{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:26:01Z","timestamp":1792571161279,"version":"4.5.0"},"reference-count":180,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"DOI":"10.1210\/en.2016-1801","type":"journal-article","created":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T19:02:12Z","timestamp":1481742132000},"page":"199-212","source":"Crossref","is-referenced-by-count":89,"title":["Gestational Hyperandrogenism in Developmental Programming"],"prefix":"10.1210","volume":"158","author":[{"given":"Christopher","family":"Hakim","sequence":"first","affiliation":[{"name":"College of Human Medicine, Michigan State University, East Lansing, Michigan 48824;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita K.","family":"Vyas","sequence":"additional","affiliation":[{"name":"College of Human Medicine, Michigan State University, East Lansing, Michigan 48824;"},{"name":"Department of Pediatrics, Texas Tech University Health Sciences Center, Permian Basin Campus, Odessa, Texas 79763"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2016,12,14]]},"reference":[{"issue":"6","key":"2019041123034146200_B1","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J Am Coll Nutr"},{"issue":"1","key":"2019041123034146200_B2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jsgi.2004.09.004","article-title":"Prenatal hypoxia and cardiac programming","volume":"12","author":"Zhang","year":"2005","journal-title":"J Soc Gynecol Investig"},{"issue":"3","key":"2019041123034146200_B3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11154-013-9266-4","article-title":"Metabolic syndrome: role of maternal undernutrition and fetal programming","volume":"14","author":"Lakshmy","year":"2013","journal-title":"Rev Endocr Metab Disord"},{"key":"2019041123034146200_B4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fgene.2011.00027","article-title":"Developmental programming in response to maternal overnutrition","volume":"2","author":"Alfaradhi","year":"2011","journal-title":"Front Genet"},{"issue":"3","key":"2019041123034146200_B5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/MCO.0b013e32835e8d80","article-title":"Impact of stress and stress physiology during pregnancy on child metabolic function and obesity risk","volume":"16","author":"Entringer","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"2019041123034146200_B6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/157015907781695955","article-title":"Effects of nicotine during pregnancy: human and experimental evidence","volume":"5","author":"Wickstr\u00f6m","year":"2007","journal-title":"Curr Neuropharmacol"},{"issue":"6","key":"2019041123034146200_B7","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: the Endocrine Society\u2019s second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr Rev"},{"issue":"5","key":"2019041123034146200_B8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/rep.1.00033","article-title":"Endocrine mechanisms of intrauterine programming","volume":"127","author":"Fowden","year":"2004","journal-title":"Reproduction"},{"issue":"4","key":"2019041123034146200_B9","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1210\/en.2016-1003","article-title":"Developmental programming, a pathway to disease","volume":"157","author":"Padmanabhan","year":"2016","journal-title":"Endocrinology"},{"issue":"24","key":"2019041123034146200_B10","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1101\/gad.843800","article-title":"Hormones in male sexual development","volume":"14","author":"Nef","year":"2000","journal-title":"Genes Dev"},{"issue":"6","key":"2019041123034146200_B11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0190-9622(93)70129-H","article-title":"Androgen biology as a basis for the diagnosis and treatment of androgenic disorders in women. II","volume":"28","author":"Sperling","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"2019041123034146200_B12","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0015-0282(02)02985-0","article-title":"Androgen production in women","volume":"77","author":"Burger","year":"2002","journal-title":"Fertil Steril"},{"key":"2019041123034146200_B13","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1016\/S0015-0282(02)02984-9","article-title":"Aromatization of androgens in women: current concepts and findings","volume":"77","author":"Simpson","year":"2002","journal-title":"Fertil Steril"},{"issue":"5","key":"2019041123034146200_B14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/clinchem\/37.5.667","article-title":"Longitudinal assessment of changes in reproductive hormones during normal pregnancy","volume":"37","author":"O\u2019Leary","year":"1991","journal-title":"Clin Chem"},{"issue":"1","key":"2019041123034146200_B15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.rbmo.2013.03.009","article-title":"Reproductive hormone concentrations in pregnancy and neonates: a systematic review","volume":"27","author":"Kuijper","year":"2013","journal-title":"Reprod Biomed Online"},{"issue":"10","key":"2019041123034146200_B16","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Sir-Petermann","year":"2002","journal-title":"Hum Reprod"},{"issue":"12","key":"2019041123034146200_B17","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/0022-4731(78)90006-7","article-title":"Dehydroisoandrosterone sulfate in peripheral blood of premenopausal, pregnant and postmenopausal women and men","volume":"9","author":"Milewich","year":"1978","journal-title":"J Steroid Biochem"},{"issue":"5","key":"2019041123034146200_B18","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1172\/JCI106917","article-title":"Metabolic clearance rate and blood production rate of testosterone and dihydrotestosterone in normal subjects, during pregnancy, and in hyperthyroidism","volume":"51","author":"Saez","year":"1972","journal-title":"J Clin Invest"},{"issue":"4","key":"2019041123034146200_B19","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/humupd\/dmu008","article-title":"Androgens in pregnancy: roles in parturition","volume":"20","author":"Makieva","year":"2014","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2019041123034146200_B20","doi-asserted-by":"crossref","first-page":"543.e1","DOI":"10.1016\/j.ajog.2007.11.012","article-title":"Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis","volume":"198","author":"Ji","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"2019041123034146200_B21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1095\/biolreprod.104.036954","article-title":"Androgens induce relaxation of contractile activity in pregnant human myometrium at term: a