{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:55:36Z","timestamp":1783940136334,"version":"3.55.0"},"reference-count":58,"publisher":"The Endocrine Society","issue":"12","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA166434"],"award-info":[{"award-number":["R21CA166434"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"DOI":"10.1210\/en.2017-00238","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T18:06:18Z","timestamp":1506621978000},"page":"4174-4188","source":"Crossref","is-referenced-by-count":13,"title":["1,25-Dihydroxyvitamin D Regulation of Glutamine Synthetase and Glutamine Metabolism in Human Mammary Epithelial Cells"],"prefix":"10.1210","volume":"158","author":[{"given":"Sarah","family":"Beaudin","sequence":"first","affiliation":[{"name":"Cancer Research Center, University at Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoEllen","family":"Welsh","sequence":"additional","affiliation":[{"name":"Cancer Research Center, University at Albany"},{"name":"Department of Environmental Health Sciences, University at Albany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"issue":"5","key":"2019041123252080100_B1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"Feldman","year":"2014","journal-title":"Nat Rev Cancer"},{"issue":"10","key":"2019041123252080100_B2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3109\/13880209.2014.988274","article-title":"Vitamin D in cancer chemoprevention","volume":"53","author":"Giammanco","year":"2015","journal-title":"Pharm Biol"},{"issue":"7","key":"2019041123252080100_B3","doi-asserted-by":"crossref","first-page":"077004","DOI":"10.1289\/EHP943","article-title":"Serum vitamin D and risk of breast cancer within five years","volume":"125","author":"O\u2019Brien","year":"2017","journal-title":"Environ Health Perspect"},{"issue":"1-2","key":"2019041123252080100_B4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0303-7207(02)00416-1","article-title":"Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice","volume":"200","author":"Zinser","year":"2003","journal-title":"Mol Cell Endocrinol"},{"issue":"12","key":"2019041123252080100_B5","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1093\/carcin\/bgh271","article-title":"Vitamin D receptor status alters mammary gland morphology and tumorigenesis in MMTV-neu mice","volume":"25","author":"Zinser","year":"2004","journal-title":"Carcinogenesis"},{"issue":"4","key":"2019041123252080100_B6","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/mc.21975","article-title":"Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling","volume":"53","author":"Keith","year":"2014","journal-title":"Mol Carcinog"},{"issue":"4","key":"2019041123252080100_B7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/jn\/136.4.887","article-title":"Human mammary epithelial cells express CYP27B1 and are growth inhibited by 25-hydroxyvitamin D-3, the major circulating form of vitamin D-3","volume":"136","author":"Kemmis","year":"2006","journal-title":"J Nutr"},{"issue":"4","key":"2019041123252080100_B8","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/jcb.21896","article-title":"Mammary epithelial cell transformation is associated with deregulation of the vitamin D pathway","volume":"105","author":"Kemmis","year":"2008","journal-title":"J Cell Biochem"},{"issue":"8","key":"2019041123252080100_B9","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/jcb.25129","article-title":"Gene signatures of 1,25-dihydroxyvitamin D3 exposure in normal and transformed mammary cells","volume":"116","author":"Simmons","year":"2015","journal-title":"J Cell Biochem"},{"key":"2019041123252080100_B10","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jsbmb.2016.04.022","article-title":"1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell","volume":"163","author":"Zhou","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041123252080100_B11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jsbmb.2015.10.012","article-title":"Identification of vitamin D3 target genes in human breast cancer tissue","volume":"164","author":"Sheng","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"2019041123252080100_B12","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/gad.1756509","article-title":"Tumor suppressors and cell metabolism: a recipe for cancer growth","volume":"23","author":"Jones","year":"2009","journal-title":"Genes Dev"},{"issue":"49","key":"2019041123252080100_B13","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2019041123252080100_B14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4331\/wjbc.v3.i8.167","article-title":"Dysregulated lipid metabolism in cancer","volume":"3","author":"Zhang","year":"2012","journal-title":"World J Biol Chem"},{"issue":"5","key":"2019041123252080100_B15","first-page":"587","article-title":"Critical roles of glutamine as nitrogen donors in purine and pyrimidine nucleotide synthesis: asparaginase treatment in childhood acute lymphoblastic leukemia","volume":"20","author":"Cory","year":"2006","journal-title":"In Vivo"},{"issue":"6","key":"2019041123252080100_B16","doi-asserted-by":"crossref","first-page":"C623","DOI":"10.1152\/ajpcell.00291.2012","article-title":"Production of free glutamate in milk requires the leucine transporter LAT1","volume":"305","author":"Matsumoto","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"2019041123252080100_B17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40104-016-0078-8","article-title":"Amino acids and mammary gland development: nutritional implications for milk production and neonatal growth","volume":"7","author":"Rezaei","year":"2016","journal-title":"J Anim Sci Biotechnol"},{"key":"2019041123252080100_B18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jsbmb.2014.09.014","article-title":"Comparative regulation of gene expression by 1,25-dihydroxyvitamin D3 in cells derived from normal mammary tissue and breast cancer","volume":"148","author":"Beaudin","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2019041123252080100_B19","first-page":"13","article-title":"[13N]Ammonia