{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:22:09Z","timestamp":1790882529998,"version":"4.1.0"},"reference-count":63,"publisher":"The Endocrine Society","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00-HD068130"],"award-info":[{"award-number":["R00-HD068130"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32DK007751-18"],"award-info":[{"award-number":["5T32DK007751-18"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Baltimore Diabetes Research Center","award":["P60DK079637"],"award-info":[{"award-number":["P60DK079637"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"DOI":"10.1210\/en.2016-1553","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T14:06:36Z","timestamp":1481724396000},"page":"531-544","source":"Crossref","is-referenced-by-count":53,"title":["Low-Dose Dihydrotestosterone Drives Metabolic Dysfunction via Cytosolic and\n          Nuclear Hepatic Androgen Receptor Mechanisms"],"prefix":"10.1210","volume":"158","author":[{"given":"Stanley","family":"Andrisse","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shameka","family":"Childress","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn","family":"Billings","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momodou L.","family":"Sonko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland 21283"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"issue":"5","key":"2019052206300166800_B1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1055\/s-2007-984741","article-title":"Neuroendocrine effects of androgens in adult polycystic ovary syndrome\n            and female puberty","volume":"25","author":"Blank","year":"2007","journal-title":"Semin Reprod Med"},{"key":"2019052206300166800_B2","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis\n            Primers"},{"issue":"6","key":"2019052206300166800_B3","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1210\/en.2011-1754","article-title":"Reproductive and metabolic phenotype of a mouse model of\n            PCOS","volume":"153","author":"van Houten","year":"2012","journal-title":"Endocrinology"},{"issue":"8","key":"2019052206300166800_B4","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1210\/en.2007-0168","article-title":"A new rat model exhibiting both ovarian and metabolic characteristics of\n            polycystic ovary syndrome","volume":"148","author":"Manner\u00e5s","year":"2007","journal-title":"Endocrinology"},{"issue":"3","key":"2019052206300166800_B5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cmet.2010.06.010","article-title":"Rescue of obesity-induced infertility in female mice due to a\n            pituitary-specific knockout of the insulin receptor","volume":"12","author":"Brothers","year":"2010","journal-title":"Cell\n            Metab"},{"issue":"5","key":"2019052206300166800_B6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1095\/biolreprod.114.120063","article-title":"High-fat diet induces significant metabolic disorders in a mouse model of\n            polycystic ovary syndrome","volume":"91","author":"Lai","year":"2014","journal-title":"Biol Reprod"},{"issue":"10","key":"2019052206300166800_B7","doi-asserted-by":"crossref","first-page":"e48643","DOI":"10.1371\/journal.pone.0048643","article-title":"Adipocyte dysfunction in a mouse model of polycystic ovary syndrome\n            (PCOS): evidence of adipocyte hypertrophy and tissue-specific\n            inflammation","volume":"7","author":"Marino","year":"2012","journal-title":"PLoS One"},{"issue":"Pt\n            3","key":"2019052206300166800_B8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1113\/jphysiol.2006.124610","article-title":"Maternal taurine supplementation in the late pregnant rat stimulates\n            postnatal growth and induces obesity and insulin resistance in adult\n            offspring","volume":"579","author":"Hultman","year":"2007","journal-title":"J Physiol"},{"issue":"8","key":"2019052206300166800_B9","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/en.2014-1196","article-title":"Characterization of reproductive, metabolic, and endocrine features of\n            polycystic ovary syndrome in female hyperandrogenic mouse models","volume":"155","author":"Caldwell","year":"2014","journal-title":"Endocrinology"},{"issue":"10","key":"2019052206300166800_B10","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1210\/jc.2003-030617","article-title":"Early endocrine, metabolic, and sonographic characteristics of polycystic\n            ovary syndrome (PCOS): comparison between nonobese and obese\n          adolescents","volume":"88","author":"Silfen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019052206300166800_B11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/cen.12935","article-title":"The diagnosis of nonclassic congenital adrenal hyperplasia due to\n            21-hydroxylase deficiency, based on serum basal or post-ACTH stimulation\n            17-hydroxyprogesterone, can lead to false-positive diagnosis","volume":"84","author":"Ambroziak","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2019052206300166800_B12","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3181\/00379727-202-43527","article-title":"The effect of neonatal sex hormone manipulation on the incidence of\n            diabetes in nonobese diabetic mice","volume":"202","author":"Hawkins","year":"1993","journal-title":"Proc Soc Exp Biol\n            Med"},{"issue":"5","key":"2019052206300166800_B13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.metabol.2006.12.021","article-title":"The