{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:39:29Z","timestamp":1790818769045,"version":"4.1.0"},"reference-count":75,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:p>Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable interest has arisen recently concerning other physiological roles of the Lin28\/let-7 axis, including its potential involvement in the control of puberty, as suggested by genome-wide association studies and functional genomics. We report herein the expression profiles of Lin28 and let-7 members in the rat hypothalamus during postnatal maturation and in selected models of altered puberty. The expression patterns of c-Myc (upstream positive regulator of Lin28), mir-145 (negative regulator of c-Myc), and mir-132 and mir-9 (putative miRNA repressors of Lin28, predicted by bioinformatic algorithms) were also explored. In male and female rats, Lin28, Lin28b, and c-Myc mRNAs displayed very high hypothalamic expression during the neonatal period, markedly decreased during the infantile-to-juvenile transition and reached minimal levels before\/around puberty. A similar puberty-related decline was observed for Lin28b in monkey hypothalamus but not in the rat cortex, suggesting species conservation and tissue specificity. Conversely, let-7a, let-7b, mir-132, and mir-145, but not mir-9, showed opposite expression profiles. Perturbation of brain sex differentiation and puberty, by neonatal treatment with estrogen or androgen, altered the expression ratios of Lin28\/let-7 at the time of puberty. Changes in the c-Myc\/Lin28b\/let-7 pathway were also detected in models of delayed puberty linked to early photoperiod manipulation and, to a lesser extent, postnatal underfeeding or chronic subnutrition. Altogether, our data are the first to document dramatic changes in the expression of the Lin28\/let-7 axis in the rat hypothalamus during the postnatal maturation and after different manipulations that disturb puberty, thus suggesting the potential involvement of developmental changes in hypothalamic Lin28\/let-7 expression in the mechanisms permitting\/leading to puberty onset.<\/jats:p>","DOI":"10.1210\/en.2012-2006","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T07:30:53Z","timestamp":1357371053000},"page":"942-955","source":"Crossref","is-referenced-by-count":114,"title":["Changes in Hypothalamic Expression of the Lin28\/let-7 System and Related MicroRNAs During Postnatal Maturation and After Experimental Manipulations of Puberty"],"prefix":"10.1210","volume":"154","author":[{"given":"S.","family":"Sangiao-Alvarellos","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"},{"name":"Department of Medicine (S.S.-A., F.C.), School of Health Science, University of A Coru\u00f1a, and Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, 15006, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Manfredi-Lozano","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ruiz-Pino","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.M.","family":"Navarro","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"S\u00e1nchez-Garrido","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Leon","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dieguez","sequence":"first","affiliation":[{"name":"Department of Physiology (C.D.), School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cordido","sequence":"first","affiliation":[{"name":"Department of Medicine (S.S.-A., F.C.), School of Health Science, University of A Coru\u00f1a, and Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a, 15006, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Matagne","sequence":"first","affiliation":[{"name":"Division of Neuroscience (V.M., G.A.D., S.R.O.), Oregon National Primate Research Center, Beaverton, Oregon 97006-3448"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.A.","family":"Dissen","sequence":"first","affiliation":[{"name":"Division of Neuroscience (V.M., G.A.D., S.R.O.), Oregon National Primate Research Center, Beaverton, Oregon 97006-3448"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Ojeda","sequence":"first","affiliation":[{"name":"Division of Neuroscience (V.M., G.A.D., S.R.O.), Oregon National Primate Research Center, Beaverton, Oregon 97006-3448"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pinilla","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tena-Sempere","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Physiology and Immunology (S.S.-A., M.M.-L., F.R.-P., V.M.N., M.A.S.-G., L.L., L.P., M.T.