{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:33:23Z","timestamp":1790415203075,"version":"4.1.0"},"reference-count":68,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"DOI":"10.1210\/en.2016-1810","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T03:05:56Z","timestamp":1491447956000},"page":"887-902","source":"Crossref","is-referenced-by-count":17,"title":["Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes"],"prefix":"10.1210","volume":"158","author":[{"given":"Andreas","family":"Beck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Weissgerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Flockerzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Freichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"key\n\t\t\t\t20170405143513_B1","volume-title":"GnRH: The Master Molecule of Reproduction","year":"2002"},{"key":"key\n\t\t\t\t20170405143513_B2","first-page":"1415","article-title":"Physiology of the gonadotropin-releasing hormone neuronal network","volume-title":"Knobil and Neill\u2019s Physiology of Reproduction","year":"2006","edition":"3rd ed."},{"key":"key\n\t\t\t\t20170405143513_B3","first-page":"1635","article-title":"Gonadotropin-releasing hormone regulation of gonadotropin biosynthesis and secretion","volume-title":"Knobil and Neill\u2019s Physiology of Reproduction","year":"2006","edition":"3rd ed."},{"key":"key\n\t\t\t\t20170405143513_B4","first-page":"1483","article-title":"Gonadotropes and lactotropes","volume-title":"Knobil and Neill\u2019s Physiology of Reproduction","year":"2006","edition":"3rd ed."},{"issue":"1","key":"key\n\t\t\t\t20170405143513_B5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1210\/endo-128-1-509","article-title":"A pulsatile gonadotropin-releasing hormone stimulus is required to increase transcription of the gonadotropin subunit genes: evidence for differential regulation of transcription by pulse frequency in vivo","volume":"128","year":"1991","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"key\n\t\t\t\t20170405143513_B6","first-page":"57","article-title":"Leptin increases L-type Ca2+ channel expression and GnRH-stimulated LH release in LbetaT2 gonadotropes","volume":"298","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"26","key":"key\n\t\t\t\t20170405143513_B7","doi-asserted-by":"crossref","first-page":"20262","DOI":"10.1074\/jbc.M110.132662","article-title":"Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope cells","volume":"285","year":"2010","journal-title":"J Biol Chem"},{"issue":"1","key":"key\n\t\t\t\t20170405143513_B8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-6273(01)80051-9","article-title":"Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs","volume":"18","year":"1997","journal-title":"Neuron"},{"issue":"3","key":"key\n\t\t\t\t20170405143513_B9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1994.sp020212","article-title":"Calcium homeostasis in identified rat gonadotrophs","volume":"477","year":"1994","journal-title":"J Physiol"},{"issue":"1","key":"key\n\t\t\t\t20170405143513_B10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/en.2012-1554","article-title":"Multiple cholinergic signaling pathways in pituitary gonadotrophs","volume":"154","year":"2013","journal-title":"Endocrinology"},{"issue":"19","key":"key\n\t\t\t\t20170405143513_B11","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1016\/j.febslet.2013.08.025","article-title":"Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms","volume":"587","year":"2013","journal-title":"FEBS Lett"},{"issue":"51","key":"key\n\t\t\t\t20170405143513_B12","doi-asserted-by":"crossref","first-page":"30530","DOI":"10.1074\/jbc.M115.682583","article-title":"Store-operated Ca2+ entry mediated by Orai1 and TRPC1 participates to insulin secretion in rat \u03b2-cells","volume":"290","year":"2015","journal-title":"J Biol Chem"},{"issue":"1","key":"key\n\t\t\t\t20170405143513_B13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ceca.2006.04.032","article-title":"TRPM4 controls insulin secretion in pancreatic beta-cells","volume":"41","year":"2007","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20170405143513_B14","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1007\/978-3-319-05161-1_16","article-title":"TRP channels in reproductive (neuro)endocrinology","volume":"223","year":"2014","journal-title":"Handb Exp Pharmacol"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B15","doi-asserted-by":"crossref","first-page":"E370","DOI":"10.1152\/ajpendo.00130.2011","article-title":"Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells","volume":"301","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"7","key":"key\n\t\t\t\t20170405143513_B16","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1210\/endo.138.7.5220","article-title":"A novel calcium-activated apamin-insensitive potassium current in pituitary