{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:33:03Z","timestamp":1790613183668,"version":"4.1.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Endoplasmic reticulum (ER) stress is profoundly involved in dysfunction of \u03b2-cells under high-fat diet and hyperglycemia. Our recent study in mice showed that \u03b3-oryzanol, a unique component of brown rice, acts as a chemical chaperone in the hypothalamus and improves feeding behavior and diet-induced dysmetabolism. However, the entire mechanism whereby \u03b3-oryzanol improves glucose metabolism throughout the body still remains unclear. In this context, we tested whether \u03b3-oryzanol reduces ER stress and improves function and survival of pancreatic \u03b2-cells using murine \u03b2-cell line MIN6. In MIN6 cells with augmented ER stress by tunicamycin, \u03b3-oryzanol decreased exaggerated expression of ER stress-related genes and phosphorylation of eukaryotic initiation factor-2\u03b1, resulting in restoration of glucose-stimulated insulin secretion and prevention of apoptosis. In islets from high-fat diet-fed diabetic mice, oral administration of \u03b3-oryzanol improved glucose-stimulated insulin secretion on following reduction of exaggerated ER stress and apoptosis. Furthermore, we examined the impact of \u03b3-oryzanol on low-dose streptozotocin-induced diabetic mice, where exaggerated ER stress and resultant apoptosis in \u03b2-cells were observed. Also in this model, \u03b3-oryzanol attenuated mRNA level of genes involved in ER stress and apoptotic signaling in islets, leading to amelioration of glucose dysmetabolism. Taken together, our findings demonstrate that \u03b3-oryzanol directly ameliorates ER stress-induced \u03b2-cell dysfunction and subsequent apoptosis, highlighting usefulness of \u03b3-oryzanol for the treatment of diabetes mellitus.<\/jats:p>","DOI":"10.1210\/en.2014-1748","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T18:19:27Z","timestamp":1421432367000},"page":"1242-1250","source":"Crossref","is-referenced-by-count":56,"title":["\u03b3-Oryzanol Protects Pancreatic \u03b2-Cells Against Endoplasmic Reticulum Stress in Male 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