{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:45:01Z","timestamp":1791207901518,"version":"4.1.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:p>Liver X receptors (LXRs) are key regulators of lipid homeostasis and are involved in multiple testicular functions. The Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212 mice have illuminated the roles of both isoforms in maintenance of the epithelium in the seminiferous tubules, spermatogenesis, and T production. The requirement for LXR\u03b2 in Sertoli cells have been emphasized by early abnormal cholesteryl ester accumulation in the Lxr\u03b2\u2212\/\u2212 and Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212 mice. Other phenotypes, such as germ cell loss and hypogonadism, occur later in life in the Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212 mice. Thus, LXR\u03b2 expression in Sertoli cells seems to be essential for normal testicular physiology. To decipher the roles of LXR\u03b2 within the Sertoli cells, we generated Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212:AMH-Lxr\u03b2 transgenic mice, which reexpress Lxr\u03b2 in Sertoli cells in the context of Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212 mice. In addition to lipid homeostasis, LXR\u03b2 is necessary for maintaining the blood-testis barrier and the integrity of the germ cell epithelium. LXR\u03b2 is also implicated in the paracrine action of Sertoli cells on Leydig cells to modulate T synthesis. The Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212 and Lxr\u03b1\u2212\/\u2212;Lxr\u03b2\u2212\/\u2212:AMH-Lxr\u03b2 mice exhibit lipid accumulation in germ cells after the Abcg8 down-regulation, suggesting an intricate LXR\u03b2-dependent cooperation between the Sertoli cells and germ cells to ensure spermiogenesis. Further analysis revealed also peritubular smooth muscle defects (abnormal lipid accumulation and disorganized smooth muscle actin) and spermatozoa stagnation in the seminiferous tubules. Together the present work elucidates specific roles of LXR\u03b2 in Sertoli cell physiology in vivo beyond lipid homeostasis.<\/jats:p>","DOI":"10.1210\/en.2015-1382","type":"journal-article","created":{"date-parts":[[2015,9,24]],"date-time":"2015-09-24T17:00:48Z","timestamp":1443114048000},"page":"4545-4557","source":"Crossref","is-referenced-by-count":13,"title":["Identification of the Functions of Liver X Receptor-\u03b2 in Sertoli Cells Using a Targeted Expression-Rescue Model"],"prefix":"10.1210","volume":"156","author":[{"given":"Salwan","family":"Maqdasy","sequence":"first","affiliation":[{"name":"Department of G\u00e9n\u00e9tique Reproduction et D\u00e9veloppement (GReD) (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., I.T., D.V., J.-M.A.L., S.B.), CECOS, Centre Hospitalier Universitaire Clermont Ferrand, Centre Hospitalier Universitaire Estaing, F-63000 Clermont-Ferrand, France"},{"name":"Universit\u00e9 Blaise Pascal, Centre de Recherche en Nutrition Humaine d'Auvergne (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., D.V., J.-M.A.L., S.B.), CECOS, Centre Hospitalier Universitaire Clermont Ferrand, Centre Hospitalier Universitaire Estaing, F-63000 Clermont-Ferrand, France"},{"name":"Centre National de la Recherche Scientifique (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., I.T., D.V., J.-M.A.L., S.B.), Unit\u00e9 Mixte de Recherche 6293, GReD, F-63177 Aubiere, France"},{"name":"INSERM (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., I.T., D.V., J.-M.A.L., S.B.), Unit\u00e9 Mixte de Recherche 6293, GReD, F-63177 Aubiere, France"},{"name":"Service d'Endocrinologie, Diab\u00e9tologie, et Maladies M\u00e9taboliques (S.M., I.T.), H\u00f4pital Gabriel Montpied, F-63003 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatim-Zohra","family":"El Hajjaji","sequence":"first","affiliation":[{"name":"Department of G\u00e9n\u00e9tique Reproduction et D\u00e9veloppement (GReD) (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., I.T., D.V., J.-M.A.L., S.B.), CECOS, Centre Hospitalier Universitaire Clermont Ferrand, Centre Hospitalier Universitaire Estaing, F-63000 Clermont-Ferrand, France"},{"name":"Universit\u00e9 Blaise Pascal, Centre de Recherche en Nutrition Humaine d'Auvergne (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., D.V., J.-M.A.L., S.B.), CECOS, Centre Hospitalier Universitaire Clermont Ferrand, Centre Hospitalier Universitaire Estaing, F-63000 Clermont-Ferrand, France"},{"name":"Centre National de la Recherche Scientifique (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., I.T., D.V., J.-M.A.L., S.B.), Unit\u00e9 Mixte de Recherche 6293, GReD, F-63177 Aubiere, France"},{"name":"INSERM (S.M., F.-Z.E.H., M.B., A.O., F.B., A.T., I.T., D.V., J.-M.A.L., S.B.), Unit\u00e9 Mixte de Recherche 6293, GReD, F-63177 Aubiere, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Baptissart","sequence":"first","affiliation":[{"name":"Department of G\u00e9n\u00e9tique Reproduction et D\u00e9veloppement (GReD) (S.M., 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