{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:42:19Z","timestamp":1765827739079,"version":"3.37.3"},"reference-count":59,"publisher":"The Endocrine Society","issue":"12","funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["445019\/2014-0"],"award-info":[{"award-number":["445019\/2014-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1210\/en.2018-00781","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T18:00:50Z","timestamp":1540836050000},"page":"4056-4064","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"159","author":[{"given":"Joabel","family":"Tonellotto dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jandui","family":"Escari\u00e3o da N\u00f3brega","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lady Katerine","family":"Serrano Mujica","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"dos Santos Amaral","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio Amadori","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela W","family":"Manta","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6539-1397","authenticated-orcid":false,"given":"Tiele Medianeira","family":"Rizzetti","sequence":"additional","affiliation":[{"name":"Laboratory of Pesticide Analysis (LARP), Department of Chemistry, Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-1785","authenticated-orcid":false,"given":"Renato","family":"Zanella","sequence":"additional","affiliation":[{"name":"Laboratory of Pesticide Analysis (LARP), Department of Chemistry, Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Fighera","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4866-5944","authenticated-orcid":false,"given":"Alfredo Quites","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-1466","authenticated-orcid":false,"given":"Paulo Bayard Dias","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-233X","authenticated-orcid":false,"given":"Fabio Vasconcellos","family":"Comim","sequence":"additional","affiliation":[{"name":"Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil"},{"name":"Department of Clinical Medicine, Health Science Center, Federal University of Santa Maria, Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"issue":"11","key":"2019041121452743900_B1","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jcem.84.11.6148","article-title":"A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile","volume":"84","author":"Diamanti-Kandarakis","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"13","key":"2019041121452743900_B2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N Engl J Med"},{"issue":"9","key":"2019041121452743900_B3","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"9588","key":"2019041121452743900_B4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"issue":"10","key":"2019041121452743900_B5","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/j.1471-0528.2006.01008.x","article-title":"PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors","volume":"113","author":"Broekmans","year":"2006","journal-title":"BJOG"},{"issue":"1","key":"2019041121452743900_B6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Hum Reprod"},{"issue":"2","key":"2019041121452743900_B7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/jc.2003-031122","article-title":"Androgen excess in women: experience with over 1000 consecutive patients","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2019041121452743900_B8","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum Reprod"},{"issue":"3","key":"2019041121452743900_B9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/jfprhc-2011-100175","article-title":"The investigation and management of hirsutism","volume":"38","author":"Franks","year":"2012","journal-title":"J Fam Plann Reprod Health Care"},{"issue":"2","key":"2019041121452743900_B10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/humupd\/dmr042","article-title":"Epidemiology, diagnosis and management of hirsutism: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"18","author":"Escobar-Morreale","year":"2011","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2019041121452743900_B11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/edrv.21.4.0404","article-title":"Role of hormones in pilosebaceous unit development","volume":"21","author":"Deplewski","year":"2000","journal-title":"Endocr Rev"},{"issue":"4","key":"2019041121452743900_B12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1530\/eje.0.1410361","article-title":"Comparison of finasteride versus flutamide in the treatment of hirsutism","volume":"141","author":"Falsetti","year":"1999","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2019041121452743900_B13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.steroids.2013.05.004","article-title":"Animal models of the polycystic ovary syndrome phenotype","volume":"78","author":"Padmanabhan","year":"2013","journal-title":"Steroids"},{"issue":"3","key":"2019041121452743900_B14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.beem.2018.03.008","article-title":"Evidence from animal models on the pathogenesis of PCOS","volume":"32","author":"Walters","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1\u20132","key":"2019041121452743900_B15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2012.10.005","article-title":"Sheep models of polycystic ovary syndrome phenotype","volume":"373","author":"Padmanabhan","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"36","key":"2019041121452743900_B16","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.2174\/1381612822666160715133437","article-title":"Translational insight into polycystic ovary syndrome (PCOS) from female monkeys with PCOS-like traits","volume":"22","author":"Abbott","year":"2016","journal-title":"Curr Pharm Des"},{"issue":"1\u20132","key":"2019041121452743900_B17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2013.01.013","article-title":"Nonhuman primate models of polycystic ovary syndrome","volume":"373","author":"Abbott","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121452743900_B18","unstructured":"Walters KA , AllanCM, HandelsmanDJ. Rodent models for human polycystic ovary syndrome. Biol Reprod. 2012;86(5):149, 1\u201312."