{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:38:04Z","timestamp":1776109084375,"version":"3.50.1"},"reference-count":65,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"DOI":"10.1210\/en.2016-1901","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T03:14:04Z","timestamp":1491448444000},"page":"743-755","source":"Crossref","is-referenced-by-count":33,"title":["RNA Sequencing Exposes Adaptive and Immune Responses to Intrauterine Growth Restriction in Fetal Sheep Islets"],"prefix":"10.1210","volume":"158","author":[{"given":"Amy C.","family":"Kelly","sequence":"first","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Bidwell","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Taska","sequence":"additional","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia E.","family":"Camacho","sequence":"additional","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean W.","family":"Limesand","sequence":"additional","affiliation":[{"name":"School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, Arizona 85719"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"issue":"3","key":"2019041121473942800_B1","first-page":"490","article-title":"Intrauterine growth restriction","volume":"99","author":"Resnik","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"10","key":"2019041121473942800_B2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1471-0528.1977.tb12486.x","article-title":"The endocrine pancreas in small-for-dates infants","volume":"84","author":"Van Assche","year":"1977","journal-title":"Br J Obstet Gynaecol"},{"issue":"8","key":"2019041121473942800_B3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1055\/s-2007-1004939","article-title":"Effects of fetal intravenous glucose challenge in normal and growth retarded fetuses","volume":"22","author":"Nicolini","year":"1990","journal-title":"Horm Metab Res"},{"issue":"6","key":"2019041121473942800_B4","doi-asserted-by":"crossref","first-page":"e100337","DOI":"10.1371\/journal.pone.0100337","article-title":"SGA children with moderate catch-up growth are showing the impaired insulin secretion at the age of 4","volume":"9","author":"Milovanovic","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"2019041121473942800_B5","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/apa.13413","article-title":"Challenges in nourishing the IUGR fetus\u2014lessons learned from studies in the IUGR fetal sheep","volume":"105","author":"Hay","year":"2016","journal-title":"Acta Paediatr"},{"issue":"1","key":"2019041121473942800_B6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/nu7010500","article-title":"Fetal adrenal demedullation lowers circulating norepinephrine and attenuates growth restriction but not reduction of endocrine cell mass in an ovine model of intrauterine growth restriction","volume":"7","author":"Davis","year":"2015","journal-title":"Nutrients"},{"issue":"3","key":"2019041121473942800_B7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1677\/JOE-09-0399","article-title":"Consequences of a compromised intrauterine environment on islet function","volume":"205","author":"Green","year":"2010","journal-title":"J Endocrinol"},{"issue":"5","key":"2019041121473942800_B8","doi-asserted-by":"crossref","first-page":"E516","DOI":"10.1152\/ajpendo.00435.2012","article-title":"Reductions in insulin concentrations and \u03b2-cell mass precede growth restriction in sheep fetuses with placental insufficiency","volume":"304","author":"Limesand","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"2019041121473942800_B9","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1210\/en.2015-1850","article-title":"Adrenal demedullation and oxygen supplementation independently increase glucose-stimulated insulin concentrations in fetal sheep with intrauterine growth restriction","volume":"157","author":"Macko","year":"2016","journal-title":"Endocrinology"},{"issue":"5","key":"2019041121473942800_B10","doi-asserted-by":"crossref","first-page":"R1297","DOI":"10.1152\/ajpregu.00494.2004","article-title":"Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction","volume":"288","author":"Limesand","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"2019041121473942800_B11","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1210\/en.2005-0900","article-title":"Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction","volume":"147","author":"Limesand","year":"2006","journal-title":"Endocrinology"},{"issue":"5","key":"2019041121473942800_B12","doi-asserted-by":"crossref","first-page":"E817","DOI":"10.1152\/ajpendo.00572.2010","article-title":"Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus","volume":"300","author":"Green","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"2019041121473942800_B13","doi-asserted-by":"crossref","first-page":"E770","DOI":"10.1152\/ajpendo.00494.2009","article-title":"Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction","volume":"298","author":"Leos","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"2019041121473942800_B14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nbt.2450","article-title":"Differential analysis of gene regulation at transcript resolution with RNA-seq","volume":"31","author":"Trapnell","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"9","key":"2019041121473942800_B15","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"issue":"3","key":"2019041121473942800_B16","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat Protoc"},{"issue":"Web Server issue","key":"2019041121473942800_B17","doi-asserted-by":"crossref","first-page":"W316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"2019041121473942800_B18","first-page":"W70","article-title":"agriGO: a GO analysis toolkit for the agricultural community","volume":"38","author":"Du","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"2019041121473942800_B19","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"2019041121473942800_B20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1258\/ebm.2012.011375","article-title":"Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas","volume":"237","author":"Chen","year":"2012","journal-title":"Exp Biol Med (Maywood)"},{"issue":"4","key":"2019041121473942800_B21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"5","key":"2019041121473942800_B22","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1113\/JP271066","article-title":"Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex","volume":"594","author":"Chang","year":"2016","journal-title":"J