{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:07:22Z","timestamp":1791144442324,"version":"4.1.0"},"reference-count":59,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Task3 K+ channels are highly expressed in the adrenal cortex and contribute to the angiotensin II and K+ sensitivity of aldosterone-producing glomerulosa cells. Adult Task3\u2212\/\u2212 mice display a partially autonomous aldosterone secretion, subclinical hyperaldosteronism, and salt-sensitive hypertension. Here, we investigated the age dependence of the adrenal phenotype of Task3\u2212\/\u2212 mice. Compared with adults, newborn Task3\u2212\/\u2212 mice displayed a severe adrenal phenotype with strongly increased plasma levels of aldosterone, corticosterone, and progesterone. This adrenocortical dysfunction was accompanied by a modified gene expression profile. The most strongly up-regulated gene was the protease renin. Real-time PCR corroborated the strong increase in adrenal renin expression, and immunofluorescence revealed renin-expressing cells in the zona fasciculata. Together with additional factors, activation of the local adrenal renin system is probably causative for the severely disturbed steroid hormone secretion of neonatal Task3\u2212\/\u2212 mice. The changes in gene expression patterns of neonatal Task3\u2212\/\u2212 mice could also be relevant for other forms of hyperaldosteronism.<\/jats:p>","DOI":"10.1210\/en.2013-1101","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T01:12:54Z","timestamp":1369271574000},"page":"2712-2722","source":"Crossref","is-referenced-by-count":42,"title":["Severe Hyperaldosteronism in Neonatal Task3 Potassium Channel Knockout Mice Is Associated With Activation of the Intraadrenal Renin-Angiotensin System"],"prefix":"10.1210","volume":"154","author":[{"given":"Sascha","family":"Bandulik","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology (S.B., P.T., D.P., I.T., C.S., R.W.), University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Tauber","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology (S.B., P.T., D.P., I.T., C.S., R.W.), University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Penton","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology (S.B., P.T., D.P., I.T., C.S., R.W.), University of Regensburg, 93053 Regensburg, Germany"},{"name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire (D.P., E.L., F.L.), Centre National de la Recherche Scientifique (CNRS), and Universit\u00e9 de Nice Sophia Antipolis, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schweda","sequence":"first","affiliation":[{"name":"Department of Physiology (F.S.), University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Tegtmeier","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology (S.B., P.T., D.P., I.T., C.S., R.W.), University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Sterner","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology (S.B., P.T., D.P., I.T., C.S., R.W.), University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Lalli","sequence":"first","affiliation":[{"name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire (D.P., E.L., F.L.), Centre National de la Recherche Scientifique (CNRS), and Universit\u00e9 de Nice Sophia Antipolis, 06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lesage","sequence":"first","affiliation":[{"name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire (D.P., E.L., F.L.), Centre National de la Recherche Scientifique (CNRS), and Universit\u00e9 de Nice Sophia Antipolis, 06560 Valbonne, France"},{"name":"Laboratories of Excellence Ion Channel Science and Therapeutics (F.L., J.B.), CNRS UMR7275 Universit\u00e9 de Nice Sophia Antipolis, F-06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Hartmann","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetology (M.H.), Steroid Research and Mass Spectrometry Unit, Center of Child and Adolescent Medicine, Justus Liebig University, 35385 Gie\u00dfen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Barhanin","sequence":"first","affiliation":[{"name":"Transport Ionique Aspects Normaux et Pathologiques (J.B.), CNRS, and Universit\u00e9 de Nice Sophia Antipolis, UMR6097, 06108 Nice Cedex, France"},{"name":"Laboratories of Excellence Ion Channel Science and Therapeutics (F.L., J.B.), CNRS UMR7275 Universit\u00e9 de Nice Sophia Antipolis, F-06560 Valbonne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Warth","sequence":"first","affiliation":[{"name":"Department of Medical Cell Biology (S.B., P.T., D.P., I.T., C.S., R.W.), University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612103078800_B1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00030.2003","article-title":"Control of aldosterone secretion: a model for convergence in cellular signaling pathways","volume":"84","author":"Sp\u00e4t","year":"2004","journal-title":"Physiol Rev"},{"key":"2020071612103078800_B2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-0031-1295438","article-title":"Prevalence of primary aldosteronism in patient's cohorts and in population-based studies\u2013a review of the current literature","volume":"44","author":"Hannemann","year":"2012","journal-title":"Horm Metab