{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:09:34Z","timestamp":1771956574103,"version":"3.50.1"},"reference-count":55,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In obesity, reduced cardiac glucose uptake and mitochondrial abnormalities are putative causes of cardiac dysfunction. However, high-fat diet (HFD) does not consistently induce cardiac insulin resistance and mitochondrial damage, and recent studies suggest HFD may be cardioprotective. To determine cardiac responses to HFD, we investigated cardiac function, glucose uptake, and mitochondrial respiration in young (3-month-old) and middle-aged (MA) (12-month-old) male Ldlr\u2212\/\u2212 mice fed chow or 3 months HFD to induce obesity, systemic insulin resistance, and hyperinsulinemia. In MA Ldlr\u2212\/\u2212 mice, HFD induced accelerated atherosclerosis and nonalcoholic steatohepatitis, common complications of human obesity. Surprisingly, HFD-fed mice demonstrated increased cardiac glucose uptake, which was most prominent in MA mice, in the absence of cardiac contractile dysfunction or hypertrophy. Moreover, hearts of HFD-fed mice had enhanced mitochondrial oxidation of palmitoyl carnitine, glutamate, and succinate and greater basal insulin signaling compared with those of chow-fed mice, suggesting cardiac insulin sensitivity was maintained, despite systemic insulin resistance. Streptozotocin-induced ablation of insulin production markedly reduced cardiac glucose uptake and mitochondrial dysfunction in HFD-fed, but not in chow-fed, mice. Insulin injection reversed these effects, suggesting that insulin may protect cardiac mitochondria during HFD. These results have implications for cardiac metabolism and preservation of mitochondrial function in obesity.<\/jats:p>","DOI":"10.1210\/en.2012-2272","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T05:43:36Z","timestamp":1369460616000},"page":"2650-2662","source":"Crossref","is-referenced-by-count":34,"title":["High-Fat Feeding-Induced Hyperinsulinemia Increases Cardiac Glucose Uptake and Mitochondrial Function Despite Peripheral Insulin Resistance"],"prefix":"10.1210","volume":"154","author":[{"given":"Anisha A.","family":"Gupte","sequence":"first","affiliation":[{"name":"Methodist Diabetes and Metabolism Institute (A.A.G., L.J.M., M.R., Y.R., D.J.H., C.J.L., W.A.H.), Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie J.","family":"Minze","sequence":"first","affiliation":[{"name":"Methodist Diabetes and Metabolism Institute (A.A.G., L.J.M., M.R., Y.R., D.J.H., C.J.L., W.A.H.), Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricela","family":"Reyes","sequence":"first","affiliation":[{"name":"Methodist Diabetes and Metabolism Institute (A.A.G., L.J.M., M.R., Y.R., D.J.H., C.J.L., W.A.H.), Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelan","family":"Ren","sequence":"first","affiliation":[{"name":"Methodist Diabetes and Metabolism Institute (A.A.G., L.J.M., M.R., Y.R., D.J.H., C.J.L., W.A.H.), Houston Methodist Research Institute, Weill Cornell Medical College, Houston, Texas 77030"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xukui","family":"Wang","sequence":"first","affiliation":[{"name":"Pre-Clinical Imaging Core Laboratory (X.W., Z.-Z.S.), Houston Methodist Research Institute, 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