{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:09:02Z","timestamp":1777320542527,"version":"3.51.4"},"reference-count":50,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:p>Cortistatin (CORT) shares high structural and functional similarities with somatostatin (SST) but displays unique sex-dependent pituitary actions. Indeed, although female CORT-knockout (CORT-KO) mice exhibit enhanced GH expression\/secretion, Proopiomelanocortin expression, and circulating ACTH\/corticosterone\/ghrelin levels, male CORT-KO mice only display increased plasma GH\/corticosterone levels. Changes in peripheral ghrelin and SST (rather than hypothalamic levels) seem to regulate GH\/ACTH axes in CORT-KOs under fed conditions. Because changes in GH\/ACTH axes during fasting provide important adaptive mechanisms, we sought to determine whether CORT absence influences GH\/ACTH axes during fasting. Accordingly, fed and fasted male\/female CORT-KO were compared with littermate controls. Fasting increased circulating GH levels in male\/female controls but not in CORT-KO, suggesting that CORT can be a relevant regulator of GH secretion during fasting. However, GH levels were already higher in CORT-KO than in controls in fed state, which might preclude a further elevation in GH levels. Interestingly, although fasting-induced pituitary GH expression was elevated in both male\/female controls, GH expression only increased in fasted female CORT-KOs, likely owing to specific changes observed in key factors controlling somatotrope responsiveness (ie, circulating ghrelin and IGF-1, and pituitary GHRH and ghrelin receptor expression). Fasting increased corticosterone levels in control and, most prominently, in CORT-KO mice, which might be associated with a desensitization to SST signaling and to an augmentation in CRH and ghrelin-signaling regulating corticotrope function. Altogether, these results provide compelling evidence that CORT plays a key, sex-dependent role in the regulation of the GH\/ACTH axes in response to fasting.<\/jats:p>","DOI":"10.1210\/en.2016-1195","type":"journal-article","created":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T17:00:49Z","timestamp":1463158849000},"page":"2810-2823","source":"Crossref","is-referenced-by-count":11,"title":["Cortistatin Is a Key Factor Regulating the Sex-Dependent Response of the GH and Stress Axes to Fasting in Mice"],"prefix":"10.1210","volume":"157","author":[{"given":"Jos\u00e9","family":"Cordoba-Chac\u00f3n","sequence":"first","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.);"},{"name":"Department of Cell Biology, Physiology, and Immunology (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.), University of C\u00f3rdoba;"},{"name":"Hospital Universitario Reina Sof\u00eda (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.), C\u00f3rdoba 14004, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.); 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C\u00f3rdoba 14004, Spain;"},{"name":"Campus de Excelencia Internacional Agroalimentario (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.), C\u00f3rdoba 14004, Spain;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"de Lecea","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences (L.d.L.), Stanford University School of Medicine, Palo Alto, California 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justo P.","family":"Casta\u00f1o","sequence":"first","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.);"},{"name":"Department of Cell Biology, Physiology, and Immunology (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.), University of C\u00f3rdoba;"},{"name":"Hospital Universitario Reina Sof\u00eda (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.), C\u00f3rdoba 14004, Spain;"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (J.C.-C., M.D.G., A.I.P.-S., J.P.C., R.M.L.); 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