Res"},{"key":"2020071612103078800_B3","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline","volume":"93","author":"Funder","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612103078800_B4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"2020071612103078800_B5","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1161\/RES.0b013e318224a359","article-title":"Mutations in KCNJ5 gene cause hyperaldosteronism","volume":"108","author":"Zennaro","year":"2011","journal-title":"Circ Res"},{"key":"2020071612103078800_B6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/HYPERTENSIONAHA.111.183996","article-title":"KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism","volume":"59","author":"Mulatero","year":"2012","journal-title":"Hypertension"},{"key":"2020071612103078800_B7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.111.187682","article-title":"The genetics of primary aldosteronism: chapter two","volume":"59","author":"Funder","year":"2012","journal-title":"Hypertension"},{"key":"2020071612103078800_B8","doi-asserted-by":"crossref","first-page":"E1532","DOI":"10.1210\/jc.2012-1334","article-title":"A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension","volume":"97","author":"Charmandari","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612103078800_B9","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1097\/HJH.0b013e328356139f","article-title":"Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma","volume":"30","author":"Murthy","year":"2012","journal-title":"J Hypertens"},{"key":"2020071612103078800_B10","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1055\/s-0029-1243601","article-title":"TASK1 and TASK3 potassium channels: determinants of aldosterone secretion and adrenocortical zonation","volume":"42","author":"Bandulik","year":"2010","journal-title":"Horm Metab Res"},{"key":"2020071612103078800_B11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.emboj.7601934","article-title":"Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis","volume":"27","author":"Heitzmann","year":"2008","journal-title":"EMBO J"},{"key":"2020071612103078800_B12","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1073\/pnas.0712000105","article-title":"TASK channel deletion in mice causes primary hyperaldosteronism","volume":"105","author":"Davies","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612103078800_B13","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1210\/en.2012-1527","article-title":"Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension","volume":"153","author":"Penton","year":"2012","journal-title":"Endocrinology"},{"key":"2020071612103078800_B14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1161\/HYPERTENSIONAHA.111.189662","article-title":"TASK-3 channel deletion in mice recapitulates low-renin essential hypertension","volume":"59","author":"Guagliardo","year":"2012","journal-title":"Hypertension"},{"key":"2020071612103078800_B15","doi-asserted-by":"crossref","first-page":"E2160","DOI":"10.1210\/jc.2012-2196","article-title":"Variations in the potassium channel genes KCNK3 and KCNK9 in relation to blood pressure and aldosterone production: an exploratory study","volume":"97","author":"Jung","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612103078800_B16","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1523\/JNEUROSCI.5764-08.2009","article-title":"Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels","volume":"29","author":"Guyon","year":"2009","journal-title":"J Neurosci"},{"key":"2020071612103078800_B17","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1210\/endo.139.10.6230","article-title":"Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11\u03b2-hydroxylase","volume":"139","author":"Wotus","year":"1998","journal-title":"Endocrinology"},{"key":"2020071612103078800_B18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"2020071612103078800_B19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1210\/me.2003-0005","article-title":"The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production","volume":"18","author":"Bassett","year":"2004","journal-title":"Mol Endocrinol"},{"key":"2020071612103078800_B20","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1210\/en.2009-0977","article-title":"Regulation of aldosterone synthase by activator transcription factor\/cAMP response element-binding protein family members","volume":"151","author":"Nogueira","year":"2010","journal-title":"Endocrinology"},{"key":"2020071612103078800_B21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1152\/physiolgenomics.00097.2004","article-title":"Angiotensin II early regulated genes in H295R human adrenocortical cells","volume":"19","author":"Romero","year":"2004","journal-title":"Physiol Genomics"},{"key":"2020071612103078800_B22","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1074\/jbc.M110.179812","article-title":"Pregnane X receptor PXR activates the GADD45\u03b2 gene, eliciting the p38 MAPK signal and cell migration","volume":"286","author":"Kodama","year":"2011","journal-title":"J Biol Chem"},{"key":"2020071612103078800_B23","first-page":"149","article-title":"Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells through the activation of GAL-R1 and GAL-R2 receptors coupled to the adenylate cyclase-dependent signaling cascade","volume":"19","author":"Andreis","year":"2007","journal-title":"Int J Mol