{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:55:31Z","timestamp":1791143731982,"version":"4.1.0"},"reference-count":63,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The syndrome of hereditary 1,25-dihydroxyvitamin D\u2013resistant rickets (HVDRR) is a genetic disease of altered mineral homeostasis due to mutations in the vitamin D receptor (VDR) gene. It is frequently, but not always, accompanied by the presence of alopecia. Mouse models that recapitulate this syndrome have been prepared through genetic deletion of the Vdr gene and are characterized by the presence of rickets and alopecia. Subsequent studies have revealed that VDR expression in hair follicle keratinocytes protects against alopecia and that this activity is independent of the protein's ability to bind 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. In the present study, we introduced into VDR-null mice a human VDR (hVDR) bacterial artificial chromosome minigene containing a mutation that converts leucine to serine at amino acid 233 in the hVDR protein, which prevents 1,25(OH)2D3 binding. We then assessed whether this transgene recreated features of the HVDRR syndrome without alopecia. RT-PCR and Western blot analysis in one strain showed an appropriate level of mutant hVDR expression in all tissues examined including skin. The hVDR-L233S mutant failed to rescue the aberrant systemic and skeletal phenotype characteristic of the VDR null mouse due to the inability of the mutant receptor to activate transcription after treatment with 1,25(OH)2D3. Importantly, however, neither alopecia nor the dermal cysts characteristic of VDR-null mice were observed in the skin of these hVDR-L233S mutant mice. This study confirms that we have created a humanized mouse model of HVDRR without alopecia that will be useful in defining additional features of this syndrome and in identifying potential novel functions of the unoccupied VDR.<\/jats:p>","DOI":"10.1210\/en.2014-1417","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T18:43:01Z","timestamp":1408732981000},"page":"4137-4148","source":"Crossref","is-referenced-by-count":25,"title":["A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D\u2013Resistant Rickets Without Alopecia"],"prefix":"10.1210","volume":"155","author":[{"given":"Seong Min","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biochemistry (S.M.L., J.W.P.), University of Wisconsin-Madison, (Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Goellner","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences (J.J.G., C.A.O.), Little Rock, Arkansas 72205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"O'Brien","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences (J.J.G., C.A.O.), Little Rock, Arkansas 72205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Wesley","family":"Pike","sequence":"first","affiliation":[{"name":"Department of Biochemistry (S.M.L., J.W.P.), University of Wisconsin-Madison, (Madison, Wisconsin 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071612023662300_B1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr Rev"},{"key":"2020071612023662300_B2","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"2020071612023662300_B3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-2133.1994.tb08547.x","article-title":"Hair follicle expression of 1,25-dihydroxyvitamin D3 receptors during the murine hair cycle","volume":"131","author":"Reichrath","year":"1994","journal-title":"Br J Dermatol"},{"key":"2020071612023662300_B4","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1210\/endo.141.6.7515","article-title":"Evaluation of keratinocyte proliferation and differentiation in vitamin D receptor knockout mice","volume":"141","author":"Sakai","year":"2000","journal-title":"Endocrinology"},{"key":"2020071612023662300_B5","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.6310748","article-title":"1,25-Dihydroxyvitamin D3 receptors in human leukocytes","volume":"221","author":"Provvedini","year":"1983","journal-title":"Science"},{"key":"2020071612023662300_B6","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/eji.200838216","article-title":"1,25-Dihydroxyvitamin D3 promotes IL-10 production in human B cells","volume":"38","author":"Heine","year":"2008","journal-title":"Eur J Immunol"},{"key":"2020071612023662300_B7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fphys.2014.00151","article-title":"Impact of vitamin D on immune function: lessons learned from genome-wide analysis","volume":"5","author":"Chun","year":"2014","journal-title":"Front Physiol"},{"key":"2020071612023662300_B8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J Clin Invest"},{"key":"2020071612023662300_B9","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.111.032680","article-title":"Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy","volume":"124","author":"Chen","year":"2011","journal-title":"Circulation"},{"key":"2020071612023662300_B10","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.2741\/1731","article-title":"Vitamin D and cancer: an update of in vitro and in vivo data","volume":"10","author":"Ordonez-Moran","year":"2005","journal-title":"Front Biosci"},{"key":"2020071612023662300_B11","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: the second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"2020071612023662300_B12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11154-011-9198-9","article-title":"Regulation of target gene expression by the vitamin D receptor\u2014an update on mechanisms","volume":"13","author":"Pike","year":"2012","journal-title":"Rev Endocr Metab Disord"},{"key":"2020071612023662300_B13","article-title":"Fundamentals of vitamin D hormone-regulated gene expression [published online November 12, 2013]","author":"Pike","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2020071612023662300_B14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90200-7","article-title":"The RXR heterodimers and orphan receptors","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"2020071612023662300_B15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/er.2003-0023","article-title":"Coregulator function: a key to understanding tissue specificity of selective receptor modulators","volume":"25","author":"Smith","year":"2004","journal-title":"Endocr Rev"},{"key":"2020071612023662300_B16","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1128\/MCB.25.1.472-487.2005","article-title":"Functional cooperation between