},{"issue":"1","key":"2019041121452743900_B19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/endo.138.1.4890","article-title":"Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque","volume":"138","author":"Obana","year":"1997","journal-title":"Endocrinology"},{"issue":"4","key":"2019041121452743900_B20","first-page":"991","article-title":"The effects of finasteride (Proscar) on hair growth, hair cycle stage, and serum testosterone and dihydrotestosterone in adult male and female stumptail macaques (Macaca arctoides)","volume":"79","author":"Rhodes","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041121452743900_B21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1515\/HMBCI.2010.026","article-title":"Effect of long-term topical application of dehydroepiandrosterone (DHEA) and oral estrogens on morphology, cell proliferation, procollagen A1 and androgen receptor levels in rat skin","volume":"2","author":"Berger","year":"2010","journal-title":"Horm Mol Biol Clin Investig"},{"issue":"9","key":"2019041121452743900_B22","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.2527\/1995.7392600x","article-title":"Acute prenatal androgen treatment increases birth weights and growth rates in lambs","volume":"73","author":"Gill","year":"1995","journal-title":"J Anim Sci"},{"key":"2019041121452743900_B23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21071\/az.v64i247.502","article-title":"L\u00e3: caracteristicas e fatores de produ\u00e7\u00e3o","volume":"64","author":"Amarilho-Silveira","year":"2015","journal-title":"Arquivos de Zootecnia."},{"issue":"03","key":"2019041121452743900_B24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S0021859600024874","article-title":"Subjective assessment of body fat in live sheep","volume":"72","author":"Russel","year":"1969","journal-title":"J Agric Sci"},{"issue":"3","key":"2019041121452743900_B25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0921-4488(00)00160-7","article-title":"Estrus synchronization in ewes treated with sponges impregnated with different doses of medroxyprogesterone acetate","volume":"38","author":"Simonetti","year":"2000","journal-title":"Small Rumin Res"},{"issue":"12","key":"2019041121452743900_B26","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1210\/endo.140.12.7205","article-title":"In utero exposure of female lambs to testosterone reduces the sensitivity of the GnRH neuronal network to inhibition by progesterone","volume":"140","author":"Robinson","year":"1999","journal-title":"Endocrinology"},{"issue":"4","key":"2019041121452743900_B27","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1095\/biolreprod.107.065904","article-title":"Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep","volume":"78","author":"Veiga-Lopez","year":"2008","journal-title":"Biol Reprod"},{"issue":"4","key":"2019041121452743900_B28","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1210\/en.2002-220965","article-title":"Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep","volume":"144","author":"Birch","year":"2003","journal-title":"Endocrinology"},{"key":"2019041121452743900_B29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.theriogenology.2017.09.020","article-title":"Hormonal therapeutic strategy on the induction of accessory corpora lutea in relation to follicle size and on the increase of progesterone in sheep","volume":"105","author":"Fernandez","year":"2018","journal-title":"Theriogenology"},{"key":"2019041121452743900_B30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mce.2016.12.015","article-title":"The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome","volume":"442","author":"Serrano Mujica","year":"2017","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2019041121452743900_B31","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/clinchem\/32.3.560","article-title":"Enzyme immunoassay of progesterone in human and bovine serum and in unextracted bovine skim milk","volume":"32","author":"Solti","year":"1986","journal-title":"Clin Chem"},{"key":"2019041121452743900_B32","doi-asserted-by":"crossref","unstructured":"Reimers TJ, Salerno VJ , LambSV. Validation and application of solid-phase chemiluminescent immunoassays for diagnosis of endocrine disease in animals. Comp Haematol Int. 1996;6:170\u2013175.","DOI":"10.1007\/BF00368462"},{"issue":"(3)","key":"2019041121452743900_B33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1590\/S0103-84781993000300023","article-title":"Compara\u00e7\u00e3o entre m\u00e9todos subjetivo e objetivo quanto a determina\u00e7\u00e3o do di\u00e2metro da l\u00e3","volume":"23","author":"Figueir\u00f3 PRP","year":"1993","journal-title":"Cienc Rural"},{"key":"2019041121452743900_B34","unstructured":"Comim FV. Data from: Prenatal androgenization of ewes as a model of hirsutism in polycystic ovary syndrome. figshare 2018. Accessed 19 October 2018. doi.org\/10.6084\/m9.figshare.7227644.v1."},{"issue":"4","key":"2019041121452743900_B35","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1210\/jc.2018-00241","article-title":"Evaluation and treatment of hirsutism in premenopausal women: an Endocrine Society clinical practice guideline","volume":"103","author":"Martin","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041121452743900_B36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2265.1985.tb00211.x","article-title":"The effect of spironolactone on hirsutism and female androgen metabolism","volume":"23","author":"Dorrington-Ward","year":"1985","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2019041121452743900_B37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0015-0282(99)00183-1","article-title":"Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism","volume":"72","author":"Falsetti","year":"1999","journal-title":"Fertil Steril"},{"issue":"4","key":"2019041121452743900_B38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1159\/000292281","article-title":"An open randomized comparative study of an oral contraceptive containing ethinyl estradiol and cyproterone acetate with and without the GnRH analogue goserelin in the long-term treatment of hirsutism","volume":"41","author":"Vegetti","year":"1996","journal-title":"Gynecol Obstet Invest"},{"issue":"12","key":"2019041121452743900_B39","first-page":"3412","article-title":"Comparison of a gonadotropin-releasing hormone agonist and a low dose oral contraceptive given alone or together in the treatment of hirsutism","volume":"80","author":"Heiner","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2019041121452743900_B40","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0022-3999(93)90056-L","article-title":"Psychological