-S.), University of C\u00f3rdoba; CIBER (Centro de Investigaci\u00f3n Biomedica en Red) Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III; and Instituto Maim\u00f3nides de Investigaciones Biom\u00e9dicas \/Hospital Universitario Reina Sof\u00eda, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2013,1,4]]},"reference":[{"key":"2020071612090849400_B1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode Caenorhabditis elegans","volume":"226","author":"Ambros","year":"1984","journal-title":"Science"},{"key":"2020071612090849400_B2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0012-1606(03)00126-X","article-title":"Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites","volume":"258","author":"Moss","year":"2003","journal-title":"Dev Biol"},{"key":"2020071612090849400_B3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4161\/rna.4.1.4364","article-title":"Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules","volume":"4","author":"Balzer","year":"2007","journal-title":"RNA Biol"},{"key":"2020071612090849400_B4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gene.2006.07.011","article-title":"Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma","volume":"384","author":"Guo","year":"2006","journal-title":"Gene"},{"key":"2020071612090849400_B5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1525-142X.2003.03044.x","article-title":"Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?","volume":"5","author":"Pasquinelli","year":"2003","journal-title":"Evol Dev"},{"key":"2020071612090849400_B6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.cell.2010.02.007","article-title":"Lin28: A microRNA regulator with a macro role","volume":"140","author":"Viswanathan","year":"2010","journal-title":"Cell"},{"key":"2020071612090849400_B7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ceb.2009.04.009","article-title":"Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells","volume":"21","author":"Chekulaeva","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"2020071612090849400_B8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs","volume":"18","author":"Roush","year":"2008","journal-title":"Trends Cell Biol"},{"key":"2020071612090849400_B9","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1101\/gad.1671708","article-title":"Drosophila let-7 microRNA is required for remodeling of the neuromusculature during metamorphosis","volume":"22","author":"Sokol","year":"2008","journal-title":"Genes Dev"},{"key":"2020071612090849400_B10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1096\/fj.06-6130com","article-title":"Post-transcriptional regulation of the let-7 microRNA during neural cell specification","volume":"21","author":"Wulczyn","year":"2007","journal-title":"FASEB J"},{"key":"2020071612090849400_B11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1262\/jrd.09-088K","article-title":"Temporal and spatial regulation of let-7a in the uterus during embryo implantation in the rat","volume":"56","author":"Xia","year":"2010","journal-title":"J Reprod Dev"},{"key":"2020071612090849400_B12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.molmed.2008.07.001","article-title":"let-7 microRNAs in development, stem cells and cancer","volume":"14","author":"Bussing","year":"2008","journal-title":"Trends Mol Med"},{"key":"2020071612090849400_B13","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/dvdy.20599","article-title":"Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis","volume":"234","author":"Schulman","year":"2005","journal-title":"Dev Dyn"},{"key":"2020071612090849400_B14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2184.2008.00493.x","article-title":"Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors","volume":"41","author":"Yamanaka","year":"2008","journal-title":"Cell Prolif"},{"key":"2020071612090849400_B15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1567-133X(03)00140-6","article-title":"Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse","volume":"3","author":"Yang","year":"2003","journal-title":"Gene Expr Patterns"},{"issue":"5","key":"2020071612090849400_B16","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jmb.2011.04.041","article-title":"Post-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc\/Lin28B\/let-7 pathway","volume":"409","author":"Leppert","year":"2011","journal-title":"J Mol Biol"},{"issue":"2","key":"2020071612090849400_B17","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1074\/jbc.M111.278705","article-title":"MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells","volume":"287","author":"Nadiminty","year":"2012","journal-title":"J Biol Chem"},{"key":"2020071612090849400_B18","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1073\/pnas.0808300106","article-title":"Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation","volume":"106","author":"Chang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020071612090849400_B19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/emboj.2008.294","article-title":"Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7","volume":"28","author":"Dangi-Garimella","year":"2009","journal-title":"EMBO J"},{"key":"2020071612090849400_B20","first-page":"170","article-title":"miR-145-mediated suppression of cell growth, invasion and metastasis","volume":"2","author":"Sachdeva","year":"2010","journal-title":"Am J Transl