples hepatic inositol-requiring enzyme 1\u03b1 to glucagon signaling in glucose metabolism.","volume":"108","author":"Mao","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612110746200_B50","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature01667","article-title":"Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1\u03b1 interaction.","volume":"423","author":"Puigserver","year":"2003","journal-title":"Nature"},{"key":"2020071612110746200_B51","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nm.2756","article-title":"NF-\u03baB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action.","volume":"18","author":"Sheng","year":"2012","journal-title":"Nat Med"},{"key":"2020071612110746200_B52","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1007\/s00125-011-2289-z","article-title":"Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.","volume":"54","author":"Norton","year":"2011","journal-title":"Diabetologia"},{"key":"2020071612110746200_B53","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00125-009-1596-0","article-title":"Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease.","volume":"53","author":"Nathanson","year":"2010","journal-title":"Diabetologia"},{"key":"2020071612110746200_B54","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2337\/diabetes.50.3.609","article-title":"Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.","volume":"50","author":"Vilsb\u00f8ll","year":"2001","journal-title":"Diabetes"},{"key":"2020071612110746200_B55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00125-007-0848-0","article-title":"Regulation of insulin secretion, glucokinase gene transcription and \u03b2 cell proliferation by adipocyte-derived Wnt signalling molecules.","volume":"51","author":"Schinner","year":"2008","journal-title":"Diabetologia"},{"key":"2020071612110746200_B56","doi-asserted-by":"crossref","first-page":"894","DOI":"10.2337\/db08-1187","article-title":"TCF7L2 regulates late events in insulin secretion from pancreatic islet \u03b2-cells.","volume":"58","author":"da Silva Xavier","year":"2009","journal-title":"Diabetes"},{"key":"2020071612110746200_B57","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1210\/er.2009-0029","article-title":"Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?","volume":"31","author":"Grant","year":"2010","journal-title":"Endocr Rev"},{"key":"2020071612110746200_B58","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s00125-010-1814-9","article-title":"Wingless-type MMTV integration site family (WNT) signalling in pancreatic \u03b2 cells-more complex than expected.","volume":"53","author":"Schinner","year":"2010","journal-title":"Diabetologia"},{"key":"2020071612110746200_B59","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1093\/hmg\/ddp178","article-title":"Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired \u03b2-cell function.","volume":"18","author":"Shu","year":"2009","journal-title":"Hum Mol Genet"},{"key":"2020071612110746200_B60","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2337\/db07-0847","article-title":"Transcription factor 7-like 2 regulates \u03b2-cell survival and function in human pancreatic islets.","volume":"57","author":"Shu","year":"2008","journal-title":"Diabetes"},{"key":"2020071612110746200_B61","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1128\/MCB.00969-10","article-title":"p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.","volume":"31","author":"Huang","year":"2011","journal-title":"Mol Cell Biol"},{"key":"2020071612110746200_B62","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1101\/gad.1880510","article-title":"A FOXO-Pak1 transcriptional pathway controls neuronal polarity.","volume":"24","author":"de la Torre-Ubieta","year":"2010","journal-title":"Genes Dev"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/1\/77\/10386008\/endo0077.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/1\/77\/10386008\/endo0077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T19:25:32Z","timestamp":1594927532000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/154\/1\/77\/2423297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2012-1781","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}