positron emission tomographic\/computed tomographic imaging targeting glutamine synthetase expression in prostate cancer","volume":"13","author":"Shi","year":"2014","journal-title":"Mol Imaging"},{"issue":"1","key":"2019041123252080100_B20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/mpa.0b013e318137a9da","article-title":"Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas","volume":"36","author":"Audard","year":"2008","journal-title":"Pancreas"},{"issue":"13","key":"2019041123252080100_B21","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3748\/wjg.v17.i13.1772","article-title":"\u03b2-Catenin accumulation in nuclei of hepatocellular carcinoma cells up-regulates glutathione-s-transferase M3 mRNA","volume":"17","author":"Li","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"24","key":"2019041123252080100_B22","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1038\/onc.2015.381","article-title":"ASCT2\/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer","volume":"35","author":"van Geldermalsen","year":"2016","journal-title":"Oncogene"},{"issue":"6","key":"2019041123252080100_B23","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.cmet.2015.09.025","article-title":"Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation","volume":"22","author":"Bott","year":"2015","journal-title":"Cell Metab"},{"issue":"1","key":"2019041123252080100_B24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.abb.2008.07.009","article-title":"Glutamine synthetase is essential for proliferation of fetal skin fibroblasts","volume":"478","author":"Vermeulen","year":"2008","journal-title":"Arch Biochem Biophys"},{"issue":"8","key":"2019041123252080100_B25","doi-asserted-by":"crossref","first-page":"e1002229","DOI":"10.1371\/journal.pgen.1002229","article-title":"Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia","volume":"7","author":"Kung","year":"2011","journal-title":"PLoS Genet"},{"issue":"5","key":"2019041123252080100_B26","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/hep.28601","article-title":"Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant \u03b2-catenin","volume":"64","author":"Tao","year":"2016","journal-title":"Hepatology"},{"issue":"5780","key":"2019041123252080100_B27","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1126863","article-title":"p53 regulates mitochondrial respiration","volume":"312","author":"Matoba","year":"2006","journal-title":"Science"},{"issue":"6","key":"2019041123252080100_B28","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2012.04.026","article-title":"Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence","volume":"149","author":"Li","year":"2012","journal-title":"Cell"},{"issue":"1","key":"2019041123252080100_B29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1101\/gad.828901","article-title":"Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells","volume":"15","author":"Elenbaas","year":"2001","journal-title":"Genes Dev"},{"issue":"12","key":"2019041123252080100_B30","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/ncb3272","article-title":"Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma","volume":"17","author":"Tardito","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"4","key":"2019041123252080100_B31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s11011-013-9439-6","article-title":"Inhibition of human glutamine synthetase by l-methionine-S,R-sulfoximine-relevance to the treatment of neurological diseases","volume":"29","author":"Jeitner","year":"2014","journal-title":"Metab Brain Dis"},{"issue":"10","key":"2019041123252080100_B32","doi-asserted-by":"crossref","first-page":"e109916","DOI":"10.1371\/journal.pone.0109916","article-title":"Rapid analysis of glycolytic and oxidative substrate flux of cancer cells in a microplate","volume":"9","author":"Pike Winer","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"2019041123252080100_B33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI70941","article-title":"Taxonomy of breast cancer based on normal cell phenotype predicts outcome","volume":"124","author":"Santagata","year":"2014","journal-title":"J Clin Invest"},{"issue":"13","key":"2019041123252080100_B34","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1242\/dev.129.13.3067","article-title":"Vitamin D3 receptor ablation alters mammary gland morphogenesis","volume":"129","author":"Zinser","year":"2002","journal-title":"Development"},{"issue":"8","key":"2019041123252080100_B35","doi-asserted-by":"crossref","first-page":"E674","DOI":"10.1152\/ajpendo.00200.2014","article-title":"Loss of vitamin D receptor signaling from the mammary epithelium or adipose tissue alters pubertal glandular development","volume":"307","author":"Johnson","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1-5","key":"2019041123252080100_B36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0960-0760(02)00277-7","article-title":"Impact of the vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer","volume":"83","author":"Welsh","year":"2002","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2019041123252080100_B37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10549-008-9900-0","article-title":"25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture","volume":"113","author":"Peng","year":"2009","journal-title":"Breast Cancer Res Treat"},{"issue":"2","key":"2019041123252080100_B38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1210\/endo-122-2-389","article-title":"1,25-Dihydroxycholecalciferol-dependent calcium uptake by mouse mammary gland in culture","volume":"122","author":"Mezzetti","year":"1988","journal-title":"Endocrinology"},{"key":"2019041123252080100_B39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jsbmb.2017.02.006","article-title":"Intramammary 1,25-dihydroxyvitamin D3 treatment increases expression of host-defense genes in mammary immune cells of lactating dairy