{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:26:22Z","timestamp":1784395582026,"version":"3.55.0"},"reference-count":67,"publisher":"The Endocrine Society","issue":"3","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1022648"],"award-info":[{"award-number":["APP1022648"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1078444"],"award-info":[{"award-number":["APP1078444"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001061","name":"Rebecca L. Cooper Medical Research Foundation","doi-asserted-by":"publisher","award":["10697"],"award-info":[{"award-number":["10697"]}],"id":[{"id":"10.13039\/501100001061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.1210\/en.2018-00966","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T09:23:33Z","timestamp":1551086613000},"page":"699-715","source":"Crossref","is-referenced-by-count":45,"title":["A Hyperandrogenic Environment Causes Intrinsic Defects That Are Detrimental to Follicular Dynamics in a PCOS Mouse Model"],"prefix":"10.1210","volume":"160","author":[{"given":"Michael J","family":"Bertoldo","sequence":"first","affiliation":[{"name":"Fertility & Research Centre, School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee S L","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique H","family":"Riepsamen","sequence":"additional","affiliation":[{"name":"Fertility & Research Centre, School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianliang","family":"Lin","sequence":"additional","affiliation":[{"name":"Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia"},{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Provincial Maternity and Children\u2019s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena B","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"School of Medicine, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"Robker","sequence":"additional","affiliation":[{"name":"School of Medicine, Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L","family":"Ledger","sequence":"additional","affiliation":[{"name":"Fertility & Research Centre, School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B","family":"Gilchrist","sequence":"additional","affiliation":[{"name":"Fertility & Research Centre, School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Handelsman","sequence":"additional","affiliation":[{"name":"Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1504-9734","authenticated-orcid":false,"given":"Kirsty A","family":"Walters","sequence":"additional","affiliation":[{"name":"Fertility & Research Centre, School of Women\u2019s and Children\u2019s Health, University of New South Wales, Sydney, New South Wales, Australia"},{"name":"Andrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"issue":"2\u20135","key":"2019041121581484000_B1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0960-0760(03)00204-8","article-title":"Androgens in women","volume":"85","author":"Davison","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1\u20132","key":"2019041121581484000_B2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0303-7207(94)90278-X","article-title":"Follicular oestrogen synthesis: the \u201ctwo-cell, two-gonadotrophin\u201d model revisited","volume":"100","author":"Hillier","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"2019041121581484000_B3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mce.2017.06.026","article-title":"Role of androgens in the ovary","volume":"465","author":"Walters","year":"2018","journal-title":"Mol Cell Endocrinol"},{"issue":"21","key":"2019041121581484000_B4","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1073\/pnas.212474399","article-title":"Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues [published correction appears in Proc Natl Acad Sci USA. 2002;99(23):15245]","volume":"99","author":"Yeh","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"31","key":"2019041121581484000_B5","doi-asserted-by":"crossref","first-page":"11209","DOI":"10.1073\/pnas.0404372101","article-title":"Subfertility and defective folliculogenesis in female mice lacking androgen receptor","volume":"101","author":"Hu","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2019041121581484000_B6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1073\/pnas.0506736102","article-title":"Premature ovarian failure in androgen receptor-deficient mice","volume":"103","author":"Shiina","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"2019041121581484000_B7","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1210\/en.2007-0248","article-title":"Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility","volume":"148","author":"Walters","year":"2007","journal-title":"Endocrinology"},{"issue":"2","key":"2019041121581484000_B8","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1210\/en.2009-0751","article-title":"Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis","volume":"151","author":"Yang","year":"2010","journal-title":"Endocrinology"},{"issue":"2","key":"2019041121581484000_B9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1095\/biolreprod61.2.353","article-title":"Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary","volume":"61","author":"Vendola","year":"1999","journal-title":"Biol Reprod"},{"issue":"1","key":"2019041121581484000_B10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1530\/jrf.0.1130027","article-title":"Effect