{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:52:03Z","timestamp":1791345123805,"version":"4.3.1"},"reference-count":68,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:p>Follicular differentiation is a tightly regulated process involving various endocrine, autocrine, and paracrine factors. The biosynthesis of progesterone and estradiol in response to FSH involves the regulation of multiple steroidogenic enzymes, such as p450 cholesterol side-chain cleavage enzyme and aromatase. Here we demonstrated that prohibitin (PHB), a multifunctional protein, inhibits FSH-induced progesterone and estradiol secretion in rat granulosa cells. The mRNA abundances of cyp11a (coding p450 cholesterol side-chain cleavage enzyme) and cyp19 (coding aromatase) were also suppressed by PHB in a time-dependent manner. It is known that a novel adipokine chemerin suppresses FSH-induced steroidogenesis in granulosa cells. Chemerin up-regulates the content of PHB, and PHB knockdown attenuates the suppressive role of chemerin on steroidogenesis. In addition, inhibition of phosphatidylinositol 3-kinase\/Akt pathway enhances the suppressive action of PHB, whereas expression of constitutively active Akt attenuates this response. These findings suggest that PHB is a novel negative regulator of FSH-induced steroidogenesis, and its action with chemerin may contribute to the dysregulation of steroidogenesis in the pathogenesis of polycystic ovarian syndrome.<\/jats:p>","DOI":"10.1210\/en.2012-1836","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:47:29Z","timestamp":1355964449000},"page":"956-967","source":"Crossref","is-referenced-by-count":57,"title":["Inhibitory Roles of Prohibitin and Chemerin in FSH-Induced Rat Granulosa Cell Steroidogenesis"],"prefix":"10.1210","volume":"154","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[{"name":"Departments of Cellular and Molecular Medicine (Q.W., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"},{"name":"University of Ottawa, and Chronic Disease Program (Q.W., A.L., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Leader","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology (A.L., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"},{"name":"University of Ottawa, and Chronic Disease Program (Q.W., A.L., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin K.","family":"Tsang","sequence":"first","affiliation":[{"name":"Departments of Cellular and Molecular Medicine (Q.W., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"},{"name":"Obstetrics and Gynaecology (A.L., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"},{"name":"University of Ottawa, and Chronic Disease Program (Q.W., A.L., B.K.T.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6"},{"name":"World Class University Biomodulation Major (B.K.T.), Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2012,12,18]]},"reference":[{"issue":"2","key":"2020071612092524300_B1","first-page":"200","article-title":"Initial and cyclic recruitment of ovarian follicles","volume":"21","author":"McGee","year":"2000","journal-title":"Endocr Rev"},{"issue":"11","key":"2020071612092524300_B2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.4161\/cc.5.11.2803","article-title":"Ovarian steroids: the good, the bad, and the signals that raise them","volume":"5","author":"Jamnongjit","year":"2006","journal-title":"Cell Cycle"},{"issue":"2","key":"2020071612092524300_B3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1677\/jme.0.0120239","article-title":"Differential regulation of cholesterol side-chain cleavage (P450scc) and aromatase (P450arom) enzyme mRNA expression by gonadotrophins and cyclic AMP in human granulosa cells","volume":"12","author":"Yong","year":"1994","journal-title":"J Mol Endocrinol"},{"issue":"4","key":"2020071612092524300_B4","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1210\/me.2006-0226","article-title":"Transcriptional regulation of the cholesterol side chain cleavage cytochrome P450 gene (CYP11A1) revisited: binding of GATA, cyclic adenosine 3\u2032,5\u2032-monophosphate response element-binding protein and activating protein (AP)-1 proteins to a distal novel cluster of cis-regulatory elements potentiates AP-2 and steroidogenic factor-1-dependent gene expression in the rodent placenta and ovary","volume":"21","author":"Sher","year":"2007","journal-title":"Mol Endocrinol"},{"issue":"3","key":"2020071612092524300_B5","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1095\/biolreprod.101.002170","article-title":"Regulation of steroidogenic genes by insulin-like growth factor-1 and follicle-stimulating hormone: differential responses of cytochrome P450 side-chain cleavage, steroidogenic acute regulatory protein, and 3\u03b2-hydroxysteroid