gonadotrophs","volume":"138","year":"1997","journal-title":"Endocrinology"},{"issue":"6","key":"key\n\t\t\t\t20170405143513_B17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/35077544","article-title":"The TRP ion channel family","volume":"2","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20170405143513_B18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev.biochem.75.103004.142819","article-title":"TRP channels","volume":"76","year":"2007","journal-title":"Annu Rev Biochem"},{"issue":"1-2","key":"key\n\t\t\t\t20170405143513_B19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0169-328X(02)00527-2","article-title":"mRNA distribution analysis of human TRPC family in CNS and peripheral tissues","volume":"109","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"key\n\t\t\t\t20170405143513_B20","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/978-94-007-0265-3_24","article-title":"Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion","volume":"704","year":"2011","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"key\n\t\t\t\t20170405143513_B21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0896-6273(03)00675-5","article-title":"A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction","volume":"40","year":"2003","journal-title":"Neuron"},{"issue":"6716","key":"key\n\t\t\t\t20170405143513_B22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/16711","article-title":"Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol","volume":"397","year":"1999","journal-title":"Nature"},{"issue":"39","key":"key\n\t\t\t\t20170405143513_B23","doi-asserted-by":"crossref","first-page":"27359","DOI":"10.1074\/jbc.274.39.27359","article-title":"Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor","volume":"274","year":"1999","journal-title":"J Biol Chem"},{"issue":"4","key":"key\n\t\t\t\t20170405143513_B24","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1073\/pnas.1522294113","article-title":"Critical roles of Gi\/o proteins and phospholipase C-\u03b41 in the activation of receptor-operated TRPC4 channels","volume":"113","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ceca.2007.03.004","article-title":"TRPC channels as STIM1-regulated store-operated channels","volume":"42","year":"2007","journal-title":"Cell Calcium"},{"issue":"23","key":"key\n\t\t\t\t20170405143513_B26","doi-asserted-by":"crossref","first-page":"17517","DOI":"10.1074\/jbc.275.23.17517","article-title":"Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"issue":"17","key":"key\n\t\t\t\t20170405143513_B27","doi-asserted-by":"crossref","first-page":"10279","DOI":"10.1074\/jbc.273.17.10279","article-title":"Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain","volume":"273","year":"1998","journal-title":"J Biol Chem"},{"issue":"49","key":"key\n\t\t\t\t20170405143513_B28","doi-asserted-by":"crossref","first-page":"34423","DOI":"10.1074\/jbc.M109.018192","article-title":"TRPC5 is a Ca2+-activated channel functionally coupled to Ca2+-selective ion channels","volume":"284","year":"2009","journal-title":"J Biol Chem"},{"issue":"5","key":"key\n\t\t\t\t20170405143513_B29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1085\/jgp.200810153","article-title":"Intracellular calcium strongly potentiates agonist-activated TRPC5 channels","volume":"133","year":"2009","journal-title":"J Gen Physiol"},{"issue":"23","key":"key\n\t\t\t\t20170405143513_B30","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1113\/jphysiol.2008.161257","article-title":"Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels","volume":"586","year":"2008","journal-title":"J Physiol"},{"issue":"44","key":"key\n\t\t\t\t20170405143513_B31","doi-asserted-by":"crossref","first-page":"18114","DOI":"10.1073\/pnas.1115387108","article-title":"Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system","volume":"108","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"key\n\t\t\t\t20170405143513_B32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0896-6273(01)00240-9","article-title":"TRPC1 and TRPC5 form a novel cation channel in mammalian brain","volume":"29","year":"2001","journal-title":"Neuron"},{"issue":"179","key":"key\n\t\t\t\t20170405143513_B33","first-page":"109","article-title":"Canonical transient receptor potential 5","year":"2007","journal-title":"Handb Exp Pharmacol"},{"issue":"11","key":"key\n\t\t\t\t20170405143513_B34","doi-asserted-by":"crossref","first-page":"7461","DOI":"10.1073\/pnas.102596199","article-title":"Subunit composition of mammalian transient receptor potential channels in living cells","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B35","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.mcn.2007.03.012","article-title":"Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current","volume":"35","year":"2007","journal-title":"Mol Cell