nongenomic action on L-type calcium channels","volume":"73","author":"Perusqu\u00eda","year":"2005","journal-title":"Biol Reprod"},{"issue":"2","key":"2019041123034146200_B22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.33549\/physiolres.932078","article-title":"Hyperandrogenic states in pregnancy","volume":"60","author":"Ka\u0148ov\u00e1","year":"2011","journal-title":"Physiol Res"},{"issue":"2","key":"2019041123034146200_B23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejogrb.2012.10.015","article-title":"Placental steroidogenesis in pregnant women with polycystic ovary syndrome","volume":"166","author":"Maliqueo","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"2019041123034146200_B24","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1158\/1055-9965.EPI-04-0869","article-title":"Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk","volume":"14","author":"Potischman","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"2019041123034146200_B25","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/bjc.1988.46","article-title":"The early in utero oestrogen and testosterone environment of blacks and whites: potential effects on male offspring","volume":"57","author":"Henderson","year":"1988","journal-title":"Br J Cancer"},{"issue":"3","key":"2019041123034146200_B26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s10552-011-9893-6","article-title":"Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates","volume":"23","author":"Agurs-Collins","year":"2012","journal-title":"Cancer Causes Control"},{"issue":"3","key":"2019041123034146200_B27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/jnci\/89.3.188","article-title":"Why do African-American men suffer more prostate cancer?","volume":"89","author":"McIntosh","year":"1997","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"2019041123034146200_B28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1043-2760(98)00030-7","article-title":"Androgen excess disorders in women","volume":"9","author":"Mehta","year":"1998","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"2019041123034146200_B29","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1530\/EJE-10-0412","article-title":"Adrenocortical carcinoma and pregnancy: clinical and biological features and prognosis","volume":"163","author":"Abiven-Lepage","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2019041123034146200_B30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S1701-2163(15)30176-6","article-title":"Hyperreactio luteinalis: maternal and fetal effects","volume":"37","author":"Malinowski","year":"2015","journal-title":"J Obstet Gynaecol Can"},{"issue":"2","key":"2019041123034146200_B31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ecl.2015.02.006","article-title":"Management of adrenal tumors in pregnancy","volume":"44","author":"Eschler","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"2019041123034146200_B32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2265.1990.tb03887.x","article-title":"The prevalence of polycystic ovaries in patients with congenital adrenal hyperplasia and their close relatives","volume":"33","author":"Hague","year":"1990","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041123034146200_B33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.2009.05225.x","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a paradigm for prenatal diagnosis and treatment","volume":"1192","author":"Nimkarn","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"2019041123034146200_B34","first-page":"555","article-title":"[Aromatase deficiency]","author":"Harada","year":"2006","journal-title":"Nihon Rinsho"},{"issue":"3","key":"2019041123034146200_B35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/146222031000094196","article-title":"Prenatal nicotine increases testosterone levels in the fetus and female offspring","volume":"5","author":"Smith","year":"2003","journal-title":"Nicotine Tob Res"},{"issue":"1 Pt 1","key":"2019041123034146200_B36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0002-9378(99)70150-X","article-title":"Androgens in preeclampsia","volume":"180","author":"Acromite","year":"1999","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"2019041123034146200_B37","doi-asserted-by":"crossref","first-page":"e0139682","DOI":"10.1371\/journal.pone.0139682","article-title":"Placental aromatase is deficient in placental ischemia and preeclampsia","volume":"10","author":"Perez-Sepulveda","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"2019041123034146200_B38","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4158\/EP15748.DSC","article-title":"American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome\u2014part 1","volume":"21","author":"Goodman","year":"2015","journal-title":"Endocr Pract"},{"issue":"3","key":"2019041123034146200_B39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tem.2014.12.003","article-title":"Metabolic risk in PCOS: phenotype and adiposity impact","volume":"26","author":"Moran","year":"2015","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"2019041123034146200_B40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-0034-1371087","article-title":"Intrauterine environment and polycystic ovary syndrome","volume":"32","author":"Dumesic","year":"2014","journal-title":"Semin Reprod Med"},{"issue":"2","key":"2019041123034146200_B41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0015-0282(16)54828-6","article-title":"Gestational hyperandrogenism","volume":"57","author":"McClamrock","year":"1992","journal-title":"Fertil Steril"},{"key":"2019041123034146200_B42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.physiol.64.081601.142703","article-title":"Aromatase\u2014a brief overview","volume":"64","author":"Simpson","year":"2002","journal-title":"Annu Rev Physiol"},{"issue":"6","key":"2019041123034146200_B43","first-page":"321","article-title":"Genetic and clinical spectrum of aromatase deficiency in infancy, childhood and adolescence","volume":"72","author":"Belgorosky","year":"2009","journal-title":"Horm Res"},{"issue":"3","key":"2019041123034146200_B44","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1210\/jc.2006-1181","article-title":"Variable phenotypes associated with aromatase (CYP19) insufficiency in humans","volume":"92","author":"Lin","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"22","key":"2019041123034146200_B45","doi-asserted-by":"crossref","first-page":"12790","DOI":"10.1073\/pnas.96.22.12790","article-title":"Steroid disorders in children: congenital adrenal hyperplasia and apparent mineralocorticoid