CCAAT\/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase","volume":"25","author":"Dhawan","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2020071612023662300_B17","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1210\/me.2013-1146","article-title":"VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system","volume":"27","author":"Kong","year":"2013","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B18","doi-asserted-by":"crossref","first-page":"18827","DOI":"10.1073\/pnas.1210037109","article-title":"Vitamin D receptor as a master regulator of the c-MYC\/MXD1 network","volume":"109","author":"Salehi-Tabar","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612023662300_B19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fphys.2014.00060","article-title":"Interaction of vitamin D with membrane-based signaling pathways","volume":"5","author":"Larriba","year":"2014","journal-title":"Front Physiol"},{"key":"2020071612023662300_B20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/en.2005-1111","article-title":"Hairless suppresses vitamin D receptor transactivation in human keratinocytes","volume":"147","author":"Xie","year":"2006","journal-title":"Endocrinology"},{"key":"2020071612023662300_B21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jsbmb.2010.02.011","article-title":"Genome-wide analysis of the VDR\/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone","volume":"121","author":"Meyer","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2020071612023662300_B22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1210\/me.2011-1109","article-title":"VDR\/RXR and TCF4\/\u03b2-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression","volume":"26","author":"Meyer","year":"2012","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B23","doi-asserted-by":"crossref","first-page":"9181","DOI":"10.1093\/nar\/gkr654","article-title":"Nuclear hormone 1\u03b1,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy","volume":"39","author":"Heikkinen","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2020071612023662300_B24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1056\/NEJM197805042981804","article-title":"Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D","volume":"298","author":"Brooks","year":"1978","journal-title":"N Engl J Med"},{"key":"2020071612023662300_B25","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1210\/jcem-47-6-1303","article-title":"A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D","volume":"47","author":"Marx","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612023662300_B26","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/bonekey.2014.5","article-title":"Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets","volume":"3","author":"Feldman","year":"2014","journal-title":"Bonekey Rep"},{"key":"2020071612023662300_B27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/B978-0-12-387829-8.00033-0","article-title":"Genetic disorders of vitamin D synthesis and action","volume-title":"Genetics of Bone Biology and Skeletal Disease","author":"Feldman","year":"2013"},{"key":"2020071612023662300_B28","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1210\/endo.142.7.8281","article-title":"Targeted inactivation of the 25-hydroxyvitamin D3-1\u03b1-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets","volume":"142","author":"Dardenne","year":"2001","journal-title":"Endocrinology"},{"key":"2020071612023662300_B29","doi-asserted-by":"crossref","first-page":"7498","DOI":"10.1073\/pnas.131029498","article-title":"Targeted ablation of the 25-hydroxyvitamin D 1\u03b1-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction","volume":"98","author":"Panda","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612023662300_B30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ng0897-391","article-title":"Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning","volume":"16","author":"Yoshizawa","year":"1997","journal-title":"Nat Genet"},{"key":"2020071612023662300_B31","doi-asserted-by":"crossref","first-page":"9831","DOI":"10.1073\/pnas.94.18.9831","article-title":"Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia","volume":"94","author":"Li","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612023662300_B32","doi-asserted-by":"crossref","first-page":"13324","DOI":"10.1073\/pnas.231474698","article-title":"Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects","volume":"98","author":"Van Cromphaut","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612023662300_B33","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1210\/mend.16.7.0866","article-title":"Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D","volume":"16","author":"Erben","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B34","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.1210\/endo.142.12.8650","article-title":"Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia","volume":"142","author":"Chen","year":"2001","journal-title":"Endocrinology"},{"key":"2020071612023662300_B35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1210\/me.2004-0415","article-title":"Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis","volume":"19","author":"Skorija","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B36","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1523-1747.2002.01727.x","article-title":"Targeted expression of human vitamin D receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice","volume":"118","author":"Kong","year":"2002","journal-title":"J Invest Dermatol"},{"key":"2020071612023662300_B37","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1210\/mend.11.8.9951","article-title":"Structural organization of the human vitamin D receptor chromosomal gene and its promoter","volume":"11","author":"Miyamoto","year":"1997","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B38","doi-asserted-by":"crossref","first-page":"10138","DOI":"10.1073\/pnas.94.19.10138","article-title":"Cloning and characterization of the mouse vitamin D receptor promoter","volume":"94","author":"Jehan","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612023662300_B39","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1210\/me.2006-0015","article-title":"Enhancers located within two introns of the vitamin D receptor gene mediate transcriptional autoregulation by 1,25-dihydroxyvitamin D3","volume":"20","author":"Zella","year":"2006","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1210\/me.2009-0140","article-title":"Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription","volume":"24","author":"Zella","year":"2010","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B41","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1210\/en.2014-1107","article-title":"Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype","volume":"155","author":"Lee","year":"2014","journal-title":"Endocrinology"},{"key":"2020071612023662300_B42","doi-asserted-by":"crossref","first-page":"15599","DOI":"10.1074\/jbc.M110.119958","article-title":"A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1\u03b1,25-dihydroxyvitamin