{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:27:10Z","timestamp":1752668830145},"reference-count":10,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"DOI":"10.1210\/en.2015-1977","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T13:43:24Z","timestamp":1451483004000},"page":"44-45","source":"Crossref","is-referenced-by-count":3,"title":["Young at Heart"],"prefix":"10.1210","volume":"157","author":[{"given":"Adam","family":"Jara","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences (A.J., J.J.K.), Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Kopchick","sequence":"first","affiliation":[{"name":"Department of Biological Sciences (J.J.K.) and Edison Biotechnology Institute (J.J.K.), Ohio University, Athens, Ohio 45701"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"issue":"2","key":"2020071612110930500_B1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10353-011-0600-3","article-title":"Cardiac aging - a review","volume":"43","author":"Czuriga","year":"2011","journal-title":"Eur Surg"},{"issue":"1","key":"2020071612110930500_B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199007053230101","article-title":"Effects of human growth hormone in men over 60 years old","volume":"323","author":"Rudman","year":"1990","journal-title":"N Engl J Med"},{"issue":"9","key":"2020071612110930500_B3","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1210\/en.2003-0374","article-title":"Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span","volume":"144","author":"Coschigano","year":"2003","journal-title":"Endocrinology"},{"issue":"1","key":"2020071612110930500_B4","first-page":"59","article-title":"Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)","volume":"75","author":"Liu","year":"1993","journal-title":"Cell"},{"issue":"6919","key":"2020071612110930500_B5","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01298","article-title":"IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice","volume":"421","author":"Holzenberger","year":"2003","journal-title":"Nature"},{"issue":"5","key":"2020071612110930500_B6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1474-9726.2007.00328.x","article-title":"Loss of pregnancy-associated plasma protein A extends lifespan in mice","volume":"6","author":"Conover","year":"2007","journal-title":"Aging Cell"},{"issue":"14","key":"2020071612110930500_B7","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1096\/fasebj.13.14.1923","article-title":"Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice","volume":"13","author":"Delaughter","year":"1999","journal-title":"FASEB J"},{"issue":"11","key":"2020071612110930500_B8","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/me.2008-0265","article-title":"Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy","volume":"22","author":"Kim","year":"2008","journal-title":"Mol Endocrinol"},{"issue":"2","key":"2020071612110930500_B9","first-page":"E213","article-title":"IGF-IR signaling attenuates the age-related decline of diastolic cardiac function","volume":"303","author":"Moellendorf","year":"2012","journal-title":"Am J Physiol Metab"},{"key":"2020071612110930500_B10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1210\/en.2015-1709","article-title":"Deletion of IGF-1 receptors in cardiomyocytes attenuates cardiac aging in male mice","volume":"157","author":"Ock","year":"2016","journal-title":"Endocrinology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/157\/1\/44\/11029069\/endo0044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/157\/1\/44\/11029069\/endo0044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T19:25:33Z","timestamp":1594927533000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/157\/1\/44\/2251824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2015-1977","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,1]]}}}