{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:08:44Z","timestamp":1790845724233,"version":"4.1.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A variety of data suggest that estrogen action on kisspeptin (Kiss1)-containing arcuate nucleus neurons (which coexpress Kiss1, neurokinin B (the product of Tac2) and dynorphin (KNDy) neurons restrains reproductive onset and function, but roles for estrogen action in these Kiss1 neurons relative to a distinct population of rostral hypothalamic Kiss1 neurons (which does not express Tac2 or dynorphin) have not been directly tested. To test the role for estrogen receptor (ER)\u03b1 in KNDy cells, we thus generated Tac2Cre and Kiss1Cre knock-in mice and bred them onto the Esr1flox background to ablate ER\u03b1 specifically in Tac2-expressing cells (ER\u03b1Tac2KO mice) or all Kiss1 cells (ER\u03b1Kiss1KO mice), respectively. Most ER\u03b1-expressing Tac2 neurons represent KNDy cells. Arcuate nucleus Kiss1 expression was elevated in ER\u03b1Tac2KO and ER\u03b1Kiss1KO females independent of gonadal hormones, whereas rostral hypothalamic Kiss1 expression was normal in ER\u03b1Tac2KO but decreased in ER\u03b1Kiss1KO females; this suggests that ER\u03b1 in rostral Kiss1 cells is crucial for control of Kiss1 expression in these cells. Both ER\u03b1Kiss1KO and ER\u03b1Tac2KO females displayed early vaginal opening, early and persistent vaginal cornification, increased gonadotropins, uterine hypertrophy, and other evidence of estrogen excess. Thus, deletion of ER\u03b1 in Tac2 neurons suffices to drive precocious gonadal hyperstimulation, demonstrating that ER\u03b1 in Tac2 neurons typically restrains pubertal onset and hypothalamic reproductive drive.<\/jats:p>","DOI":"10.1210\/en.2015-1928","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T18:38:52Z","timestamp":1455129532000},"page":"1555-1565","source":"Crossref","is-referenced-by-count":48,"title":["ER\u03b1 in Tac2 Neurons Regulates Puberty Onset in Female Mice"],"prefix":"10.1210","volume":"157","author":[{"given":"Megan L.","family":"Greenwald-Yarnell","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program (M.L.G.-Y., S.M.M., M.G.M.); University of Michigan, Ann Arbor, Michigan 48109"},{"name":"Division of Metabolism, Endocrinology and Diabetes (M.L.G.-Y., M.B.A., C.M.P., C.K., A.M., S.M.M., M.G.M.), Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Marsh","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program (M.L.G.-Y., S.M.M., M.G.M.); University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret B.","family":"Allison","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes (M.L.G.-Y., M.B.A., C.M.P., C.K., A.M., S.M.M., M.G.M.), Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109"},{"name":"Molecular and Integrative Physiology (M.B.A., R.C., C.F.E., S.M.M., M.G.M.), University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa M.","family":"Patterson","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes (M.L.G.-Y., M.B.A., C.M.P., C.K., A.M., S.M.M., M.G.M.), Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109"},{"name":"Departments of Obstetrics and Gynecology (C.M., C.F.E., S.M.M.) University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Kasper","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes (M.L.G.-Y., M.B.A., C.M.P., C.K., A.M., S.M.M., M.G.M.), Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"MacKenzie","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes (M.L.G.-Y., M.B.A., C.M.P., C.K., A.M., S.M.M., M.G.M.), Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Cravo","sequence":"first","affiliation":[{"name":"Neuroscience Graduate Program (M.L.G.-Y., S.M.M., M.G.M.); University of Michigan, Ann Arbor, Michigan 48109"},{"name":"Molecular and Integrative Physiology (M.B.A., R.C., C.F.E., S.M.M., M.G.M.), University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol F.","family":"Elias","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology (C.M., C.F.E., S.M.M.) University of Michigan, Ann Arbor, Michigan 48109"},{"name":"Molecular and Integrative Physiology (M.B.A., R.C., C.F.E., S.M.M., M.G.M.), University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne M.","family":"Moenter","sequence":"first","affiliation":[{"name":"Division of Metabolism, Endocrinology and Diabetes (M.L.G.-Y., M.B.A., C.M.P., C.K., A.M., S.M.M., M.G.M.), Department of Internal Medicine University of Michigan, Ann Arbor, Michigan 48109"},{"name":"Departments of Obstetrics and Gynecology (C.M., C.F.E., S.M.M.) 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