{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:52:03Z","timestamp":1777449123733,"version":"3.51.4"},"reference-count":136,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:p>Steroid sex hormones and genetic sex regulate the phenotypes of motivated behaviors and relevant disorders. Most studies seeking to elucidate the underlying neuroendocrine mechanisms have focused on how 17\u03b2-estradiol modulates the role of dopamine in striatal brain regions, which express membrane-associated estrogen receptors. Dopamine action is an important component of striatal function, but excitatory synaptic neurotransmission has also emerged as a key striatal substrate and target of estradiol action. Here, we focus on excitatory synaptic input onto medium spiny neurons (MSNs) in the striatal region nucleus accumbens core (AcbC). In adult AcbC, miniature excitatory postsynaptic current (mEPSC) frequency is increased in female compared with male MSNs. We tested whether increased mEPSC frequency in female MSNs exists before puberty, whether this increased excitability is due to the absence of estradiol or testosterone during the early developmental critical period, and whether it is accompanied by stable neuron intrinsic membrane properties. We found that mEPSC frequency is increased in female compared with male MSNs before puberty. Increased mEPSC frequency in female MSNs is abolished after neonatal estradiol or testosterone exposure. MSN intrinsic membrane properties did not differ by sex. These data indicate that neonatal masculinization via estradiol and\/or testosterone action is sufficient for down-regulating excitatory synaptic input onto MSNs. We conclude that excitatory synaptic input onto AcbC MSNs is organized long before adulthood via steroid sex hormone action, providing new insight into a mechanism by which sex differences in motivated behavior and other AbcC functions may be generated or compromised.<\/jats:p>","DOI":"10.1210\/en.2016-1160","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T20:26:45Z","timestamp":1465590405000},"page":"3181-3196","source":"Crossref","is-referenced-by-count":41,"title":["Neonatal Masculinization Blocks Increased Excitatory Synaptic Input in Female Rat Nucleus Accumbens Core"],"prefix":"10.1210","volume":"157","author":[{"given":"Jinyan","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Biological Sciences (J.C., D.M.D., J.M.), North Carolina State University, Raleigh, North Carolina 27695;"},{"name":"W.M. Keck Center for Behavioral Biology (J.C., J.M.), North Carolina State University, Raleigh, North Carolina 27695;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Dorris","sequence":"first","affiliation":[{"name":"Department of Biological Sciences (J.C., D.M.D., J.M.), North Carolina State University, Raleigh, North Carolina 27695;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Meitzen","sequence":"first","affiliation":[{"name":"Department of Biological Sciences (J.C., D.M.D., J.M.), North Carolina State University, Raleigh, North Carolina 27695;"},{"name":"W.M. Keck Center for Behavioral Biology (J.C., J.M.), North Carolina State University, Raleigh, North Carolina 27695;"},{"name":"Center for Human Health and the Environment (J.M.), North Carolina State University, Raleigh, North Carolina 27695;"},{"name":"Comparative Medicine Institute (J.M.), North Carolina State University, Raleigh, North Carolina 27695"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"2020071612114489200_B1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1073\/pnas.1320954111","article-title":"Fundamental sex difference in human brain architecture","volume":"111","author":"Cahill","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071612114489200_B2","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1523\/JNEUROSCI.5372-11.2012","article-title":"Sex differences in the brain: the not so inconvenient truth","volume":"32","author":"McCarthy","year":"2012","journal-title":"J Neurosci"},{"key":"2020071612114489200_B3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13293-015-0032-z","article-title":"Sex differences in the brain: a whole body perspective","volume":"6","author":"de Vries","year":"2015","journal-title":"Biol Sex Differ"},{"key":"2020071612114489200_B4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/1871524914666141226103135","article-title":"Estradiol, dopamine and motivation","volume":"14","author":"Yoest","year":"2014","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"2020071612114489200_B5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: focus on addiction","volume":"68","author":"Becker","year":"2016","journal-title":"Pharmacol Rev"},{"key":"2020071612114489200_B6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yhbeh.2009.10.001","article-title":"Sex differences and ovarian hormones in animal models of drug dependence","volume":"58","author":"Carroll","year":"2010","journal-title":"Horm Behav"},{"key":"2020071612114489200_B7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000368279","article-title":"The nucleus accumbens: a comprehensive review","volume":"93","author":"Salgado","year":"2015","journal-title":"Stereotact Funct Neurosurg"},{"key":"2020071612114489200_B8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.neuroscience.2015.06.033","article-title":"The ins and outs of the striatum: role in drug addiction","volume":"301","author":"Yager","year":"2015","journal-title":"Neuroscience"},{"key":"2020071612114489200_B9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cpr.2009.05.003","article-title":"Brave men and timid women? 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