{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:28:52Z","timestamp":1789972132452,"version":"4.0.1"},"reference-count":46,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:p>Periodontitis, an inflammatory disease of periodontal tissues, is characterized by excessive alveolar bone resorption. An increase in the receptor activator of nuclear factor-\u03baB ligand (RANKL) to osteoprotegerin (OPG) ratio is thought to reflect the severity of periodontitis. Here, we examined alveolar bone loss in OPG-deficient (OPG\u2212\/\u2212) mice and RANKL-overexpressing transgenic (RANKL-Tg) mice. Alveolar bone loss in OPG\u2212\/\u2212 mice at 12 weeks was significantly higher than that in RANKL-Tg mice. OPG\u2212\/\u2212 but not RANKL-Tg mice exhibited severe bone resorption especially in cortical areas of the alveolar bone. An increased number of osteoclasts was observed in the cortical areas in OPG\u2212\/\u2212 but not in RANKL-Tg mice. Immunohistochemical analyses showed many OPG-positive signals in osteocytes but not osteoblasts. OPG-positive osteocytes in the cortical area of alveolar bones and long bones were abundant in both wild-type and RANKL-Tg mice. This suggests the resorption in cortical bone areas to be prevented by OPG produced locally. To test the usefulness of OPG\u2212\/\u2212 mice as an animal model for screening drugs to prevent alveolar bone loss, we administered an antimouse RANKL antibody or risedronate, a bisphosphonate, to OPG\u2212\/\u2212 mice. They suppressed alveolar bone resorption effectively. OPG\u2212\/\u2212 mice are useful for screening therapeutic agents against alveolar bone loss.<\/jats:p>","DOI":"10.1210\/en.2012-1928","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T07:30:53Z","timestamp":1357371053000},"page":"773-782","source":"Crossref","is-referenced-by-count":56,"title":["Osteoprotegerin-Deficient Male Mice as a Model for Severe Alveolar Bone Loss: Comparison With RANKL-Overexpressing Transgenic Male Mice"],"prefix":"10.1210","volume":"154","author":[{"given":"Masanori","family":"Koide","sequence":"first","affiliation":[{"name":"Institute for Oral Science (M.K., Y.K., T.N., N.T., N.U.), Matsumoto Dental University, Nagano 399-0781, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Institute for Oral Science (M.K., Y.K., T.N., N.T., N.U.), Matsumoto Dental University, Nagano 399-0781, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Ninomiya","sequence":"first","affiliation":[{"name":"Institute for Oral Science (M.K., Y.K., T.N., N.T., N.U.), Matsumoto Dental University, Nagano 399-0781, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Nakamura","sequence":"first","affiliation":[{"name":"Departments of Biochemistry (M.N., N.U.), Matsumoto Dental University, Nagano 399-0781, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Yasuda","sequence":"first","affiliation":[{"name":"Planning and Development (H.Y.), Bioindustry Division, Oriental Yeast Co, Ltd, Tokyo 174-8505, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Arai","sequence":"first","affiliation":[{"name":"Nihon University School of Dentistry (Y.A.), Tokyo 101-8310, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Okahashi","sequence":"first","affiliation":[{"name":"Department of Oral Frontier Biology (N.O.), Center for Frontier Oral Science, Osaka University Graduate School of Dentistry, Suita-Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Yoshinari","sequence":"first","affiliation":[{"name":"Periodontology (N.Y.), Matsumoto Dental University, Nagano 399-0781, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Institute for Oral Science (M.K., Y.K., T.N., N.T., N.U.), Matsumoto Dental University, Nagano 399-0781, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Udagawa","sequence":"first","affiliation":[{"name":"Institute for Oral Science (M.K., Y.K., T.N., N.T., N.U.), Matsumoto Dental University, Nagano 399-0781, 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