Physiol"},{"issue":"1","key":"2019041121473942800_B23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00125-005-0079-1","article-title":"Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas","volume":"49","author":"De Breuck","year":"2006","journal-title":"Diabetologia"},{"issue":"12","key":"2019041121473942800_B24","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.2337\/db07-0291","article-title":"Stromal cell derived factor-1 (SDF-1)\/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt","volume":"56","author":"Yano","year":"2007","journal-title":"Diabetes"},{"issue":"1","key":"2019041121473942800_B25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1210\/en.2012-1814","article-title":"Trefoil factor 2 promotes cell proliferation in pancreatic \u03b2-cells through CXCR-4-mediated ERK1\/2 phosphorylation","volume":"154","author":"Orime","year":"2013","journal-title":"Endocrinology"},{"issue":"Pt 19","key":"2019041121473942800_B26","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1242\/jcs.027730","article-title":"p21 differentially regulates DNA replication and DNA-repair-associated processes after UV irradiation","volume":"121","author":"Soria","year":"2008","journal-title":"J Cell Sci"},{"issue":"2","key":"2019041121473942800_B27","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12020-010-9421-6","article-title":"Molecular mechanism of pancreatic \u03b2-cell adaptive proliferation: studies during pregnancy in rats and in vitro","volume":"39","author":"Chen","year":"2011","journal-title":"Endocrine"},{"issue":"2","key":"2019041121473942800_B28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1091\/mbc.6.2.185","article-title":"The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis","volume":"6","author":"Sudakin","year":"1995","journal-title":"Mol Biol Cell"},{"issue":"29","key":"2019041121473942800_B29","doi-asserted-by":"crossref","first-page":"20955","DOI":"10.1074\/jbc.M113.486746","article-title":"Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes","volume":"288","author":"Tsutsui","year":"2013","journal-title":"J Biol Chem"},{"issue":"10","key":"2019041121473942800_B30","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/nm1299","article-title":"Cdk5-dependent regulation of glucose-stimulated insulin secretion","volume":"11","author":"Wei","year":"2005","journal-title":"Nat Med"},{"issue":"3","key":"2019041121473942800_B31","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/frne.1999.0183","article-title":"Somatostatin and its receptor family","volume":"20","author":"Patel","year":"1999","journal-title":"Front Neuroendocrinol"},{"key":"2019041121473942800_B32","doi-asserted-by":"crossref","first-page":"717509","DOI":"10.1155\/2015\/717509","article-title":"Analysis of chromosome 17 miRNAs and their importance in medulloblastomas","volume":"2015","author":"L\u00f3pez-Ochoa","year":"2015","journal-title":"BioMed Res Int"},{"issue":"15","key":"2019041121473942800_B33","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1101\/gad.1670808","article-title":"On the origin of the beta cell","volume":"22","author":"Oliver-Krasinski","year":"2008","journal-title":"Genes Dev"},{"issue":"5","key":"2019041121473942800_B34","doi-asserted-by":"crossref","first-page":"E587","DOI":"10.1152\/ajpendo.00177.2012","article-title":"Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity","volume":"303","author":"Bonomi","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"2019041121473942800_B35","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.cell.2012.04.031","article-title":"Insights into RNA biology from an atlas of mammalian mRNA-binding proteins","volume":"149","author":"Castello","year":"2012","journal-title":"Cell"},{"issue":"3","key":"2019041121473942800_B36","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/genetics\/147.3.1063","article-title":"Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells","volume":"147","author":"Edwards","year":"1997","journal-title":"Genetics"},{"issue":"9","key":"2019041121473942800_B37","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2337\/diab.43.9.1164","article-title":"Opposite effects of beta-cell differentiation and growth on reg expression in human fetal pancreatic cells","volume":"43","author":"Otonkoski","year":"1994","journal-title":"Diabetes"},{"issue":"10","key":"2019041121473942800_B38","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1177\/1535370213493715","article-title":"Cellular mechanisms underlying failed beta cell regeneration in offspring of protein-restricted pregnant mice","volume":"238","author":"Cox","year":"2013","journal-title":"Exp Biol Med (Maywood)"},{"issue":"2","key":"2019041121473942800_B39","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1128\/MCB.19.2.1262","article-title":"A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development","volume":"19","author":"Nielsen","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"3","key":"2019041121473942800_B40","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1677\/joe.0.1560431","article-title":"Expression of nerve growth factor and its high-affinity receptor Trk-A in the rat pancreas during embryonic and fetal life","volume":"156","author":"Miralles","year":"1998","journal-title":"J Endocrinol"},{"issue":"5","key":"2019041121473942800_B41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.2337\/diabetes.50.5.1056","article-title":"Proteome analysis of interleukin-1beta\u2013induced changes in protein expression in rat islets of Langerhans","volume":"50","author":"Larsen","year":"2001","journal-title":"Diabetes"},{"issue":"10","key":"2019041121473942800_B42","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s001250100650","article-title":"NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro","volume":"44","author":"Pierucci","year":"2001","journal-title":"Diabetologia"},{"issue":"11","key":"2019041121473942800_B43","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.2337\/diabetes.49.11.1751","article-title":"Triggering and amplifying pathways of regulation of insulin secretion by glucose","volume":"49","author":"Henquin","year":"2000","journal-title":"Diabetes"},{"issue":"1","key":"2019041121473942800_B44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1042\/BJ20070962","article-title":"A role for PFK-2\/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells","volume":"411","author":"Arden","year":"2008","journal-title":"Biochem