morbidity in women referred for treatment of hirsutism","volume":"37","author":"Barth","year":"1993","journal-title":"J Psychosom Res"},{"issue":"3","key":"2019041121452743900_B41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/14647270802078179","article-title":"Health-related quality of life in PCOS and related infertility: how can we assess this","volume":"11","author":"Jones","year":"2009","journal-title":"Hum Fertil (Camb)"},{"issue":"7","key":"2019041121452743900_B42","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1210\/en.2015-1235","article-title":"Developmental programming: prenatal and postnatal androgen antagonist and insulin sensitizer interventions prevent advancement of puberty and improve LH surge dynamics in prenatal testosterone-treated sheep","volume":"156","author":"Padmanabhan","year":"2015","journal-title":"Endocrinology"},{"issue":"2","key":"2019041121452743900_B43","doi-asserted-by":"crossref","first-page":"e56263","DOI":"10.1371\/journal.pone.0056263","article-title":"The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS)","volume":"8","author":"Rae","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2019041121452743900_B44","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1210\/en.2009-1015","article-title":"Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females","volume":"151","author":"Padmanabhan","year":"2010","journal-title":"Endocrinology"},{"issue":"5","key":"2019041121452743900_B45","doi-asserted-by":"crossref","first-page":"E801","DOI":"10.1152\/ajpendo.00107.2005","article-title":"Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone","volume":"289","author":"Recabarren","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"2019041121452743900_B46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2265.1990.tb00857.x","article-title":"Differences in clinical and endocrine features between obese and non-obese subjects with polycystic ovary syndrome: an analysis of 263 consecutive cases","volume":"32","author":"Kiddy","year":"1990","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2019041121452743900_B47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1530\/REP-10-0094","article-title":"Theca: the forgotten cell of the ovarian follicle","volume":"140","author":"Young","year":"2010","journal-title":"Reproduction"},{"issue":"1","key":"2019041121452743900_B48","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Polycystic ovary syndrome","volume":"375","author":"McCartney","year":"2016","journal-title":"N Engl J Med"},{"key":"2019041121452743900_B49","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1017\/S1462399408000598","article-title":"Polycystic ovarian syndrome: pathophysiology, molecular aspects and clinical implications","volume":"10","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Expert Rev Mol Med"},{"key":"2019041121452743900_B50","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"9","key":"2019041121452743900_B51","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1210\/en.2014-1266","article-title":"Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep","volume":"155","author":"Padmanabhan","year":"2014","journal-title":"Endocrinology"},{"issue":"4","key":"2019041121452743900_B52","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/humrep\/dex036","article-title":"Clustering of PCOS-like traits in naturally hyperandrogenic female rhesus monkeys","volume":"32","author":"Abbott","year":"2017","journal-title":"Hum Reprod"},{"key":"2019041121452743900_B53","doi-asserted-by":"crossref","unstructured":"Azmahani A , NakamuraY, FelizolaSJ, Ozawa Y, Ise K, Inoue T, McNamara KM, Doi M, Okamura H, Zouboulis CC, Aiba S, Sasano H. Steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions. J Steroid Biochem Mol Biol. 2014;144(Pt B):268\u2013279.","DOI":"10.1016\/j.jsbmb.2014.07.010"},{"key":"2019041121452743900_B54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsbmb.2013.02.006","article-title":"Steroidogenesis in the skin: implications for local immune functions","volume":"137","author":"Slominski","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"2019041121452743900_B55","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/JOE-14-0323","article-title":"Expression of steroidogenic enzymes in human sebaceous glands","volume":"222","author":"Inoue","year":"2014","journal-title":"J Endocrinol"},{"issue":"6","key":"2019041121452743900_B56","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1210\/jc.2002-021875","article-title":"Beyond adrenal and ovarian androgen generation: Increased peripheral 5 alpha-reductase activity in women with polycystic ovary syndrome","volume":"88","author":"Fassnacht","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019041121452743900_B57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/120347549800300103","article-title":"Androgen receptor polymorphisms (CAG repeat lengths) in androgenetic alopecia, hirsutism, and acne","volume":"3","author":"Sawaya","year":"1998","journal-title":"J Cutan Med Surg"},{"issue":"4","key":"2019041121452743900_B58","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1365-2230.2006.02146.x","article-title":"Content of 5-alpha-reductase (type 1 and type 2) mRNA in dermal papillae from the lower abdominal region in women with hirsutism","volume":"31","author":"Ska\u0142ba","year":"2006","journal-title":"Clin Exp Dermatol"},{"issue":"3","key":"2019041121452743900_B59","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s004030050277","article-title":"5 Alpha-reductase activity in the human hair follicle concentrates in the dermal papilla","volume":"290","author":"Eicheler","year":"1998","journal-title":"Arch Dermatol Res"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/159\/12\/4056\/26762296\/en.2018-00781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T21:34:27Z","timestamp":1720733667000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/159\/12\/4056\/5145118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":59,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,10,29]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2018-00781","relation":{},"ISSN":["1945-7170"],"issn-type":[{"type":"electronic","value":"1945-7170"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,10,29]]}}}