dehydrogenase\/isomerase in rat granulosa cells","volume":"67","author":"Eimerl","year":"2002","journal-title":"Biol Reprod"},{"issue":"5","key":"2020071612092524300_B6","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1530\/REP-08-0485","article-title":"Studies of granulosa cell maturation in dominant and subordinate bovine follicles: novel extracellular matrix focimatrix is co-ordinately regulated with cholesterol side-chain cleavage CYP11A1","volume":"137","author":"Irving-Rodgers","year":"2009","journal-title":"Reproduction"},{"issue":"2","key":"2020071612092524300_B7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1210\/me.2006-0281","article-title":"Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase","volume":"21","author":"Hong","year":"2007","journal-title":"Mol Endocrinol"},{"issue":"10","key":"2020071612092524300_B8","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1210\/en.2007-0175","article-title":"Chemerin is a novel adipokine associated with obesity and metabolic syndrome","volume":"148","author":"Bozaoglu","year":"2007","journal-title":"Endocrinology"},{"issue":"7","key":"2020071612092524300_B9","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.20030382","article-title":"Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids","volume":"198","author":"Wittamer","year":"2003","journal-title":"J Exp Med"},{"issue":"41","key":"2020071612092524300_B10","doi-asserted-by":"crossref","first-page":"34661","DOI":"10.1074\/jbc.M504868200","article-title":"Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades","volume":"280","author":"Zabel","year":"2005","journal-title":"J Biol Chem"},{"issue":"45","key":"2020071612092524300_B11","doi-asserted-by":"crossref","first-page":"39520","DOI":"10.1074\/jbc.M111.258954","article-title":"Chemerin158K protein is the dominant chemerin isoform in synovial and cerebrospinal fluids but not in plasma","volume":"286","author":"Zhao","year":"2011","journal-title":"J Biol Chem"},{"issue":"5","key":"2020071612092524300_B12","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1210\/jc.2010-0042","article-title":"Chemerin, a novel adipokine in the regulation of angiogenesis","volume":"95","author":"Bozaoglu","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2020071612092524300_B13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.5483\/BMBRep.2010.43.7.491","article-title":"Cloning of porcine chemerin, ChemR23 and GPR1 and their involvement in regulation of lipogenesis","volume":"43","author":"Huang","year":"2010","journal-title":"BMB Rep"},{"issue":"38","key":"2020071612092524300_B14","doi-asserted-by":"crossref","first-page":"28175","DOI":"10.1074\/jbc.M700793200","article-title":"Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism","volume":"282","author":"Goralski","year":"2007","journal-title":"J Biol Chem"},{"issue":"10","key":"2020071612092524300_B15","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.4049\/jimmunol.0901037","article-title":"Mouse ChemR23 is expressed in dendritic cell subsets and macrophages, and mediates an anti-inflammatory activity of chemerin in a lung disease model","volume":"183","author":"Luangsay","year":"2009","journal-title":"J Immunol"},{"issue":"5\u20136","key":"2020071612092524300_B16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2011.11.004","article-title":"Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism","volume":"22","author":"Bondue","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"issue":"4","key":"2020071612092524300_B17","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1084\/jem.20071601","article-title":"Synthetic chemerin-derived peptides suppress inflammation through ChemR23","volume":"205","author":"Cash","year":"2008","journal-title":"J Exp Med"},{"issue":"9","key":"2020071612092524300_B18","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.2337\/db08-1528","article-title":"Insulin and metformin regulate circulating and adipose tissue chemerin","volume":"58","author":"Tan","year":"2009","journal-title":"Diabetes"},{"issue":"11","key":"2020071612092524300_B19","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1210\/en.2012-1424","article-title":"Chemerin, a novel regulator of follicular steroidogenesis and its potential involvement in polycystic ovarian syndrome","volume":"153","author":"Wang","year":"2012","journal-title":"Endocrinology"},{"issue":"3","key":"2020071612092524300_B20","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1128\/MCB.11.3.1372","article-title":"Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells","volume":"11","author":"Nuell","year":"1991","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2020071612092524300_B21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0531-5565(94)00069-7","article-title":"Prohibitin: potential role in senescence, development, and tumor suppression","volume":"30","author":"McClung","year":"1995","journal-title":"Exp Gerontol"},{"issue":"11","key":"2020071612092524300_B22","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1128\/MCB.02142-05","article-title":"Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes","volume":"26","author":"Rastogi","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2020071612092524300_B23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jcp.1041570211","article-title":"Cell cycle activity and expression of prohibitin mRNA","volume":"157","author":"Roskams","year":"1993","journal-title":"J Cell Physiol"},{"issue":"12","key":"2020071612092524300_B24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.4014\/jmb.1107.07056","article-title":"Time-dependent hepatic proteome analysis in lean and diet-induced obese mice","volume":"21","author":"Oh","year":"2011","journal-title":"J Microbiol Biotechnol"},{"issue":"3","key":"2020071612092524300_B25","doi-asserted-by":"crossref","first-page":"e34315","DOI":"10.1371\/journal.pone.0034315","article-title":"Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"2020071612092524300_B26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/(SICI)1097-0185(19990901)256:1<40::AID-AR6>3.0.CO;2-X","article-title":"Immunolocalization and expression of prohibitin, a mitochondrial associated protein within the rat ovaries","volume":"256","author":"Thompson","year":"1999","journal-title":"Anat Rec"},{"issue":"1","key":"2020071612092524300_B27","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1095\/biolreprod.103.024125","article-title":"Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary","volume":"71","author":"Thompson","year":"2004","journal-title":"Biol Reprod"},{"issue":"1","key":"2020071612092524300_B28","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1210\/en.2006-0187","article-title":"Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin","volume":"148","author":"Chowdhury","year":"2007","journal-title":"Endocrinology"},{"key":"2020071612092524300_B29","doi-asserted-by":"crossref","first-page":"690","DOI":"10.2741\/e410","article-title":"The emerging roles of prohibitins in folliculogenesis","volume":"4","author":"Chowdhury","year":"2012","journal-title":"Front Biosci (Elite Ed)"},{"issue":"4","key":"2020071612092524300_B30","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1095\/biolreprod21.4.773","article-title":"Ovarian granulosa cells isolated with EGTA and hypertonic sucrose: cellular integrity and function","volume":"21","author":"Campbell","year":"1979","journal-title":"Biol Reprod"},{"issue":"10","key":"2020071612092524300_B31","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1210\/me.2005-0446","article-title":"Role and regulation of nodal\/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia","volume":"20","author":"Wang","year":"2006","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2020071612092524300_B32","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1210\/endo-112-1-194","article-title":"Effects of long term androgen and estradiol exposure on the hypothalamus","volume":"112","author":"Brawer","year":"1983","journal-title":"Endocrinology"},{"issue":"10","key":"2020071612092524300_B33","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1210\/jc.2003-030617","article-title":"Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents","volume":"88","author":"Silfen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2020071612092524300_B34","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1210\/jc.2002-021875","article-title":"Beyond adrenal and ovarian androgen generation: Increased peripheral 5\u03b1-reductase activity in women with polycystic ovary syndrome","volume":"88","author":"Fassnacht","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2020071612092524300_B35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2[\u2212\u0394\u0394C(T)] method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"2020071612092524300_B36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/REP-09-0050","article-title":"IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase\/AKT in bovine granulosa cells","volume":"139","author":"Mani","year":"2010","journal-title":"Reproduction"},{"issue":"19","key":"2020071612092524300_B37","doi-asserted-by":"crossref","first-page":"19431","DOI":"10.1074\/jbc.M401235200","article-title":"Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase\/AKT\/Ras homolog enriched in brain (Rheb)\/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation","volume":"279","author":"Alam","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"2020071612092524300_B38","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1210\/en.2003-0293","article-title":"Protein