{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:10:10Z","timestamp":1790691010119,"version":"4.1.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"3","funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["123"],"award-info":[{"award-number":["123"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.1210\/en.2018-01047","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T14:09:52Z","timestamp":1547561392000},"page":"557-567","source":"Crossref","is-referenced-by-count":93,"title":["Characterization of GnRH Pulse Generator Activity in Male Mice Using GCaMP Fiber Photometry"],"prefix":"10.1210","volume":"160","author":[{"given":"Su Young","family":"Han","sequence":"first","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Kane","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaiah","family":"Cheong","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-3022","authenticated-orcid":false,"given":"Allan E","family":"Herbison","sequence":"additional","affiliation":[{"name":"Centre for Neuroendocrinology and Department of Physiology, University of Otago School of Biomedical Sciences, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"issue":"4368","key":"2019041121303032800_B1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.100883","article-title":"Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone","volume":"202","author":"Belchetz","year":"1978","journal-title":"Science"},{"issue":"1","key":"2019041121303032800_B2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1210\/edrv-7-1-11","article-title":"Hypogonadotropic disorders in men and women: diagnosis and therapy with pulsatile gonadotropin-releasing hormone","volume":"7","author":"Santoro","year":"1986","journal-title":"Endocr Rev"},{"issue":"2","key":"2019041121303032800_B3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0091-3022(03)00013-X","article-title":"Mechanisms underlying episodic gonadotropin-releasing hormone secretion","volume":"24","author":"Moenter","year":"2003","journal-title":"Front Neuroendocrinol"},{"issue":"11","key":"2019041121303032800_B4","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1210\/en.2018-00653","article-title":"The gonadotropin-releasing hormone pulse generator","volume":"159","author":"Herbison","year":"2018","journal-title":"Endocrinology"},{"issue":"17","key":"2019041121303032800_B5","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1056\/NEJMoa035322","article-title":"The GPR54 gene as a regulator of puberty","volume":"349","author":"Seminara","year":"2003","journal-title":"N Engl J Med"},{"issue":"12","key":"2019041121303032800_B6","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1210\/en.2013-1502","article-title":"Development of a methodology for and assessment of pulsatile luteinizing hormone secretion in juvenile and adult male mice","volume":"154","author":"Steyn","year":"2013","journal-title":"Endocrinology"},{"issue":"3","key":"2019041121303032800_B7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jne.12257","article-title":"Lack of pulse and surge modes and glutamatergic stimulation of luteinising hormone release in Kiss1 knockout rats","volume":"27","author":"Uenoyama","year":"2015","journal-title":"J Neuroendocrinol"},{"issue":"42","key":"2019041121303032800_B8","doi-asserted-by":"crossref","first-page":"13109","DOI":"10.1073\/pnas.1512243112","article-title":"Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion","volume":"112","author":"Han","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"47","key":"2019041121303032800_B9","doi-asserted-by":"crossref","first-page":"E10216","DOI":"10.1073\/pnas.1713897114","article-title":"Definition of the hypothalamic GnRH pulse generator in mice","volume":"114","author":"Clarkson","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"2019041121303032800_B10","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1210\/en.2018-00389","article-title":"KNDy cells revisited","volume":"159","author":"Moore","year":"2018","journal-title":"Endocrinology"},{"issue":"5 Pt 1","key":"2019041121303032800_B11","first-page":"E658","article-title":"Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone","volume":"254","author":"Spratt","year":"1988","journal-title":"Am J Physiol"},{"issue":"1","key":"2019041121303032800_B12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1095\/biolreprod.107.066126","article-title":"Age-related changes in diurnal rhythms and levels of gonadotropins, testosterone, and inhibin B in male rhesus monkeys (Macaca mulatta)","volume":"79","author":"Schlatt","year":"2008","journal-title":"Biol Reprod"},{"issue":"1","key":"2019041121303032800_B13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.theriogenology.2007.03.023","article-title":"The introduction of rams induces an increase in pulsatile LH secretion in cyclic ewes during the breeding season","volume":"68","author":"Hawken","year":"2007","journal-title":"Theriogenology"},{"issue":"2","key":"2019041121303032800_B14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1210\/endo.135.2.8033822","article-title":"Effect of undernutrition on pulsatile luteinizing hormone (LH) secretion in castrate and intact male rats using an ultrasensitive immunofluorometric LH assay","volume":"135","author":"Dong","year":"1994","journal-title":"Endocrinology"},{"issue":"3","key":"2019041121303032800_B15","first-page":"E257","article-title":"Luteinizing hormone and testosterone secretion in young and old male mice","volume":"243","author":"Coquelin","year":"1982","journal-title":"Am J Physiol"},{"issue":"10","key":"2019041121303032800_B16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/BF03349621","article-title":"Pulsatile secretion of luteinizing hormone in agonadal men before and during testosterone replacement therapy","volume":"13","author":"Genazzani","year":"1990","journal-title":"J Endocrinol Invest"},{"issue":"6","key":"2019041121303032800_B17","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1210\/endo-110-6-1905","article-title":"Effects of orchidectomy and testosterone replacement treatment on pulsatile luteinizing hormone secretion in the adult rhesus monkey (Macaca mulatta)","volume":"110","author":"Plant","year":"1982","journal-title":"Endocrinology"},{"issue":"1","key":"2019041121303032800_B18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1530\/jrf.0.0820263","article-title":"Effect of time after castration on secretion of LHRH and LH in the ram","volume":"82","author":"Caraty","year":"1988","journal-title":"J Reprod Fertil"},{"issue":"Pt 1","key":"2019041121303032800_B19","first-page":"E130","article-title":"Mapping episodic fluctuations in plasma LH in orchidectomized