{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:26:12Z","timestamp":1792599972473,"version":"4.5.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"DOI":"10.1210\/en.2016-1930","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T02:59:02Z","timestamp":1491447542000},"page":"950-962","source":"Crossref","is-referenced-by-count":106,"title":["Steroid Hormones Are Key Modulators of Tissue Mechanical Function via Regulation of Collagen and Elastic Fibers"],"prefix":"10.1210","volume":"158","author":[{"given":"Shanmugasundaram","family":"Nallasamy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and"},{"name":"Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Columbia University, New York, New York 10027; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Akins","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and"},{"name":"Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Columbia University, New York, New York 10027; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Iozzo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anatomy, and Cell Biology"},{"name":"Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mala","family":"Mahendroo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and"},{"name":"Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, Texas 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"issue":"12","key":"2019041123145683700_B1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm3902","article-title":"Extracellular matrix assembly: a multiscale deconstruction","volume":"15","author":"Mouw","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"2019041123145683700_B2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"Humphrey","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2019041123145683700_B3"},{"issue":"4","key":"2019041123145683700_B4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1530\/REP-11-0466","article-title":"Cervical remodeling in term and preterm birth: insights from an animal model","volume":"143","author":"Mahendroo","year":"2012","journal-title":"Reproduction"},{"issue":"3","key":"2019041123145683700_B5","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2010.090735","article-title":"Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species","volume":"176","author":"O\u2019Brien","year":"2010","journal-title":"Am J Pathol"},{"issue":"1","key":"2019041123145683700_B6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.130.1.227","article-title":"A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling","volume":"130","author":"Liu","year":"1995","journal-title":"J Cell Biol"},{"issue":"6","key":"2019041123145683700_B7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tem.2010.01.011","article-title":"Cervical remodeling during pregnancy and parturition","volume":"21","author":"Timmons","year":"2010","journal-title":"Trends Endocrinol Metab"},{"issue":"9","key":"2019041123145683700_B8","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jbiomech.2015.02.065","article-title":"The mechanical role of the cervix in pregnancy","volume":"48","author":"Myers","year":"2015","journal-title":"J Biomech"},{"issue":"7","key":"2019041123145683700_B9","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1210\/en.2011-1950","article-title":"Dynamic changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth","volume":"153","author":"Akgul","year":"2012","journal-title":"Endocrinology"},{"key":"2019041123145683700_B10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2015.02.003","article-title":"Proteoglycan form and function: a comprehensive nomenclature of proteoglycans","volume":"42","author":"Iozzo","year":"2015","journal-title":"Matrix Biol"},{"issue":"2","key":"2019041123145683700_B11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1530\/REP-07-0032","article-title":"Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice","volume":"134","author":"Read","year":"2007","journal-title":"Reproduction"},{"issue":"5","key":"2019041123145683700_B12","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1095\/biolreprod.110.089599","article-title":"Cervical softening during pregnancy: regulated changes in collagen cross-linking and composition of matricellular proteins in the mouse","volume":"84","author":"Akins","year":"2011","journal-title":"Biol Reprod"},{"issue":"11","key":"2019041123145683700_B13","doi-asserted-by":"crossref","first-page":"e112391","DOI":"10.1371\/journal.pone.0112391","article-title":"Quantitative evaluation of collagen crosslinks and corresponding tensile mechanical properties in mouse cervical tissue during normal pregnancy","volume":"9","author":"Yoshida","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"2019041123145683700_B14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.actbio.2007.04.009","article-title":"Mechanical and biochemical properties of human cervical tissue","volume":"4","author":"Myers","year":"2008","journal-title":"Acta Biomater"},{"issue":"11","key":"2019041123145683700_B15","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1177\/1933719116650756","article-title":"Progesterone receptor\u2013mediated actions regulate remodeling of the cervix in preparation for preterm parturition","volume":"23","author":"Kirby","year":"2016","journal-title":"Reprod Sci"},{"issue":"3","key":"2019041123145683700_B16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1095\/biolreprod.111.091983","article-title":"Remodeling of the cervix and parturition in mice lacking the progesterone receptor B isoform","volume":"85","author":"Yellon","year":"2011","journal-title":"Biol Reprod"},{"issue":"2","key":"2019041123145683700_B17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1095\/biolreprod.114.118638","article-title":"Effect of vaginal or systemic estrogen on dynamics of collagen assembly in the rat vaginal wall","volume":"92","author":"Montoya","year":"2015","journal-title":"Biol Reprod"},{"issue":"4","key":"2019041123145683700_B18","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1152\/japplphysiol.90935.2008","article-title":"Effect of estrogen on tendon collagen synthesis, tendon structural characteristics, and biomechanical properties in postmenopausal women","volume":"106","author":"Hansen","year":"2009","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"2019041123145683700_B19","first-page":"283","article-title":"Effect of estrogens on skin aging and the potential role of SERMs","volume":"2","author":"Stevenson","year":"2007","journal-title":"Clin Interv Aging"},{"issue":"1","key":"2019041123145683700_B20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1095\/biolreprod.113.112540","article-title":"Inhibitory effect of progesterone on cervical tissue formation in a three-dimensional culture system with human cervical fibroblasts","volume":"90","author":"House","year":"2014","journal-title":"Biol