excess","volume":"96","author":"New","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2019041123034146200_B46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0889-8529(08)70018-5","article-title":"Congenital adrenal hyperplasia owing to 21-hydroxylase deficiency","volume":"30","author":"Speiser","year":"2001","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"5","key":"2019041123034146200_B47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1034\/j.1399-0004.2001.590501.x","article-title":"CYP21 mutations and congenital adrenal hyperplasia","volume":"59","author":"Lee","year":"2001","journal-title":"Clin Genet"},{"issue":"4","key":"2019041123034146200_B48","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.OGX.0000062966.93819.5B","article-title":"Fertility in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"58","author":"Stikkelbroeck","year":"2003","journal-title":"Obstet Gynecol Surv"},{"issue":"7","key":"2019041123034146200_B49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/humrep\/den118","article-title":"Fertility and pregnancy outcome in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"23","author":"Hagenfeldt","year":"2008","journal-title":"Hum Reprod"},{"issue":"2","key":"2019041123034146200_B50","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.4158\/EP10209.CR","article-title":"Virilization of a female infant by a maternal adrenocortical carcinoma","volume":"17","author":"Morris","year":"2011","journal-title":"Endocr Pract"},{"issue":"1-3","key":"2019041123034146200_B51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2007.08.008","article-title":"In utero exposure to the environmental androgen trenbolone masculinizes female Sprague-Dawley rats","volume":"174","author":"Hotchkiss","year":"2007","journal-title":"Toxicol Lett"},{"issue":"4","key":"2019041123034146200_B52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11154-016-9326-7","article-title":"Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)","volume":"16","author":"Palioura","year":"2015","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"2019041123034146200_B53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2174\/1568008043340017","article-title":"DI-2-ethylhexyl phthalate and endocrine disruption: a review","volume":"4","author":"Latini","year":"2004","journal-title":"Curr Drug Targets Immune Endocr Metabol Disord"},{"issue":"1-2","key":"2019041123034146200_B54","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mce.2007.10.010","article-title":"Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells","volume":"283","author":"Zhou","year":"2008","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"2019041123034146200_B55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1507\/endocrj.51.165","article-title":"Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction","volume":"51","author":"Takeuchi","year":"2004","journal-title":"Endocr J"},{"issue":"4","key":"2019041123034146200_B56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1507\/endocrj.K06-032","article-title":"Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity","volume":"53","author":"Takeuchi","year":"2006","journal-title":"Endocr J"},{"key":"2019041123034146200_B57","article-title":"Di (2-ethylhexyl) phthalate impairs steroidogenesis in ovarian follicular cells of prepuberal mice [published online July 12, 2016]","author":"Lai","journal-title":"Arch Toxicol"},{"key":"2019041123034146200_B58","article-title":"Prenatal exposure to endocrine disruptors: a developmental etiology for polycystic ovary syndrome [published online June 23, 2016]","author":"Hewlett","journal-title":"Reprod Sci"},{"key":"2019041123034146200_B59","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.envpol.2012.07.016","article-title":"Fate and occurrence of steroids in swine and dairy cattle farms with different farming scales and wastes disposal systems","volume":"170","author":"Liu","year":"2012","journal-title":"Environ Pollut"},{"issue":"6","key":"2019041123034146200_B60","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/etc.5620220623","article-title":"Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow","volume":"22","author":"Ankley","year":"2003","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"2019041123034146200_B61","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.marenvres.2008.02.018","article-title":"Effect of parental exposure to trenbolone and the brominated flame retardant BDE-47 on fertility in rainbow trout (Oncorhynchus mykiss)","volume":"66","author":"Schultz","year":"2008","journal-title":"Mar Environ Res"},{"issue":"3","key":"2019041123034146200_B62","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin Perinatol"},{"issue":"3","key":"2019041123034146200_B63","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyg094","article-title":"Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies","volume":"32","author":"Troisi","year":"2003","journal-title":"Int J Epidemiol"},{"issue":"5","key":"2019041123034146200_B64","first-page":"390","article-title":"The relationship between serum concentration of free testosterone and pre-eclampsia","volume":"59","author":"Ghorashi","year":"2008","journal-title":"Endokrynol Pol"},{"issue":"3","key":"2019041123034146200_B65","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/HYPERTENSIONAHA.111.00486","article-title":"Testosterone alters maternal vascular adaptations: role of the endothelial NO system","volume":"61","author":"Chinnathambi","year":"2013","journal-title":"Hypertension"},{"issue":"2","key":"2019041123034146200_B66","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.beem.2013.02.004","article-title":"Metabolic complications of obesity","volume":"27","author":"Pedersen","year":"2013","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"2019041123034146200_B67","first-page":"37","article-title":"Obesity and polycystic ovary syndrome","volume":"40","author":"Naderpoor","year":"2015","journal-title":"Minerva Endocrinol"},{"issue":"1","key":"2019041123034146200_B68","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000194971","article-title":"Obesity and polycystic ovary syndrome","volume":"2","author":"Vrbikova","year":"2009","journal-title":"Obes Facts"},{"issue":"2","key":"2019041123034146200_B69","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1467-789X.2012.01053.x","article-title":"The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis","volume":"14","author":"Lim","year":"2013","journal-title":"Obes Rev"},{"issue":"4","key":"2019041123034146200_B70","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.steroids.2011.12.003","article-title":"Inflammation