of androgens on the development of mouse follicles growing in vitro","volume":"113","author":"Murray","year":"1998","journal-title":"J Reprod Fertil"},{"issue":"11","key":"2019041121581484000_B11","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1210\/endo.142.11.8482","article-title":"Effect of adrenal and ovarian androgens on type 4 follicles unresponsive to FSH in immature mice","volume":"142","author":"Wang","year":"2001","journal-title":"Endocrinology"},{"issue":"4","key":"2019041121581484000_B12","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1210\/en.2016-1538","article-title":"Androgen stimulates growth of mouse preantral follicles in vitro: interaction with follicle-stimulating hormone and with growth factors of the TGF\u03b2 superfamily","volume":"158","author":"Laird","year":"2017","journal-title":"Endocrinology"},{"issue":"8","key":"2019041121581484000_B13","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1073\/pnas.1318978111","article-title":"Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression","volume":"111","author":"Sen","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"2019041121581484000_B14","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1016\/j.fertnstert.2010.06.077","article-title":"Androgen excess down-regulates connexin43 in a human granulosa cell line","volume":"94","author":"Wu","year":"2010","journal-title":"Fertil Steril"},{"issue":"11","key":"2019041121581484000_B15","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.2527\/1994.72112930x","article-title":"Administration of testosterone during the follicular phase increased the number of corpora lutea in gilts","volume":"72","author":"C\u00e1rdenas","year":"1994","journal-title":"J Anim Sci"},{"issue":"4","key":"2019041121581484000_B16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1530\/rep.0.1230527","article-title":"Increased ovulation rate in gilts treated with dihydrotestosterone","volume":"123","author":"C\u00e1rdenas","year":"2002","journal-title":"Reproduction"},{"issue":"12","key":"2019041121581484000_B17","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1172\/JCI2081","article-title":"Androgens stimulate early stages of follicular growth in the primate ovary","volume":"101","author":"Vendola","year":"1998","journal-title":"J Clin Invest"},{"issue":"3","key":"2019041121581484000_B18","doi-asserted-by":"crossref","first-page":"R141","DOI":"10.1530\/JOE-14-0296","article-title":"Androgen actions in the ovary: balance is key","volume":"222","author":"Prizant","year":"2014","journal-title":"J Endocrinol"},{"issue":"4","key":"2019041121581484000_B19","doi-asserted-by":"crossref","first-page":"R193","DOI":"10.1530\/REP-14-0517","article-title":"Role of androgens in normal and pathological ovarian function","volume":"149","author":"Walters","year":"2015","journal-title":"Reproduction"},{"issue":"5","key":"2019041121581484000_B20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1095\/biolreprod.111.097808","article-title":"Rodent models for human polycystic ovary syndrome","volume":"86","author":"Walters","year":"2012","journal-title":"Biol Reprod"},{"issue":"1\u20132","key":"2019041121581484000_B21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2012.10.005","article-title":"Sheep models of polycystic ovary syndrome phenotype","volume":"373","author":"Padmanabhan","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"2019041121581484000_B22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/humupd\/dmi013","article-title":"Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome","volume":"11","author":"Abbott","year":"2005","journal-title":"Hum Reprod Update"},{"issue":"3","key":"2019041121581484000_B23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/MED.0b013e32832afd4d","article-title":"Androgens and polycystic ovary syndrome","volume":"16","author":"Nisenblat","year":"2009","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2019041121581484000_B24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000342179","article-title":"Non-classic adrenal hyperplasia due to the deficiency of 21-hydroxylase and its relation to polycystic ovarian syndrome","volume":"40","author":"Pignatelli","year":"2013","journal-title":"Front Horm Res"},{"issue":"6","key":"2019041121581484000_B25","first-page":"702","article-title":"Polycystic ovaries in female-to-male transsexuals","volume":"39","author":"Pache","year":"1993","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2019041121581484000_B26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril"},{"issue":"1","key":"2019041121581484000_B27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1385\/ENDO:30:1:27","article-title":"Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment","volume":"30","author":"Gorry","year":"2006","journal-title":"Endocrine"},{"issue":"5","key":"2019041121581484000_B28","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"issue":"3","key":"2019041121581484000_B29","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/humrep\/12.3.474","article-title":"The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome","volume":"12","author":"Sengoku","year":"1997","journal-title":"Hum