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The objectives of this study were to identify mechanisms by which the chemotherapeutic agent cisplatin alters lipid metabolism and to establish the role of ghrelin in reversing cachexia. Cisplatin-induced weight and fat loss were prevented by ghrelin. Cisplatin increased markers of lipolysis in white adipose tissue (WAT) and of \u03b2-oxidation in liver and WAT and suppressed lipogenesis in liver, WAT, and muscle. Ghrelin prevented the imbalance between lipolysis, \u03b2-oxidation, and lipogenesis in WAT and muscle. Pair-feeding experiments demonstrated that the effects of cisplatin and ghrelin on lipogenesis, but not on lipolysis and \u03b2-oxidation, were due to a reduction in food intake. Thus, ghrelin prevents cisplatin-induced weight and fat loss by restoring adipose tissue functionality. An increase in caloric intake further enhances the anabolic effects of ghrelin.<\/jats:p>","DOI":"10.1210\/en.2013-1179","type":"journal-article","created":{"date-parts":[[2013,7,6]],"date-time":"2013-07-06T04:48:49Z","timestamp":1373086129000},"page":"3118-3129","source":"Crossref","is-referenced-by-count":108,"title":["Inhibition of Cisplatin-Induced Lipid Catabolism and Weight Loss by Ghrelin in Male Mice"],"prefix":"10.1210","volume":"154","author":[{"given":"Jose M.","family":"Garcia","sequence":"first","affiliation":[{"name":"Department of Medicine and Molecular and Cell Biology (J.M.G., J.-a.C., B.G., V.P., J.S.), Baylor College of Medicine, Houston, Texas 77030"},{"name":"Center for Translational Research in Inflammatory Diseases, Michael E. 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