Reprod"},{"issue":"3","key":"2019041123145683700_B21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1083\/jcb.136.3.729","article-title":"Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility","volume":"136","author":"Danielson","year":"1997","journal-title":"J Cell Biol"},{"issue":"1","key":"2019041123145683700_B22","doi-asserted-by":"crossref","first-page":"e29627","DOI":"10.1371\/journal.pone.0029627","article-title":"Uterine dysfunction in biglycan and decorin deficient mice leads to dystocia during parturition","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"2019041123145683700_B23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.matbio.2009.03.004","article-title":"Analysis of dermal elastic fibers in the absence of fibulin-5 reveals potential roles for fibulin-5 in elastic fiber assembly","volume":"28","author":"Choi","year":"2009","journal-title":"Matrix Biol"},{"key":"2019041123145683700_B24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.actbio.2016.03.005","article-title":"Material properties of mouse cervical tissue in normal gestation","volume":"36","author":"Yoshida","year":"2016","journal-title":"Acta Biomater"},{"issue":"6","key":"2019041123145683700_B25","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1074\/jbc.M109540200","article-title":"Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1","volume":"277","author":"Reinboth","year":"2002","journal-title":"J Biol Chem"},{"issue":"Pt 14","key":"2019041123145683700_B26","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1242\/jcs.115.14.2817","article-title":"Elastic fibres","volume":"115","author":"Kielty","year":"2002","journal-title":"J Cell Sci"},{"issue":"4","key":"2019041123145683700_B27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bdrc.20111","article-title":"New insights into elastic fiber assembly","volume":"81","author":"Wagenseil","year":"2007","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"7","key":"2019041123145683700_B28","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.biocel.2010.03.009","article-title":"Unraveling the mechanism of elastic fiber assembly: the roles of short fibulins","volume":"42","author":"Yanagisawa","year":"2010","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"2019041123145683700_B29","doi-asserted-by":"crossref","first-page":"578","DOI":"10.2353\/ajpath.2007.060662","article-title":"Pelvic organ prolapse in fibulin-5 knockout mice: pregnancy-induced changes in elastic fiber homeostasis in mouse vagina","volume":"170","author":"Drewes","year":"2007","journal-title":"Am J Pathol"},{"issue":"1","key":"2019041123145683700_B30","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2353\/ajpath.2009.080212","article-title":"Failure of pelvic organ support in mice deficient in fibulin-3","volume":"174","author":"Rahn","year":"2009","journal-title":"Am J Pathol"},{"issue":"2","key":"2019041123145683700_B31","doi-asserted-by":"crossref","first-page":"026020","DOI":"10.1117\/1.3381184","article-title":"Second harmonic generation imaging as a potential tool for staging pregnancy and predicting preterm birth","volume":"15","author":"Akins","year":"2010","journal-title":"J Biomed Opt"},{"issue":"2","key":"2019041123145683700_B32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1210\/endo-109-2-618","article-title":"Lysyl oxidase activity in the mouse uterine cervix is physiologically regulated by estrogen","volume":"109","author":"Ozasa","year":"1981","journal-title":"Endocrinology"},{"issue":"1","key":"2019041123145683700_B33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrm3496","article-title":"Protein homeostasis: live long, won\u2019t prosper","volume":"14","author":"Toyama","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"2019041123145683700_B34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/03008208509152400","article-title":"Elastin turnover in the rat uterus","volume":"13","author":"Starcher","year":"1985","journal-title":"Connect Tissue Res"},{"issue":"1","key":"2019041123145683700_B35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0003-9861(83)90501-5","article-title":"The content of elastin in the uterine cervix","volume":"222","author":"Leppert","year":"1983","journal-title":"Arch Biochem Biophys"},{"key":"2019041123145683700_B36","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.actbio.2015.07.011","article-title":"Elastin governs the mechanical response of medial collateral ligament under shear and transverse tensile loading","volume":"25","author":"Henninger","year":"2015","journal-title":"Acta Biomater"},{"key":"2019041123145683700_B37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.actbio.2015.01.003","article-title":"Selective enzymatic removal of elastin and collagen from human abdominal aortas: uniaxial mechanical response and constitutive modeling","volume":"17","author":"Schriefl","year":"2015","journal-title":"Acta Biomater"},{"issue":"5","key":"2019041123145683700_B38","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.ajog.2004.03.080","article-title":"Physical and biomechanical characteristics of rat cervical ripening are not consistent with increased collagenase activity","volume":"191","author":"Buhimschi","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"2019041123145683700_B39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/ped.12878","article-title":"CHST14\/D4ST1 deficiency: new form of Ehlers\u2013Danlos syndrome","volume":"58","author":"Kosho","year":"2016","journal-title":"Pediatr Int"},{"issue":"3","key":"2019041123145683700_B40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.placenta.2008.12.007","article-title":"Connective tissue and related disorders and preterm birth: clues to genes contributing to prematurity","volume":"30","author":"Anum","year":"2009","journal-title":"Placenta"},{"issue":"8","key":"2019041123145683700_B41","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/humu.21300","article-title":"Loss-of-function mutations of CHST14 in a new type of Ehlers\u2013Danlos syndrome","volume":"31","author":"Miyake","year":"2010","journal-title":"Hum Mutat"},{"issue":"1","key":"2019041123145683700_B42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajog.2015.10.934","article-title":"Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety","volume":"214","author":"O\u2019Brien","year":"2016","journal-title":"Am J Obstet Gynecol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/158\/4\/950\/11160808\/en.2016-1930.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T07:25:36Z","timestamp":1658906736000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/158\/4\/950\/2991885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,2,13]]},"published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2016-1930","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4,1]]},"published":{"date-parts":[[2017,2,13]]}}}