adipose cell lineage is not intrinsically insulin resistant in\n            polycystic ovary syndrome","volume":"56","author":"Corbould","year":"2007","journal-title":"Metabolism"},{"issue":"5","key":"2019052206300166800_B14","doi-asserted-by":"crossref","first-page":"E1047","DOI":"10.1152\/ajpendo.00361.2004","article-title":"Insulin resistance in the skeletal muscle of women with PCOS involves\n            intrinsic and acquired defects in insulin signaling","volume":"288","author":"Corbould","year":"2005","journal-title":"Am J\n            Physiol Endocrinol Metab"},{"issue":"2 Pt\n            1","key":"2019052206300166800_B15","first-page":"E197","article-title":"Insulin resistance in polycystic ovary syndrome: decreased expression of\n            GLUT-4 glucose transporters in adipocytes","volume":"264","author":"Rosenbaum","year":"1993","journal-title":"Am J\n          Physiol"},{"issue":"3","key":"2019052206300166800_B16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.2337\/diabetes.55.03.06.db05-0453","article-title":"Enhanced mitogenic signaling in skeletal muscle of women with polycystic\n            ovary syndrome","volume":"55","author":"Corbould","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"2019052206300166800_B17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2337\/db11-0956","article-title":"Reproductive tissues maintain insulin sensitivity in diet-induced\n            obesity","volume":"61","author":"Wu","year":"2012","journal-title":"Diabetes"},{"issue":"15","key":"2019052206300166800_B18","doi-asserted-by":"crossref","first-page":"14579","DOI":"10.1074\/jbc.M306143200","article-title":"Androgen receptor mediates non-genomic activation of phosphatidylinositol\n            3-OH kinase in androgen-sensitive epithelial cells","volume":"279","author":"Baron","year":"2004","journal-title":"J Biol\n            Chem"},{"issue":"1","key":"2019052206300166800_B19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.canlet.2015.08.001","article-title":"Androgen receptor inhibits epithelial-mesenchymal transition, migration,\n            and invasion of PC-3 prostate cancer cells","volume":"369","author":"Huo","year":"2015","journal-title":"Cancer\n          Lett"},{"issue":"5","key":"2019052206300166800_B20","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cellsig.2016.01.013","article-title":"The importance of non-nuclear AR signaling in prostate cancer progression\n            and therapeutic resistance","volume":"28","author":"Zarif","year":"2016","journal-title":"Cell Signal"},{"issue":"1","key":"2019052206300166800_B21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1128\/MCB.23.1.104-118.2003","article-title":"AKT-independent protection of prostate cancer cells from apoptosis\n            mediated through complex formation between the androgen receptor and\n            FKHR","volume":"23","author":"Li","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"1","key":"2019052206300166800_B22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(91)90410-Z","article-title":"Cloning of PI3 kinase-associated p85 utilizing a novel method for\n            expression\/cloning of target proteins for receptor tyrosine kinases","volume":"65","author":"Skolnik","year":"1991","journal-title":"Cell"},{"issue":"5573","key":"2019052206300166800_B23","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","article-title":"The phosphoinositide 3-kinase pathway","volume":"296","author":"Cantley","year":"2002","journal-title":"Science"},{"issue":"1","key":"2019052206300166800_B24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1073\/pnas.012581799","article-title":"Increased insulin sensitivity in mice lacking p85beta subunit of\n            phosphoinositide 3-kinase","volume":"99","author":"Ueki","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2019052206300166800_B25","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1210\/en.2004-0767","article-title":"Western diet modulates insulin signaling, c-Jun N-terminal kinase\n            activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific\n            fashion","volume":"146","author":"Prada","year":"2005","journal-title":"Endocrinology"},{"issue":"Pt\n            3","key":"2019052206300166800_B26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/bj3620513","article-title":"The glucose-6-phosphatase system","volume":"362","author":"van Schaftingen","year":"2002","journal-title":"Biochem\n            J"},{"issue":"3","key":"2019052206300166800_B27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cyto.2003.10.006","article-title":"Sex steroid-mediated regulation of macrophage\/monocyte function in a\n            two-hit model of trauma-hemorrhage and sepsis","volume":"25","author":"Dienstknecht","year":"2004","journal-title":"Cytokine"},{"issue":"3-5","key":"2019052206300166800_B28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jsbmb.2010.02.001","article-title":"Measurement of sex steroids in murine blood and reproductive tissues by\n            liquid chromatography-tandem mass spectrometry","volume":"121","author":"McNamara","year":"2010","journal-title":"J Steroid\n            Biochem Mol Biol"},{"issue":"9-10","key":"2019052206300166800_B29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dmm.006239","article-title":"Standard operating procedures for describing and performing metabolic\n            tests of glucose homeostasis in mice","volume":"3","author":"Ayala","year":"2010","journal-title":"Dis Model