Res"},{"key":"2020071612090849400_B21","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1073\/pnas.0808042106","article-title":"p53 represses c-Myc through induction of the tumor suppressor miR-145","volume":"106","author":"Sachdeva","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020071612090849400_B22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/ng.125","article-title":"Identification of ten loci associated with height highlights new biological pathways in human growth","volume":"40","author":"Lettre","year":"2008","journal-title":"Nat Genet"},{"key":"2020071612090849400_B23","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng.385","article-title":"Genome-wide association studies identify loci associated with age at menarche and age at natural menopause","volume":"41","author":"He","year":"2009","journal-title":"Nat Genet"},{"key":"2020071612090849400_B24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/ng.382","article-title":"Genetic variation in LIN28B is associated with the timing of puberty","volume":"41","author":"Ong","year":"2009","journal-title":"Nat Genet"},{"key":"2020071612090849400_B25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.386","article-title":"Meta-analysis of genome-wide association data identifies two loci influencing age at menarche","volume":"41","author":"Perry","year":"2009","journal-title":"Nat Genet"},{"key":"2020071612090849400_B26","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/ng.383","article-title":"Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche","volume":"41","author":"Sulem","year":"2009","journal-title":"Nat Genet"},{"key":"2020071612090849400_B27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ajhg.2010.03.010","article-title":"Distinct variants at LIN28B influence growth in height from birth to adulthood","volume":"86","author":"Widen","year":"2010","journal-title":"Am J Hum Genet"},{"key":"2020071612090849400_B28","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1210\/jc.2009-2344","article-title":"LIN28B in constitutional delay of growth and puberty","volume":"95","author":"Tommiska","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612090849400_B29","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ng.714","article-title":"Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies","volume":"42","author":"Elks","year":"2010","journal-title":"Nat Genet"},{"key":"2020071612090849400_B30","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ng.593","article-title":"Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies","volume":"42","author":"Zhu","year":"2010","journal-title":"Nat Genet"},{"key":"2020071612090849400_B31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/1756-0500-4-363","article-title":"LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty","volume":"4","author":"Tommiska","year":"2011","journal-title":"BMC Res Notes"},{"key":"2020071612090849400_B32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000342212","article-title":"Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty","volume":"78","author":"Silveira-Neto","year":"2012","journal-title":"Horm Res Paediatr"},{"key":"2020071612090849400_B33","first-page":"2061","article-title":"Puberty in the rat","volume-title":"The Physiology of Reproduction","author":"Ojeda","year":"2006"},{"key":"2020071612090849400_B34","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1210\/er.2002-0019","article-title":"The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration","volume":"24","author":"Parent","year":"2003","journal-title":"Endocr Rev"},{"key":"2020071612090849400_B35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000262527","article-title":"New concepts on the control of the onset of puberty","volume":"17","author":"Ojeda","year":"2010","journal-title":"Endocr Dev"},{"key":"2020071612090849400_B36","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1210\/en.2005-1136","article-title":"Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach?","volume":"147","author":"Ojeda","year":"2006","journal-title":"Endocrinology"},{"key":"2020071612090849400_B37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jri.2011.01.004","article-title":"MicroRNAs in pregnancy","volume":"88","author":"Prieto","year":"2011","journal-title":"J Reprod Immunol"},{"key":"2020071612090849400_B38","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2826.2010.01994.x","article-title":"Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism","volume":"22","author":"Sangiao-Alvarellos","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"2020071612090849400_B39","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1210\/en.2008-0954","article-title":"Insulin-like growth factor-I activates KiSS-1 gene expression in the brain of the prepubertal female rat","volume":"150","author":"Hiney","year":"2009","journal-title":"Endocrinology"},{"key":"2020071612090849400_B40","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1172\/JCI31752","article-title":"Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis","volume":"117","author":"Heger","year":"2007","journal-title":"J