{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:57:11Z","timestamp":1779256631292,"version":"3.51.4"},"reference-count":70,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In pregnancies complicated by placental insufficiency and intrauterine growth restriction (IUGR), fetal glucose and oxygen concentrations are reduced, whereas plasma norepinephrine and epinephrine concentrations are elevated throughout the final third of gestation. Here we study the effects of chronic hypoxemia and hypercatecholaminemia on \u03b2-cell function in fetal sheep with placental insufficiency-induced IUGR that is produced by maternal hyperthermia. IUGR and control fetuses underwent a sham (intact) or bilateral adrenal demedullation (AD) surgical procedure at 0.65 gestation. As expected, AD-IUGR fetuses had lower norepinephrine concentrations than intact-IUGR fetuses despite being hypoxemic and hypoglycemic. Placental insufficiency reduced fetal weights, but the severity of IUGR was less with AD. Although basal plasma insulin concentrations were lower in intact-IUGR and AD-IUGR fetuses compared with intact-controls, glucose-stimulated insulin concentrations were greater in AD-IUGR fetuses compared with intact-IUGR fetuses. Interestingly, AD-controls had lower glucose- and arginine-stimulated insulin concentrations than intact-controls, but AD-IUGR and AD-control insulin responses were not different. To investigate chronic hypoxemia in the IUGR fetus, arterial oxygen tension was increased to normal levels by increasing the maternal inspired oxygen fraction. Oxygenation of IUGR fetuses enhanced glucose-stimulated insulin concentrations 3.3-fold in intact-IUGR and 1.7-fold in AD-IUGR fetuses but did not lower norepinephrine and epinephrine concentrations. Together these findings show that chronic hypoxemia and hypercatecholaminemia have distinct but complementary roles in the suppression of \u03b2-cell responsiveness in IUGR fetuses.<\/jats:p>","DOI":"10.1210\/en.2015-1850","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T18:00:56Z","timestamp":1457028056000},"page":"2104-2115","source":"Crossref","is-referenced-by-count":42,"title":["Adrenal Demedullation and Oxygen Supplementation Independently Increase Glucose-Stimulated Insulin Concentrations in Fetal Sheep With Intrauterine Growth Restriction"],"prefix":"10.1210","volume":"157","author":[{"given":"Antoni R.","family":"Macko","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin T.","family":"Yates","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochuan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie A.","family":"Shelton","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Kelly","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa A.","family":"Davis","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia E.","family":"Camacho","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda J.","family":"Anderson","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean W.","family":"Limesand","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"2020071611593429600_B1","first-page":"490","article-title":"Intrauterine growth restriction","volume":"99","author":"Resnik","year":"2002","journal-title":"Obstet Gynecol"},{"key":"2020071611593429600_B2","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM199303113281004","article-title":"Diagnostic value of blood sampling in fetuses with growth retardation","volume":"328","author":"Pardi","year":"1993","journal-title":"N Engl J Med"},{"key":"2020071611593429600_B3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0002-9378(89)90167-1","article-title":"Plasma insulin in appropriate- and small-for-gestational-age fetuses","volume":"160","author":"Economides","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"2020071611593429600_B4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-2007-1004939","article-title":"Effects of fetal intravenous glucose challenge in normal and growth retarded fetuses","volume":"22","author":"Nicolini","year":"1990","journal-title":"Horm Metab Res"},{"key":"2020071611593429600_B5","first-page":"541","article-title":"Endocrine pancreatic function in growth-retarded fetuses","volume":"77","author":"Hubinont","year":"1991","journal-title":"Obstet Gynecol"},{"key":"2020071611593429600_B6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1447-0756.1991.tb00284.x","article-title":"Catecholamines in experimentally growth-retarded rat fetus","volume":"17","author":"Hiraoka","year":"1991","journal-title":"Asia Oceania J Obstet Gynaecol"},{"key":"2020071611593429600_B7","first-page":"77","article-title":"Studies on experimental growth retardation in sheep. Plasma catecholamines in fetuses with small placenta","volume":"5","author":"Jones","year":"1983","journal-title":"J Dev Physiol"},{"key":"2020071611593429600_B8","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0002-9378(80)90639-0","article-title":"Catecholamine metabolites in amniotic fluid as indicators of intrauterine stress","volume":"136","author":"Lagercrantz","year":"1980","journal-title":"Am J Obstet Gynecol"},{"key":"2020071611593429600_B9","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1210\/en.2005-0900","article-title":"Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction","volume":"147","author":"Limesand","year":"2006","journal-title":"Endocrinology"},{"key":"2020071611593429600_B10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000263584","article-title":"Catecholamine levels and their correlation to blood gases in umbilical venous blood obtained by cordocentesis","volume":"5","author":"Okamura","year":"1990","journal-title":"Fetal Diagn Ther"},{"key":"2020071611593429600_B11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0378-3782(90)90124-2","article-title":"Human fetal sympathoadrenal responsiveness","volume":"23","author":"Greenough","year":"1990","journal-title":"Early Hum Dev"},{"key":"2020071611593429600_B12","doi-asserted-by":"crossref","first-page":"R2179","DOI":"10.1152\/ajpregu.2000.279.6.R2179","article-title":"Control of fetal insulin secretion","volume":"279","author":"Jackson","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2020071611593429600_B13","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1203\/00006450-198003000-00005","article-title":"Adrenergic modulation of pancreatic hormone secretion in utero: studies in fetal sheep","volume":"14","author":"Sperling","year":"1980","journal-title":"Pediatr 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