{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:54:02Z","timestamp":1791298442427,"version":"4.1.0"},"reference-count":55,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Induction of the iron regulatory hormone hepcidin contributes to the anemia of inflammation. Bone morphogenetic protein 6 (BMP6) signaling is a central regulator of hepcidin expression in the liver. Recently, the TGF-\u03b2\/BMP superfamily member activin B was implicated in hepcidin induction by inflammation via noncanonical SMAD1\/5\/8 signaling, but its mechanism of action and functional significance in vivo remain uncertain. Here, we show that low concentrations of activin B, but not activin A, stimulate prolonged SMAD1\/5\/8 signaling and hepcidin expression in liver cells to a similar degree as canonical SMAD2\/3 signaling, and with similar or modestly reduced potency compared with BMP6. Activin B stimulates hepcidin via classical activin type II receptors ACVR2A and ACVR2B, noncanonical BMP type I receptors activin receptor-like kinase 2 and activin receptor-like kinase 3, and SMAD5. The coreceptor hemojuvelin binds to activin B and facilitates activin B-SMAD1\/5\/8 signaling. Activin B-SMAD1\/5\/8 signaling has some selectivity for hepatocyte-derived cells and is not enabled by hemojuvelin in other cell types. Liver activin B mRNA expression is up-regulated in multiple mouse models of inflammation associated with increased hepcidin and hypoferremia, including lipopolysaccharide, turpentine, and heat-killed Brucella abortus models. Finally, the activin inhibitor follistatin-315 blunts hepcidin induction by lipopolysaccharide or B. abortus in mice. Our data elucidate a novel mechanism for noncanonical SMAD activation and support a likely functional role for activin B in hepcidin stimulation during inflammation in vivo.<\/jats:p>","DOI":"10.1210\/en.2015-1747","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T18:03:17Z","timestamp":1452103397000},"page":"1146-1162","source":"Crossref","is-referenced-by-count":104,"title":["Activin B Induces Noncanonical SMAD1\/5\/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice"],"prefix":"10.1210","volume":"157","author":[{"given":"Susanna","family":"Canali","sequence":"first","affiliation":[{"name":"Program in Anemia Signaling Research (S.C., A.B.C., K.B.Z.-B., M.M., C.-Y.W., J.L.B.), Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"},{"name":"Center for Hemochromatosis (S.C., A.P.), University Hospital of Modena and Reggio Emilia, Modena Italy 41124"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda B.","family":"Core","sequence":"first","affiliation":[{"name":"Program in Anemia Signaling Research (S.C., A.B.C., K.B.Z.-B., M.M., C.-Y.W., J.L.B.), Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly B.","family":"Zumbrennen-Bullough","sequence":"first","affiliation":[{"name":"Program in Anemia Signaling Research (S.C., A.B.C., K.B.Z.-B., M.M., C.-Y.W., J.L.B.), Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Merkulova","sequence":"first","affiliation":[{"name":"Program in Anemia Signaling Research (S.C., A.B.C., K.B.Z.-B., M.M., C.-Y.W., J.L.B.), Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Program in Anemia Signaling Research (S.C., A.B.C., K.B.Z.-B., M.M., C.-Y.W., J.L.B.), Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan L.","family":"Schneyer","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Science (A.S.), University of Massachusetts Amherst, Amherst, Massachusetts 01003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Pietrangelo","sequence":"first","affiliation":[{"name":"Center for Hemochromatosis (S.C., A.P.), University Hospital of Modena and Reggio Emilia, Modena Italy 41124"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie L.","family":"Babitt","sequence":"first","affiliation":[{"name":"Program in Anemia Signaling Research (S.C., A.B.C., K.B.Z.-B., M.M., C.-Y.W., J.L.B.), Division of Nephrology, Program in Membrane Biology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,1,6]]},"reference":[{"issue":"4","key":"2020071612054455100_B1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/ajh.23110","article-title":"Targeting the hepcidin-ferroportin axis to develop new 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