in polycystic ovary syndrome: underpinning of insulin resistance and ovarian dysfunction","volume":"77","author":"Gonz\u00e1lez","year":"2012","journal-title":"Steroids"},{"issue":"4","key":"2019041123034146200_B71","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1095\/biolreprod61.4.993","article-title":"Tumor necrosis factor-alpha stimulates proliferation of rat ovarian theca-interstitial cells","volume":"61","author":"Spaczynski","year":"1999","journal-title":"Biol Reprod"},{"issue":"2","key":"2019041123034146200_B72","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1074\/jbc.M113.534172","article-title":"De novo synthesis of steroids and oxysterols in adipocytes","volume":"289","author":"Li","year":"2014","journal-title":"J Biol Chem"},{"issue":"8","key":"2019041123034146200_B73","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.steroids.2013.05.004","article-title":"Animal models of the polycystic ovary syndrome phenotype","volume":"78","author":"Padmanabhan","year":"2013","journal-title":"Steroids"},{"issue":"4","key":"2019041123034146200_B74","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/humupd\/dmi013","article-title":"Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?","volume":"11","author":"Abbott","year":"2005","journal-title":"Hum Reprod Update"},{"key":"2019041123034146200_B75","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mce.2015.11.030","article-title":"Effect of maternal PCOS and PCOS-like phenotype on the offspring\u2019s health","volume":"435","author":"Puttabyatappa","year":"2016","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"2019041123034146200_B76","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/adc.2002.011312","article-title":"Early assessment of ambiguous genitalia","volume":"89","author":"Ogilvy-Stuart","year":"2004","journal-title":"Arch Dis Child"},{"issue":"9477","key":"2019041123034146200_B77","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/S0140-6736(05)66736-0","article-title":"Congenital adrenal hyperplasia","volume":"365","author":"Merke","year":"2005","journal-title":"Lancet"},{"issue":"10","key":"2019041123034146200_B78","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S1701-2163(16)32642-1","article-title":"Maternal luteoma of pregnancy presenting with virilization of the female infant","volume":"29","author":"Spitzer","year":"2007","journal-title":"J Obstet Gynaecol Can"},{"issue":"2","key":"2019041123034146200_B79","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1530\/ror.0.0030130","article-title":"Sexual differentiation of reproductive neuroendocrine function in sheep","volume":"3","author":"Wood","year":"1998","journal-title":"Rev Reprod"},{"issue":"2","key":"2019041123034146200_B80","doi-asserted-by":"crossref","first-page":"e16502","DOI":"10.5812\/ijem.16502","article-title":"The time of prenatal androgen exposure affects development of polycystic ovary syndrome-like phenotype in adulthood in female rats","volume":"12","author":"Ramezani Tehrani","year":"2014","journal-title":"Int J Endocrinol Metab"},{"issue":"3","key":"2019041123034146200_B81","first-page":"1000139","article-title":"Effects of prenatal testosterone exposure on sexually dimorphic gene expression in the neonatal mouse cortex and hippocampus","volume":"5","author":"Armoskus","year":"2014","journal-title":"J Steroids Horm Sci"},{"key":"2019041123034146200_B82","first-page":"332","article-title":"Intrauterine growth retardation (IUGR): epidemiology and etiology","volume":"6","author":"Romo","year":"2009","journal-title":"Pediatr Endocrinol Rev"},{"issue":"5","key":"2019041123034146200_B83","doi-asserted-by":"crossref","first-page":"1592S","DOI":"10.1093\/jn\/133.5.1592S","article-title":"The epidemiology of adverse pregnancy outcomes: an overview","volume":"133","author":"Kramer","year":"2003","journal-title":"J Nutr"},{"issue":"3","key":"2019041123034146200_B84","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MCO.0000000000000051","article-title":"Impact of intrauterine growth restriction on long-term health","volume":"17","author":"Salam","year":"2014","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"2","key":"2019041123034146200_B85","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1203\/00006450-199408000-00004","article-title":"Maternal hypoxia as a model for intrauterine growth retardation: effects on insulin-like growth factors and their binding proteins","volume":"36","author":"Tapanainen","year":"1994","journal-title":"Pediatr Res"},{"issue":"2 Suppl","key":"2019041123034146200_B86","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.fertnstert.2007.12.041","article-title":"Environmental contaminants and pregnancy outcomes","volume":"89","author":"Windham","year":"2008","journal-title":"Fertil Steril"},{"issue":"3","key":"2019041123034146200_B87","first-page":"292","article-title":"The implications and consequences of maternal obesity on fetal intrauterine growth restriction","volume":"6","author":"Radulescu","year":"2013","journal-title":"J Med Life"},{"issue":"3-4","key":"2019041123034146200_B88","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.etp.2007.05.007","article-title":"Nicotine-induced prenatal overexposure to maternal glucocorticoid and intrauterine growth retardation in rat","volume":"59","author":"Chen","year":"2007","journal-title":"Exp Toxicol Pathol"},{"issue":"2","key":"2019041123034146200_B89","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1677\/joe.1.06039","article-title":"Dexamethasone-induced intrauterine growth restriction impacts the placental prolactin family, insulin-like growth factor-II and the Akt signaling pathway","volume":"185","author":"Ain","year":"2005","journal-title":"J Endocrinol"},{"key":"2019041123034146200_B90","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000113181","article-title":"Undernutrition and growth restriction in pregnancy","volume":"61","author":"Bergmann","year":"2008","journal-title":"Nestle Nutr Workshop Ser Pediatr Program"},{"issue":"2","key":"2019041123034146200_B91","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1530\/eje.1.02200","article-title":"Maternal testosterone levels during pregnancy are associated with offspring size at birth","volume":"155","author":"Carlsen","year":"2006","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2019041123034146200_B92","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1095\/biolreprod.112.107235","article-title":"Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring","volume":"88","author":"Mossa","year":"2013","journal-title":"Biol