Mech"},{"issue":"4","key":"2019052206300166800_B30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/0023677213501659","article-title":"Fasting of mice: a review","volume":"47","author":"Jensen","year":"2013","journal-title":"Lab Anim"},{"issue":"6","key":"2019052206300166800_B31","doi-asserted-by":"crossref","first-page":"e66027","DOI":"10.1371\/journal.pone.0066027","article-title":"ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in\n            skeletal muscle","volume":"8","author":"Andrisse","year":"2013","journal-title":"PLoS One"},{"key":"2019052206300166800_B32","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.redox.2014.03.004","article-title":"Role of GLUT1 in regulation of reactive oxygen species","volume":"2","author":"Andrisse","year":"2014","journal-title":"Redox Biol"},{"issue":"2","key":"2019052206300166800_B33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2337\/db12-0135","article-title":"Neuronal androgen receptor regulates insulin sensitivity via suppression\n            of hypothalamic NF-\u03baB-mediated PTP1B expression","volume":"62","author":"Yu","year":"2013","journal-title":"Diabetes"},{"issue":"1","key":"2019052206300166800_B34","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1210\/en.2013-1491","article-title":"Insulin-like 3-induced rat preantral follicular growth is mediated by\n            growth differentiation factor 9","volume":"155","author":"Xue","year":"2014","journal-title":"Endocrinology"},{"key":"2019052206300166800_B35"},{"issue":"22","key":"2019052206300166800_B36","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1038\/onc.2010.623","article-title":"Regulation of transcription of hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) by\n            heat shock factors HSF2 and HSF4","volume":"30","author":"Chen","year":"2011","journal-title":"Oncogene"},{"issue":"4","key":"2019052206300166800_B37","doi-asserted-by":"crossref","first-page":"976","DOI":"10.2337\/diabetes.54.4.976","article-title":"Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular\n            glucose production via elevated liver activating protein\/liver inhibitory protein\n            ratio","volume":"54","author":"Shao","year":"2005","journal-title":"Diabetes"},{"issue":"3","key":"2019052206300166800_B38","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BJ20070481","article-title":"Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP\n            activation of the glucose-6-phosphatase gene","volume":"407","author":"Kodama","year":"2007","journal-title":"Biochem\n          J"},{"issue":"10","key":"2019052206300166800_B39","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1210\/jc.2012-1382","article-title":"Polycystic ovary syndrome with hyperandrogenism is characterized by an\n            increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and\n            healthy controls, independent of obesity and insulin resistance","volume":"97","author":"Jones","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2019052206300166800_B40","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1128\/MCB.00079-07","article-title":"The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates\n            c-Jun N-terminal kinase-mediated insulin resistance","volume":"27","author":"Taniguchi","year":"2007","journal-title":"Mol Cell\n            Biol"},{"issue":"1","key":"2019052206300166800_B41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(01)03021-6","article-title":"Tyrosine phosphorylation of the catalytic subunit p110 of\n            phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase\n            activity in L6 myoblasts","volume":"508","author":"Nakagawa","year":"2001","journal-title":"FEBS Lett"},{"issue":"5","key":"2019052206300166800_B42","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/ncb2731","article-title":"FBXL2- and PTPL1-mediated degradation of p110-free p85\u03b2 regulatory\n            subunit controls the PI(3)K signaling cascade","volume":"15","author":"Kuchay","year":"2013","journal-title":"Nat Cell\n            Biol"},{"issue":"29","key":"2019052206300166800_B43","doi-asserted-by":"crossref","first-page":"27455","DOI":"10.1074\/jbc.M100556200","article-title":"Tyrosine phosphorylation of p85 relieves its inhibitory activity on\n            phosphatidylinositol 3-kinase","volume":"276","author":"Cuevas","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"2019052206300166800_B44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biocel.2011.10.001","article-title":"Transcription factors and coactivators controlling\n            nutrient and hormonal regulation of hepatic gluconeogenesis","volume":"44","author":"Jitrapakdee","year":"2012","journal-title":"Int\n            J Biochem Cell Biol"},{"issue":"10","key":"2019052206300166800_B45","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1128\/MCB.01313-10","article-title":"Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential\n            function in cell survival","volume":"31","author":"Kumar","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2019052206300166800_B46","doi-asserted-by":"crossref","first-page":"e56263","DOI":"10.1371\/journal.pone.0056263","article-title":"The pancreas is altered by in utero androgen exposure: implications for\n            clinical conditions such as polycystic ovary syndrome (PCOS)","volume":"8","author":"Rae","year":"2013","journal-title":"PLoS One"},{"issue":"18","key":"2019052206300166800_B47","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1073\/pnas.0308058101","article-title":"Prenatal androgens alter GABAergic drive