{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:31:30Z","timestamp":1767853890398,"version":"3.49.0"},"reference-count":55,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>External genitalia are prominent organs showing hormone-dependent sexual differentiation. Androgen is an essential regulator of masculinization of the genital tubercle, which is the anlage of external genitalia. We have previously shown that v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB) is an androgen-inducible regulator of embryonic urethral masculinization in mice. However, it remains unclear how androgen regulates Mafb expression. The current study suggests that the Mafb 3\u2032 untranslated region (UTR) is an essential region for its regulation by androgen. We identified 2 functional androgen response elements (AREs) in Mafb 3\u2032UTR. Androgen receptor is bound to such AREs in 3\u2032UTR during urethral masculinization. In addition to 3\u2032UTR, Mafb 5\u2032UTR also showed androgen responsiveness. Moreover, we also demonstrated that \u03b2-catenin, one of genital tubercle masculinization factors, may be an additional regulator of Mafb expression during urethral masculinization. This study provides insights to elucidate mechanisms of gene regulation through AREs present in Mafb 3\u2032UTR for a better understanding of the processes of urethral masculinization.<\/jats:p>","DOI":"10.1210\/en.2015-1586","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T18:00:40Z","timestamp":1449252040000},"page":"844-857","source":"Crossref","is-referenced-by-count":25,"title":["Androgen Regulates Mafb Expression Through its 3\u2032UTR During Mouse Urethral Masculinization"],"prefix":"10.1210","volume":"157","author":[{"given":"Shoko","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Developmental Genetics (S.M., K.S., G.Y.), Institute of Advanced Medicine, Wakayama Medical University, Wakayama 641-8509, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Developmental Genetics (S.M., K.S., G.Y.), Institute of 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