cattle","volume":"173","author":"Merriman","year":"2017","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2019041123252080100_B40","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/s41598-017-04521-y","article-title":"Vitamin D modulation of TRAIL expression in human milk and mammary epithelial cells","volume":"7","author":"Sambandam","year":"2017","journal-title":"Sci Rep"},{"key":"2019041123252080100_B41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41523-017-0019-5","article-title":"Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women","volume":"3","author":"Mason","year":"2017","journal-title":"NPJ Breast Cancer"},{"issue":"9","key":"2019041123252080100_B42","first-page":"3861","article-title":"Vitamin D favorably alters the cancer promoting prostaglandin cascade","volume":"33","author":"Qin","year":"2013","journal-title":"Anticancer Res"},{"issue":"3","key":"2019041123252080100_B43","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00726-012-1332-9","article-title":"Hormonal regulation of leucine catabolism in mammary epithelial cells","volume":"45","author":"Lei","year":"2013","journal-title":"Amino Acids"},{"issue":"11","key":"2019041123252080100_B44","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1210\/me.2005-0106","article-title":"Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes","volume":"19","author":"Wang","year":"2005","journal-title":"Mol Endocrinol"},{"issue":"12","key":"2019041123252080100_B45","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.4161\/auto.22152","article-title":"Glutamine metabolism links growth factor signaling to the regulation of autophagy","volume":"8","author":"van der Vos","year":"2012","journal-title":"Autophagy"},{"issue":"9","key":"2019041123252080100_B46","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1210\/me.2003-0469","article-title":"Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice","volume":"18","author":"Zinser","year":"2004","journal-title":"Mol Endocrinol"},{"issue":"48","key":"2019041123252080100_B47","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1073\/pnas.0810199105","article-title":"Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction","volume":"105","author":"Wise","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"2019041123252080100_B48","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.2967\/jnumed.110.084244","article-title":"Role of glutamine in cancer: therapeutic and imaging implications","volume":"52","author":"Rajagopalan","year":"2011","journal-title":"J Nucl Med"},{"issue":"10","key":"2019041123252080100_B49","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2019041123252080100_B50","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/jcp.1041430120","article-title":"Metabolic basis for differential glutamine requirements of human leukemia cell lines","volume":"143","author":"Kitoh","year":"1990","journal-title":"J Cell Physiol"},{"issue":"2","key":"2019041123252080100_B51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0039-6060(97)90039-8","article-title":"Regulation of glutamine synthetase in human breast carcinoma cells and experimental tumors","volume":"122","author":"Collins","year":"1997","journal-title":"Surgery"},{"issue":"8","key":"2019041123252080100_B52","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1002\/jcb.25775","article-title":"GLUL promotes cell proliferation in breast cancer","volume":"118","author":"Wang","year":"2017","journal-title":"J Cell Biochem"},{"issue":"12","key":"2019041123252080100_B53","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI6871","article-title":"Mitogen-activated protein kinase inhibits 1,25-dihydroxyvitamin D3-dependent signal transduction by phosphorylating human retinoid X receptor alpha","volume":"103","author":"Solomon","year":"1999","journal-title":"J Clin Invest"},{"issue":"1-2","key":"2019041123252080100_B54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jsbmb.2004.05.007","article-title":"Ras activation is associated with vitamin D receptor mRNA instability in HC11 mammary cells","volume":"92","author":"Rozenchan","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2019041123252080100_B55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1207\/S15327914NC4501_11","article-title":"1,25-Dihydroxyvitamin D inhibits vitamin E succinate-induced apoptosis in C3H10T1\/2 cells but not Harvey ras-transfected cells","volume":"45","author":"Stedman","year":"2003","journal-title":"Nutr Cancer"},{"issue":"11","key":"2019041123252080100_B56","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.cellsig.2007.06.025","article-title":"Transcriptomal profiling of site-specific Ras signals","volume":"19","author":"Agudo-Ib\u00e1\u00f1ez","year":"2007","journal-title":"Cell Signal"},{"issue":"2","key":"2019041123252080100_B57","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/nar\/gkj460","article-title":"Regulation of the human p21(waf1\/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor","volume":"34","author":"Saram\u00e4ki","year":"2006","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"2019041123252080100_B58","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1158\/0008-5472.CAN-05-2562","article-title":"Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation","volume":"66","author":"Maruyama","year":"2006","journal-title":"Cancer Res"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/158\/12\/4174\/22107354\/en.2017-00238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T16:53:52Z","timestamp":1659545632000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/158\/12\/4174\/4210370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,28]]},"references-count":58,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,9,28]]},"published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2017-00238","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"value":"0013-7227","type":"print"},{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,12,1]]},"published":{"date-parts":[[2017,9,28]]}}}