to gonadotropin-releasing\n            hormone neurons: implications for a common fertility disorder","volume":"101","author":"Sullivan","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"2019052206300166800_B48","doi-asserted-by":"crossref","first-page":"E801","DOI":"10.1152\/ajpendo.00107.2005","article-title":"Postnatal developmental consequences of altered insulin sensitivity in\n            female sheep treated prenatally with testosterone","volume":"289","author":"Recabarren","year":"2005","journal-title":"Am J Physiol\n            Endocrinol Metab"},{"issue":"1","key":"2019052206300166800_B49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0015-0282(01)02947-8","article-title":"Ovarian hyperandrogenism in adult female rhesus monkeys exposed to\n            prenatal androgen excess","volume":"77","author":"Eisner","year":"2002","journal-title":"Fertil Steril"},{"issue":"1","key":"2019052206300166800_B50","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/JOE-12-0577","article-title":"Prenatal androgen excess programs metabolic derangements in pubertal\n            female rats","volume":"217","author":"Yan","year":"2013","journal-title":"J Endocrinol"},{"issue":"2","key":"2019052206300166800_B51","doi-asserted-by":"crossref","first-page":"E262","DOI":"10.1152\/ajpendo.90208.2008","article-title":"Transient prenatal androgen exposure produces metabolic syndrome in adult\n            female rats","volume":"295","author":"Demissie","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1-2","key":"2019052206300166800_B52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jri.2004.04.002","article-title":"Effects of dehydroepiandrosterone on ovarian cystogenesis and immune\n            function","volume":"64","author":"Luchetti","year":"2004","journal-title":"J Reprod Immunol"},{"issue":"2","key":"2019052206300166800_B53","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/JOE-15-0453","article-title":"Reproductive alterations in hyperinsulinemic but normoandrogenic MSG\n            obese female rats","volume":"229","author":"Gaspar","year":"2016","journal-title":"J Endocrinol"},{"issue":"6","key":"2019052206300166800_B54","doi-asserted-by":"crossref","first-page":"e11302","DOI":"10.1371\/journal.pone.0011302","article-title":"Androgen excess produces systemic oxidative stress and predisposes to\n            beta-cell failure in female mice","volume":"5","author":"Liu","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"2019052206300166800_B55","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/REP-11-0239","article-title":"Effect of androgen treatment during foetal and\/or neonatal life on\n            ovarian function in prepubertal and adult rats","volume":"143","author":"Tyndall","year":"2012","journal-title":"Reproduction"},{"issue":"1","key":"2019052206300166800_B56","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/MCB.24.1.320-329.2004","article-title":"p50alpha\/p55alpha phosphoinositide 3-kinase knockout mice exhibit\n            enhanced insulin sensitivity","volume":"24","author":"Chen","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2019052206300166800_B57"},{"issue":"2","key":"2019052206300166800_B58","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/6023","article-title":"Increased insulin sensitivity and hypoglycaemia in mice lacking the p85\n            alpha subunit of phosphoinositide 3-kinase","volume":"21","author":"Terauchi","year":"1999","journal-title":"Nat Genet"},{"issue":"5","key":"2019052206300166800_B59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cmet.2006.04.005","article-title":"Divergent regulation of hepatic glucose and lipid metabolism by\n            phosphoinositide 3-kinase via Akt and PKClambda\/zeta","volume":"3","author":"Taniguchi","year":"2006","journal-title":"Cell\n          Metab"},{"issue":"3","key":"2019052206300166800_B60","doi-asserted-by":"crossref","first-page":"e0149684","DOI":"10.1371\/journal.pone.0149684","article-title":"Dynamic modeling and analysis of the cross-talk between\n            insulin\/AKT and MAPK\/ERK signaling pathways","volume":"11","author":"Arkun","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"2019052206300166800_B61","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical nodes in signalling pathways: insights into insulin\n            action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"16","key":"2019052206300166800_B62","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1101\/gad.1564207","article-title":"Cell- and gene-specific regulation of primary target genes by the\n            androgen receptor","volume":"21","author":"Bolton","year":"2007","journal-title":"Genes Dev"},{"issue":"1-5","key":"2019052206300166800_B63","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0960-0760(00)00154-0","article-title":"Selective DNA binding by the androgen receptor as a mechanism for\n            hormone-specific gene regulation","volume":"76","author":"Claessens","year":"2001","journal-title":"J Steroid Biochem Mol\n            Biol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/158\/3\/531\/28690986\/en.2016-1553.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T07:43:45Z","timestamp":1558511025000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/158\/3\/531\/3053378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,12,14]]},"published-print":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2016-1553","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,3,1]]},"published":{"date-parts":[[2016,12,14]]}}}