rats","volume":"247","author":"Ellis","year":"1984","journal-title":"Am J Physiol"},{"issue":"6","key":"2019041121303032800_B20","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1210\/endo-111-6-2055","article-title":"Regulation of luteinizing hormone pulse frequency and amplitude by testosterone in the adult male rat","volume":"111","author":"Steiner","year":"1982","journal-title":"Endocrinology"},{"issue":"11","key":"2019041121303032800_B21","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12435","article-title":"Visualisation of Kiss1 neurone distribution using a Kiss1-CRE transgenic mouse","volume":"28","author":"Yeo","year":"2016","journal-title":"J Neuroendocrinol"},{"issue":"12","key":"2019041121303032800_B22","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1210\/en.2016-1351","article-title":"Pulse and surge profiles of luteinizing hormone secretion in the mouse","volume":"157","author":"Czieselsky","year":"2016","journal-title":"Endocrinology"},{"issue":"3 Pt 1","key":"2019041121303032800_B23","first-page":"E338","article-title":"Interpulse interval sequence of LH in normal men essentially constitutes a renewal process","volume":"250","author":"Butler","year":"1986","journal-title":"Am J Physiol"},{"issue":"5 Pt 1","key":"2019041121303032800_B24","first-page":"E795","article-title":"Stochastic modeling of the hypothalamic pulse generator activity","volume":"267","author":"Camproux","year":"1994","journal-title":"Am J Physiol"},{"issue":"1","key":"2019041121303032800_B25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0006-8993(92)90324-3","article-title":"Hypothalamic electrical activity that relates to the pulsatile release of luteinizing hormone exhibits diurnal variation in ovariectomized rats","volume":"582","author":"Hiruma","year":"1992","journal-title":"Brain Res"},{"issue":"12","key":"2019041121303032800_B26","doi-asserted-by":"crossref","first-page":"e12660","DOI":"10.1111\/jne.12660","article-title":"Sex- and sub region-dependent modulation of arcuate kisspeptin neurones by vasopressin and vasoactive intestinal peptide","volume":"30","author":"Schafer","year":"2018","journal-title":"J Neuroendocrinol"},{"issue":"21","key":"2019041121303032800_B27","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1073\/pnas.87.21.8580","article-title":"Duration of phasic electrical activity of the hypothalamic gonadotropin-releasing hormone pulse generator and dynamics of luteinizing hormone pulses in the rhesus monkey","volume":"87","author":"Williams","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"2019041121303032800_B28","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1523\/JNEUROSCI.2925-16.2017","article-title":"Spike and neuropeptide-dependent mechanisms control GnRH neuron nerve terminal Ca2+ over diverse time scales","volume":"37","author":"Iremonger","year":"2017","journal-title":"J Neurosci"},{"issue":"51","key":"2019041121303032800_B29","doi-asserted-by":"crossref","first-page":"18387","DOI":"10.1073\/pnas.1415226112","article-title":"Optogenetic activation of GnRH neurons reveals minimal requirements for pulsatile luteinizing hormone secretion","volume":"111","author":"Campos","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041121303032800_B30","doi-asserted-by":"crossref","first-page":"e16246","DOI":"10.7554\/eLife.16246","article-title":"High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons","volume":"5","author":"Qiu","year":"2016","journal-title":"eLife"},{"key":"2019041121303032800_B31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35656","article-title":"Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females","volume":"7","author":"Qiu","year":"2018","journal-title":"eLife"},{"issue":"11","key":"2019041121303032800_B32","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.1210\/en.2011-1143","article-title":"Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse","volume":"152","author":"Navarro","year":"2011","journal-title":"Endocrinology"},{"issue":"7","key":"2019041121303032800_B33","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1210\/en.2016-1807","article-title":"Tac1 signaling is required for sexual maturation and responsiveness of GnRH neurons to kisspeptin in the male mouse","volume":"158","author":"Maguire","year":"2017","journal-title":"Endocrinology"},{"issue":"8","key":"2019041121303032800_B34","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1210\/en.2013-1268","article-title":"Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and \u03ba-opioid receptors in adult male mice","volume":"154","author":"Ruka","year":"2013","journal-title":"Endocrinology"},{"key":"2019041121303032800_B35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-1-4614-6199-9_16","article-title":"Electrophysiology of kisspeptin neurons","volume":"784","author":"Alreja","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"2019041121303032800_B36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnins.2015.00029","article-title":"Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human","volume":"9","author":"Skrapits","year":"2015","journal-title":"Front Neurosci"},{"issue":"10","key":"2019041121303032800_B37","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1210\/en.2017-00382","article-title":"Long-term recordings of arcuate nucleus kisspeptin neurons reveal patterned activity that is modulated by gonadal steroids in male mice","volume":"158","author":"Vanacker","year":"2017","journal-title":"Endocrinology"},{"issue":"11","key":"2019041121303032800_B38","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1210\/en.2012-1616","article-title":"Spontaneous kisspeptin neuron firing in the adult mouse reveals marked sex and brain region differences but no support for a direct role in negative feedback","volume":"153","author":"de Croft","year":"2012","journal-title":"Endocrinology"},{"key":"2019041121303032800_B39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yfrne.2014.05.006","article-title":"Electrical properties of kisspeptin neurons and their regulation of GnRH neurons","volume":"36","author":"Piet","year":"2015","journal-title":"Front Neuroendocrinol"}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/article-pdf\/160\/3\/557\/27887263\/en.2018-01047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T05:41:10Z","timestamp":1555047670000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/160\/3\/557\/5288756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,1,15]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/en.2018-01047","relation":{},"ISSN":["1945-7170"],"issn-type":[{"value":"1945-7170","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2019,1,15]]}}}