Reprod"},{"issue":"1","key":"2019041121581484000_B30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/humupd\/dmi036","article-title":"A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome","volume":"12","author":"Heijnen","year":"2006","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2019041121581484000_B31","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.rbmo.2016.01.010","article-title":"Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes: the predictive value of anti-M\u00fcllerian hormone","volume":"32","author":"Ramezanali","year":"2016","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"2019041121581484000_B32","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tem.2016.11.008","article-title":"Oocyte competence in women with polycystic ovary syndrome","volume":"28","author":"Palomba","year":"2017","journal-title":"Trends Endocrinol Metab"},{"issue":"9389","key":"2019041121581484000_B33","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0140-6736(03)14410-8","article-title":"Formation and early development of follicles in the polycystic ovary","volume":"362","author":"Webber","year":"2003","journal-title":"Lancet"},{"issue":"11","key":"2019041121581484000_B34","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1210\/jc.2004-0643","article-title":"Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome","volume":"89","author":"Maciel","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2019041121581484000_B35","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1210\/jc.2007-0729","article-title":"Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division","volume":"92","author":"Stubbs","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2019041121581484000_B36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/humupd\/dmh010","article-title":"The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest","volume":"10","author":"Jonard","year":"2004","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2019041121581484000_B37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1095\/biolreprod.108.072801","article-title":"Developmental programming: differential effects of prenatal testosterone and dihydrotestosterone on follicular recruitment, depletion of follicular reserve, and ovarian morphology in sheep","volume":"80","author":"Smith","year":"2009","journal-title":"Biol Reprod"},{"issue":"7","key":"2019041121581484000_B38","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1210\/en.2004-1444","article-title":"Fetal programming: prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment","volume":"146","author":"Steckler","year":"2005","journal-title":"Endocrinology"},{"issue":"8","key":"2019041121581484000_B39","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/en.2014-1196","article-title":"Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models","volume":"155","author":"Caldwell","year":"2014","journal-title":"Endocrinology"},{"issue":"11","key":"2019041121581484000_B40","doi-asserted-by":"crossref","first-page":"e113155","DOI":"10.1371\/journal.pone.0113155","article-title":"Impaired glucose metabolism in response to high fat diet in female mice conceived by in vitro fertilization (IVF) or ovarian stimulation alone","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"2019041121581484000_B41","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1210\/en.2004-1108","article-title":"In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER)alpha and ERbeta null mice indicate a role for ERbeta in follicular maturation","volume":"146","author":"Emmen","year":"2005","journal-title":"Endocrinology"},{"key":"2019041121581484000_B42","unstructured":"RRID:AB_443014."},{"key":"2019041121581484000_B43","author":"Salvetti"},{"issue":"5","key":"2019041121581484000_B44","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1530\/REP-08-0491","article-title":"Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance","volume":"137","author":"Ortega","year":"2009","journal-title":"Reproduction"},{"issue":"1\u20132","key":"2019041121581484000_B45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2009.09.003","article-title":"Development and validation of a sensitive liquid chromatography\u2013tandem mass spectrometry assay to simultaneously measure androgens and estrogens in serum without derivatization","volume":"409","author":"Harwood","year":"2009","journal-title":"Clin Chim Acta"},{"issue":"14","key":"2019041121581484000_B46","doi-asserted-by":"crossref","first-page":"7180","DOI":"10.1021\/acs.analchem.5b01042","article-title":"Measurement of estradiol in human serum by LC-MS\/MS using a novel estrogen-specific derivatization reagent","volume":"87","author":"Keski-Rahkonen","year":"2015","journal-title":"Anal Chem"},{"issue":"1","key":"2019041121581484000_B47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.rbmo.2018.10.006","article-title":"Steroid profiles by liquid chromatography-mass spectrometry of matched serum and single dominant ovarian follicular fluid from women undergoing IVF","volume":"38","author":"Walters","year":"2019","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"2019041121581484000_B48","doi-asserted-by":"crossref","first-page":"e0122370","DOI":"10.1371\/journal.pone.0122370","article-title":"Impaired oocyte quality induced by dehydroepiandrosterone is partially rescued by metformin treatment","volume":"10","author":"Huang","year":"2015","journal-title":"PLoS One"},{"key":"2019041121581484000_B49"},{"key":"2019041121581484000_B50"},{"issue":"2","key":"2019041121581484000_B51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1095\/biolreprod.114.118471","article-title":"Prematuration