Med"},{"key":"2020071612103078800_B24","first-page":"859","article-title":"Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade","volume":"20","author":"Belloni","year":"2007","journal-title":"Int J Mol Med"},{"key":"2020071612103078800_B25","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1210\/jcem-63-6-1372","article-title":"Localization and molecular forms of galanin in human adrenals: elevated levels in pheochromocytomas","volume":"63","author":"Bauer","year":"1986","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612103078800_B26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/07435809409035866","article-title":"The possible involvement of galanin in the modulation of the function of rat pituitary-adrenocortical axis under basal and stressful conditions","volume":"20","author":"Malendowicz","year":"1994","journal-title":"Endocr Res"},{"key":"2020071612103078800_B27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF02576294","article-title":"Effects of galanin on the secretory activity of the rat adrenal cortex: in vivo and in vitro studies","volume":"192","author":"Mazzocchi","year":"1992","journal-title":"Res Exp Med (Berl)"},{"key":"2020071612103078800_B28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jemt.10335","article-title":"Adrenal neuropeptides: regulation and interaction with ACTH and other adrenal regulators","volume":"61","author":"Whitworth","year":"2003","journal-title":"Microsc Res Tech"},{"key":"2020071612103078800_B29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0143-4179(90)90074-9","article-title":"Effects of neuropeptide-Y and substance-P on the secretory activity of dispersed zona-glomerulosa cells of rat adrenal gland","volume":"17","author":"Neri","year":"1990","journal-title":"Neuropeptides"},{"key":"2020071612103078800_B30","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0196-9781(98)00017-5","article-title":"Role of tachykinins in the regulation of the hypothalamo-pituitary-adrenal axis","volume":"19","author":"Nussdorfer","year":"1998","journal-title":"Peptides"},{"key":"2020071612103078800_B31","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1128\/MCB.23.11.3951-3964.2003","article-title":"Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice","volume":"23","author":"Beuschlein","year":"2003","journal-title":"Mol Cell Biol"},{"key":"2020071612103078800_B32","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1677\/joe.0.1780479","article-title":"Expression of activin\/inhibin signaling components in the human adrenal gland and the effects of activins and inhibins on adrenocortical steroidogenesis and apoptosis","volume":"178","author":"V\u00e4nttinen","year":"2003","journal-title":"J Endocrinol"},{"key":"2020071612103078800_B33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ceca.2012.01.009","article-title":"The role of mitochondrial Ca(2+) and NAD(P)H in the control of aldosterone secretion","volume":"52","author":"Sp\u00e4t","year":"2012","journal-title":"Cell Calcium"},{"key":"2020071612103078800_B34","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/ng.2299","article-title":"Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency","volume":"44","author":"Meimaridou","year":"2012","journal-title":"Nat Genet"},{"key":"2020071612103078800_B35","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1073\/pnas.0813346106","article-title":"A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry","volume":"106","author":"Liao","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612103078800_B36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbrc.2012.03.123","article-title":"Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca2+ release and ion channel trafficking","volume":"421","author":"Hong","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071612103078800_B37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/002215540305100107","article-title":"Localization of messenger ribonucleic acids for somatostatin receptor subtypes (sstr1\u20135) in the rat adrenal gland","volume":"51","author":"O'Carroll","year":"2003","journal-title":"J Histochem Cytochem"},{"key":"2020071612103078800_B38","doi-asserted-by":"crossref","first-page":"15879","DOI":"10.1073\/pnas.0907843106","article-title":"Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues","volume":"106","author":"Ziegler","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612103078800_B39","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1093\/hmg\/dds333","article-title":"Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex","volume":"21","author":"El Wakil","year":"2012","journal-title":"Hum Mol Genet"},{"key":"2020071612103078800_B40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm.2061","article-title":"Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6","volume":"16","author":"Doi","year":"2010","journal-title":"Nat Med"},{"key":"2020071612103078800_B41","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.neuroscience.2007.12.011","article-title":"Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice","volume":"151","author":"Aller","year":"2008","journal-title":"Neuroscience"},{"key":"2020071612103078800_B42","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1677\/joe.0.0760303","article-title":"Perinatal changes in plasma and adrenal corticosterone and aldosterone concentrations