Clin Invest"},{"key":"2020071612090849400_B41","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1210\/endo-125-1-92","article-title":"In vivo release of luteinizing hormone releasing hormone increases with puberty in the female rhesus monkey","volume":"125","author":"Watanabe","year":"1989","journal-title":"Endocrinology"},{"key":"2020071612090849400_B42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Lewis","year":"2003","journal-title":"Cell"},{"key":"2020071612090849400_B43","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human MicroRNA targets","volume":"2","author":"John","year":"2004","journal-title":"PLoS Biol"},{"key":"2020071612090849400_B44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng1536","article-title":"Combinatorial microRNA target predictions","volume":"37","author":"Krek","year":"2005","journal-title":"Nat Genet"},{"key":"2020071612090849400_B45","doi-asserted-by":"crossref","first-page":"W273","DOI":"10.1093\/nar\/gkp292","article-title":"DIANA-microT web server: elucidating microRNA functions through target prediction","volume":"37","author":"Maragkakis","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"2020071612090849400_B46","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1210\/en.2008-0580","article-title":"Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation","volume":"150","author":"Navarro","year":"2009","journal-title":"Endocrinology"},{"key":"2020071612090849400_B47","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1677\/joe.0.1650345","article-title":"Neonatal exposure to estrogen differentially alters estrogen receptor alpha and beta mRNA expression in rat testis during postnatal development","volume":"165","author":"Tena-Sempere","year":"2000","journal-title":"J Endocrinol"},{"key":"2020071612090849400_B48","first-page":"671","article-title":"Reproductive disruption by exposure to exogenous estrogenic compounds during sex differentiation: lessons from the neonatally estrogenized male rat","volume":"3","author":"Tena-Sempere","year":"2000","journal-title":"Curr Top Steroid Res"},{"key":"2020071612090849400_B49","first-page":"208","article-title":"The pineal and pubertal development","volume":"117","author":"Sizonenko","year":"1985","journal-title":"Ciba Found Symp"},{"key":"2020071612090849400_B50","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000122527","article-title":"Entrainment of the adrenal rhythm to photoperiod prior to puberty: effects of early experience on the adrenal rhythm and puberty","volume":"21","author":"Ramaley","year":"1976","journal-title":"Neuroendocrinology"},{"key":"2020071612090849400_B51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-079X.1988.tb00769.x","article-title":"Photoperiodic sensitivity of prepubertal female Fisher 344 rats","volume":"5","author":"Leadem","year":"1988","journal-title":"J Pineal Res"},{"key":"2020071612090849400_B52","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1210\/en.2010-1415","article-title":"Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system","volume":"152","author":"Castellano","year":"2011","journal-title":"Endocrinology"},{"key":"2020071612090849400_B53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2337\/diabetes.54.1.197","article-title":"Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood: its relationship with the metabolic syndrome","volume":"54","author":"Boullu-Ciocca","year":"2005","journal-title":"Diabetes"},{"key":"2020071612090849400_B54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387038-4.00001-X","article-title":"Let's make it happen: the role of let-7 microRNA in development","volume":"99","author":"Mondol","year":"2012","journal-title":"Curr Top Dev Biol"},{"key":"2020071612090849400_B55","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1210\/en.2005-0337","article-title":"Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition","volume":"146","author":"Castellano","year":"2005","journal-title":"Endocrinology"},{"key":"2020071612090849400_B56","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1210\/en.2007-0634","article-title":"Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty","volume":"148","author":"Roth","year":"2007","journal-title":"Endocrinology"},{"key":"2020071612090849400_B57","doi-asserted-by":"crossref","first-page":"13167","DOI":"10.1523\/JNEUROSCI.4238-06.2006","article-title":"Deletion of the Ttf1 gene in differentiated neurons disrupts female reproduction without impairing basal ganglia function","volume":"26","author":"Mastronardi","year":"2006","journal-title":"J Neurosci"},{"key":"2020071612090849400_B58","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1210\/endo.140.8.6941","article-title":"The Oct-2 POU domain gene in the neuroendocrine brain: a transcriptional regulator of mammalian