Reprod"},{"issue":"2","key":"2019041123034146200_B93","doi-asserted-by":"crossref","first-page":"F166","DOI":"10.1136\/adc.2004.049320","article-title":"Fetal plasma testosterone correlates positively with cortisol","volume":"90","author":"Gitau","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"8","key":"2019041123034146200_B94","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1093\/humrep\/dei009","article-title":"Birth weight in offspring of mothers with polycystic ovarian syndrome","volume":"20","author":"Sir-Petermann","year":"2005","journal-title":"Hum Reprod"},{"issue":"5","key":"2019041123034146200_B95","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1210\/jc.2009-2651","article-title":"Infants of women with polycystic ovary syndrome have lower cord blood androstenedione and estradiol levels","volume":"95","author":"Anderson","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019041123034146200_B96","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.bpobgyn.2009.06.003","article-title":"Risk factors for small for gestational age infants","volume":"23","author":"McCowan","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"2019041123034146200_B97","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1365-2265.2001.01359.x","article-title":"Mothers with congenital adrenal hyperplasia and their children: outcome of pregnancy, birth and childhood","volume":"55","author":"Krone","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2019041123034146200_B98","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jmwh.12500","article-title":"Endocrine-disrupting chemicals and reproductive health","volume":"61","author":"Zlatnik","year":"2016","journal-title":"J Midwifery Womens Health"},{"issue":"2","key":"2019041123034146200_B99","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1210\/en.2003-0478","article-title":"Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep","volume":"145","author":"Manikkam","year":"2004","journal-title":"Endocrinology"},{"issue":"1","key":"2019041123034146200_B100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/toxsci\/65.1.71","article-title":"Effects of prenatal testosterone propionate on the sexual development of male and female rats: a dose-response study","volume":"65","author":"Wolf","year":"2002","journal-title":"Toxicol Sci"},{"issue":"1","key":"2019041123034146200_B101","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/hbeh.2000.1608","article-title":"Timing of prenatal androgen exposure: anatomical and endocrine effects on juvenile male and female rhesus monkeys","volume":"38","author":"Herman","year":"2000","journal-title":"Horm Behav"},{"issue":"11","key":"2019041123034146200_B102","doi-asserted-by":"crossref","first-page":"E1373","DOI":"10.1152\/ajpendo.00421.2012","article-title":"Maternal androgen excess reduces placental and fetal weights, increases placental steroidogenesis, and leads to long-term health effects in their female offspring","volume":"303","author":"Sun","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2019041123034146200_B103","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1477-7827-9-110","article-title":"Prenatal testosterone-induced fetal growth restriction is associated with down-regulation of rat placental amino acid transport","volume":"9","author":"Sathishkumar","year":"2011","journal-title":"Reprod Biol Endocrinol"},{"issue":"2","key":"2019041123034146200_B104","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1530\/REP-14-0055","article-title":"Developmental programing: impact of testosterone on placental differentiation","volume":"148","author":"Beckett","year":"2014","journal-title":"Reproduction"},{"issue":"6","key":"2019041123034146200_B105","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/humrep\/dem046","article-title":"International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care","volume":"22","author":"Boivin","year":"2007","journal-title":"Hum Reprod"},{"issue":"4","key":"2019041123034146200_B106","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bpobgyn.2014.10.014","article-title":"Female obesity and infertility","volume":"29","author":"Talmor","year":"2015","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"2","key":"2019041123034146200_B107","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/toxsci\/kfq103","article-title":"Long-term consequences of fetal and neonatal nicotine exposure: a critical review","volume":"116","author":"Bruin","year":"2010","journal-title":"Toxicol Sci"},{"issue":"6","key":"2019041123034146200_B108","doi-asserted-by":"crossref","first-page":"R185","DOI":"10.1530\/REP-15-0295","article-title":"Adverse effects of perinatal nicotine exposure on reproductive outcomes","volume":"150","author":"Wong","year":"2015","journal-title":"Reproduction"},{"issue":"1","key":"2019041123034146200_B109","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/1008-682X.122199","article-title":"Similar causes of various reproductive disorders in early life","volume":"16","author":"Svechnikov","year":"2014","journal-title":"Asian J Androl"},{"issue":"3","key":"2019041123034146200_B110","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/14647270500320121","article-title":"Nutritional paradigms of ovine fetal growth restriction: implications for human pregnancy","volume":"8","author":"Luther","year":"2005","journal-title":"Hum Fertil (Camb)"},{"issue":"1","key":"2019041123034146200_B111","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/7.1.3","article-title":"Polycystic ovarian disease: heritability and heterogeneity","volume":"7","author":"Crosignani","year":"2001","journal-title":"Hum Reprod Update"},{"issue":"6","key":"2019041123034146200_B112","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1210\/jc.2008-2836","article-title":"Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome","volume":"94","author":"Sir-Petermann","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019041123034146200_B113","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1203\/00006450-199512000-00024","article-title":"Longitudinal change of sonographic ovarian aspects and endocrine parameters in irregular cycles of adolescence","volume":"38","author":"Venturoli","year":"1995","journal-title":"Pediatr Res"},{"issue":"5","key":"2019041123034146200_B114","doi-asserted-by":"crossref","first-page":"790","DOI":"10.4103\/2230-8210.117196","article-title":"Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"17","author":"Mnif","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"issue":"3","key":"2019041123034146200_B115","first-page":"529","article-title":"Intrauterine exposure to preeclampsia and adolescent