J"},{"issue":"3","key":"2019041121473942800_B45","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1073\/pnas.1317400111","article-title":"UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation","volume":"111","author":"Vozza","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2019041121473942800_B46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2006.04.010","article-title":"Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets","volume":"3","author":"Zhang","year":"2006","journal-title":"Cell Metab"},{"issue":"1","key":"2019041121473942800_B47","doi-asserted-by":"crossref","first-page":"E58","DOI":"10.1152\/ajpendo.00517.2013","article-title":"Enhanced insulin responsiveness and islet adrenergic desensitization after discontinuing chronic norepinephrine suppression in fetal sheep","volume":"306","author":"Chen","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"2019041121473942800_B48","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/JOE-16-0445","article-title":"Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine","volume":"232","author":"Chen","year":"2017","journal-title":"J Endocrinol"},{"key":"2019041121473942800_B49","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.physiol.010908.163119","article-title":"Transcriptional control of mitochondrial biogenesis and function","volume":"71","author":"Hock","year":"2009","journal-title":"Annu Rev Physiol"},{"issue":"5","key":"2019041121473942800_B50","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.beem.2012.03.012","article-title":"Developmental origins of diabetes: the role of oxidative stress","volume":"26","author":"Simmons","year":"2012","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"23","key":"2019041121473942800_B51","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1091\/mbc.e13-06-0302","article-title":"Syntaxin 16 is a master recruitment factor for cytokinesis","volume":"24","author":"Neto","year":"2013","journal-title":"Mol Biol Cell"},{"issue":"Pt 6","key":"2019041121473942800_B52","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1113\/jphysiol.2008.168005","article-title":"Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+-induced glucagon exocytosis in pancreas","volume":"587","author":"Gustavsson","year":"2009","journal-title":"J Physiol"},{"issue":"4","key":"2019041121473942800_B53","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1189\/jlb.1004624","article-title":"Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro","volume":"78","author":"Geutskens","year":"2005","journal-title":"J Leukoc Biol"},{"issue":"10","key":"2019041121473942800_B54","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1084\/jem.20150496","article-title":"The pancreas anatomy conditions the origin and properties of resident macrophages","volume":"212","author":"Calderon","year":"2015","journal-title":"J Exp Med"},{"issue":"8","key":"2019041121473942800_B55","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/14767051003774942","article-title":"Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-alpha in normal pregnancies and in pregnancies complicated by preeclampsia","volume":"23","author":"Tosun","year":"2010","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5","key":"2019041121473942800_B56","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.2337\/db13-1226","article-title":"Neutralizing Th2 inflammation in neonatal islets prevents \u03b2-cell failure in adult IUGR rats","volume":"63","author":"Jaeckle Santos","year":"2014","journal-title":"Diabetes"},{"issue":"5","key":"2019041121473942800_B57","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1017\/S2040174413000093","article-title":"Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced \u03b2-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation","volume":"4","author":"Macko","year":"2013","journal-title":"J Dev Orig Health Dis"},{"issue":"3","key":"2019041121473942800_B58","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000343260","article-title":"Intrauterine growth restriction and the innate immune system in preterm infants of \u226432 weeks gestation","volume":"103","author":"Tr\u00f6ger","year":"2013","journal-title":"Neonatology"},{"issue":"4","key":"2019041121473942800_B59","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/0002-9378(89)90770-9","article-title":"Blood gases, pH, and lactate in appropriate- and small-for-gestational-age fetuses","volume":"161","author":"Nicolaides","year":"1989","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"2019041121473942800_B60","first-page":"17","article-title":"Some aspects of placental function in chronically heat-stressed ewes","volume":"9","author":"Bell","year":"1987","journal-title":"J Dev Physiol"},{"issue":"2","key":"2019041121473942800_B61","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2337\/db14-0462","article-title":"Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep","volume":"64","author":"Rozance","year":"2015","journal-title":"Diabetes"},{"issue":"11","key":"2019041121473942800_B62","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00125-010-1858-x","article-title":"Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation","volume":"53","author":"Huang","year":"2010","journal-title":"Diabetologia"},{"issue":"3","key":"2019041121473942800_B63","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.bbrc.2005.10.105","article-title":"Endothelial stress induces the release of vitamin D-binding protein, a novel growth factor","volume":"338","author":"Raymond","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2019041121473942800_B64","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1096\/fj.05-3788com","article-title":"Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma","volume":"19","author":"Maynard","year":"2005","journal-title":"FASEB J"},{"issue":"6","key":"2019041121473942800_B65","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/sj.cr.7310072","article-title":"Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha","volume":"16","author":"Li","year":"2006","journal-title":"Cell Res"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/158\/4\/743\/11160785\/en.2016-1901.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T07:26:06Z","timestamp":1658906766000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/158\/4\/743\/2991881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":65,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,13]]},"published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2016-1901","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4,1]]},"published":{"date-parts":[[2017,2,13]]}}}