kinase B is obligatory for follicle-stimulating hormone-induced granulosa cell differentiation","volume":"144","author":"Zeleznik","year":"2003","journal-title":"Endocrinology"},{"issue":"9","key":"2020071612092524300_B39","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ijo.2011.227","article-title":"2011 Prohibitin has an important role in adipocyte differentiation","volume":"36","author":"Ande","year":"2012","journal-title":"Int J Obes (Lond)"},{"issue":"48","key":"2020071612092524300_B40","doi-asserted-by":"crossref","first-page":"47853","DOI":"10.1074\/jbc.M305171200","article-title":"Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling","volume":"278","author":"Fusaro","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"2020071612092524300_B41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/BJ20060364","article-title":"Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites","volume":"401","author":"Joshi","year":"2007","journal-title":"Biochem J"},{"issue":"2","key":"2020071612092524300_B42","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.fertnstert.2009.03.058","article-title":"Ovarian and adipose tissue dysfunction in polycystic ovary syndrome: report of the 4th special scientific meeting of the Androgen Excess and PCOS Society","volume":"94","author":"Yildiz","year":"2010","journal-title":"Fertil Steril"},{"issue":"8","key":"2020071612092524300_B43","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1210\/en.2007-0168","article-title":"A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome","volume":"148","author":"Manneras","year":"2007","journal-title":"Endocrinology"},{"issue":"11","key":"2020071612092524300_B44","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.2337\/db10-0362","article-title":"Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet","volume":"59","author":"Becker","year":"2010","journal-title":"Diabetes"},{"issue":"45","key":"2020071612092524300_B45","doi-asserted-by":"crossref","first-page":"46835","DOI":"10.1074\/jbc.M409340200","article-title":"Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes","volume":"279","author":"Brasaemle","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"2020071612092524300_B46","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1742-4658.2005.05090.x","article-title":"Prohibitin attenuates insulin-stimulated glucose and fatty acid oxidation in adipose tissue by inhibition of pyruvate carboxylase","volume":"273","author":"Vessal","year":"2006","journal-title":"FEBS J"},{"issue":"3","key":"2020071612092524300_B47","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/edrv-9-3-295","article-title":"Molecular biology of steroid hormone synthesis","volume":"9","author":"Miller","year":"1988","journal-title":"Endocr Rev"},{"issue":"8","key":"2020071612092524300_B48","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1210\/me.2007-0020","article-title":"Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation","volume":"21","author":"Wayne","year":"2007","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2020071612092524300_B49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12020-008-9064-z","article-title":"Inhibition of rat granulosa cell differentiation by overexpression of G\u03b1q","volume":"33","author":"Escamilla-Hernandez","year":"2008","journal-title":"Endocrine"},{"issue":"5","key":"2020071612092524300_B50","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1210\/endo-99-5-1411","article-title":"Androgens augment FSH-induced progesterone secretion by cultured rat granulosa cells","volume":"99","author":"Armstrong","year":"1976","journal-title":"Endocrinology"},{"issue":"6","key":"2020071612092524300_B51","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1210\/endo-122-6-2780","article-title":"Factors influencing follicle-stimulating hormone-responsive steroidogenesis in marmoset granulosa cells: effects of androgens and the stage of follicular maturity","volume":"122","author":"Harlow","year":"1988","journal-title":"Endocrinology"},{"issue":"3","key":"2020071612092524300_B52","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1095\/biolreprod57.3.660","article-title":"Follicle-stimulating hormone and intracellular second messengers regulate steroidogenic acute regulatory protein messenger ribonucleic acid in luteinized porcine granulosa cells","volume":"57","author":"Pescador","year":"1997","journal-title":"Biol Reprod"},{"issue":"2","key":"2020071612092524300_B53","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1210\/me.2007-0400","article-title":"A repressive role for prohibitin in estrogen