blood pressure, body size, and age at menarche in female offspring","volume":"101","author":"Vatten","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"1-2","key":"2019041123034146200_B116","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2012.10.005","article-title":"Sheep models of polycystic ovary syndrome phenotype","volume":"373","author":"Padmanabhan","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"2019041123034146200_B117","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0015-0282(97)81873-0","article-title":"Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood","volume":"67","author":"Dumesic","year":"1997","journal-title":"Fertil Steril"},{"issue":"6","key":"2019041123034146200_B118","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1095\/biolreprod.105.039800","article-title":"Neuroendocrine consequences of prenatal androgen exposure in the female rat: absence of luteinizing hormone surges, suppression of progesterone receptor gene expression, and acceleration of the gonadotropin-releasing hormone pulse generator","volume":"72","author":"Foecking","year":"2005","journal-title":"Biol Reprod"},{"issue":"4","key":"2019041123034146200_B119","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1210\/en.2002-220965","article-title":"Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep","volume":"144","author":"Birch","year":"2003","journal-title":"Endocrinology"},{"issue":"6","key":"2019041123034146200_B120","doi-asserted-by":"crossref","first-page":"E998","DOI":"10.1152\/ajpendo.00032.2010","article-title":"Prenatal testosterone excess alters Sertoli and germ cell number and testicular FSH receptor expression in rams","volume":"299","author":"Rojas-Garc\u00eda","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"12","key":"2019041123034146200_B121","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1210\/en.2008-0785","article-title":"Prenatal testosterone excess reduces sperm count and motility","volume":"149","author":"Recabarren","year":"2008","journal-title":"Endocrinology"},{"issue":"6","key":"2019041123034146200_B122","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jdiacomp.2006.07.005","article-title":"Prevalence and trends of insulin resistance, impaired fasting glucose, and diabetes","volume":"21","author":"Ioannou","year":"2007","journal-title":"J Diabetes Complications"},{"issue":"11","key":"2019041123034146200_B123","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.2337\/dc06-0289","article-title":"Trends in hyperinsulinemia among nondiabetic adults in the U.S","volume":"29","author":"Li","year":"2006","journal-title":"Diabetes Care"},{"issue":"12","key":"2019041123034146200_B124","first-page":"698","article-title":"Epidemiology of diabetes","volume":"42","author":"Forouhi","year":"2014","journal-title":"Medicine (Abingdon)"},{"key":"2019041123034146200_B125","first-page":"237.e1","article-title":"Maternal obesity and high-fat diet program offspring metabolic syndrome","volume-title":"Am J Obstet Gynecol","author":"Desai","year":"2014"},{"issue":"9","key":"2019041123034146200_B126","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4239\/wjd.v2.i9.137","article-title":"Developmental programming of the metabolic syndrome\u2014critical windows for intervention","volume":"2","author":"Vickers","year":"2011","journal-title":"World J Diabetes"},{"issue":"6","key":"2019041123034146200_B127","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1097\/AOG.0000000000000852","article-title":"Implications of polycystic ovary syndrome for pregnancy and for the health of offspring","volume":"125","author":"Doherty","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"6","key":"2019041123034146200_B128","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dml036","article-title":"A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome","volume":"12","author":"Boomsma","year":"2006","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2019041123034146200_B129","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1210\/jc.2007-2256","article-title":"Metabolic profile in sons of women with polycystic ovary syndrome","volume":"93","author":"Recabarren","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019041123034146200_B130","first-page":"1421","article-title":"Insulin insensitivity in adrenal hyperplasia due to nonclassical steroid 21-hydroxylase deficiency","volume":"75","author":"Speiser","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041123034146200_B131","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1113\/expphysiol.2005.032854","article-title":"Developmental programming of obesity in mammals","volume":"92","author":"Taylor","year":"2007","journal-title":"Exp Physiol"},{"issue":"3","key":"2019041123034146200_B132","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00125-006-0558-z","article-title":"Pre-eclampsia and the later development of type 2 diabetes in mothers and their children: an intergenerational study from the Walker cohort","volume":"50","author":"Libby","year":"2007","journal-title":"Diabetologia"},{"issue":"3","key":"2019041123034146200_B133","doi-asserted-by":"crossref","first-page":"e637","DOI":"10.1542\/peds.2013-0106","article-title":"Bisphenol A and chronic disease risk factors in US children","volume":"132","author":"Eng","year":"2013","journal-title":"Pediatrics"},{"issue":"5","key":"2019041123034146200_B134","doi-asserted-by":"crossref","first-page":"E741","DOI":"10.1152\/ajpendo.00058.2010","article-title":"Experimentally induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring","volume":"299","author":"Abbott","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"2019041123034146200_B135","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/JOE-12-0577","article-title":"Prenatal androgen excess programs metabolic derangements in pubertal female rats","volume":"217","author":"Yan","year":"2013","journal-title":"J Endocrinol"},{"issue":"2","key":"2019041123034146200_B136","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1210\/en.2009-1015","article-title":"Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females","volume":"151","author":"Padmanabhan","year":"2010","journal-title":"Endocrinology"},{"issue":"11","key":"2019041123034146200_B137","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1210\/en.2010-0666","article-title":"Developmental programming: differential effects of prenatal testosterone excess on insulin target tissues","volume":"151","author":"Nada","year":"2010","journal-title":"Endocrinology"},{"issue":"5","key":"2019041123034146200_B138","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1095\/biolreprod.115.136283","article-title":"Developmental