with cyclic adenosine monophosphate modulators alters cumulus cell and oocyte metabolism and enhances developmental competence of in vitro-matured mouse oocytes","volume":"91","author":"Zeng","year":"2014","journal-title":"Biol Reprod"},{"issue":"1\u20132","key":"2019041121581484000_B52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2013.01.013","article-title":"Nonhuman primate models of polycystic ovary syndrome","volume":"373","author":"Abbott","year":"2013","journal-title":"Mol Cell Endocrinol"},{"issue":"16","key":"2019041121581484000_B53","doi-asserted-by":"crossref","first-page":"E3334","DOI":"10.1073\/pnas.1616467114","article-title":"Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome","volume":"114","author":"Caldwell","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"2019041121581484000_B54","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/en.2016-1851","article-title":"The steroid metabolome in the isolated ovarian follicle and its response to androgen exposure and antagonism","volume":"158","author":"Lebbe","year":"2017","journal-title":"Endocrinology"},{"issue":"4","key":"2019041121581484000_B55","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humupd\/dmn015","article-title":"Follicle dynamics and anovulation in polycystic ovary syndrome","volume":"14","author":"Franks","year":"2008","journal-title":"Hum Reprod Update"},{"issue":"5","key":"2019041121581484000_B56","first-page":"1355","article-title":"Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid","volume":"79","author":"Mason","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041121581484000_B57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/oxfordjournals.humrep.a137638","article-title":"Granulosa cells of polycystic ovaries: are they normal or abnormal","volume":"7","author":"Erickson","year":"1992","journal-title":"Hum Reprod"},{"issue":"11","key":"2019041121581484000_B58","first-page":"3984","article-title":"Premature response to luteinizing hormone of granulosa cells from anovulatory women with polycystic ovary syndrome: relevance to mechanism of anovulation","volume":"83","author":"Willis","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041121581484000_B59","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ando.2010.02.007","article-title":"Aberrant follicle development and anovulation in polycystic ovary syndrome","volume":"71","author":"Franks","year":"2010","journal-title":"Ann Endocrinol (Paris)"},{"issue":"3","key":"2019041121581484000_B60","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.beem.2018.03.008","article-title":"Evidence from animal models on the pathogenesis of PCOS","volume":"32","author":"Walters","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"2019041121581484000_B61","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/en.2005-1281","article-title":"Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles","volume":"147","author":"Tsai-Turton","year":"2006","journal-title":"Endocrinology"},{"issue":"2","key":"2019041121581484000_B62","doi-asserted-by":"crossref","first-page":"190","DOI":"10.14310\/horm.2002.1580","article-title":"Androgens as double-edged swords: induction and suppression of follicular development","volume":"14","author":"Pan","year":"2015","journal-title":"Hormones (Athens)"},{"issue":"9","key":"2019041121581484000_B63","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1210\/en.2014-1266","article-title":"Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep","volume":"155","author":"Padmanabhan","year":"2014","journal-title":"Endocrinology"},{"issue":"6","key":"2019041121581484000_B64","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1210\/mend.13.6.0311","article-title":"Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells from polycystic ovaries","volume":"13","author":"Nelson","year":"1999","journal-title":"Mol Endocrinol"},{"issue":"12","key":"2019041121581484000_B65","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1210\/jcem.86.12.8088","article-title":"The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome","volume":"86","author":"Nelson","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019041121581484000_B66","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13048-016-0250-y","article-title":"Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption","volume":"9","author":"Veiga-Lopez","year":"2016","journal-title":"J Ovarian Res"},{"issue":"2","key":"2019041121581484000_B67","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/toxsci\/kfl064","article-title":"Dehydroepiandrosterone inhibits complex I of the mitochondrial respiratory chain and is neurotoxic in vitro and in vivo at high concentrations","volume":"93","author":"Safiulina","year":"2006","journal-title":"Toxicol Sci"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/160\/3\/699\/27979687\/en.2018-00966.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T08:48:50Z","timestamp":1555058930000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/160\/3\/699\/5289709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":67,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,1,16]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2018-00966","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2019,1,16]]}}}