D3","volume":"285","author":"Meyer","year":"2010","journal-title":"J Biol Chem"},{"key":"2020071612023662300_B43","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.89.10.4658","article-title":"Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor","volume":"89","author":"Ignar-Trowbridge","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612023662300_B44","first-page":"910","article-title":"Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3","volume":"8","author":"Ma","year":"1994","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0960-0760(95)00177-2","article-title":"Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: consequence on DNA binding","volume":"55","author":"Arnold","year":"1995","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2020071612023662300_B46","first-page":"835","article-title":"Divergent pathways regulate ligand-independent activation of ER\u03b1 in SK-N-BE neuroblastoma and COS-1 renal carcinoma cells","volume":"12","author":"Patrone","year":"1998","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B47","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cell.2009.04.056","article-title":"Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer","volume":"138","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"2020071612023662300_B48","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1210\/me.2013-1037","article-title":"Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor","volume":"27","author":"Malloy","year":"2013","journal-title":"Mol Endocrinol"},{"key":"2020071612023662300_B49","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/bonekey.2013.216","article-title":"Regulation of gene expression by 1,25-dihydroxyvitamin D3 in bone cells: exploiting new approaches and defining new mechanisms","volume":"3","author":"Pike","year":"2014","journal-title":"Bonekey Rep"},{"key":"2020071612023662300_B50","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin D receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science"},{"key":"2020071612023662300_B51","doi-asserted-by":"crossref","first-page":"14723","DOI":"10.1016\/S0021-9258(17)36685-1","article-title":"1,25-Dihydroxyvitamin D3 potentiates the keratinocyte response to calcium","volume":"269","author":"Su","year":"1994","journal-title":"J Biol Chem"},{"key":"2020071612023662300_B52","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1172\/JCI118075","article-title":"1,25-Dihydroxyvitamin D3 upregulates the phosphatidylinositol signaling pathway in human keratinocytes by increasing phospholipase C levels","volume":"96","author":"Pillai","year":"1995","journal-title":"J Clin Invest"},{"key":"2020071612023662300_B53","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1074\/jbc.272.10.6573","article-title":"Cloning of the human phospholipase C-\u03b31 promoter and identification of a DR6-type vitamin D-responsive element","volume":"272","author":"Xie","year":"1997","journal-title":"J Biol Chem"},{"key":"2020071612023662300_B54","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.0022-202X.2004.22424.x","article-title":"25 Hydroxyvitamin D 1\u03b1-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis","volume":"122","author":"Bikle","year":"2004","journal-title":"J Invest Dermatol"},{"key":"2020071612023662300_B55","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1093\/carcin\/23.12.2103","article-title":"Vitamin D3 receptor ablation sensitizes skin to chemically induced tumorigenesis","volume":"23","author":"Zinser","year":"2002","journal-title":"Carcinogenesis"},{"key":"2020071612023662300_B56","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1038\/jid.2011.196","article-title":"Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor-null mice","volume":"131","author":"Teichert","year":"2011","journal-title":"J Invest Dermatol"},{"key":"2020071612023662300_B57","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1038\/jid.2008.131","article-title":"Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis","volume":"128","author":"Ellison","year":"2008","journal-title":"J Invest Dermatol"},{"key":"2020071612023662300_B58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1126\/science.6251551","article-title":"Photosynthesis of previtamin D3 in human skin and the physiologic consequences","volume":"210","author":"Holick","year":"1980","journal-title":"Science"},{"key":"2020071612023662300_B59","first-page":"888","article-title":"Extrarenal expression of 25-hydroxyvitamin D3-1\u03b1-hydroxylase","volume":"86","author":"Zehnder","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071612023662300_B60","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1124\/mol.108.053660","article-title":"Regulation of human vitamin D3 25-hydroxylases in dermal fibroblasts and prostate cancer LNCaP cells","volume":"75","author":"Ellfolk","year":"2009","journal-title":"Mol Pharmacol"},{"key":"2020071612023662300_B61","doi-asserted-by":"crossref","first-page":"9534","DOI":"10.1016\/S0021-9258(18)43422-9","article-title":"1,25-Dihydroxyvitamin D3 receptors. Differential quantitation of endogenously occupied and unoccupied sites","volume":"255","author":"Hunziker","year":"1980","journal-title":"J Biol Chem"},{"key":"2020071612023662300_B62","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj2210129","article-title":"Development of a radioligand immunoassay for 1,25-dihydroxycholecalciferol receptors utilizing monoclonal antibody","volume":"221","author":"Dokoh","year":"1984","journal-title":"Biochem J"},{"key":"2020071612023662300_B63","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1242\/dev.01303","article-title":"The co-repressor hairless has a role in epithelial cell differentiation in the skin","volume":"131","author":"Zarach","year":"2004","journal-title":"Development"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/155\/11\/4137\/10827665\/endo4137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/155\/11\/4137\/10827665\/endo4137.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T10:41:52Z","timestamp":1650019312000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/155\/11\/4137\/2422423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,1]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2014-1417","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,1]]}}}