{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:39:00Z","timestamp":1790163540302,"version":"4.1.0"},"reference-count":83,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leptin (LEP) is reported to play important roles in controlling energy balance in vertebrates, including birds. However, it remains an open question whether an authentic \u201cLEP gene\u201d exists and functions in birds. Here, we identified and characterized a LEP gene (zebra finch LEP [zbLEP]) encoding a 172-amino acid precursor in zebra finches. Despite zbLEP showing limited amino acid sequence identity (26%\u201329%) to human and mouse LEPs, synteny analysis proved that zbLEP is orthologous to mammalian LEP. Using a pAH32 luciferase reporter system and Western blot analysis, we demonstrated that the recombinant zbLEP protein could potently activate finch and chicken LEP receptors (zbLEPR; cLEPR) expressed in human embryonic kidney 293 cells and enhance signal transducer and activator of transcription 3 phosphorylation, further indicating that zbLEP is a functional ligand for avian LEPRs. Interestingly, quantitative real-time RT-PCR revealed that zbLEP mRNA is expressed nearly exclusively in the pituitary and various brain regions but undetectable in adipose tissue and liver, whereas zbLEPR mRNA is widely expressed in adult finch tissues examined with abundant expression noted in pituitary, implying that unlike mammalian LEP, finch LEP may not act as an adipocyte-derived signal to control energy balance. As in finches, a LEP highly homologous to zbLEP was also identified in budgerigar genome. Strikingly, finch and budgerigar LEPs show little homology with chicken LEP (cLEP) previously reported, suggesting that the so-called cLEP is incorrect. Collectively, our data provide convincing evidence for the existence of an authentic functional LEP in avian species and suggest an important role of brain- and pituitary-derived LEP played in vertebrates.<\/jats:p>","DOI":"10.1210\/en.2014-1084","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T17:56:33Z","timestamp":1400003793000},"page":"3385-3396","source":"Crossref","is-referenced-by-count":54,"title":["Discovery of a Novel Functional Leptin Protein (LEP) in Zebra Finches: Evidence for the Existence of an Authentic Avian Leptin Gene Predominantly Expressed in the Brain and Pituitary"],"prefix":"10.1210","volume":"155","author":[{"given":"Guian","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education (G.H., J.L., X.L., Y.W.) Sichuan University, Chengdu 610065, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education (G.H., J.L., X.L., Y.W.) Sichuan University, Chengdu 610065, People's Republic of China"},{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province (J.L., H.W., Y.W.), College of Life Sciences, Sichuan University, Chengdu 610065, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongning","family":"Wang","sequence":"first","affiliation":[{"name":"Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province (J.L., H.W., Y.W.), College of Life Sciences, Sichuan University, Chengdu 610065, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Lan","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education (G.H., J.L., X.L., Y.W.) Sichuan University, Chengdu 610065, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajun","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Bio-Resources and Eco-Environment of Ministry of Education (G.H., J.L., X.L., Y.W.) 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