puberty","volume":"140","author":"Ojeda","year":"1999","journal-title":"Endocrinology"},{"key":"2020071612090849400_B59","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tem.2009.05.007","article-title":"Meta-regulation: microRNA regulation of glucose and lipid metabolism","volume":"20","author":"Lynn","year":"2009","journal-title":"Trends Endocrinol Metab"},{"key":"2020071612090849400_B60","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jneumeth.2012.05.033","article-title":"MicroRNA expression profiling of hypothalamic arcuate and paraventricular nuclei from single rats using Illumina sequencing technology","volume":"209","author":"Amar","year":"2012","journal-title":"J Neurosci Methods"},{"key":"2020071612090849400_B61","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"2020071612090849400_B62","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1154040","article-title":"Selective blockade of microRNA processing by Lin28","volume":"320","author":"Viswanathan","year":"2008","journal-title":"Science"},{"key":"2020071612090849400_B63","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.biocel.2009.02.023","article-title":"Lin-28: an early embryonic sentinel that blocks Let-7 biogenesis","volume":"42","author":"Newman","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"key":"2020071612090849400_B64","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1261\/rna.1155108","article-title":"Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing","volume":"14","author":"Newman","year":"2008","journal-title":"RNA"},{"key":"2020071612090849400_B65","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.molcel.2008.09.014","article-title":"Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA","volume":"32","author":"Heo","year":"2008","journal-title":"Mol Cell"},{"key":"2020071612090849400_B66","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ncb1759","article-title":"A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment","volume":"10","author":"Rybak","year":"2008","journal-title":"Nat Cell Biol"},{"key":"2020071612090849400_B67","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2011.10.039","article-title":"Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms","volume":"147","author":"Piskounova","year":"2011","journal-title":"Cell"},{"key":"2020071612090849400_B68","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nsmb0409-346","article-title":"miR-9 and TLX: chasing tails in neural stem cells","volume":"16","author":"Denli","year":"2009","journal-title":"Nat Struct Mol Biol"},{"key":"2020071612090849400_B69","doi-asserted-by":"crossref","first-page":"R173","DOI":"10.1186\/gb-2007-8-8-r173","article-title":"MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system","volume":"8","author":"Kapsimali","year":"2007","journal-title":"Genome Biol"},{"key":"2020071612090849400_B70","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1261\/rna.5980303","article-title":"A microRNA array reveals extensive regulation of microRNAs during brain development","volume":"9","author":"Krichevsky","year":"2003","journal-title":"RNA"},{"key":"2020071612090849400_B71","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1210\/en.2011-1541","article-title":"Hypothalamic EAP1 (enhanced at puberty 1) is required for menstrual cyclicity in nonhuman primates","volume":"153","author":"Dissen","year":"2012","journal-title":"Endocrinology"},{"key":"2020071612090849400_B72","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1158\/1078-0432.CCR-11-2503","article-title":"Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients","volume":"18","author":"Ciarimboli","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2020071612090849400_B73","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/path.2443","article-title":"TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival","volume":"217","author":"Perner","year":"2009","journal-title":"J Pathol"},{"key":"2020071612090849400_B74","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/sj.onc.1203385","article-title":"EAP1\/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes","volume":"19","author":"Li","year":"2000","journal-title":"Oncogene"},{"key":"2020071612090849400_B75","doi-asserted-by":"crossref","first-page":"32582","DOI":"10.1074\/jbc.M702806200","article-title":"Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells","volume":"282","author":"Shi","year":"2007","journal-title":"J Biol Chem"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/2\/942\/8983495\/endo0942.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/2\/942\/8983495\/endo0942.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T19:15:47Z","timestamp":1594926947000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/154\/2\/942\/2423748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,4]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2012-2006","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,4]]}}}