Neurosci"},{"issue":"6","key":"key\n\t\t\t\t20170405143513_B36","doi-asserted-by":"crossref","first-page":"e573","DOI":"10.1371\/journal.pone.0000573","article-title":"Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain","volume":"2","year":"2007","journal-title":"PLoS One"},{"issue":"4","key":"key\n\t\t\t\t20170405143513_B37","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1210\/en.2010-1285","article-title":"Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels","volume":"152","year":"2011","journal-title":"Endocrinology"},{"issue":"17","key":"key\n\t\t\t\t20170405143513_B38","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1523\/JNEUROSCI.5352-07.2008","article-title":"Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels","volume":"28","year":"2008","journal-title":"J Neurosci"},{"issue":"8","key":"key\n\t\t\t\t20170405143513_B39","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1210\/en.2013-1180","article-title":"Kisspeptin activation of TRPC4 channels in female GnRH neurons requires PIP2 depletion and cSrc kinase activation","volume":"154","year":"2013","journal-title":"Endocrinology"},{"issue":"3","key":"key\n\t\t\t\t20170405143513_B40","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1210\/en.2015-1836","article-title":"Molecular plasticity of male and female murine gonadotropes revealed by mRNA sequencing","volume":"157","year":"2016","journal-title":"Endocrinology"},{"issue":"6","key":"key\n\t\t\t\t20170405143513_B41","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1210\/en.2007-1502","article-title":"Functional characterization of genetically labeled gonadotropes","volume":"149","year":"2008","journal-title":"Endocrinology"},{"issue":"4","key":"key\n\t\t\t\t20170405143513_B42","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1210\/en.2010-1208","article-title":"Genetic identification of GnRH receptor neurons: a new model for studying neural circuits underlying reproductive physiology in the mouse brain","volume":"152","year":"2011","journal-title":"Endocrinology"},{"issue":"6","key":"key\n\t\t\t\t20170405143513_B43","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.neuron.2014.04.038","article-title":"Norepinephrine controls astroglial responsiveness to local circuit activity","volume":"82","year":"2014","journal-title":"Neuron"},{"issue":"7371","key":"key\n\t\t\t\t20170405143513_B44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature10567","article-title":"Melanopsin signalling in mammalian iris and retina","volume":"479","year":"2011","journal-title":"Nature"},{"issue":"4","key":"key\n\t\t\t\t20170405143513_B45","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","year":"2001","journal-title":"Methods"},{"issue":"38","key":"key\n\t\t\t\t20170405143513_B46","doi-asserted-by":"crossref","first-page":"33436","DOI":"10.1074\/jbc.M111.274167","article-title":"Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4\/C5 ion channels","volume":"286","year":"2011","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170405143513_B47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jneumeth.2015.01.020","article-title":"Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging","volume":"243","year":"2015","journal-title":"J Neurosci Methods"},{"issue":"3","key":"key\n\t\t\t\t20170405143513_B48","doi-asserted-by":"crossref","first-page":"e58260","DOI":"10.1371\/journal.pone.0058260","article-title":"Membrane potential measurements of isolated neurons using a voltage-sensitive dye","volume":"8","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"key\n\t\t\t\t20170405143513_B49","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","year":"2010","journal-title":"Nat Biotechnol"},{"issue":"3","key":"key\n\t\t\t\t20170405143513_B50","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1210\/en.2009-0718","article-title":"Gonadotropin-releasing hormone inhibits ether-\u00e0-go-go-related gene K+ currents in mouse gonadotropes","volume":"151","year":"2010","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170405143513_B51","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/ncomms1612","article-title":"Existence of long-lasting experience-dependent plasticity in endocrine cell networks","volume":"3","year":"2012","journal-title":"Nat Commun"},{"issue":"1","key":"key\n\t\t\t\t20170405143513_B52","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/bph.12436","article-title":"Riluzole activates TRPC5 channels independently of PLC activity","volume":"171","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"12","key":"key\n\t\t\t\t20170405143513_B53","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1002\/anie.201411511","article-title":"(-)-Englerin\u2005A is a potent and selective activator of TRPC4 and TRPC5 calcium channels","volume":"54","year":"2015","journal-title":"Angew Chem Int Ed