{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:09:05Z","timestamp":1792008545471,"version":"4.4.0"},"reference-count":70,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:p>To address the neural mediation of the eating-inhibitory effect of circulating glucagon-like peptide-1 (GLP-1), we investigated the effects of 1) intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on the eating-inhibitory effect of intrameal hepatic portal vein (HPV) GLP-1 infusion in adult male rats. To evaluate the physiological relevance of the observed effect we examined 3) the influence of GLP-1 on flavor acceptance in a 2-bottle conditioned flavor avoidance test, and 4) measured active GLP-1 in the HPV and vena cava (VC) in relation to a meal and in the VC after HPV GLP-1 infusion. Intrameal HPV GLP-1 infusion (1 nmol\/kg body weight-5 min) specifically reduced ongoing meal size by almost 40% (P &amp;lt; .05). Intra-fourth ventricular exendin-9 (10 \u03bcg\/rat) itself did not affect eating, but attenuated (P &amp;lt; .05) the satiating effect of HPV GLP-1. Area postrema lesion also blocked (P &amp;lt; .05) the eating-inhibitory effect of HPV GLP-1. Pairing consumption of flavored saccharin solutions with HPV GLP-1 infusion did not alter flavor acceptance, indicating that HPV GLP-1 can inhibit eating without inducing malaise. A regular chow meal transiently increased (P &amp;lt; .05) HPV, but not VC, plasma active GLP-1 levels, whereas HPV GLP-1 infusion caused a transient supraphysiological increase (P &amp;lt; .01) in VC GLP-1 concentration 3 minutes after infusion onset. The results implicate hindbrain GLP-1 receptors and the area postrema in the eating-inhibitory effect of circulating GLP-1, but question the physiological relevance of the eating-inhibitory effect of iv infused GLP-1 under our conditions.<\/jats:p>","DOI":"10.1210\/en.2013-1447","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T15:25:38Z","timestamp":1394119538000},"page":"1690-1699","source":"Crossref","is-referenced-by-count":60,"title":["Circulating Glucagon-like Peptide-1 (GLP-1) Inhibits Eating in Male Rats by Acting in the Hindbrain and Without Inducing Avoidance"],"prefix":"10.1210","volume":"155","author":[{"given":"Mukesh","family":"Punjabi","sequence":"first","affiliation":[{"name":"Physiology and Behavior Laboratory, Institute of Food, Nutrition, and Health, Swiss Federal Institute of Technology Zurich (ETH Zurich), 8603 Schwerzenbach, 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