{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:14:56Z","timestamp":1788210896453,"version":"build-2803163510"},"reference-count":42,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"DOI":"10.1210\/en.2016-1654","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T14:17:37Z","timestamp":1474467457000},"page":"4434-4445","source":"Crossref","is-referenced-by-count":45,"title":["Human Parturition Involves Phosphorylation of Progesterone Receptor-A at Serine-345 in Myometrial Cells"],"prefix":"10.1210","volume":"157","author":[{"given":"Peyvand","family":"Amini","sequence":"first","affiliation":[{"name":"Physiology and Biophysics (P.A., D.M., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Michniuk","sequence":"additional","affiliation":[{"name":"Physiology and Biophysics (P.A., D.M., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Kuo","sequence":"additional","affiliation":[{"name":"Case Western Reserve University, and Department of Obstetrics and Gynecology (K.K., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Yi","sequence":"additional","affiliation":[{"name":"Departments of Reproductive Biology (L.Y., Y.S.-P., G.AP., H.T., J.W., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelenna","family":"Skomorovska-Prokvolit","sequence":"additional","affiliation":[{"name":"Departments of Reproductive Biology (L.Y., Y.S.-P., G.AP., H.T., J.W., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Peters","sequence":"additional","affiliation":[{"name":"Departments of Reproductive Biology (L.Y., Y.S.-P., G.AP., H.T., J.W., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Tan","sequence":"additional","affiliation":[{"name":"Departments of Reproductive Biology (L.Y., Y.S.-P., G.AP., H.T., J.W., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junye","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Reproductive Biology (L.Y., Y.S.-P., G.AP., H.T., J.W., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Malemud","sequence":"additional","affiliation":[{"name":"Medicine (C.J.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Mesiano","sequence":"additional","affiliation":[{"name":"Departments of Reproductive Biology (L.Y., Y.S.-P., G.AP., H.T., J.W., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"},{"name":"Physiology and Biophysics (P.A., D.M., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"},{"name":"Case Western Reserve University, and Department of Obstetrics and Gynecology (K.K., S.M.), University Hospitals Cleveland Medical Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,9,21]]},"reference":[{"key":"2019041122235383400_B1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/aja.1000980206","article-title":"Progesterone \u201cblock.\u201d","volume":"98","author":"Csapo","year":"1956","journal-title":"Am J Anat"},{"key":"2019041122235383400_B2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/0002-9378(75)90111-8","article-title":"The \u201cseesaw\u201d theory of the regulatory mechanism of pregnancy","volume":"121","author":"Caspo","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122235383400_B3","first-page":"95","volume-title":"Hormones and Reproduction of Vertebrates","author":"Young","year":"2011"},{"key":"2019041122235383400_B4","first-page":"111","article-title":"The mechanism of initiation of parturition in the ewe","volume":"29","author":"Liggins","year":"1973","journal-title":"Recent Prog Horm Res"},{"key":"2019041122235383400_B5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/B978-0-12-522601-1.50018-4","volume-title":"Fetal Endocrinol","author":"Liggins","year":"1981"},{"key":"2019041122235383400_B6","first-page":"686","article-title":"Maternal serum estrogen and progesterone concentrations preceding normal labor","volume":"51","author":"Boroditsky","year":"1978","journal-title":"Obstet Gynecol"},{"key":"2019041122235383400_B7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1210\/jcem-58-4-629","article-title":"Daily hormonal changes in the maternal, fetal, and amniotic fluid compartments before parturition in a primate species","volume":"58","author":"Walsh","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122235383400_B8","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","article-title":"Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy","volume":"112","author":"Tulchinsky","year":"1972","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122235383400_B9","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium","volume":"87","author":"Mesiano","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122235383400_B10","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2007-0077","article-title":"Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A","volume":"92","author":"Merlino","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122235383400_B11","doi-asserted-by":"crossref","first-page":"E719","DOI":"10.1210\/jc.2011-3251","article-title":"Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition","volume":"97","author":"Tan","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122235383400_B12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0015-0282(16)54527-0","article-title":"Mifepristone (RU486) alone or in combination with a prostaglandin analogue for termination of early pregnancy: a review","volume":"56","author":"Avrech","year":"1991","journal-title":"Fertil Steril"},{"key":"2019041122235383400_B13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.med.48.1.129","article-title":"RU486 (mifepristone): mechanisms of action and clinical uses","volume":"48","author":"Cadepond","year":"1997","journal-title":"Annu Rev Med"},{"key":"2019041122235383400_B14","first-page":"972","article-title":"Labor induction in women at term with mifepristone (RU 486): a double-blind, randomized, placebo-controlled study","volume":"80","author":"Frydman","year":"1992","journal-title":"Obstet Gynecol"},{"key":"2019041122235383400_B15","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","article-title":"Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B","volume":"9","author":"Kastner","year":"1990","journal-title":"EMBO J"},{"key":"2019041122235383400_B16","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1128\/MCB.14.12.8356","article-title":"The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells","volume":"14","author":"Wen","year":"1994","journal-title":"Mol Cell Biol"},{"key":"2019041122235383400_B17","first-page":"291","article-title":"The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene","volume":"54","author":"Giangrande","year":"1998","journal-title":"Recent Prog Horm