Engl"},{"issue":"5","key":"key\n\t\t\t\t20170405143513_B54","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1124\/mol.114.093229","article-title":"Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5","volume":"86","year":"2014","journal-title":"Mol Pharmacol"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B55","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0304-3940(00)01033-8","article-title":"Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells","volume":"285","year":"2000","journal-title":"Neurosci Lett"},{"issue":"21","key":"key\n\t\t\t\t20170405143513_B56","doi-asserted-by":"crossref","first-page":"17029","DOI":"10.1074\/jbc.M111.326553","article-title":"Selective G\u03b1i subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels","volume":"287","year":"2012","journal-title":"J Biol Chem"},{"issue":"10","key":"key\n\t\t\t\t20170405143513_B57","first-page":"1673","article-title":"Thyrotropin-releasing hormone and gonadotropin-releasing hormone receptors activate phospholipase C by coupling to the guanosine triphosphate-binding proteins Gq and G11","volume":"6","year":"1992","journal-title":"Mol Endocrinol"},{"issue":"1","key":"key\n\t\t\t\t20170405143513_B58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0026-895X(25)08650-X","article-title":"The gonadotrophin-releasing hormone receptor of alpha T3-1 pituitary cells regulates cellular levels of both of the phosphoinositidase C-linked G proteins, Gq alpha and G11 alpha, equally","volume":"46","year":"1994","journal-title":"Mol Pharmacol"},{"issue":"5104","key":"key\n\t\t\t\t20170405143513_B59","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.8385366","article-title":"Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes","volume":"260","year":"1993","journal-title":"Science"},{"issue":"7","key":"key\n\t\t\t\t20170405143513_B60","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1210\/mend-5-7-949","article-title":"Spontaneous and agonist-induced calcium oscillations in pituitary gonadotrophs","volume":"5","year":"1991","journal-title":"Mol Endocrinol"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B61","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0003-9861(89)90388-3","article-title":"Calcium mobilization and influx during the biphasic cytosolic calcium and secretory responses in agonist-stimulated pituitary gonadotrophs","volume":"275","year":"1989","journal-title":"Arch Biochem Biophys"},{"issue":"7","key":"key\n\t\t\t\t20170405143513_B62","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1210\/mend.15.7.0668","article-title":"Differential expression of ionic channels in rat anterior pituitary cells","volume":"15","year":"2001","journal-title":"Mol Endocrinol"},{"issue":"15","key":"key\n\t\t\t\t20170405143513_B63","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1093\/emboj\/17.15.4274","article-title":"A novel capacitative calcium entry channel expressed in excitable cells","volume":"17","year":"1998","journal-title":"EMBO J"},{"issue":"4","key":"key\n\t\t\t\t20170405143513_B64","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.cell.2009.03.039","article-title":"Essential role for TRPC5 in amygdala function and fear-related behavior","volume":"137","year":"2009","journal-title":"Cell"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B65","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1124\/mol.112.082271","article-title":"Canonical transient receptor channel 5 (TRPC5) and TRPC1\/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms","volume":"83","year":"2013","journal-title":"Mol Pharmacol"},{"key":"key\n\t\t\t\t20170405143513_B66","first-page":"127","article-title":"GnRH-Induced Ca(2+) signaling patterns and gonadotropin secretion in pituitary gonadotrophs: functional adaptations to both ordinary and extraordinary physiological demands","volume":"4","year":"2013","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"key\n\t\t\t\t20170405143513_B67","first-page":"38","article-title":"Castration-induced modifications of GnRH-elicited [Ca2+](i) signaling patterns in male mouse pituitary gonadotrophs in situ: studies in the acute pituitary slice preparation","volume":"88","year":"2013","journal-title":"Biol Reprod"},{"issue":"50","key":"key\n\t\t\t\t20170405143513_B68","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1073\/pnas.1010849107","article-title":"Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood","volume":"107","year":"2010","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/158\/4\/887\/11160716\/en.2016-1810.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T21:02:43Z","timestamp":1750194163000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article-lookup\/doi\/10.1210\/en.2016-1810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,30]]},"references-count":68,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,1,30]]},"published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2016-1810","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,30]]}}}