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This process occurs primarily in brown and beige adipose tissue. Thermogenesis is regulated by many factors, including lipid derived paracrine and endocrine hormones called lipokines. Recently, technologic advances for identifying new lipid biomarkers of thermogenic activity have shed light on a diverse set of lipokines that act through different pathways to regulate energy expenditure. In this review, we highlight a few examples of lipokines that regulate thermogenesis. The biosynthesis, regulation, and effects of the thermogenic lipokines in several families are reviewed, including oloeylethanolamine, endocannabinoids, prostaglandin E2, and 12,13-diHOME. These thermogenic lipokines present potential therapeutic targets to combat states of excess energy storage, such as obesity and related metabolic disorders.<\/jats:p>","DOI":"10.1210\/en.2019-00337","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T18:45:57Z","timestamp":1565203557000},"page":"2314-2325","source":"Crossref","is-referenced-by-count":34,"title":["Lipokines and Thermogenesis"],"prefix":"10.1210","volume":"160","author":[{"given":"Matthew D","family":"Lynes","sequence":"first","affiliation":[{"name":"Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean D","family":"Kodani","sequence":"additional","affiliation":[{"name":"Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2053-9559","authenticated-orcid":false,"given":"Yu-Hua","family":"Tseng","sequence":"additional","affiliation":[{"name":"Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts"},{"name":"Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"issue":"4","key":"2020072320064579200_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1139\/y89-063","article-title":"Role of thermogenesis in the regulation of energy balance in relation to obesity","volume":"67","author":"Himms-Hagen","year":"1989","journal-title":"Can J Physiol 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