Res"},{"key":"2019041122235383400_B18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0039-128X(03)00126-0","article-title":"Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms","volume":"68","author":"Conneely","year":"2003","journal-title":"Steroids"},{"key":"2019041122235383400_B19","doi-asserted-by":"crossref","first-page":"9744","DOI":"10.1073\/pnas.1732707100","article-title":"Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform","volume":"100","author":"Mulac-Jericevic","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122235383400_B20","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1126\/science.289.5485.1751","article-title":"Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform","volume":"289","author":"Mulac-Jericevic","year":"2000","journal-title":"Science"},{"key":"2019041122235383400_B21","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1210\/me.2005-0242","article-title":"Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-\u03baB may contribute to the onset of labor through inhibition of PR function","volume":"20","author":"Condon","year":"2006","journal-title":"Mol Endocrinol"},{"key":"2019041122235383400_B22","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1128\/MCB.20.9.3102-3115.2000","article-title":"The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding","volume":"20","author":"Giangrande","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2019041122235383400_B23","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1210\/me.2006-0112","article-title":"Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-\u03baB activation of cyclooxygenase 2 expression","volume":"20","author":"Hardy","year":"2006","journal-title":"Mol Endocrinol"},{"key":"2019041122235383400_B24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/molehr\/7.9.875","article-title":"Interactions between progesterone receptor isoforms in myometrial cells in human labour","volume":"7","author":"Pieber","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"2019041122235383400_B25","first-page":"1256","article-title":"Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors","volume":"7","author":"Tung","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041122235383400_B26","first-page":"1244","article-title":"Human progesterone receptor A form is a cell-and promoter-specific repressor of human progesterone receptor B function","volume":"7","author":"Vegeto","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041122235383400_B27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jsbmb.2013.12.008","article-title":"Post-translational modifications of the progesterone receptors","volume":"140","author":"Abdel-Hafiz","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041122235383400_B28","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1074\/jbc.271.32.19546","article-title":"Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system","volume":"271","author":"Beck","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041122235383400_B29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/me.2007-0437","article-title":"Progesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors","volume":"22","author":"Faivre","year":"2008","journal-title":"Mol Endocrinol"},{"key":"2019041122235383400_B30","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/S0002-9378(99)70400-X","article-title":"Cytokine abundance in placental tissues: evidence of inflammatory activation in gestational membranes with term and preterm parturition","volume":"181","author":"Keelan","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122235383400_B31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/humrep\/15.1.229","article-title":"Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process","volume":"14","author":"Thomson","year":"1999","journal-title":"Hum Reprod"},{"key":"2019041122235383400_B32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"2019041122235383400_B33","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJM200005183422007","article-title":"Intrauterine infection and preterm delivery","volume":"342","author":"Epstein","year":"2000","journal-title":"N Engl J Med"},{"key":"2019041122235383400_B34","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0002-9378(93)90050-S","article-title":"Amniotic fluid interleukin-6 levels correlate with histologic chorioamnionitis and amniotic fluid cultures in patients in premature labor with intact membranes","volume":"169","author":"Greig","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122235383400_B35","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1095\/biolreprod67.2.506","article-title":"Telomerase immortalization of human myometrial cells","volume":"67","author":"Condon","year":"2002","journal-title":"Biol Reprod"},{"key":"2019041122235383400_B36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/REP-07-0461","article-title":"Pro-labour myometrial gene expression: are preterm labour and term labour the same?","volume":"135","author":"Tattersall","year":"2008","journal-title":"Reproduction"},{"key":"2019041122235383400_B37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jsgi.2003.12.004","article-title":"Myometrial progesterone responsiveness and the control of human parturition","volume":"11","author":"Mesiano","year":"2004","journal-title":"J Soc Gynecol Investig"},{"key":"2019041122235383400_B38","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1073\/pnas.1633616100","article-title":"A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition","volume":"100","author":"Condon","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122235383400_B39","first-page":"105","article-title":"Phosphorylation of steroid hormone receptors","volume":"13","author":"Orti","year":"1992","journal-title":"Endocr Rev"},{"key":"2019041122235383400_B40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/rep.1.00197","article-title":"The role of nuclear factor \u03baB in human labour","volume":"130","author":"Lindstr\u00f6m","year":"2005","journal-title":"Reproduction"},{"key":"2019041122235383400_B41","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","article-title":"Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy","volume":"112","author":"Tulchinsky","year":"1972","journal-title":"Am J Obstet Gynecol"},{"key":"2019041122235383400_B42","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/molehr\/7.6.581","article-title":"Human labour is associated with nuclear factor-\u03baB activity which mediates cyclo-oxygenase-2 expression and is involved with the \u2018functional progesterone withdrawal.\u2019","volume":"7","author":"Allport","year":"2001","journal-title":"Mol Hum Reprod"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/157\/11\/4434\/10843130\/endo4434.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T12:53:06Z","timestamp":1555073586000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/157\/11\/4434\/2758422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,21]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,9,21]]},"published-print":{"date-parts":[[2016,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2016-1654","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,21]]}}}