signaling","volume":"22","author":"He","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"12","key":"2020071612092524300_B54","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1038\/sj.onc.1210806","article-title":"Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways","volume":"27","author":"Choi","year":"2008","journal-title":"Oncogene"},{"issue":"12","key":"2020071612092524300_B55","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1210\/endo.141.12.7808","article-title":"Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and NR5A2, in equine ovarian cells during the ovulatory process","volume":"141","author":"Boerboom","year":"2000","journal-title":"Endocrinology"},{"issue":"1-2","key":"2020071612092524300_B56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0303-7207(03)00257-0","article-title":"Expression of LRH-1 and SF-1 in the mouse ovary: localization in different cell types correlates with differing function","volume":"207","author":"Hinshelwood","year":"2003","journal-title":"Mol Cell Endocrinol"},{"issue":"1-2","key":"2020071612092524300_B57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0303-7207(98)00257-3","article-title":"Transcriptional regulation of the StAR gene","volume":"151","author":"Reinhart","year":"1999","journal-title":"Mol Cell Endocrinol"},{"issue":"1-2","key":"2020071612092524300_B58","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jsbmb.2009.05.003","article-title":"cAMP-dependent regulation of CYP19 gene in rabbit preovulatory granulosa cells and corpus luteum","volume":"116","author":"Andrieu","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"2020071612092524300_B59","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.bbrc.2009.10.101","article-title":"Prohibitin interacts with phosphatidylinositol 3,4,5-triphosphate (PIP3) and modulates insulin signaling","volume":"390","author":"Ande","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"2A","key":"2020071612092524300_B60","first-page":"957","article-title":"Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells","volume":"28","author":"Han","year":"2008","journal-title":"Anticancer Res"},{"issue":"8","key":"2020071612092524300_B61","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bbamcr.2009.05.008","article-title":"Insulin induced phosphorylation of prohibitin at tyrosine 114 recruits Shp1","volume":"1793","author":"Ande","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"43","key":"2020071612092524300_B62","doi-asserted-by":"crossref","first-page":"40146","DOI":"10.1074\/jbc.M106710200","article-title":"Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells","volume":"276","author":"Salvador","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"2020071612092524300_B63","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1210\/mend.13.1.0222","article-title":"Follicle-stimulating hormone promotes histone H3 phosphorylation on serine-10","volume":"13","author":"DeManno","year":"1999","journal-title":"Mol Endocrinol"},{"issue":"9","key":"2020071612092524300_B64","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cellsig.2006.02.011","article-title":"FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A","volume":"18","author":"Hunzicker-Dunn","year":"2006","journal-title":"Cell Signal"},{"issue":"Pt 3","key":"2020071612092524300_B65","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj3460561","article-title":"The PI3K-PDK1 connection: more than just a road to PKB","volume":"346","author":"Vanhaesebroeck","year":"2000","journal-title":"Biochem J"},{"issue":"5385","key":"2020071612092524300_B66","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1126\/science.281.5385.2042","article-title":"Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1","volume":"281","author":"Le Good","year":"1998","journal-title":"Science"},{"issue":"5351","key":"2020071612092524300_B67","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.279.5351.707","article-title":"Phosphorylation and activation of p70s6k by PDK1","volume":"279","author":"Pullen","year":"1998","journal-title":"Science"},{"issue":"17","key":"2020071612092524300_B68","doi-asserted-by":"crossref","first-page":"9849","DOI":"10.1073\/pnas.95.17.9849","article-title":"Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase","volume":"95","author":"Cheng","year":"1998","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/2\/956\/8983612\/endo0956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/2\/956\/8983612\/endo0956.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T19:28:27Z","timestamp":1643916507000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/154\/2\/956\/2423768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,18]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2012-1836","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,18]]}}}