{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:20:57Z","timestamp":1789543257499,"version":"build-2803163510"},"reference-count":66,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sulfated neurosteroids pregnenolone sulfate (\u03945PS) and dehydroepiandrosterone sulfate (DHEAS) are known to play a role in the control of reproductive behavior. In the frog Pelophylax ridibundus, the enzyme hydroxysteroid sulfotransferase (HST), responsible for the biosynthesis of \u03945PS and DHEAS, is expressed in the magnocellular nucleus and the anterior preoptic area, two hypothalamic regions that are richly innervated by GnRH1-containing fibers. This observation suggests that GnRH1 may regulate the formation of sulfated neurosteroids to control sexual activity. Double labeling of frog brain slices with HST and GnRH1 antibodies revealed that GnRH1-immunoreactive fibers are located in close vicinity of HST-positive neurons. The cDNAs encoding 3 GnRH receptors (designated riGnRHR-1, -2, and -3) were cloned from the frog brain. RT-PCR analyses revealed that riGnRHR-1 is strongly expressed in the hypothalamus and the pituitary whereas riGnRHR-2 and -3 are primarily expressed in the brain. In situ hybridization histochemistry indicated that GnRHR-1 and GnRHR-3 mRNAs are particularly abundant in preoptic area and magnocellular nucleus whereas the concentration of GnRHR-2 mRNA in these 2 nuclei is much lower. Pulse-chase experiments using tritiated \u03945P and DHEA as steroid precursors, and 3\u2032-phosphoadenosine 5\u2032-phosphosulfate as a sulfonate moiety donor, showed that GnRH1 stimulates, in a dose-dependent manner, the biosynthesis of \u03945PS and DHEAS in frog diencephalic explants. Because \u03945PS and DHEAS, like GnRH, stimulate sexual activity, our data strongly suggest that some of the behavioral effects of GnRH could be mediated via the modulation of sulfated neurosteroid production.<\/jats:p>","DOI":"10.1210\/en.2013-1095","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T07:07:22Z","timestamp":1365059242000},"page":"2114-2128","source":"Crossref","is-referenced-by-count":13,"title":["Gonadotropin-Releasing Hormone Stimulates the Biosynthesis of Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate in the Hypothalamus"],"prefix":"10.1210","volume":"154","author":[{"given":"Delphine","family":"Burel","sequence":"first","affiliation":[{"name":"Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (D.B., J-L.D-R, H.V.), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U982, Research Institute for Biomedecine (IRIB), International Associated Laboratory Samuel de Champlain, University of Rouen, 76821 Mont-Saint Aignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Hua","family":"Li","sequence":"first","affiliation":[{"name":"Hormone Research Center (J.H.L., A.F.W., H.B.K.), Chonnam National University, Gwangju 500-757, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Do-Rego","sequence":"first","affiliation":[{"name":"Laboratory of Neuronal and Neuroendocrine Differentiation and Communication (D.B., J-L.D-R, H.V.), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U982, Research Institute for Biomedecine (IRIB), International Associated Laboratory Samuel de Champlain, University of Rouen, 76821 Mont-Saint Aignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai Fen","family":"Wang","sequence":"first","affiliation":[{"name":"Hormone Research Center (J.H.L., A.F.W., H.B.K.), Chonnam National University, Gwangju 500-757, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van","family":"Luu-The","sequence":"first","affiliation":[{"name":"Research Center in Molecular Endocrinology, Oncology and Genetics (V.L.T., G.P., H.V.), Laval University Hospital Center, Qu\u00e9bec, Ontario, G1V4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Pelletier","sequence":"first","affiliation":[{"name":"Research Center in Molecular Endocrinology, Oncology and Genetics (V.L.T., G.P., H.V.), Laval University Hospital Center, Qu\u00e9bec, Ontario, G1V4G2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Tillet","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive Physiology and Behaviors (Y.T., C.T.), Unit\u00e9 Mixte de Recherche MR 6175 Institut National de la Recherche Agronomique-Centre National de la Recherche Scientifique, University of Tours-Haras Nationaux, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Taragnat","sequence":"first","affiliation":[{"name":"Laboratory of Reproductive Physiology and Behaviors (Y.T., C.T.), Unit\u00e9 Mixte de Recherche MR 6175 Institut National de la Recherche Agronomique-Centre National de la Recherche Scientifique, University of Tours-Haras Nationaux, 37380 Nouzilly, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk Bang","family":"Kwon","sequence":"first","affiliation":[{"name":"Hormone Research Center (J.H.L., A.F.W., H.B.K.), Chonnam National University, Gwangju 500-757, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Seong","sequence":"first","affiliation":[{"name":"Laboratory of G-Protein-Coupled Receptors (J.Y.S), Graduate School of Medicine, Korea University, Seoul 136-705, 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