{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:03:19Z","timestamp":1791201799087,"version":"4.2.0"},"reference-count":52,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:p>Chronic inflammation is involved in the pathogenesis of obesity and type 2 diabetes. Recently teasaponin, an extract from tea, has been shown to have antiinflammatory effects. We examined the effect of teasaponin on obesity, inflammation, glucose metabolism, and central leptin sensitivity in obese mice fed a high-fat (HF) diet for 16 weeks. Intraperitoneal injections of teasaponin (10 mg\/kg, daily) for 21 days significantly decreased the food intake and body weight of HF diet-induced obese mice. Teasaponin treatment also reduced the protein levels of proinflammatory cytokines (TNF-\u03b1, IL-6, and\/or IL-1\u03b2) and nuclear factor-\u03baB signaling (phosphorylated inhibitory-\u03baB kinase and phosphorylated inhibitory-\u03baB\u03b1) in adipose tissue and the liver. The antiinflammatory effects of teasaponin were associated with improved glycemic status in the treated animals, evidenced by improved glucose tolerance, homeostasis model assessment, and fasting plasma insulin. In the hypothalamus, teasaponin decreased both proinflammatory cytokines and inflammatory signaling in the mediobasal hypothalamus. Teasaponin treatment also enhanced the anorexigenic effect of central leptin administration, restored leptin phosphorylated signal transducer and activator of transcription-3 (p-STAT3) signaling in the arcuate nucleus, and increased hypothalamic expression of the anorexigenic peptide proopiomelanocortin. These results identify a potential novel application for teasaponin as an antiobesity and antiinflammatory agent.<\/jats:p>","DOI":"10.1210\/en.2013-1218","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T04:02:16Z","timestamp":1370923336000},"page":"3130-3140","source":"Crossref","is-referenced-by-count":54,"title":["Teasaponin Reduces Inflammation and Central Leptin Resistance in Diet-Induced Obese Male Mice"],"prefix":"10.1210","volume":"154","author":[{"given":"Yinghua","family":"Yu","sequence":"first","affiliation":[{"name":"Illawarra Health and Medical Research Institute (Y.Y., Y.W., A.S., Z.W., H.W., X.-F.H.), School of Health Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia"},{"name":"Department of Food Science and Nutrition (Y.Y., D.L.), Zhejiang University, Hangzhou 310058, 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