{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:26:57Z","timestamp":1790810817447,"version":"4.1.0"},"reference-count":84,"publisher":"The Endocrine Society","issue":"3","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD057549"],"award-info":[{"award-number":["R01 HD057549"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007602","name":"University of California, Riverside","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008457","name":"University of Virginia","doi-asserted-by":"publisher","award":["U54-HD28934"],"award-info":[{"award-number":["U54-HD28934"]}],"id":[{"id":"10.13039\/100008457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gonadotropin-releasing hormone (GnRH) from the hypothalamus regulates synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gonadotropes. LH and FSH are heterodimers composed of a common \u03b1-subunit and unique \u03b2-subunits, which provide biological specificity and are limiting components of mature hormone synthesis. Gonadotrope cells respond to GnRH via specific expression of the GnRH receptor (Gnrhr). GnRH induces the expression of gonadotropin genes and of the Gnrhr by activation of specific transcription factors. The JUN (c-Jun) transcription factor binds to AP-1 sites in the promoters of target genes and mediates induction of the FSH\u03b2 gene and of the Gnrhr in gonadotrope-derived cell lines. To analyze the role of JUN in reproductive function in vivo, we generated a mouse model that lacks JUN specifically in GnRH receptor\u2012expressing cells (conditional JUN knockout; JUN-cKO). JUN-cKO mice displayed profound reproductive anomalies such as reduced LH levels resulting in lower gonadal steroid levels, longer estrous cycles in females, and diminished sperm numbers in males. Unexpectedly, FSH levels were unchanged in these animals, whereas Gnrhr expression in the pituitary was reduced. Steroidogenic enzyme expression was reduced in the gonads of JUN-cKO mice, likely as a consequence of reduced LH levels. GnRH receptor\u2012driven Cre activity was detected in the hypothalamus but not in the GnRH neuron. Female, but not male, JUN-cKO mice exhibited reduced GnRH expression. Taken together, our results demonstrate that GnRH receptor\u2012expression levels depend on JUN and are critical for reproductive function.<\/jats:p>","DOI":"10.1210\/en.2017-00844","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T19:07:17Z","timestamp":1517598437000},"page":"1496-1510","source":"Crossref","is-referenced-by-count":23,"title":["GnRH Receptor Expression and Reproductive Function Depend on JUN in GnRH Receptor\u2012Expressing Cells"],"prefix":"10.1210","volume":"159","author":[{"given":"Carrie R","family":"Jonak","sequence":"first","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M","family":"Lainez","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Boehm","sequence":"additional","affiliation":[{"name":"Experimental Pharmacology, Center for Molecular Signaling, Saarland University School of Medicine, Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djurdjica","family":"Coss","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,2,2]]},"reference":[{"issue":"5","key":"2020071621591534600_B1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/1043-2760(94)90078-7","article-title":"Gonadotropin-releasing hormone neurons: intrinsic pulsatility and receptor-mediated regulation","volume":"5","author":"Stojilkovic","year":"1994","journal-title":"Trends Endocrinol 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