programming: prenatal testosterone excess and insulin signaling disruptions in female sheep","volume":"94","author":"Lu","year":"2016","journal-title":"Biol Reprod"},{"issue":"3","key":"2019041123034146200_B139","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-0031-1275519","article-title":"Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming","volume":"29","author":"Padmanabhan","year":"2011","journal-title":"Semin Reprod Med"},{"issue":"3","key":"2019041123034146200_B140","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000381830","article-title":"Steroidogenic versus metabolic programming of reproductive neuroendocrine, ovarian and metabolic dysfunctions","volume":"102","author":"Cardoso","year":"2015","journal-title":"Neuroendocrinology"},{"issue":"3","key":"2019041123034146200_B141","first-page":"1206","article-title":"Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys","volume":"85","author":"Eisner","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041123034146200_B142","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/oby.2003.42","article-title":"Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation","volume":"11","author":"Eisner","year":"2003","journal-title":"Obes Res"},{"issue":"5","key":"2019041123034146200_B143","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/en.2012-2145","article-title":"Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep","volume":"154","author":"Veiga-Lopez","year":"2013","journal-title":"Endocrinology"},{"issue":"2","key":"2019041123034146200_B144","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1210\/en.2015-1565","article-title":"Developmental programming: impact of gestational steroid and metabolic milieus on adiposity and insulin sensitivity in prenatal testosterone-treated female sheep","volume":"157","author":"Cardoso","year":"2016","journal-title":"Endocrinology"},{"issue":"1-3","key":"2019041123034146200_B145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2011.01.035","article-title":"Let\u2019s shift lipid burden\u2014from large to small adipocytes","volume":"656","author":"M\u00fcller","year":"2011","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2019041123034146200_B146","first-page":"e29","article-title":"Heart disease and stroke statistics\u20142015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"issue":"3","key":"2019041123034146200_B147","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1530\/REP-10-0077","article-title":"Impact of maternal obesity on offspring obesity and cardiometabolic disease risk","volume":"140","author":"Drake","year":"2010","journal-title":"Reproduction"},{"issue":"5","key":"2019041123034146200_B148","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1111\/j.1476-5381.2011.01488.x","article-title":"Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring","volume":"164","author":"Lim","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"1","key":"2019041123034146200_B149","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.yfrne.2013.12.001","article-title":"Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease","volume":"35","author":"Goldstein","year":"2014","journal-title":"Front Neuroendocrinol"},{"key":"2019041123034146200_B150","doi-asserted-by":"crossref","first-page":"710613","DOI":"10.1155\/2015\/710613","article-title":"The link between fetal programming, inflammation, muscular strength, and blood pressure","volume":"2015","author":"Lopez-Lopez","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"6","key":"2019041123034146200_B151","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jpeds.2012.11.086","article-title":"Cardiac function in congenital adrenal hyperplasia: a pattern of reversible cardiomyopathy","volume":"162","author":"Minette","year":"2013","journal-title":"J Pediatr"},{"issue":"10","key":"2019041123034146200_B152","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1097\/HJH.0b013e328331b8c6","article-title":"Preeclampsia and increased blood pressure in the offspring: meta-analysis and critical review of the evidence","volume":"27","author":"Ferreira","year":"2009","journal-title":"J Hypertens"},{"issue":"6","key":"2019041123034146200_B153","doi-asserted-by":"crossref","first-page":"E1837","DOI":"10.1152\/ajpendo.00668.2006","article-title":"Hypertension caused by prenatal testosterone excess in female sheep","volume":"292","author":"King","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"2019041123034146200_B154","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/HYPERTENSIONAHA.114.04521","article-title":"Prenatal testosterone exposure induces hypertension in adult females via androgen receptor-dependent protein kinase C\u03b4-mediated mechanism","volume":"65","author":"Blesson","year":"2015","journal-title":"Hypertension"},{"key":"2019041123034146200_B155","article-title":"Fetal programming: prenatal testosterone excess leads to compromised cardiac development","author":"Padmanabhan"},{"key":"2019041123034146200_B156","doi-asserted-by":"crossref","first-page":"28335","DOI":"10.1038\/srep28335","article-title":"Prenatal programming: adverse cardiac programming by gestational testosterone excess","volume":"6","author":"Vyas","year":"2016","journal-title":"Sci Rep"},{"key":"2019041123034146200_B157","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jsbmb.2013.05.015","article-title":"Sex and sex hormones in cardiac stress\u2014mechanistic insights","volume":"137","author":"Bell","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"2019041123034146200_B158","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nn.2834","article-title":"Reframing sexual differentiation of the brain","volume":"14","author":"McCarthy","year":"2011","journal-title":"Nat Neurosci"},{"issue":"5749","key":"2019041123034146200_B159","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1115455","article-title":"Sex differences in the brain: implications for explaining autism","volume":"310","author":"Baron-Cohen","year":"2005","journal-title":"Science"},{"issue":"Pt 1","key":"2019041123034146200_B160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1348\/000712608X311731","article-title":"Fetal testosterone and autistic traits","volume":"100","author":"Auyeung","year":"2009","journal-title":"Br J Psychol"},{"issue":"8","key":"2019041123034146200_B161","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0306-4530(02)00121-X","article-title":"Spatial abilities following prenatal androgen abnormality: targeting and mental rotations performance in individuals with congenital