{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:01:06Z","timestamp":1771063266736,"version":"3.50.1"},"reference-count":52,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:p>There has been great interest in the extent of \u03b2-cell regeneration after pancreatic duct ligation (PDL) and whether \u03b1- to \u03b2-cell conversion might account for \u03b2-cell regeneration after near-complete \u03b2-cell loss. To assess these questions, we established a PDL-model in adult male rats after almost complete beta-cell depletion achieved by giving a single high dose of streptozocin (STZ) in the fasted state. Because of the resultant severe diabetes, rats were given islet cell transplants to allow long-term follow-up. Although animals were followed up to 10 months, there was no meaningful \u03b2-cell regeneration, be it through replication, neogenesis, or \u03b1- to \u03b2-cell conversion. In contrast, the acinar cell compartment underwent massive changes with first severe acinar degeneration upon PDL injury followed by the appearance of pancreatic adipocytes, and finally near-complete reappearance of acini. We conclude that \u03b2-cells and acinar cells, although originating from the same precursors during development, have very distinct regenerative potentials in our PDL model in adult rats.<\/jats:p>","DOI":"10.1210\/en.2013-1463","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T03:19:48Z","timestamp":1379042388000},"page":"4493-4502","source":"Crossref","is-referenced-by-count":36,"title":["Pancreatic Duct Ligation After Almost Complete \u03b2-Cell Loss: Exocrine Regeneration but No Evidence of \u03b2-Cell Regeneration"],"prefix":"10.1210","volume":"154","author":[{"given":"Claudia","family":"Cavelti-Weder","sequence":"first","affiliation":[{"name":"Joslin Diabetes Center, Section on Islet Cell and Regenerative Biology, Harvard Medical School, Boston, Massachusetts 02215"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Shtessel","sequence":"first","affiliation":[{"name":"Joslin Diabetes Center, Section on Islet Cell 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