in the mouse","volume":"76","author":"Dalle","year":"1978","journal-title":"J Endocrinol"},{"key":"2020071612103078800_B43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of local renin-angiotensin systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol Rev"},{"key":"2020071612103078800_B44","doi-asserted-by":"crossref","first-page":"I124","DOI":"10.1161\/01.HYP.6.2_Pt_2.I124","article-title":"Effect of changes in sodium or potassium balance, and nephrectomy, on adrenal renin and aldosterone concentrations","volume":"6","author":"Doi","year":"1984","journal-title":"Hypertension"},{"key":"2020071612103078800_B45","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1210\/endo.140.2.6489","article-title":"Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-angiotensin system","volume":"140","author":"Peters","year":"1999","journal-title":"Endocrinology"},{"key":"2020071612103078800_B46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ajh\/2.4.311","article-title":"Active and inactive renin in the adrenal","volume":"2","author":"Inagami","year":"1989","journal-title":"Am J Hypertens"},{"key":"2020071612103078800_B47","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1210\/jcem-57-3-482","article-title":"Renin exists in human adrenal tissue","volume":"57","author":"Naruse","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612103078800_B48","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1161\/01.HYP.33.4.1025","article-title":"Local renin-angiotensin system is involved in K+-induced aldosterone secretion from human adrenocortical NCI-H295 cells","volume":"33","author":"Hilbers","year":"1999","journal-title":"Hypertension"},{"key":"2020071612103078800_B49","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/ar.1092270114","article-title":"Renin immunohistochemistry in the adrenal gland of the mouse fetus and neonate","volume":"227","author":"Kon","year":"1990","journal-title":"Anat Rec"},{"key":"2020071612103078800_B50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1210\/mend-4-3-375","article-title":"Expression of murine renin genes during fetal development","volume":"4","author":"Jones","year":"1990","journal-title":"Mol Endocrinol"},{"key":"2020071612103078800_B51","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1210\/en.2004-1102","article-title":"Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice","volume":"146","author":"Lee","year":"2005","journal-title":"Endocrinology"},{"key":"2020071612103078800_B52","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1210\/en.2006-1509","article-title":"Disabled-2 is expressed in adrenal zona glomerulosa and is involved in aldosterone secretion","volume":"148","author":"Romero","year":"2007","journal-title":"Endocrinology"},{"key":"2020071612103078800_B53","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/en.2003-0968","article-title":"Novel action of activin and bone morphogenetic protein in regulating aldosterone production by human adrenocortical cells","volume":"145","author":"Suzuki","year":"2004","journal-title":"Endocrinology"},{"key":"2020071612103078800_B54","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1507\/endocrj1954.38.383","article-title":"Immunohistochemical localization of follistatin in rat tissues","volume":"38","author":"Kogawa","year":"1991","journal-title":"Endocrinol Jpn"},{"key":"2020071612103078800_B55","doi-asserted-by":"crossref","first-page":"e1000980","DOI":"10.1371\/journal.pgen.1000980","article-title":"Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice","volume":"6","author":"Sahut-Barnola","year":"2010","journal-title":"PLoS Genet"},{"key":"2020071612103078800_B56","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1055\/s-2006-950500","article-title":"Adenovirus-delivered DKK3\/WNT4 and steroidogenesis in primary cultures of adrenocortical cells","volume":"38","author":"Chen","year":"2006","journal-title":"Horm Metab Res"},{"key":"2020071612103078800_B57","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/endo.143.5.8817","article-title":"Activation of 5-HT(7) receptor in rat glomerulosa cells is associated with an increase in adenylyl cyclase activity and calcium influx through T-type calcium channels","volume":"143","author":"Lenglet","year":"2002","journal-title":"Endocrinology"},{"key":"2020071612103078800_B58","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1210\/jcem.86.10.7917","article-title":"Production and metabolism of serotonin (5-HT) by the human adrenal cortex: paracrine stimulation of aldosterone secretion by 5-HT","volume":"86","author":"Lefebvre","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612103078800_B59","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1124\/pr.111.004697","article-title":"Serotonin and blood pressure regulation","volume":"64","author":"Watts","year":"2012","journal-title":"Pharmacol Rev"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/8\/2712\/10390764\/endo2712.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/154\/8\/2712\/10390764\/endo2712.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T19:22:26Z","timestamp":1594927346000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/154\/8\/2712\/2423834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2013-1101","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}