adrenal hyperplasia","volume":"28","author":"Hines","year":"2003","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"2019041123034146200_B162","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1095\/biolreprod.114.126409","article-title":"Developmental programming by androgen affects the circadian timing system in female mice","volume":"92","author":"Mereness","year":"2015","journal-title":"Biol Reprod"},{"issue":"1","key":"2019041123034146200_B163","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11325-009-0276-0","article-title":"A comparison of polysomnographic variables between obese adolescents with polycystic ovarian syndrome and healthy, normal-weight and obese adolescents","volume":"14","author":"de Sousa","year":"2010","journal-title":"Sleep Breath"},{"issue":"4","key":"2019041123034146200_B164","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jpeds.2011.04.027","article-title":"Screening for sleep-disordered breathing and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome","volume":"159","author":"Nandalike","year":"2011","journal-title":"J Pediatr"},{"issue":"2","key":"2019041123034146200_B165","first-page":"1","article-title":"Prevalence of autism spectrum disorder among children aged 8 years\u2014autism and developmental disabilities monitoring network, 11 sites, United States, 2010","volume":"63","author":"Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators","year":"2014","journal-title":"MMWR Surveill Summ"},{"issue":"4","key":"2019041123034146200_B166","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/GIM.0b013e3181ff67ba","article-title":"Autism spectrum disorders\u2014a genetics review","volume":"13","author":"Miles","year":"2011","journal-title":"Genet Med"},{"issue":"10","key":"2019041123034146200_B167","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/08830738060210101601","article-title":"Fetal testosterone and sex differences in typical social development and in autism","volume":"21","author":"Knickmeyer","year":"2006","journal-title":"J Child Neurol"},{"issue":"3","key":"2019041123034146200_B168","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/mp.2014.48","article-title":"Elevated fetal steroidogenic activity in autism","volume":"20","author":"Baron-Cohen","year":"2015","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2019041123034146200_B169","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2040-2392-3-17","article-title":"Prenatal versus postnatal sex steroid hormone effects on autistic traits in children at 18 to 24 months of age","volume":"3","author":"Auyeung","year":"2012","journal-title":"Mol Autism"},{"key":"2019041123034146200_B170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40478-014-0141-7","article-title":"Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the striatum, amygdala and cerebellum","volume":"2","author":"Wegiel","year":"2014","journal-title":"Acta Neuropathol Commun"},{"issue":"10","key":"2019041123034146200_B171","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/mp.2015.183","article-title":"Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden","volume":"21","author":"Kosidou","year":"2016","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2019041123034146200_B172","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.yhbeh.2006.02.006","article-title":"Androgens and autistic traits: a study of individuals with congenital adrenal hyperplasia","volume":"50","author":"Knickmeyer","year":"2006","journal-title":"Horm Behav"},{"issue":"1","key":"2019041123034146200_B173","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10803-015-2549-8","article-title":"Association between maternal obesity and autism spectrum disorder in offspring: a meta-analysis","volume":"46","author":"Li","year":"2016","journal-title":"J Autism Dev Disord"},{"issue":"1","key":"2019041123034146200_B174","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1192\/bjp.bp.108.051672","article-title":"Prenatal risk factors for autism: comprehensive meta-analysis","volume":"195","author":"Gardener","year":"2009","journal-title":"Br J Psychiatry"},{"issue":"2","key":"2019041123034146200_B175","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/jamapediatrics.2014.2645","article-title":"Preeclampsia, placental insufficiency, and autism spectrum disorder or developmental delay","volume":"169","author":"Walker","year":"2015","journal-title":"JAMA Pediatr"},{"issue":"24","key":"2019041123034146200_B176","doi-asserted-by":"crossref","first-page":"9956","DOI":"10.1073\/pnas.1214056110","article-title":"Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure","volume":"110","author":"Kundakovic","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"2019041123034146200_B177","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.neuro.2009.01.011","article-title":"Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age","volume":"30","author":"Larsson","year":"2009","journal-title":"Neurotoxicology"},{"issue":"4","key":"2019041123034146200_B178","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1095\/biolreprod.108.073429","article-title":"Juvenile rank can predict male-typical adult mating behavior in female sheep treated prenatally with testosterone","volume":"80","author":"Roberts","year":"2009","journal-title":"Biol Reprod"},{"issue":"1","key":"2019041123034146200_B179","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1095\/biolreprod.107.067074","article-title":"Differential effects of prenatal testosterone timing and duration on phenotypic and behavioral masculinization and defeminization of female sheep","volume":"79","author":"Roberts","year":"2008","journal-title":"Biol Reprod"},{"issue":"6","key":"2019041123034146200_B180","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1210\/en.2014-2006","article-title":"Developmental programming: exposure to testosterone excess disrupts steroidal and metabolic environment in pregnant sheep","volume":"156","author":"Abi Salloum","year":"2015","journal-title":"Endocrinology"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/158\/2\/199\/10012483\/en.2016-1801.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T23:37:47Z","timestamp":1601249867000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/158\/2\/199\/2965956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,14]]},"references-count":180,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2016,12,14]]},"published-print":{"date-parts":[[2017,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2016-1801","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,2,1]]},"published":{"date-parts":[[2016,12,14]]}}}