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Food intake and c-Fos proteins (a product of the c-Fos immediate-early gene) were assessed. i4vt Apo AIV and\/or ip CCK at effective doses reduced food intake and activated c-Fos proteins in the NTS and hypothalamic arcuate nucleus and paraventricular nucleus. Blockade of the CCK-1R by i4vt lorglumide adjacent to the NTS attenuated the satiating and c-Fos-stimulating effects of CCK and Apo AIV, alone or in combination. Maintenance on a high-fat diet (HFD) for 10 weeks resulted in weight gain and attenuation of both the behavioral and c-Fos responses to a greater extent than occurred in low-fat diet-fed and pair-fed HFD animals. These observations suggest that NTS Apo AIV or\/and peripheral CCK requires vagal CCK-1R signaling to elicit satiation and that maintenance on a HFD reduces the satiating capacity of these 2 signals.<\/jats:p>","DOI":"10.1210\/en.2013-1846","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T20:43:52Z","timestamp":1393274632000},"page":"1700-1707","source":"Crossref","is-referenced-by-count":20,"title":["Intraperitoneal CCK and Fourth-Intraventricular Apo AIV Require Both Peripheral and NTS CCK1R to Reduce Food Intake in Male Rats"],"prefix":"10.1210","volume":"155","author":[{"given":"Chunmin C.","family":"Lo","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Sean Davidson","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie K.","family":"Hibbard","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Georgievsky","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Lee","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Tso","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Woods","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Behavioral Neuroscience (S.C.W.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237\u20130507"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612194497000_B1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1172\/JCI111809","article-title":"Cholecystokinin bioactivity in human plasma. 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